In this paper Atlantic blue marlin (ABM) optimization algorithm, Boops optimization (BO) algorithm, Chironex fleckeri Search Optimization (CSO) algorithm, General practitioner -Sick person (PS) optimization algorithm are applied for solving factual power loss reduction problem. The regular actions of Atlantic blue marlin are emulated to design the Atlantic blue marlin (ABM) optimization algorithm and populace in the examination space is capriciously stimulated. Boops optimization (BO) algorithm is designed by imitating the actions of Boops. Boops possess the obliging stalking physiognomies. As a cluster they stalk the quarry by forming the key and subordinate clusters CSO is based on the drive and search behaviour of Chironex fleckeri. Obviously Chironex fleckeri will exploit the limbs to paralyze the pray by injecting the rancour. In real time world a General practitioner will treat the Sick person with various procedures and it has been imitated to model the Projected PS algorithm. In general people will be inoculated and then with respect to disorder and disease- medical treatment will be given by medicines. Inoculation, medicine and operation are the procedures have been considered as the phases of the projected PS algorithm. Atlantic blue marlin (ABM) optimization algorithm, Boops optimization (BO) algorithm, Chironex fleckeri Search Optimization (CSO) algorithm, General practitioner -Sick person (PS) optimization algorithm validated in IEEE 57, 300 systems and 220 KV network. Factual power loss lessening, power divergence restraining, and power constancy index amplification has been attained.
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