Factors In Hemodialysis Patients Research Articles

Irritable bowel syndrome frequency and related factors in hemodialysis patients

Irritable bowel syndrome (IBS) is a functional bowel disease that is common in society, does not threaten life, impairs quality of life, and causes serious economic losses. Gastrointestinal system complaints and especially IBS are common in patients with chronic kidney disease. It has also been shown that psychiatric diseases are more common in patients with IBS. In this study, we aimed to determine the frequency of IBS in hemodialysis patients and to investigate the factors associated with IBS. In this cross-sectional study, the questionnaire prepared to evaluate depression, anxiety, and abdominal pain was administered face-to-face to 686 patients by the same researcher in seven dialysis centers; 404 patients without exclusion criteria were included in the study. The diagnosis of IBS was made according to Rome IV criteria. A multivariate logistic regression model was used to identify factors that are significantly related to IBS. In 69 (17.1%) of the patients included in the study, symptoms were consistent with IBS. Binominal logistic regression analysis was performed to evaluate the effect of age, dialysis duration, diabetes, proton pump inhibitor, non-steroidal anti-inflammatory drugs, calcium acetate use, Hamilton depression and anxiety scores associated with IBS in the presence of IBS of the participants. The logistic regression model was statistically significant, χ2 (3) = 69.748, P < 0.001. Independent risk factors for IBS in hemodialysis patients were determined as anxiety, long-term dialysis treatment, and using calcium acetate as a phosphorus binder. In hemodialysis patients, IBS occurs approximately twice as often as in a healthy population. Independent risk factors for IBS in hemodialysis patients are anxiety, long-term dialysis treatment, and using calcium acetate as a phosphorus binder.

Predictive model of bleeding following endoscopic sphincterotomy for the treatment of choledocholithiasis in hemodialysis patients: A retrospective multicenter study.

Background and AimAlthough hemodialysis (HD) is a strong risk factor for postendoscopic sphincterotomy (ES) bleeding, additional risk factors in HD patients remain unclear. There is no model for predicting post‐ES bleeding risk in HD patients. Therefore, we conducted a retrospective multicenter study to reveal these risk factors and develop a predictive model of post‐ES bleeding in HD patients.MethodsWe retrospectively reviewed the medical records of HD patients who underwent ES at eight hospitals between January 2006 and December 2016, with post‐ES bleeding as the main outcome measure. Univariate analyses were performed to extract possible risk factors for post‐ES bleeding. Factors that were clinically important and statistically significant in our univariate analyses were then included in our logistic regression analysis for the development of a multivariate predictive model of post‐ES bleeding. This predictive model was visualized using a predictive nomogram.ResultsPost‐ES bleeding occurred in 20 (16.3%) of 123 HD patients. Based on clinically important factors and the results of our univariate analyses, platelet count, prothrombin time (international normalized ratio), and HD duration were included in our predictive model of post‐ES bleeding. Receiver operating characteristic analysis found that this model had an area under the curve of 0.715 (95% confidence interval, 0.609–0.822). We developed a predictive nomogram based on these results.ConclusionsWe demonstrated that post‐ES bleeding is more common in HD patients than in the general population and succeeded in constructing a predictive model that can effectively identify HD patients at risk of post‐ES bleeding.

The prevalence of malnutrition in hemodialysis patients

Introduction: Malnutrition is a complex, multi-factorial and common problem in patients with end-stage renal disease (ESRD) undergoing hemodialysis that increases morbidity and mortality rate in them. Objectives: To assess the prevalence of malnutrition and associated factors in hemodialysis patients. Patients and Methods: This cross-sectional study was conducted on 239 hemodialysis patients (162 males and 77 females) referred to three dialysis centers in Ahvaz, Iran in 2018. The nutritional statuswas measured using subjective global assessment (SGA)tool. The anthropometric indices, body mass index (BMI) and biochemical parameters including albumin, triglyceride, C-reactive protein (CRP), and adequacy of dialysis (Kt/V) were also measured in all patients. Results: Based on SGA, 45 (18.8%) patients including 32 males and 13 females had mild to moderate malnutrition while 26 (10.9%) patients consisting of 11 men and 15 women had severe malnutrition. We found a significant association between patients’ gender and malnutrition status (P=0.013). In addition, a significant association was seen between age (P=0.024), BMI (P=0.0001), CRP (P=0.047) and serum albumin concentration (P=0.007) with nutritional status. However, we did not find any significant association between triglyceride, Kt/V and duration of hemodialysis per week with malnutrition (P&gt;0.05). Moreover, BMI, patient’s gender and serum albumin were the significant predictors of severe malnutrition in hemodialysis patients (P&lt;0.05). Conclusion: According to high prevalence of malnutrition in ESRD patients undergoing hemodialysis, periodic assessment of nutritional status is necessary for them. Moreover, female patients, CRP, serum albumin and BMI showed a significant correlation with SGA score, which are important to determine the nutritional status of hemodialysis patients (HD) patients.

Impact of curcumin supplementation on expression of inflammatory transcription factors in hemodialysis patients: A pilot randomized, double-blind, controlled study.

Chronic kidney disease (CKD) patients have numerous complications associated with inflammation, which is a potential driver for cardiovascular disease. Curcumin, a compound of the curcuminoid class produced by the Curcuma longa, has been reported to activate nuclear factor erythroid factor 2-related (Nrf2) and inhibit nuclear factor kappa-B (NF-kB). Our aim was to evaluate the effects of curcumin juice on the expression of inflammatory transcription factors in hemodialysis (HD) patients. This double-blind randomized pilot study included 31 HD patients divided into two groups: curcumin group (receiving 100mL of orange juice with 12g of carrot and 2.5g of turmeric after each dialysis session/week for 3 months) and control group (receiving the same juice without curcumin); 14 patients in each arm completed the study. The mRNA expression of Nrf2, NF-kB, NLRP3 inflammasome and IL-1β in peripheral blood mononuclear cells (PBMC; using real-time quantitative polymerase chain reaction, qPCR) and routine biochemistries, food intake and anthropometrics were analyzed. After three months of supplementation, the curcumin group showed a significant decrease in NF-kB mRNA expression (AU) [from 1.08 (0.77-1.38) to 0.52 (0.32-0.95),p=0.02] and in plasma high sensitivity C-reactive protein (hsCRP) levels [from 3.8 (2.5-6.8) to 2.0 (1.1-3.8) mg/L, p=0.04]. There was no change in the other evaluated markers. Three months treatment with curcumin in CKD patients undergoing HD resulted in decreased markers of inflammation, NF-kB mRNA expression and hsCRP, suggesting that oral supplementation of curcumin may have an anti-inflammatory effect in this patient group. Approved by the Ethics Committee of the Faculty of Medicine/UFF, number: 2.346.933. This study was registered within ClinicalTrials.gov under the number NCT03475017.

SUN-063 Evaluation of serum selenium level and its related factors in hemodialysis patients

Selenium (se) is an essential dietary trace element that influences immune system, reproductive system, DNA synthesis, antioxidant defence and has a key role in a wide variety of metabolic pathways and biological processes. Many studies have shown that serum selenium level is reduced in hemodialysis patients. This paper tries to measure and examine the influence of age, duration of dialysis and KT/V on the selenium level in hemodialysis patients. A descriptive cross-sectional study was designed. Data was collected by using patient’s file and sending blood sample to the lab. Through using the sample measurement method, the sample size has come to 215. But due to limitations we could only collect 189 patient’s data. Data were analyzed by Pearson correlation coefficient using SPSS (Ver. 22) software. The mean level of selenium in hemodialysis patients (15-79 years old) was 44.4±9.7 μg/dl. There was a significant relationship between serum selenium level and KT/V (p=0.04) but there was no significant relationship between serum selenium and age (p=0.79), dialysis duration (p=0.77), dialysis weekly (p=0.99), duration of dialysis year (p=0.11) (p>0.05). According to the key role of selenium in cardiovascular disease, anemia, cancer, immune system and its importance to hemodialysis patients we can prevent these by controlling selenium level properly. This study would have benefited from a bigger sample size and measurement of selenium level in normal people.

Prevalence of Cardiovascular Risk Factors in Chronic Hemodialysis Patients at the University Hospital Center of Point G in Bamako, Mali

Introduction: A cardiovascular risk factor (FDRCV) is defined as a physiological, pathological or environmental attribute or characteristic that results in an increased likelihood of developing cardiovascular disease in the individual in whom it is detected. The objective of this study was to determine the prevalence of cardiovascular risk factors in hemodialysis patients on hemodialysis at the University Hospital of Point G. Patients and Methods: This was a cross-sectional descriptive study with prospective data collection from March 3, 2009 to March 5, 2010 (13 months). Included were all patients with end-stage renal disease (ESRD) receiving chronic hemodialysis in the Nephrology and Hemodialysis Department of the University Hospital of Point G during the study period. Results: Eighty-eight patients were enrolled. The M/F sex ratio was 1.26. The mean age was 41.32 years with extremes of 17 and 81 years. The classic cardiovascular risk factors in order of frequency were: hypertension (90.9%), sedentary lifestyle (71.6%), male sex (54.5%), age ≥ 55 years (21.6%), obesity (13.6%), diabetes (8%), tobacco (8%), alcohol (3.4%). Cardiovascular risk factors related to CKD were: anemia (98.9%), phosphocalcic disorders (85.2%), arteriovenous fistula (AVF) (80%), lipid abnormalities (36.5%), hydrosodium inflation (29.5%). Predominant cardiovascular complications were hypertensive heart disease (62.5%), acute pulmonary oedema (APO) (50%), rhythm disorders (23.9%), coronary insufficiency (18.2%). The mortality rate was 17%. Conclusion: Cardiovascular risk factors are frequent in chronic hemodialysis. They contribute to the excess mortality of these patients. Adequate management of these risk factors can slow down serious cardiovascular complications and reduce the risk of mortality in this fragile population.

Self-care Agency and Its Influential Factors in Hemodialysis Patients

Self-care Agency and Its Influential Factors in Hemodialysis Patients

Study of Lifestyle, Sleep Quality, and Related Factors in Hemodialysis Patients

Study of Lifestyle, Sleep Quality, and Related Factors in Hemodialysis Patients

Investigation of factors related to N-terminal pro-B type natriuretic peptide levels in hemodialysis patients; a single center study

Introduction: Introduction: N-terminal pro-B type natriuretic peptide (NT-proBNP) can be used to diagnose cardiac and renal disease. The association of NT-pro BNP with demographic, clinical and biochemical factors in hemodialysis is unclear. Objectives: This study aimed to examine association of NT-pro BNP and mentioned factors in hemodialysis patients. Patients and Methods: This study was conducted on 78 end-stage renal disease (ESRD) patients under hemodialysis. Demographic data, lipid profile and electrolytes were recorded. NT-proBNP was checked simultaneously and its association with mentioned factors were assessed. Results: The average NT-pro BNP level was 890.52±700.87 pg/mL (range: 0.1-3343 pg/mL). Serum level of NT-pro BNP was statistically in association with total cholesterol (P=0.002; r=-0.348), low density lipoprotein (LDL) (P=0.09; r= -0.292), high density lipoprotein (HDL) (P=0.06; r=-0.310) and serum triglyceride (P=0.018; r=-0.269) while having a direct relationship with serum ferritin (P=0.022; r=0.274), alkaline phosphatase (ALP) (P=0.048; r=0.224) and duration of hemodialysis (P=0.005; r=0.321). Conclusion: Lipid profile and ferritin are associated with NT-pro BNP levels. This can reflect possible prognostic role of NT-proBNP among ESRD patients on hemodialysis.

FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KEPATUHAN MENJALANI TERAPI HEMODIALISA PADA PASIEN GAGAL GINJAL KRONIK DI RSU. ROYAL

Obodience is one of the problem factors in hemodialysis patients who experience chronic kidney disese. Noncompliance can lead to therapiutic failur thereby decreasing the patient’s quality of life,increasing mortality and morbidity. The severy of renal impairment determines the type of treatment and treatment given. In some cases, damage to kidney failur and circulation can be prevented by taking medication to control blood pressure and control blood cholesterol levels. At least 1 out of 100 people with kidney stroke will have kidney failur. People with chronic renal failur require furtur treatment to replace a number of kidney functions such as performing hemodialysis. The purpose of this study was to determine the factor associated with hepatitis undergoing hemodyalis in patien with chronic renal failure in Royal prima hospital, patient with chronic renal failur who undergo hemodyalisis in royal prima hospital 114 patients in september.The type of research used is analytic with cross sctional design. The population of 114 respondents and the sample is 29 respondents. Sampling technique in this research is by perposive sampling technique. Data is processed and analyzed by Chi-square test. Data colection method by filling queationer.Based on the result of this research,there is a significant corelation between adherence with motivation (p=0,069), age (p=0,002), family support (p= 0,002). The concclusion of this research is that there is connection between the faktors associated with our live hemodialisa in patients with kidney failur in patients with kidney failur in royal prima hospital in 2018.

Common Sleep Disorders and Risk Factors in Hemodialysis Patients

Common Sleep Disorders and Risk Factors in Hemodialysis Patients

Study of Self-care and Its Related Factors in Hemodialysis Patients in Kermanshah

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25(OH) vitamin D: Serum levels and related factors in hemodialysis patients

Background and Objective: Advanced chronic renal failure leads to changes in calcium metabolism that cause disturbances in the parathyroid, vascular system, and bones. The 25(OH) Vitamin D plays a key role in regulating calcium metabolism and preventing these complications. The objective of this study was to determine 25(OH) Vitamin D levels in dialysis patients and to relate to clinical and sociodemographic characteristics. Methods: This was a cross-sectional study. The data collection was given by interview and consultation in electronic records, and the dosage of 25(OH) Vitamin D was performed on heparinized plasma samples collected at the beginning of the dialysis session. Results: Of the 77 patients studied, noted that seven (9.1%) showed poor values of 25(OH) Vitamin D and 19 (24.7%) showed insufficient values. As for the presence of comorbidities, 31 (40.3%) reported having diabetes mellitus, and 54 (70.1%) reported having arterial hypertension. It was also observed that the serum levels of 25(OH) Vitamin D are inferior in the carriers of diabetes mellitus and decrease with the increase of age and with the elevation of serum creatinine. The use of Vitamin D supplements presented positive correlation with serum calcium levels. Conclusion: The insufficiency of 25(OH) Vitamin D is frequent in dialysis patients especially in the carriers of diabetes mellitus.

Aerobic Exercise Training and Nontraditional Cardiovascular Risk Factors in Hemodialysis Patients: Results from a Prospective Randomized Trial

Introduction: Chronic kidney disease (CKD) patients have a high incidence of cardiovascular diseases (CVD) which increases their morbidity and mortality. A sedentary lifestyle in CKD is directly linked to the onset of CVD. Physical activity can bring beneficial effects to CKD patients. Aims: The aim of this study was assess the impact of aerobic training on nontraditional cardiovascular risk factors in CKD patients on hemodialysis. Materials and Methods: This is a prospective, controlled, and randomized clinical trial with analysis of intention to treat. Thirty patients underwent an exercise treadmill test, an arterial stiffness evaluation, echocardiography and analysis of endothelial reactivity, and carotid ultrasound and laboratorial tests, including analysis of serum aldosterone. The intervention group (IG) (n =15) underwent aerobic exercise during hemodialysis 3 times a week for 4 months. The control group (CG) (n =15) had no intervention. All of the patients were reassessed after 4 months. Results: In the IG, there was a statistically significant improvement in flow-mediated vasodilation (FMV; p = 0.002) and a reduction in left ventricular hypertrophy (p = 0.006) and serum aldosterone (p = 0.016). There was an increase in C-reactive protein in the CG (p = 0.002). Conclusion: This aerobic training protocol was able to improve endothelial function with enhanced FMV and reduce left ventricular hypertrophy and serum aldosterone, which could have a positive impact on the reduction of nontraditional cardiovascular risk factors in CKD patients on hemodialysis.

Common Sleep Disorders and Risk Factors in Hemodialysis Patients

Common Sleep Disorders and Risk Factors in Hemodialysis Patients

Epidemiologic Pattern of Patients with Chronic Renal Failure and Related Factors in Hemodialysis Patients of Shahid Ayatollah Ashrafi Esfahani Hospital in Tehran in 2017

Epidemiologic Pattern of Patients with Chronic Renal Failure and Related Factors in Hemodialysis Patients of Shahid Ayatollah Ashrafi Esfahani Hospital in Tehran in 2017

Uremic pruritus and associated factors in hemodialysis patients: A multi-center study.

BackgroundUremic pruritus is a common and disturbing problem in hemodialysis patients. Although its pathogenesis is not completely understood, it is thought to be multifactorial. The aim of this study was to identify risk factors of uremic pruritus in hemodialysis patients.MethodsA total of 249 patients from four dialysis centers were included in this study. Data were collected using a questionnaire, the visual analogue scale, and the Hospital Anxiety and Depression Scale. We investigated whether socio-demographic and biochemical parameters were correlated to uremic pruritus.ResultsPruritus was present in 53.4% of the hemodialysis patients. The mean visual analogue scale severity was 6.47 ± 1.56. Patients with white blood cell (WBC) counts > 6.7 × 103/μL had 1.73 times (95% confidence interval [CI], 1.360–2.888; P = 0.036) more pruritus than did those with WBC counts < 6.7 × 103/μL. Patients with dry skin were 0.2 times (95% CI, 0.070–0.182; P = 0.028) more likely to suffer from very severe pruritus than were those with normal skin.ConclusionUremic pruritus remains a serious problem in dialysis patients. The WBC level and presence of dry skin are thought to be among its causes. Therefore, data regarding the possible risk factors of uremic pruritus must be followed closely in patients at risk.

Evaluation of the Prevalence of Oral Manifestations and the Related Factors in Hemodialysis Patients at Selected Hospitals of Tehran Province in 2016

Evaluation of the Prevalence of Oral Manifestations and the Related Factors in Hemodialysis Patients at Selected Hospitals of Tehran Province in 2016

Comparison of cardiovascular risk factors in maintenance hemodialysis patients based on phase angle of bioimpedance analysis

Mortality and morbidity rate, especially from cardiovascular disease in hemodialysis patients in Indonesia is still quite high. One of indicator to assess the predictive value of mortality is the phase angle (PhA) of bioimpedance analysis (BIA) scan examination. Determining the comparison of BMI and laboratory data as cardiovascular risk factors in hemodialysis patients based on PhA.A cross-sectional analytical study was done on 155 outpatientsin RasyidaRenal Hospital, Medan in 2016. Patients were two groups, namely PhA<4 group and ≥ 4 group. The comparison of BMI and laboratory data based on PhA were by analyzingthe independent T-test. A P-value <0.05 was considered statistically significant. Most of thepatients are male (56.7%), obese (39.4%), with age 40-59 years (56.1%). Based on PhA, 56.7% patients have PhA ≥4. There are differences in the profile of age (p: 0.01), BMI (p: 0.028) and hemoglobin (p: 0.00) between two groups, but not in the profile of albumin (p: 0.071), total cholesterol (p: 0.65), HDL (p: 0.06), LDL (p: 0.07), triglyceride (p: 0.87), calcium (p: 0.59) and phosphorus (p: 0.17).Based onPhA, the cardiovascular risk factors of hemodialysis patients were determined by age, BMI, and hemoglobin.

Assessment of volume status with cardiovascular risk factors in hemodialysis patients

Assessment of volume status with cardiovascular risk factors in hemodialysis patients