AbstractAn autops‐ case of a 32‐ear old nulliparous woman who died of acute fatt‐ liver of pregnanc‐ (AFLP) associated with h‐perlipidemia, acute hemorrhagic pancreatitis and disseminated intravascular coagulation (DIC) is reported. Although acute pancreatitis has been reported as one of the major complications of AFLP, their interrelationships are poorl‐ understood because of the rarit‐ and the fulminating nature of this disease. H‐perlipidemia has been interpreted as the etiological factor in acute pancreatitis. It is also known that an increase in circulating lipids occurs during pregnanc‐ ph‐siologicall‐. AFLP presents itself onl‐ in the last trimester of pregnanc‐. The intention of the following report is to document a case of AFLP with evidence of supra‐ph‐siologic h‐perlipidemia and to discuss the pathogenesis of AFLP and acute pancreatitis.