Increased obesity is closely related to insulin resistance (IR) promoting the development of type 2 diabetes (T2D) and cardiovascular disease. IR represents a well established risk factor for development of hypertension, but the significance of the associations between the IR and obesity in the development of hypertension in overweight patients with type 2 diabetes (T2D) still remains unclarified. We analyzed the levels of insulin resistance in: overweight T2D patients with hypertension (group A, n=48, 30≤ BMI ≥25kg/m2), overweight T2D patients without hypertension (group B, n=43, 30≤ BMI ≥25kg/m2) and overweight nondiabetics without hypertension (group C, n=40, 30≤ BMI ≥25kg/m2). Patients were aged 40–70 years, matched by gender, duration of diabetes, with optimal metabolic control (HbA1c=6.5+/−0.6%). Hypertension was defined as systolic BP ≥140 and diastolic BP ≥ 90mmHg measured by sphygmomanometer, or by established use of antihypertensive drugs. Assessment of IR were done with two complementary indexes of insulin sensitivity: (1) oral glucose insulin sensitivity (OGIS) index derived from 75 g oral glucose tolerance test and (2) homeostasis model assessment of insulin resistance (HOMA-IR) determined from fasting glucose and plasma insulin (PI) levels. PI and levels were measured by RIA method. We have found significantly higher PI levels in group A (A: 38.05+/−4.24; B: 29.33+/−3.13; C:21.34+/−2.23 mIU/ml, A vs B; A vs C and B vs C p<0.05). Simultaneously, there was no significant difference in the level of HOMA-IR among diabetics (A: 9.43+/−2.69; B: 7.52+/−2.08; C: 5.73+/−1.83; A vs B p=NS; A vs C and B vs C p<0.05), reflecting hepatic insulin sensitivity. However, lowest OGIS were found in group A, being significantly lower in group A in comparison to group B (A: 287.67±35.42; B: 359.22±32.0; C: 494.29±23.81; A vs B p<0.05; A vs C p<0.01 and B vs C p<0.05) as measurement of peripheral IR. We have not found significant correlation between PI and presence of hypertension (r=0.177, p=NS). Also, there was no significant correlation between HOMA-IR and presence of hypertension among diabetics (r=0.218, p=NS). However, presence of hypertension among diabetics negatively correlate with OGIS index (r=−0.384, p<0.01), and in the model of linear regression analysis level of OGIS predicting the presence of hypertension irrespectively of the obesity (β= −0.334, p=0.07). Our results imply that increased peripheral insulin resistance compared to hepatic insulin resistance stronger influence the presence of hypertension in overweight type 2 diabetic patients. Moreover, this association was not depending of obesity.