Abstract
To test the hypothesis that sustained shivering is a determining factor in development of hypertension in rats subjected to prolonged exposure to cold, the effect of cold exposure to 6°C was examined in two experimental models with reduced shivering response to cold: aged (18 months old) rats and adult rats (8 months old) preacclimated to a less severe cold. The slow increase of colonic temperature in response to 6°C cold, characteristic for reduced shivering, was observed in both experimental groups, while systolic pressure failed to increase. Results support the hypothesis that sustained shivering is a determining factor in development of cold-induced hypertension.
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