The COVID-19 pandemic has posed a global challenge, leading different nations to adopt diverse strategies for prevention and control. In Thailand, Village Health Volunteers (VHVs) have played a pivotal role in the fight against the virus. As the pandemic unfolded, the critical role of VHVs became apparent, prompting a closer examination of their practices and the underlying factors contributing to their effectiveness. This study aimed to uncover the underlying factors and indicators contributing to the successful prevention and control of COVID-19 by VHVs in Thailand. The sample group included 10,400 VHVs nationwide. Data were collected from October 2020 to February 2021 using five-point Likert rating scale online questionnaires. Data were analyzed using the Exploratory Factor Analysis technique, with Principal Component Analysis and the orthogonal Varimax method. The study revealed nine effective factors and 52 indicators contributing to the prevention and control of COVID-19 in Thailand. The identified factors are as follows: 1) Personal precautions, 2) Proactive disease control strategy, 3) Awareness of COVID-19 severity, 4) Pride and job motivation, 5) Adequate medical equipment and support, 6) Communication, planning, and monitoring processes, 7) Self-care for health, 8) Data collection, record maintenance, and report submission, and 9) Proper hand washing. This research emphasizes the importance of a holistic approach to community-based health interventions. It highlights the crucial role of VHVs in disseminating information, ensuring preparedness, and fostering a sense of responsibility among community members. This strategic approach will effectively contribute to ongoing efforts to successfully prevent and control the spread of COVID-19 and potential future outbreaks.