Statement of the Problem: When replacing the maxillary central incisor (MCI) or adjusting its dimensions, Syrian dentists may have difficulties in selecting the appropriate size due to the lack of a dental anthropometric database for Syrian society. Purpose: The purpose of this observational study was to investigate the correlation between MCI dimensions and face length and width in Syrian females and males. Materials and Methods: The study included 180 Syrian participants (90 females and 90 males) without facial or dental defects and aged between 20 and 25 years. A digital photograph of each individual's face was taken to measure face length and width. Maxillary stone casts were made for each individual to assess the MCI width and height using a digital caliper. The correlation between facial and dental variables was investigated with the Pearson correlation coefficient. Moreover, intersex variations were tested using an independent-sample t-test (p < 0.05 considered significant). Results: The mean MCI width was 8.58 mm, the mean MCI cervical width was 7.96 mm, the mean MCI height was 9.69 mm, the average MCI width-to-height ratio was 89%, and the average MCI cervical width-to-height ratio was 82%. The intersex variations in dental values were not statistically significant. None of the studied facial dimensions showed any significant correlation with any of the MCI measurements. Conclusion: The faces of Syrian men were larger than those of Syrian women, but their MCIs had similar proportions and sizes. Facial height and width were not the appropriate parameters for determining MCI size for Syrians.