A 3-month-old otherwise healthy girl with known eczema presented to the Department of Pediatrics with acute onset of a facial rash and fever of 39 °C. On examination, the infant was systemically well and stable hemodynamically. She had confluent areas of skin crusting and weeping over the entire face, with disseminated monomorphic, umbilicated, vesiculopapular lesions (Figure 1, A). Facial edema and cervical lymphadenopathy were also present. Despite therapy with oral cefaclor (30 mg/kg/d, 3 times daily) and cetirizine hydrochloride liquid drops (0.25 mg/kg/d, twice daily) for 3 consecutive days, eczema lesions worsened.