Tunnel structure are often subjected to continuous deformation caused by the creep effect of soft rock, leading to posing significant long-term operational risks. This paper focuses on ensuring the safe operation of a typical soft rock tunnel in the complex and dangerous mountainous area of western China. On the basis of studying the structural mechanic characteristics of the tunnel under the influence of soft rock creep, the VlseKriterijumska Optimizacija I Kompromisno Resenje (VIKOR) model based on Analytic Hierarchy Process (AHP) and Entropy Weight Method (EWM) to determine subjective and objective weights, and game theory (GT) to obtain comprehensive weights was established. Additionally, the differential evolution-grey wolf optimization (DE-GWO) improved extreme learning machine (ELM) model was also constructed. By comparing the safety evaluation results of the two models on typical monitoring sections of soft rock tunnel structure, it is demonstrated that the proposed knowledge-based decision-making and data-driven models effectively and accurately evaluated the long-term safety of typical monitoring sections. Ulteriorly, to address the issue of structure safety evaluation caused by the inability to comprehensively monitor the entire tunnel (missing monitoring data), the DE-GWO improved ELM model was further adopted, and the structure safety status of the entire tunnel was precisely deduced.