Extramedullary Ewing's Sarcoma Research Articles

Drop metastasis from the extradural to the intradural space in spinal Ewing's sarcoma - a novel case report.

Spinal Ewing's Sarcoma is a rare tumour predominantly affecting children and adolescents. We describe the case of an 18-year-old male patient who first presented with a primary extradural cervical Ewing's sarcoma tumour, and 5 years later had a recurrence with thoracolumbar and lumbosacral intradural extramedullary Ewing's sarcoma tumours. Both presentations were successfully treated by surgical resection and adjuvant chemo- and radiotherapy, and he remains disease-free at 12 months follow-up. This is the first reported case of seeding of tumour from an extradural primary Ewing's sarcoma to intradural metastases. Total surgical resection of his initial cervical tumour, performed at another centre, was complicated by a dural tear and CSF leak. Thus, we propose that isolated drop metastasis via CSF fistula is the most likely mechanism for tumour spread in this case. Thus, clinicians may wish to counsel patients on the possibility of such spread if a CSF leak is encountered, and potentially increase the frequency of imaging surveillance of the whole spine in this context.

Childhood spinal extradural EWING'S sarcoma: A case report

Extraosseous, extradural and extramedullary Ewing's sarcoma is a rare tumor that usually affects young people. We report a 10 years old child operated for Inguinal Hernia at the age of 4 years which presents a lumbar spinal syndrome for 4 months, the second is a 3 years old child with a history of falls on stairs 4 months ago, presented for 14 days before his admission a right leg paresis at ⅗ on the muscular testing, associated with fever. Both patients underwent magnetic resonance imaging that showed a compressive extradural process from L2 to L5 for the first case and a compressive extradural process from L4 to S2 for the second case. The patients benefited from macroscopic total resection by laminectomy. Histology confirms the diagnosis of Ewing’s Sarcoma. Both patients were referred at discharge to the pediatric oncology department for complementary chemotherapy management. The long-term follow-up at three years was good clinically with no recurrence on imaging. Spinal Ewing’s Sarcoma extradural without bone involvement remains rare and its overall survival at 5 years is still poor.

Cervical primary ewing's sarcoma in intradural and extramedullary location and skip metastasis to cauda equine

Ewing's Sarcoma (ES) is a rare malignant tumor that commonly arises from skeletal bone but rarely has an extraskeletal origin. Intradural ES is rare in childhood and adulthood. Intradural metastasis is very rarely encountered in clinical observations. There are only two reports of intradural ES skip metastasis in the literature to date. Here we present the case of a 39-year-old female who was admitted to our hospital with complaints of left upper limb pain and numbness for one year. Cervical magnetic resonance imaging showed a C4-C6 primary intradural and extramedullary Ewing's sarcoma. Skip metastasis to cauda equina was observed three years following the first surgery and chemoradiotherapy.

Intradural Extramedullary Ewing's Sarcoma Recurrence with Acute Clinical Presentation and Literature Review

The intradural extramedullary space is an extremely unusual site for the onset of Ewing's sarcoma. We describe a case of recurrence of intradural extramedullary Ewing's sarcoma and review the literature available on this topic.

A rare case of intradural extramedullary Ewing's sarcoma with skip metastasis in the spine

Spinal cord tumors are rare and fortunately affect only a minority of the population. These tumors are classified based on their anatomic location in relation to the dura mater and spinal cord as epidural, intradural extramedullary or intradural intramedullary. Intradural extramedullary Ewing's sarcoma is extremely rare. Here, we are reporting a case of intradural extramedullary Ewing's sarcoma. This is the fourth such case to be reported in English literature. A 26-year-old gentleman presented to us with low backache and progressive paraparesis from a spinal tumor. Magnetic resonance imaging showed multiple intradural, extramedullary mass lesions extending from the T11 to S2 level. Neither osteolytic nor osteosclerotic changes were seen in the vertebral bodies. Extraskeletal Ewing's sarcoma was diagnosed histopathologically. He was treated by surgery, local radiotherapy and chemotherapy. Two months after treatment, he developed a new skip lesion in the spine at T6-T7 level. The new lesion was treated with local radiotherapy and chemotherapy. Presently, the patient has completed treatment and is clinically doing fine. Intradural extramedullary Ewing's sarcoma is a rare aggressive neoplasm with high propensity for skip metastasis.