To compare short-term results of intracorporeal (IA) and extracorporeal anastomosis (EA) in laparoscopic right-sided hemicolectomy. A retrospective and prospective analysis included 105 patients who underwent laparoscopic right-sided hemicolectomy with intracorporeal and extracorporeal anastomosis between 2016 and February 2021. We analyzed 105 patients including 64 women and 41 men. Mean age of patients was 62.8±1.5 years in the EA group and 64.7±3.9 years in the IA group. Mean BMI was 24.8±0.5 kg/m2 in the EA group (range 19 - 34.5) and 24.3±1.0 kg/m2 in the IA group (range 21 - 30.4). Intracorporeal anastomosis was performed in 33 patients, extracorporeal anastomosis - in 72 ones. Surgery time was 180.0±7.3 min in the EA group and 214.2±17.7 min in the IA group. There were 8 complications in the EA group (p=0.046). No mortality was observed. Redo surgery rate was 4.16% in the EA group, while there were no redo procedures in the IA group. Postoperative hospital-stay was 12.2±0.5 days in the EA group and 8.8±1.0 days in the IA group. Intracorporeal anastomosis is a safe approach for laparoscopic right-sided hemicolectomy.