This paper presents the development of a numerical model that simulates the fire response of reinforced concrete (RC) slabs externally strengthened with carbon fiber-reinforced polymer (CFRP)laminates using two different techniques, externally bonded (EB) and near-surface mounted (NSM). A three-dimensional (3D) nonlinear finite element (FE) model is developed to predict the thermal and structural behavior of strengthened RC slabs subjected to fire. The model incorporates temperature-dependent thermal and mechanical properties of concrete, steel reinforcement, and CFRP, as well as mechanical bond interaction between CFRP and concrete interfaces. The predicted temperature profiles, ultimate loads, and midspan deflections are compared with previously published experimental data. Results from the proposed model show a good correlation with the experimental data throughout the fire exposure duration. The validated model can be adapted to conduct parametric studies intended to inspect the effect of important factors that influence the behavior of strengthened RC slabs under fire.