The research work is devoted to euphemistic nominations, created according to the pragmatic principle of politeness, which contain national and cultural information. The object of the research work was the euphemisms of gender (about 100 units), obtained by continuous sampling from the most representative explanatory dictionaries of the Uzbek, Russian and English languages. The subject of the research work is the linguistic and cultural specificity of euphemistic nominations of gender. The purpose of the research work is to identify the linguacultural specifics of euphemistic gender-related nominations. Since euphemistic substitutes are used in a particular community and are influenced by socio-cultural factors, they are strongly marked by socio-cultural features used by male and female representatives of Uzbek, Russian and English society. Using the cross-cultural method, we found that in addition to the idiosyncratic national context, there are phenomena in language systems, both universal and differential, including semantic universals and linguo-pragmatic maxims. The novelty of the research work lies in the comparative analysis, which makes it possible to identify universal and differential approaches to the use of euphemistic nominations in different cultures and social contexts. This is an innovative approach that contributes to the understanding of how sociolinguistic factors influence the formation and use of euphemisms in different languages. The results of the research work showed that gender-polite euphemistic nominations that arose within the framework of politically correct ideology contribute to the preservation of the communicant's cognitive space, recognizing the rights of women and expressing respect. They prevent insults but are not necessarily sincere expressions of sympathy and interest, rather, as the analysis of the study showed, these are formal and etiquette constructions. It has been proved that the specifics of the national culture and lifestyle of the Uzbek (in family relations, male family members refer to the female gender by certain word forms), Russian and English peoples, as well as the unique features of their mentality, are the basis for using euphemistic nominations to describe the gender-thematic group.