This paper reviews the challenges and opportunities associated with implementing health informatics in rural healthcare settings. It examines the unique barriers rural communities face, such as infrastructure limitations, workforce shortages, and financial constraints, which can impede the adoption and utilization of health informatics solutions. However, it also explores the promising opportunities afforded by health informatics, including telemedicine, electronic health records (EHRs), and mobile health technologies, to overcome these challenges and improve healthcare access, quality, and efficiency in rural areas. By addressing these challenges and leveraging the opportunities presented by health informatics, stakeholders can work towards achieving equitable healthcare outcomes for rural populations. By addressing these challenges and leveraging the opportunities presented by health informatics, stakeholders can work towards achieving equitable healthcare outcomes for rural populations. Health informatics holds immense potential to revolutionize healthcare delivery, particularly in rural settings where access to quality care is often limited Health informatics holds immense potential to revolutionize healthcare delivery, particularly in rural settings where access to quality care is often limited. Health informatics holds immense potential to revolutionize healthcare delivery, particularly in rural settings where access to quality care is often limited. Telemedicine, for instance, enables remote consultations and diagnostic services, breaking down geographic barriers and providing rural patients with access to specialists and healthcare expertise they may not have locally. Electronic Health Records (EHRs) streamline administrative processes, improve care coordination, and enhance patient safety by ensuring that vital health information is readily accessible to healthcare providers regardless of location. Mobile health technologies, including smartp hone apps and wearable devices, empower rural residents to monitor their health, track chronic conditions, and engage in self-management activities from the comfort of their homes.By embracing these innovations and overcoming infrastructure challenges, stakeholders in rural healthcare can significantly improve healthcare access, quality, and efficiency. Additionally, leveraging health informatics can help address workforce shortages by enabling healthcare providers to deliver more effective and integrated care, even in remote areas. Ultimately, by harnessing the opportunities presented by health informatics while addressing the unique challenges of rural healthcare, stakeholders can work towards achieving equitable healthcare outcomes for rural populations. Keywords: Health Informatics, Rural Healthcare, Electronic Health Records (EHRS), Mobile Health, Challenges.