Pregnancy and childbirth are universally celebrated events, Yet childbirth is one of the most common stressed and painful situation which adversely affect the maternal health. The present study was to assess the effectiveness of selected nursing intervention on maternal and newborn outcome among primigravida mothers at selected hospitals, Tamil Nadu. The objective of the study was 1. To assess the maternal and newborn outcome in experimental and control group among primigravida mothers. 2. To evaluate the effectiveness of selected nursing intervention on maternal and newborn outcome among experimental and control group. 3. To find out the association between post test scores on maternal and newborn outcome among experimental and control group with their selected demographic variables. Design: A one group true experimental post-test only design was adopted for the study. Setting: Annai Theresa hospital and Narayanaa hospital, Chennai. By using simple random sampling 230 primigravida mothers completed 36 weeks of gestation were selected. Methods: Nursing interventions like breathing exercise, massage, position changes implemented during intrapartum period and level of pain perception assessed with universal pain assessment tool during uterine contractions of first stage of labour. Followed by the delivery, early initiation of breast feeding done through breast crawl technique. Effectiveness of selected nursing intervention on Maternal and Newborn outcome among primigravida mothers were measured by Visual Analogue Scale, observational check list and Apgar score chart. Results: The selected nursing interventions are effective in experimental group, the maternal outcome t test value was 10.69(p<0.005) significant, Apgar score t test value was 3.14(p<0.005) significant, newborn outcome t test value was 8.95(p<0.005) significant than control group. Conclusion: The results of the study showed that selected nursing interventions was effective in reducing the level of pain and promote maternal and newborn outcome.