Experience In Use Research Articles

Pegvisomant and current approaches to the medical treatment of acromegaly (literature review and case report)

This review provides the main results of clinical trials and the literature on the experience of using pegvisomant, the first drug from the class of growth hormone receptor antagonists. The mechanism of action of the drug, its effectiveness with respect to disease control and its effect on complications, information on adverse events, and brief information on the experience of use during pregnancy are discussed in detail. In conclusion, a clinical observation of successful use of pegvisomant in resistant to standart treatment acromegaly is given. A discussion of the available literature data, the results of clinical studies and practical experience allows us to conclude that the drug is highly effective in terms of achieving biochemical remission of acromegaly, and also has a number of additional valuable properties: it is capable of improvement of patients glucose metabolism and quality of life and has a minimal amount of adverse events. Pegvisomant is currently registered in the Russian Federation only for use in monotherapy; the possibility of combination therapy with somatostatin analogues will additionally allow to reliably control the growth of the pituitary adenoma and significantly cut treatment costs by reducing the dose of pegvisomant. These features of the drug make it very relevant when discussing issues related to drug therapy of acromegaly, and suggest a good prospect for use in clinical practice.

Experience in use of collagen-based drugs in complex treatment of recurrent aphthous stomatitis

Recurrent aphthous stomatitis is characterized by a recurrent course, torpidity to conventional therapy and painful ulcerations. Despite the continual improvement of the diagnostic methods and treatment of the disease, the incidence of RAS tends to increase. So, the search for new drugs and the treatment of this pathology is important and justified. The article presents the case of complex treatment of recurrent aphthous stomatitis, using collagen biodegradable drugs in the local treatment regimen, which showed the good clinical result.

Next-generation sequencing of microbial cell-free DNA for rapid noninvasive diagnosis of infectious diseases in immunocompromised hosts

Background: Cell-free DNA (cfDNA) sequencing has emerged as an effective laboratory method for rapid and noninvasive diagnosis in prenatal screening testing, organ transplant rejection screening, and oncology liquid biopsies but clinical experience for use of this technology in diagnostic evaluation of infections in immunocompromised hosts is limited. Methods: We conducted an exploratory study using next-generation sequencing (NGS) for detection of microbial cfDNA in a cohort of ten immunocompromised patients with febrile neutropenia, pneumonia or intra-abdominal infection. Results: Pathogen identification by cfDNA NGS demonstrated positive agreement with conventional diagnostic laboratory methods in 7 (70%) cases, including patients with proven/probable invasive aspergillosis, Pneumocystis jirovecii pneumonia, Stenotrophomonas maltophilia bacteremia, Cytomegalovirus and Adenovirus viremia. NGS results were discordant in 3 (30%) cases including two patients with culture negative sepsis who had undergone hematopoietic stem cell transplant in whom cfDNA testing identified the etiological agent of sepsis; and one kidney transplant recipient with invasive aspergillosis who had received >6 months of antifungal therapy prior to NGS testing. Conclusion: These observations support the clinical utility of measurement of microbial cfDNA sequencing from peripheral blood for rapid noninvasive diagnosis of infections in immunocompromised hosts. Larger studies are needed.

Experience in using povidone-iodine to treat superficial and full-thickness burns

Thermal injuries are now ranked number one among injuries, and incidence of injury-related complications, especially infectious and purulent, does not decrease in surgical practice, despite the modern methods for treatment and prevention. Purulent complications depress the speed and quality of wound healing and increase the number of bed-days and treatment costs. Moreover, infection spreading complicates treatment and increases mortality and disability of patients with burn injuries. Choosing the most effective antiseptic agent for burn injuries is crutial both from the perspective of effective local treatment of wounds and wound complications and from the perspective of pharmacoeconomic aspects. At the current time, povidone iodine solution and ointment are one of the leading antiseptics used at all stages of care for burn patients. Its efficacy has been proven by clinical trials and many years’ experience of use by specialists and patients. We have also gained extensive positive experience in using this drug to treat 269 patients with burns of 5 to 35% total body surface area (TBSA) and various thickness without development of resistance and pain in patients and with a pronounced antiseptic effect during its use on the basis of City Clinical Hospital No. 2 of Stavropol, which once again proved high efficacy and feasibility of the widespread use of povidone-iodine in practice due to antimicrobial activity, high bioavailability, ease of use and economic benefits.

A cross-cultural analysis of perceived product quality, perceived risk and purchase intention in e-commerce platforms

PurposeWhile there have always been cultural differences between countries and between individuals, the virtualisation of markets is rendering the impact of these differences even more salient. There is clear evidence that cultural dimensions are relevant in the adoption and use of e-commerce. The purpose of this paper is to analyse the significant effects of individual cultural dimensions on perceived product quality, perceived risk and purchase intention in e-commerce platforms.Design/methodology/approachA questionnaire was developed to serve as a tool of measurement. A confirmatory factor analysis was conducted to examine whether all the indicators for the constructs are reliable. A multiple regression analysis was carried out to test the hypotheses.FindingsThe results reveal that, in the case of e-commerce platforms, the cultural dimensions uncertainty-avoidance and collectivism exert a significant influence on perceived product quality, perceived risk and purchase intention.Research limitations/implicationsThe present study is based on real well-known e-commerce platforms which could have influenced the responses of the sample due to potential past experiences of use. An experimental design based on fictitious platforms could offer more objective findings.Practical implicationsThis research contributes to the understanding of e-commerce and the behaviour of consumers during online purchasing, taking into account the cultural differences that may exist between them.Originality/valueThe literature on individual cultural dimensions – that is, non-national cases – and the variables analysed in the present study suffers from great limitations. This study complements a growing interest in analysing the individual cultural dimensions and their effects on the sphere of e-commerce, specifically on perceived product quality, purchase intention and perceived risk during browsing, measured in terms of the six types of risk prevalent in e-commerce platforms.

Isavuconazole Prophylaxis during Early Phases of Allogeneic HSC Transplantation Is Not Associated to an Increase Need of Cyclosporin-a Dose Modification

Background: Isavuconazole is an effective treatment of invasive fungal infections (IFI). Since its broad spectrum of activity and favorable toxicity, it could also be used as a prophylaxis. Experience in use of isavuconazole as prophylaxis of IFI is, however, limited. In allogeneic transplant setting, its feasibility should also be assessed in regard of changes of Cyclosporine (CYA) metabolism. Aim: To evaluate feasibility of the administration of Isavuconazole as short term prophylaxis during early phase of allogeneic transplantation and to study its influence on CYA trough blood levels and CYA dosing. Methods: In a prospective study from July 2017 to April 2019, we treated 34 HSC transplantation using Isavuconazole (ISA) prophylaxis, ISA was administered at dosage of 200 mg /day i.v. (with a loading-dose of 200 mg x 3 /days for the first 48 hours) from day + 2 after HSCT infusion and until day + 30. The patients were selected using the criteria: any underlying diagnosis; age 18-70; any type of allogeneic donor; GVHD prophylaxis including CYA i.v.. Blood trough levels of CYA were measured bi-weekly by ELISA. Blood CYA level was maintained between 100 - 300 mcg/ml by dose adjustment. The need for CYA dose modification, IFI rate and patient outcome (TRM, OS) was studied and compared to an historical control group who received prophylaxis using Fluconazole during day +2 to day +30 (n 29). Results: Groups receiving Isavuconazole or Fluconazole were not significanly different in diagnosis, age, sex, disease status at transplant, donor type, stem cell-source, GVHD-prophylaxis and conditioning regimen. No patients in the Fluco-group had a previous invasive fungal infection (IFI), while 2 patients had a previously IFI in the Isa-group. All patients reached engraftment, neutrophils engraftment was reached in a mean of 19 days and 18 days in the Isa and Fluco-group, respectively. No IFI occurred in the fluco-group, while 1 proven IFI (Blastoschyzomyces Capitatus blood-stream infection) occurred in the Isa-group. Mucositis occurred in 56 patients (88%). Mucositis grade III-IV grade of was registered in 62% and 61%, in the Isa- and Fluco-Group respectively. Isavuconazole was well tolerated, without significant toxicity, no patient needed dose-reduction or suspension. Mean values of trough CyA blood-levels were compared at for 1st, 2nd, 3rd and 4th week and no difference was found between the two groups (Mann Whitney U test p value: 0.2, 0.5, 0.8, 0.9 respectively for 1st, 2nd, 3rd and 4th week), Fig 1. Mean number of CYA-dose adjustments was 1.3 /patient in Isa-group and 1.2/patient in Fluco-group. Difference was not significant (p = 0.6, Mann-Whitney U-test). Overall survival (OS) at 1 year was 64 % in Fluco-group (95% CI: 44-79%) and 66% in Isa-group (95% CI: 44-81%) (log-rank, p value: 0.9). Non-relapse mortality (NRM) at 1 year was 16.3% (95% CI: 5.7-31%) in Isa-group and 14.2% (95% CI:4.3-29%) in Fluco-group (Gray test, p: 0.61). Conclusions: In this prospective study, short term prophylaxis using Isavuconazole, after allogeneic HSC transplant, was found to be feasible. No significant difference with standard fluconazole prophylaxis was found in trough CYA blood levels and in the need of cyclosporin dose modification. Further studies are needed extending the lenght of Isavuconazole prophylaxis. Figure 1 Disclosures No relevant conflicts of interest to declare.

MEASURING CLIENT EXPERIENCE IN RESIDENTIAL AGED CARE TO INFORM AND SUPPORT CONSUMER CHOICE

The Australian Government Aged Care Quality and Safety Commission (prior to January 2019 known as the Australian Aged Care Quality Agency) is responsible for accreditation of Australian aged care services which are audited against the Australian Accreditation Standards. Accreditation reports are publicly available. Prior to 2017, some clients were interviewed about their experiences, but the resulting information could not represent the client experience within a service due to low numbers, biased sampling, and an unsystematic approach to asking questions. La Trobe University was engaged to develop and pilot an interview tool to measure client experience for use in accreditation. Potential questions were identified through a literature review, mapped against the Accreditation Standards, and workshopped with an expert reference group. Twenty-four questions and a visual analogue were then piloted. Consumer groups and groups of Indigenous and culturally diverse clients in residential aged care homes were consulted. The perspective of Quality Agency surveyors was sought on the questions’ usability. Statistical analyses sought to identify questions that minimised missing data, were responded to similarly by residents and their representatives, and elicited stable responses on retest. Twelve questions were identified as optimal. The 10 quantitative questions proved to reflect a single underlying dimension (consumer experience) and, when summed and explored through regression analyses, differentiated services significantly. The consumer experience interview tool is now used in all accreditation audits in Australia. Results are then used to generate consumer experience reports, which are published online and can support consumer choice of a residential aged care home.

Student Online Services Consumption: Routine Practices or Mistrust to Digital Service?

The article aims to study the practices of students’ use of services in the conditions of digitalization. The leading methods for the study of this problem are the methods of questioning and testing, allowing to make a qualitative analysis of student consumption practices in the conditions of digitization of services. These methods allowed revealing the peculiarities of online consumption practices by students. The authors found that the majority of students who are not actively using online services, to some extent had experience using online services, but almost every tenth of them had negative result. It is established that students are distrustful of new methods to obtain services, especially when it comes to any operations related to money. It is shown that students who do not practice online services have a feeling that the provided online services are of poor quality, and informants are ready to experience some discomfort in exchange for the usual, guaranteed and high quality, in their opinion, service. In addition, students who are not actively using online services note that it is not easy for them to adapt to new technologically advanced things, but the rest of the students believe that they can adapt to innovations, but the way of providing services that is now perceived as traditional one is the most acceptable for them. It is established that the leader in the use of online services is a taxi. This service is used by all students to some extent, followed by the service of food delivery and only then online banking, online shopping and public services. The novelty and originality of the study lies in the fact that the features of consumption practices among students actively practicing online services and avoiding them are revealed. It is established that students who have little recourse to online services are wary of modern services, which is based either on the previous negative experience of use, or on the unsatisfactory experience of friends, believe that those techniques and applications that are now on the market are not optimal for them and the usual methods of obtaining services for them remain more comfortable and familiar, even though more time spent on obtaining a particular service. The practical significance lies in the fact that the data obtained in the work can be used in social psychology, age psychology, labor psychology, management, sociology, as well as for further theoretical development of this issue.

ОСОБЛИВОСТІ ВПРОВАДЖЕННЯ ЕЛЕКТРОННОГО ПОСІБНИКА З НАВЧАННЯ АНГЛІЙСЬКОЇ МОВИ У ДЕРЖАВНІЙ ПРИКОРДОННІЙ СЛУЖБІ УКРАЇНИ

У статті представлено аналіз результатів впровадження електронного посібника (ЕП) «Англійська мова для прикордонників» у навчальних закладах Державної прикордонної служби України (ДПСУ) та пунктах пропуску через державний кордон. В експерименті взяли участь 298 прикордонників, які навчались на тримісячних курсах інтенсивного вивчення англійської мови в Національній академії Державної прикордонної служби України імені Богдана Хмельницького, та 1158 осіб після завершення навчання на дистанційних курсах вивчення англійської мови в навчальних центрах ДПСУ. Анкетування проводилось за такими блоками: варіанти використання ЕП, вікові групи та статева приналежність, вихідний рівень іншомовної підготовки користувачів, загальні враження користувачів від роботи з ЕП, досвід використання, структура та користування ЕП, рівень удосконалення мовленнєвих навичок користувачів, ступінь насиченості розділів навчальним матеріалом, характеристика вправ ЕП. Аналіз анкет зворотного зв’язку та результатів опитування доводить, що реалізація ЕП в ДПСУ була успішною і відповідає особливим потребам прикордонників, що працюють у пунктах пропуску через державний кордон України, оскільки він був спеціально розроблений діючими представниками прикордонних відомств для подальшого використання прикордонниками. Оцінка результатів використання ЕП прикордонниками довела ефективність удосконалення іншомовної підготовки, необхідної для виконання прикордонниками повсякденних завдань, шляхом використання навчальних відео- й аудіоматеріалів, які відповідають справжнім ситуаціям на робочому місці представника прикордонного відомства. У результаті проведеного аналізу анкет було з’ясовано, що практична більшість респондентів (93%) погоджуються і усвідомлюють важливість вивчення англійської мови та вдосконалення іншомовних мовленнєвих навичок з метою спрощення виконання завдань у пунктах пропуску через державний кордон під час інтерв’ювання іноземців і участі в спільних міжнародних операціях. Водночас 7% користувачів частково або цілком не погоджуються з даним твердженням, що обумовлюється, насамперед, тим фактом, що ЕП виявився для них занадто складним через їх особистий низький рівень базової підготовки з англійської мови. Використання ЕП надало змогу прикордонникам легше і більш впевнено спілкуватися з пасажирами, що перетинають державний кордон, з’ясовувати обставини порушення законодавства й ефективно спілкуватись зі своїми колегами з інших європейських країн.

Experience of use of erp-systems in the life cycle of manufacturing of machine-building production

At the present stage of innovative development of machine building in Ukraine, the aviation and rocket and space industries are the driving forces that determine the country's competitiveness and directions in the development of science.Despite the progressiveness of the aforementioned industries, their development is nowhere near as dynamic as it is in the face of a lack of financial and human resources. In this regard, the problem of organizing the process of managing resource-intensive production of high-tech products is becoming especially relevant.A number of papers are devoted to strategic resource management. Their detailed analysis showed that this problem is not solved sufficiently and does not reveal approaches to solving the problem of optimizing the resource creation of high-tech products at different stages of its life cycle, taking into account industry features and modern analytical tools, including using the WEB environment. This justifies the need to improve existing and develop new appropriate methodological tools aimed at improving resource efficiency.One of the most effective and less costly approaches to addressing this issue is the use of specialized enterprise resource planning (ERP) systems.

Factores de uso de los medios de pago móviles en millennials y centennials

Las tecnologías de información implementadas en los sistemas de pago han incrementado la oferta de servicios mediante medios móviles, con una adopción aún limitada. Por ello, la relevancia de investigar sobre la utilización de los medios de pago virtuales a través de la identificación de los factores que inciden en la adopción de la banca móvil por jóvenes millennials y centennials de Medellín, mediante el análisis factorial exploratorio y análisis factorial confirmatorio de las variables: actitud de uso, conciencia percibida, credibilidad percibida, confianza percibida, intención de uso y experiencia de uso. La investigación empleó un análisis factorial exploratorio con un enfoque cuantitativo y de alcance exploratorio-descriptivo. Se concluye que las variables más relevantes en la decisión de usar pagos móviles son la experiencia en uso y la conciencia percibida.

Reasons for requesting removal of the hormonal implant, Implanon NXT, at an urban reproductive health clinic in KwaZulu-Natal, South Africa.

The contraceptive implant, Implanon NXT, was introduced in South Africa (SA) in 2014 and, although it offers multiple advantages, users may request to have it removed early for several reasons. The number of insertions of Implanon NXT has declined in SA and there have been concerns about early removals. To gain an understanding of patterns of Implanon NXT use, reasons for requesting removal and duration of use at the time of requesting removal. This was a cross-sectional study conducted at an urban public-sector reproductive health clinic in the eThekwini District of KwaZulu-Natal, SA. A total of 120 women ≥18 years of age requesting removal of Implanon NXT completed an interviewer-administered questionnaire that probed experiences of use and reasons for removal. Data were collected electronically on Wits REDCap (Research Electronic Data Capture) and analysed using Stata 14 (StataCorp, USA). The study was conducted from 2017 to 2018. A total of 120 women were interviewed. Their mean age was 28 (range 19 - 44) years and most women (n=103; 85.8%) had completed secondary school. The majority were black (n=115; 95.8%) and unmarried (n=102; 85%). Implants had been inserted primarily by nurses (n=110; 91.7%) at public-sector clinics (n=91; 75.8%). Three-quarters of the women (n=91; 75.8%) requested removal of Implanon NXT because it had reached the intended 3-year duration. Reasons for early removal were mainly due to side-effects, e.g. bleeding problems (n=19; 15.8%), weight gain (n=7; 5.8%), loss of libido (n=2; 1.7%), headaches (n=5; 4.2%), dizziness (n=4; 3.3%) and pain/numbness in the arm (n=2; 1.7%). Just more than half (57.1%) of the women who had received the implant for the intended 3-year duration had requested reinsertion of Implanon NXT. The main reason for requesting removal was that Implanon NXT had reached its intended 3-year duration, and more than half of the women requested reinsertion of the device following removal. Implanon NXT is a highly effective, safe, acceptable, long-acting contraceptive and important in the SA contraceptive method mix.

Experience of use of 2-ethyl-6-methyl-3-hydroxypyridine succinate in complex therapy of stable angina

The aim — to evaluate the efficacy and tolerability of the use of different doses (200 and 500 mg/day) of 2‑ethyl‑6‑methyl‑3‑hydroxypyridine succinate (Venokor, Lekhim, Ukraine) in the complex therapy of patients with coronary heart disease and stable angina pectoris of II — III functional class.Materials and methods. The study involved 60 patients with ischemic heart disease and stable angina pectoris of II — III functional class aged 48 to 76 years. The patients were divided into three groups. Patients of the 1st (n = 20) and 2nd (n = 20) groups, in addition to the medical treatment of ischemic heart disease according to the recommendations, were prescribed 2‑ethyl‑6‑methyl‑3‑hydroxypyridine succinate parenterally at a dose of 200 and 500 mg/day, respectively. Patients of the control group received only standard treatment (b‑blockers, calcium antagonists, acetylsalicylic acid, statins). The effect of treatment was evaluated on the 14th day from the beginning of therapy.Results and discussion. The number of angina attacks per week decreased with the use of 2‑ethyl‑6‑methyl‑3‑hydroxypyridine succinate at a dose of 200 and 500 mg/day compared to patients who were prescribed standard angina therapy (p < 0.05 and p < 0.01, respectively). The need for nitroglycerin tablets decreased statistically significantly in the two main groups compared to the control group (p < 0.01 and p < 0.001, respectively). This decrease was statistically significantly (p < 0.001) greater in patients of the 2nd group compared to the patients of the 1st group. Patients of the two main groups improved their quality of life scores on the scales of pain intensity (p < 0.01), physical functioning, overall mental health (p < 0.01), total physical health score of the SF‑36 questionnaire (p = 0.005).Conclusions. Addition of 2‑ethyl‑6‑methyl‑3‑hydroxypyridine succinate to a standard treatment regimen for patients with coronary heart disease and stable angina pectoris of II — III functional class helps to reduce the need for nitroglycerin and improves patients’ quality of life.

Next-generation sequencing of microbial cell-free DNA for rapid noninvasive diagnosis of infectious diseases in immunocompromised hosts

Background: Cell-free DNA (cfDNA) sequencing has emerged as an effective laboratory method for rapid and noninvasive diagnosis in prenatal screening testing, organ transplant rejection screening, and oncology liquid biopsies but clinical experience for use of this technology in diagnostic evaluation of infections in immunocompromised hosts is limited. Methods: We conducted an exploratory study using next-generation sequencing (NGS) for detection of microbial cfDNA in a cohort of ten immunocompromised patients with febrile neutropenia, pneumonia or intra-abdominal infection. Results: Pathogen identification by cfDNA NGS demonstrated positive agreement with conventional diagnostic laboratory methods in 7 (70%) cases, including patients with proven/probable invasive aspergillosis, Pneumocystis jirovecii pneumonia, Stenotrophomonas maltophilia bacteremia, Cytomegalovirus and Adenovirus viremia. NGS results were discordant in 3 (30%) cases including two patients with culture negative sepsis who had undergone hematopoietic stem cell transplant in whom cfDNA testing identified the potential etiological agent of sepsis; and one kidney transplant recipient with invasive aspergillosis who had received >6 months of antifungal therapy prior to NGS testing. Conclusion: These observations support the clinical utility of measurement of microbial cfDNA sequencing from peripheral blood for rapid noninvasive diagnosis of infections in immunocompromised hosts. Larger studies are needed.

Reconstruction of the bridge using heavy lifting technique

In work the problem of use of Heavy Lifting technology («Rise of heavy constructions») for dismantling of the flying structure of the bridge at its reconstruction is considered. The questions of development and application vertically of drawbridges are raised. Contribution of foreign designers to development of adjustable flights. Experience of modern construction of bridges, using a method, for mounting of metal constructions of bridges is considered. The importance of short-term repair and reconstruction of bridge constructions as most important components of a transport network of the country is noted. Reconstruction of the bridge through the Tobol River on federal highway R-404 in the Tyumen region is briefly considered. Works of authors, about technology of safe use of lifting frames for rise and lowering of segments of steel concrete bridges and beams for a sliding of flying buildings from previously strained concrete. Foreign and domestic experience of use of Heavy Lifting technology for mounting and dismantling of bridge constructions is considered. On the example of works on dismantling of the flying building at reconstruction of the bridge through the Yuganskaya River of a channel on km 740,863 highways R-404 Tyumen-Tobolsk-Khanty-Mansiysk are shown to feature of works on this technology, the arising problems and ways of their solution. It is noted that use of Heavy Lifting technology allows carrying out reconstruction to the shortest possible time, having saved considerable resources.

Assessment of Spontaneous Use and Experience of Use of The Affected Upper Limb in 6-Year-Old Infantile Hemiplegia After Applying Combined Intensive Therapy. Case Series

Assessment of Spontaneous Use and Experience of Use of The Affected Upper Limb in 6-Year-Old Infantile Hemiplegia After Applying Combined Intensive Therapy. Case Series

On the role of interaction mode and story structure in virtual reality serious games

Educational Environmental Narrative (EEN) games in Virtual Reality (VR) provide rich, high-fidelity environments that provide a fully immersive and interactive storytelling experience for use in teaching. Yet, it is not fully known how learning experience is affected by freely exploring the environment (interaction mode) and having an explicit story structure. A randomized controlled 2 × 2 study with 42 adolescents was performed to correct this omission and find the effect that these two factors have on recalling important information and on how a player feels when playing a game. They explored an EEN VR game with different interaction modes (active vs passive) and story structures (explicit vs implicit) and then completed a knowledge test and standardized questionnaires, regarding their sense of presence, cognitive interest and engagement during the game. Results show that allowing players to navigate freely through the game has positive effects on cognitive interest and a feeling of presence. An implicitly structured game leads to increased recall of spatial information. However, for optimal learning of factual knowledge, guidance is beneficial.

Use Medicine Zyman in Complex Treatment of Chronic Inflammatory Diseases of Genitals at Men

It is shown positive experience of use of medicine Zyman of manufacture firms «МЕGA WE CARE» (Australia) at 31 patients with the chronic inflammatory diseases of genitals at men. Its high clinical (89,7–94,4%) and bacteriological (95,8%) efficiency was established. The preparation is well transferred and possesses the no by-effects.

Внедрение электронной системы мониторинга беременных как один из эффективных способов управления качеством медицинской помощи

One of the effective ways of an improvement of the quality of a medical care for pregnant women is the electronic monitoring (distant monitoring) over
 state of pregnant women, women in labour, puerperas. The article presents the experience of use of the information system of pregnant women monitoring
 in several regions of the Russian Federation, analyses advantages and limitations of given systems, proposes the standardize system of a monitoring.

Informal carers\u2019 experience of assistive technology use in dementia care at home: a systematic review

BackgroundDementia is a health and care priority globally. Caring for persons with dementia is a challenge and can lead to negative psychological, physiological and financial consequences for informal carers. Advances in technology have the potential to assist persons with dementia and their carers, through assistive technology devices such as electronic medication dispensers, robotic devices trackers and motion detectors. However, little is known about carers’ experience and the impact of these technologies on them. This review aims to investigate the outcomes and experience of carers of persons with dementia, who live at home and use assistive technology.MethodsA systematic search in seven databases and manual searches were carried out using pre-defined inclusion and exclusion criteria to identify studies on carers of persons with dementia involving the use of assistive technology. The search identified 56 publications with quantitative, qualitative and mixed-method designs.ResultsThe studies reported positive and negative findings and focused on a wide variety of assistive technology devices. There were large differences in the uses of assistive technology, outcome measures used and the quality of studies. Knowledge and acceptance, competence to use and ethical issues when using assistive technology were themes that emerged from the studies. Carers generally appreciated using assistive technology and their experience of use varied.ConclusionsThe intention of this systematic review is to list and classify the various types of assistive technology used by carers of persons with dementia and explores the positive and negative aspects, knowledge, acceptance and ethical issues in the use of assistive technology by carers of persons with dementia. We recommend the use of a standard and person-centred system of classifying and naming assistive technology devices and systems and for future research efforts in assistive technology to incorporate a family/carer centred model.Systematic review registrationPROSPERO - CRD42017082268.