This study investigates the performance of a 4-MIX engine utilizing hydrogen combustion in pure oxygen, water injection, and the application of the early-intake valve closure (EIVC) Miller cycle. Transitioning from a standard petrol–oil mix to hydrogen fuel with pure oxygen combustion aims to reduce emissions. Performance comparisons between baseline and oxyhydrogen engines showed proportional growth in the energy input rate with increasing rotational speed. The oxyhydrogen engine exhibited smoother reductions in brake torque and thermal efficiency as rotational speed increased compared to the baseline, attributed to hydrogen’s higher heating value. Water injection targeted cylinder and exhaust temperature reduction while maintaining a consistent injected mass. The results indicated a threshold of around 2.5 kg/h for the optimal water injection rate, beyond which positive effects on engine performance emerged. Investigation into the EIVC Miller cycle revealed improvements in brake torque, thermal efficiency, and brake specific fuel consumption as early-intake valve closure increased. Overall, the EIVC model exhibited superior energy efficiency, torque output, and thermal efficiency compared to alternative models, effectively addressing emissions and cylinder temperature concerns.