Exercise Intervention Program Research Articles

Digitally Delivered Exercise and Education Treatment Program for Low Back Pain: Longitudinal Observational Cohort Study.

BackgroundExercise and education is recommended as first-line treatment by evidence-based, international guidelines for low back pain (LBP). Despite consensus regarding the treatment, there is a gap between guidelines and what is offered to patients. Digital LBP treatments are an emerging way of delivering first-line treatment.ObjectiveThe aim of this study is to evaluate outcomes after participation in a 3-month digitally delivered treatment program for individuals with subacute or chronic LBP.MethodsWe analyzed data from 2593 consecutively recruited participants in a digitally delivered treatment program, available via the national health care system in Sweden. The program consists of video-instructed and progressive adaptable exercises, education through text lessons, and a chat and video function connecting participants with a personal physiotherapist. The primary outcome was mean change and proportion reaching a minimal clinically important change (MCIC) for LBP (2 points or 30% decrease) assessed with the numerical rating scale (average pain during the past week, discrete boxes, 0-10, best to worst). Secondary outcomes were mean change and proportion reaching MCIC (10 points or 30%) in disability, assessed with the Oswestry Disability Index (ODI; 0-100, best to worst) and a question on patient acceptable symptom state (PASS).ResultsThe mean participant age was 63 years, 73.85% (1915/2593) were female, 54.72% (1419/2593) had higher education, 50.56% (1311/2593) were retired, and the mean BMI was 26.5 kg/m2. Participants completed on average 84% of the prescribed exercises and lessons, with an adherence of ≥80% in 69.26% (1796/2593) and ≥90% in 50.13% (1300/2593) of the participants. Mean reduction in pain from baseline to 3 months was 1.7 (95% CI –1.8 to –1.6), corresponding to a 35% relative change. MCIC was reached by 58.50% (1517/2593) of participants. ODI decreased 4 points (95% CI –4.5 to –3.7), and 36.48% (946/2593) reached an MCIC. A change from no to yes in PASS was seen in 30.35% (787/2593) of participants. Multivariable analysis showed positive associations between reaching an MCIC in pain and high baseline pain (odds ratio [OR] 1.9, 95% CI 1.6-2.1), adherence (OR 1.5, 95% CI 1.3-1.8), and motivation (OR 1.2, 95% CI 1.0-1.5), while we found negative associations for wish for surgery (OR 0.6, 95% CI 0.5-0.9) and pain in other joints (OR 0.9, 95% CI 0.7-0.9). We found no associations between sociodemographic characteristics and pain reduction.ConclusionsParticipants in this digitally delivered treatment for LBP had reduced pain at 3-month follow-up, and 58.50% (1517/2593) reported an MCIC in pain. Our findings suggest that digital treatment programs can reduce pain at clinically important levels for people with high adherence to treatment but that those with such severe LBP problems that they wish to undergo surgery may benefit from additional support.Trial RegistrationClinicalTrials.gov NCT05226156; https://clinicaltrials.gov/ct2/show/NCT05226156

The Effectiveness of Exercise as a Treatment of Major Depressive Disorder in Adolescents: A Systematic Literature Review of Randomised Control Trials

AimsMajor depressive disorder (MDD) is the most prevalent mental health condition among adolescents. Current treatments have limited effectiveness, accessibility and questionable safety profiles. Exercise is becoming a more widely recognised intervention for MDD in adults. However, evidence and research for its effectiveness in adolescents is lacking. This review aimed to establish if exercise is effective at reducing MDD symptoms and severity in adolescents, and thus its first-line treatment potential.MethodsElectronic databases were searched for randomised control trials studying effects of exercise in adolescents, clinically diagnosed with MDD. Trials were excluded if participants’ depression was secondary to another disorder or health condition. The primary outcome measure was depression symptom severity, assessed by a validated depression symptom scale. Six trials met the eligibility criteria and were included in this review.ResultsFour trials found reduced depression scores in the exercise intervention group compared to control immediately post-intervention; of the four trials which included follow-up data, all reported higher rates of remission in the exercise intervention group compared to control. The length of exercise intervention programme seems important, needing to be greater than 6-weeks for a therapeutic effect. The type of exercise doesn't appear critical.ConclusionGiven the small sample sizes and methodological limitations presented by the trials, it is difficult to draw definitive conclusions. Further and larger-scale studies are needed before exercise can become a recognised and readily recommended treatment for MDD in adolescents; but thus far, it seems to have a promising therapeutic potential in both short and long term.

MO590: A Home-Based Exercise and Physical Activity Intervention After Kidney Transplantation: Impact of Exercise Intensity. The Phoenix-Kidney Study Protocol

Abstract BACKGROUND AND AIMS Advances in the field of kidney transplantation have led to improved postoperative survival rates, but age-standardized mortality nonetheless remains 2- to 7-fold higher in kidney transplant recipients—with cardiovascular disease representing the leading cause of death in recipients with a functioning graft. Poor physical fitness, not completely recovering after transplantation, adds to the heightened cardiovascular risk of hypertension, diabetes, dyslipidemia and obesity. So does the post-transplant continuation of gut microbial dysbiosis, which recently emerged as a modulator of muscular, metabolic and cardiovascular health. Exercise-based rehabilitation and physical activity interventions may prove pivotal in the care of kidney transplant recipients to address aforementioned outcomes. METHOD At 3 months post-transplant, a probability sample of 147 adult kidney transplant recipients from two independent Belgian transplant centers will be randomly allocated to either 6 months of home-based moderate-intensity training (MIT, n = 49), concurrent moderate- and high-intensity training (MHIT, n = 49) or usual care (CON, n = 49) (Figure1). High-intensity training sessions in MHIT are based on the Scandinavian model (four blocks of 4 min at high intensity interspersed by 3 min of active recovery), performed twice a week, and of equivalent energy expenditure as moderate-intensity training (Figure2). MIT and MHIT will perform similar muscle strengthening exercises, twice a week. The training intervention will be followed by an individualized activity intervention aiming for long-term physical activity maintenance in MIT and MHIT; using motivational interviewing techniques, co-creation of an action plan adapted to the patients’ preferences, goal-setting, gradually decreasing follow-up prompts over time and self-monitoring of physical activity behavior. Study participants will be followed-up till 2 years after transplantation. We hypothesize that the study intervention will improve our primary outcome cardiorespiratory fitness, assessed as peak oxygen uptake, at 9 months post-transplant. Secondary outcomes include muscle fitness, motor fitness, body composition, cardiovascular health, gut microbiome characteristics, health-related quality of life, safety, cost-effectiveness and implementation outcomes (Figure1). The role of training intensity and the role of baseline gut microbiome characteristics as predictor of individuals’ training response will be explored. RESULTS Results from this two-phased RCT will provide novel insights in the safety, implementation potential, cost-effectiveness and effectiveness of a home-based exercise program and physical activity intervention in de novo kidney transplant recipients to improve physical fitness, cardiovascular health, gut microbiome characteristics and health-related quality of life. CONCLUSION PHOENIX-kidney represents the first adequately powered multicenter RCT evaluating basic, clinical and health-economic outcome parameters in response to an exercise training and physical activity intervention in kidney transplant recipients.

규칙적인 운동이 한국 지적장애인의 건강체력요인에 미치는 효과에 대한 체계적문헌고찰 및 메타분석

[Objective] The purpose of this study is to evaluate the effects of regular exercise on health-related physical fitness factors in individuals with intellectual disabilities. [Methods] Literatures were searched for using RISS, KISS, and the national assembly library to derive conclusions. Cochrane ROB was used for the qualitative evaluation of selected researches. Mean difference, standardized mean difference(SMD), and 95% CI were selected and a random-effect model were used for effect size. Moreover, heterogeneity of included researches was assessed using Cochran’s Q statistics and I2. [Results] Regular exercise improved muscular endurance(ES=1.44, 95% CI .53-2.35, p=.002), flexibility(ES=.63, 95% CI .08-1.17, p=.02), and agility(.62, 95% CI .08-1.16, p=.03) in individuals with intellectual disabilities. The effect size of muscular strength(ES=1.23, 95%CI .39-2.85, p=.14) and cardiorespiratory endurance(ES=.49, 95% CI-.50-1.49, p=.33) was comparatively high but was not statistically significant. [Conclusions] It is confirmed that regular exercise is an effective method to improve health-related physical fitness factors in individuals with intellectual disabilities. Moreover, it is found that physical fitness factors which can be improved are different according to an exercise intervention program. The results will be applied as basic data to design more precise exercise programs to improve the health-related physical fitness factors of individuals with intellectual disabilities.

PRehabIlitatiOn with pReoperatIve exercise and educaTion for patients undergoing major abdominal cancer surgerY: protocol for a multicentre randomised controlled TRIAL (PRIORITY TRIAL)

BackgroundRadical surgery is the mainstream treatment for patients presenting with advanced primary or recurrent gastrointestinal cancers; however, the rate of postoperative complications is exceptionally high. The current evidence suggests that improving patients’ fitness during the preoperative period may enhance postoperative recovery. Thus, the primary aim of this study is to establish the effectiveness of prehabilitation with a progressive, individualised, preoperative exercise and education program compared to usual care alone in reducing the proportion of patients with postoperative in-hospital complications. The secondary aims are to investigate the effectiveness of the preoperative intervention on reducing the length of intensive care unit and hospital stay, improving quality of life and morbidity, and reducing costs.MethodsThis is a multi-centre, assessor-blinded, pragmatic, comparative, randomised controlled trial. A total of 172 patients undergoing pelvic exenteration, cytoreductive surgery, oesophagectomy, hepatectomy, gastrectomy or pancreatectomy will be recruited. Participants will be randomly allocated to prehabilitation with a preoperative exercise and education program (intervention group), delivered over 4 to 8 weeks before surgery by community physiotherapists/exercise physiologists, or usual care alone (control group). The intervention will comprise 12 to 24 individualised, progressive exercise sessions (including aerobic/anaerobic, resistance, and respiratory exercises), recommendations of home exercises (16 to 32 sessions), and daily incidental physical activity advice. Outcome measures will be collected at baseline, the week prior to surgery, during the hospital stay, and on the day of discharge from hospital, and 1 month and 1 months postoperatively. The primary outcome will be the development of in-hospital complications. Secondary outcomes include the length of intensive care unit and hospital stay, quality of life, postoperative morbidity and costs.DiscussionThe successful completion of this trial will provide robust and high-quality evidence on the efficacy of a preoperative community- and home-based exercise and education intervention on important postoperative outcomes of patients undergoing major gastrointestinal cancer surgery.Trial registrationThis trial was registered prospectively with the Australian New Zealand Clinical Trials Registry (ACTRN12621000617864) on 24th May 2021.

Comparison of the open kinetic chain and closed kinetic chain strengthening exercises on pain perception\xa0and lower limb biomechanics of patients with mild knee osteoarthritis: a randomized controlled trial\xa0protocol

BackgroundClinical recommendations suggest exercises as the main treatment modality for patients with knee osteoarthritis (OA). This study aimed to compare the effects of two different exercise interventions, i.e., open kinetic chain (OKC) and closed kinetic chain (CKC) exercises, on the pain and lower limb biomechanics of patients with mild knee OA.MethodA total of 66 individuals with painful early knee OA, aged 50 years and above, with body mass index (BMI) between 18.9kg/m2 and 29.9 kg/m2 in Kelantan, Malaysia, will be recruited in this study. Participants will be randomly allocated into three different groups, either the OKC, CKC, or control groups. All three groups will attend an individual session with a physiotherapist. The participants in the OKC and CKC groups will perform the exercises three times weekly for 8 weeks at their home. The control group will receive education about clinical manifestations, risk factors, diagnosis, treatment, and nursing care for knee via printed materials. The primary outcomes include self-reported pain scores (visual analog scale), disability scores (Western Ontario and McMaster Universities Arthritis Index), and quality of life scores (Osteoarthritis Knee and Hip Quality of Life). Secondary outcomes include lower limb biomechanics during gait and sit-to-stand as well as isokinetic knee strength. The outcomes will be measured before and after the intervention.DiscussionThe present study will compare the effects of two different home-based exercise intervention programs among patients with mild knee OA. The study findings will provide vital information that can be used to design an effective exercise program that aims at delaying the OA progression.Trial registrationThe protocol was registered on 22 December 2020 at ClinicalTrials.gov (registration number: NCT04678609).

Working memory interventions via physical activity and ICTs: A strategic issue for the improvement of school students' learning performance

Nowadays, there is a great need for schools to be transformed into more innovative learning environments with more innovative approaches to learning and teaching so as students to be allowed to develop their various skills and abilities to their fullest extent. Therefore, we present the role of physical activity and ICT-based interventions for working memory enhancement as a strategic issue for the improvement of students’ learning outcomes. According to research findings, multi-component exercise and ICT-based intervention programs can significantly contribute to the improvement of children’s and adolescents’ working memory and thus can have a positive effect on children’s and adolescents’ learning performance. Finally, this paper could trigger educators and policy-makers towards the ideal planning of innovative multi-component physical activity and ICT-based intervention programs and their incorporation into the school curriculum aiming at the working memory enhancement in children and adolescents and the improvement of their learning outcomes

Effects of an isometric exercise training program on muscular strength, ankle mobility, and balance in patients with diabetic peripheral neuropathy in the lower legs in South Africa.

BackgroundPatients who suffer from diabetic peripheral neuropathy in the lower leg experience a greater risk of falls due to a decrease in strength of the lower extremities.MethodsFourteen participants, diagnosed with diabetic peripheral neuropathy or nocturnal allodynia in either one or both extremities, volunteered to participate in this study. Participants were purposively selected from two private Podiatry practices based on their signs and symptoms, age, gender, and doctor’s clearance to participate in any form of physical activity. Dependent variables included isometric muscle strength of the hip, knee and ankle, range of motion of the ankle in plantarflexion and dorsiflexion and an assessment of balance, which were measured pre- and post-intervention. The researcher developed a scientifically based exercise intervention program to target the entire kinetic chain, and to develop a standard isometric protocol for patients with DPN. The intervention program consisted of a combination of ankle, hip, and knee specific rehabilitation. The intervention took place 3 times a week for 45 min per session.ResultsThe Mann-Whitney test was used to evaluate the differences in dependent variables from pre- to post-intervention. The level of significance was set at p<0.05. Notable increases were observed in range of motion in ankle plantarflexion and in balance time in the intervention group, post-intervention.ConclusionsAlthough many of the changes noted were insignificant, the trends indicated an improvement in the intervention group over the 10-week intervention period. These improvements can be considered clinically important.

The Effectiveness of Bedtime Exercises on Sleep Quality Parameters and Chronic Nonspecific Chronic Low Back Pain After Sleep in the Elderly Male

Objectives The elderly population is increasing, and one of the common problems in the elderly is a sleep disorder. Poor sleep quality causes various musculoskeletal problems, including chronic nonspecific Low back pain. In this regard, this study aimed to evaluate the effectiveness of pre-sleep exercises on sleep quality parameters and chronic nonspecific chronic low back pain after sleep in the elderly. Methods &amp; Materials This study was quasi-experimental. A total of 40 retirees over 60 years old of Isfahan University of Technology with a Mean±SD age of 64.52±3.18 years, a weight of 81.99±7.35 kg, and a BMI of 27.91±2.21 in a targeted manner available were selected and randomly divided into two experimental and control groups of 20 people. The Pittsburgh Standard Questionnaire was used to assess sleep quality parameters; the VAS Pain Intensity Questionnaire was used to assess low back pain and the Oswestry Low Back Pain Disability Questionnaire. The exercise program intervention was performed for 28 sessions for 15 minutes. Descriptive statistics were used to analyze the data; also, the analysis of variance (ANOVA) with repeated measures was used. All analyzes were performed using SPSS software v. 24. Results The results showed a significant difference between groups in sleep quality parameters such as mental quality of sleep (P=0.001), delay in falling asleep (P=0.019), duration of sleep (P=0.006), sleep efficiency and effectiveness (P=0.001), sleep disorder (P=0.016), use of sleeping pills (P=0.001), inappropriate performance during the day (P=0.002). The overall sleep quality among elderly males was P=0.001. Also, bedtime exercises can significantly affect nonspecific chronic low back pain parameters such as pain intensity (P=0.039) and disability (P=0.014) in this age group. Conclusion Doing light exercise before bed on a light to moderate basis, according to the exercise program presented in this study, can improve the disability and reduce pain severity. This seems to be one of the most critical problems in old age, namely the quality of sleep and related parameters in the elderly male with nonspecific chronic low back pain. Therefore, it is recommended that the elderly engage in regular exercise.

Effects of physical exercise on sarcopenia after bariatric surgery: Study protocol of a randomized controlled trial

Introduction: Bariatric surgery is the treatment of severe obesity with associated pathologies, with proven evidence in its benefits. By treating overweight allows a better and even reversal of pathologies associated with obesity. Weight loss associated with bariatric surgery is greatly associated with a significant reduction of skeletal muscle and bone mineral mass, which leads us to induce that after bariatric surgery, patients incur an increased risk of sarcopenia. The need for prophylactic programs that prevent sarcopenia in bariatric surgery patients seems to be one of the crucial points for the framing of long-term surgical success of bariatric and metabolic surgery. The aim of this randomized clinical trial will be to study the effects of a 16-week supervised exercise intervention program on the prevention of sarcopenia after bariatric surgery Method: This randomized controlled trial study will include 60 patients of both sexes on the waiting list for bariatric surgery and who have subsequently performed the surgery. They will be randomized into 2 groups, experimental and control. The intervention will take place 1 month after surgery, for a total of 16 weeks. Parameters of body composition, metabolic risk, quality of life, physical activity and sedentary behavior will be determined. Results: Assessments will take place in five moments, the surgery, the intervention, the post-intervention, six months after the intervention, twelve months after the intervention.

Impact of Digital Device, Exercise, and Music Intervention Programs on the Cognition and Depression of the Elderly in South Korea: A Meta-Regression Analysis.

Background: This study examined the effect of digital devices, exercise, and music intervention programs for the elderly in Korea on their cognition and depression. Methods: This study selected 70 cognition programs and 46 depression programs for the elderly in Korea. This study controlled the characteristics of the programs and participants, and conducted a meta-regression analysis to estimate the intervention effect size of digital devices, exercise, and music on cognition and depression. Results: The meta-regression analysis revealed that digital device programs had a smaller effect size with respect to the improvement of cognitive functions than programs that did not use digital devices. The exercise programs had a small effect size on depression, but their effect size on cognition was not significantly different. Discussion: These findings provide implications for developing a program that combines music therapy with digital devices and exercise interventions, which can be effective in addressing both cognition and depression.

Protocol for the Exercise, Cancer and Cognition - The ECCO-Study: A Randomized Controlled Trial of Simultaneous Exercise During Neo-/Adjuvant Chemotherapy in Breast Cancer Patients and Its Effects on Neurocognition.

IntroductionEpidemiological studies show that increased physical activity is linked to a lower risk of breast cancer and mortality. As a result, physical activity can significantly improve patients' quality of life (QOL) both during and after therapy.Many breast cancer patients demonstrate a decrease in cognitive capacity, referred to as the symptom-complex cancer related cognitive impairment (CRCI). Most frequently reported impairments are mild to moderate deficits in processing speed, attention, memory, and executive functions. Cognitive symptoms persist for months or even years, following medical treatment in roughly 35% of afflicted people, impairing everyday functioning, limiting the ability to return to work, and lowering the overall QOL. Recent studies point toward a key role of inflammatory pathways in the CRCI genesis. Attention to physical activity as a potential supportive care option is therefore increasing. However, evidence for the positive effects of exercise on preventing CRCI is still lacking.Patients and MethodsAgainst this background, the prospective, two-arm, 1:1 randomized, controlled trial investigates the influence of first line chemotherapy accompanied by exercise training on preventing CRCI in 126 patients with breast cancer at the local University Hospital. The study will evaluate biomarkers and secondary assessments suspected to be involved in the pathogenesis of CRCI in addition to objective (primary outcome) and subjective cognitive function. CRCI is believed to be connected to either functional and/or morphological hippocampal damage due to chemotherapy. Thus, cerebral magnetic resonance imaging (MRI) and hippocampal volume measurements are performed. Furthermore, a specific neuropsychological test battery for breast cancer patients has been developed to detect early signs of cognitive impairments in patients and to be integrated into practice.DiscussionThis study will explore how a long-term supervised exercise intervention program might prevent CRCI, enables optimization of supportive care and objectifies limits of psychological and physical resilience in breast cancer patients during and after chemotherapy treatment.Trial RegistrationClinicalTrials.gov: Identifier: NCT04789187. Registered on 09 March 2021.

The Benefits of a Therapeutic Exercise and Educational Intervention Program on Central Sensitization Symptoms and Pain-Related Fear Avoidance in Breast Cancer Survivors

BackgroundCentral sensitization symptoms and pain-related fear avoidance are two common problems in breast cancer survivors. Non-pharmacologic interventions such as therapeutic exercise and patient education can be effective in this population. AimsThis study aimed to: (1) analyze the benefits of a therapeutic exercise and educational program on central sensitization symptoms and pain-related fear avoidance in breast cancer survivors, and (2) explore the association between pain-related fear avoidance and central sensitization symptoms. DesignA single group pre–post intervention study was conducted. MethodsPatients were recruited from the service of Medical Oncology of the University Clinical Hospital Virgen de la Victoria, in Málaga (Spain). The intervention consisted of a therapeutic exercise and educational program that lasted 12 weeks, twice a week, for 1 hour. Two instruments were used: the Spanish version of the Central Sensitization Inventory and the Spanish Fear Avoidance Components Scale. ResultsA total of 82 breast cancer survivors participated in the study. Pre–post change on Central Sensitization Inventory was statistically significant (p = .007). There was a trend towards a significant difference for the Spanish Fear Avoidance Components Scale (p = .062). There was a statistically significant correlation between pain-related fear avoidance and central sensitization symptoms (r = 0.536, p < .001). ConclusionsThe current study has provided preliminary evidence on the benefits of this intervention in pain-related fear avoidance and central sensitization symptoms in breast cancer survivors. The Spanish version of the Central Sensitization Inventory and the Spanish Fear Avoidance Components Scale demonstrated responsiveness to change.

Effect of a physical exercise program on plasma concentration of adiponectin in overweight and obese children

Adiponectin is considered a biomarker of health status, and high levels are associated with good health. Science discusses the results on the effects of physical activity on increasing adiponectin levels, especially in child with obesity. The scope of the present study was to evaluate a physical exercise intervention program, after 10 months of duration, in the plasma concentration of adiponectin in students from six to nine years of age with overweight and obesity. This is a randomized clinical study of a near-experimental intervention of the type before and after. The physical exercise resulted in a significant reduction in the percentage of body fat (%BF) and triglycerides. Adiponectin there was a non-significant increase. The present study showed that the practice of physical exercise did not increase adiponectin levels, but was responsible for a great improvement in the children lipid profile and reduction in %BF.

Be Healthy in Pregnancy (BHIP): A Randomized Controlled Trial of Nutrition and Exercise Intervention from Early Pregnancy to Achieve Recommended Gestational Weight Gain.

A randomized two-arm prospective superiority trial tested the efficacy of a novel structured and monitored nutrition (bi-weekly counselling for individualized energy and high dairy protein diet) and exercise program (walking goal of 10,000 steps/day) (intervention) compared to usual care (control) in pregnant women to achieve gestational weight gain (GWG) within current recommendations. Women recruited in communities in southern Ontario, Canada were randomized at 12–17 weeks gestation with stratification by site and pre-pregnancy BMI to intervention (n = 119) or control (n = 122). The primary outcome was the proportion of women who achieved GWG within the Institute of Medicine recommendations. Although the intervention compared to control group was more likely to achieve GWG within recommendations (OR = 1.51; 95% CI (0.81, 2.80)) and total GWG was lower by 1.45 kg (95% CI: (−11.9, 8.88)) neither reached statistical significance. The intervention group achieved significantly higher protein intake at 26–28 week (mean difference (MD); 15.0 g/day; 95% CI (8.1, 21.9)) and 36–38 week gestation (MD = 15.2 g/day; 95% CI (9.4, 21.1)) and higher healthy diet scores (22.5 ± 6.9 vs. 18.7 ± 8.5, p < 0.005) but step counts were similar averaging 6335 steps/day. Pregnancy and infant birth outcomes were similar between groups. While the structured and monitored nutrition with counselling improved diet quality and protein intake and may have benefited GWG, the exercise goal of 10,000 steps/day was unachievable. The results can inform future recommendations for diet and physical activity in pregnancy.

Effects of Exercise Programs on Physical Factors and Safety in Adult Patients with Cancer and Haematopoietic Stem Cell Transplantation: A Systematic Review.

This study looks at the effects of exercise programs on physical factors and safety in adult patients with cancer and hematopoietic stem cell transplantation (HSCT) or bone marrow transplantation (BMT). A systematic search was performed in the PubMed and Web of Science databases (from inception to 26 August 2021). A review was carried out following the Preferred Reporting Items for Systematic review and Meta-Analyses (PRISMA) checklist. The methodological quality of the included studies was assessed with the Physiotherapy Evidence Database (PEDro) scale, based, in turn, on the Delphi list. A total of 25 randomized controlled trials studies were included, comprising 1434 patients. The most significant result of this systematic review is that exercise program interventions are safe and produce positive changes in cardiorespiratory fitness, muscle strength, and the functional mobility-state in adult patients with cancer and HSCT or BMT. Only 3 patients from the 711 participants in the exercise interventions (i.e., 0.42%) reported adverse events related to exercise interventions. Moreover, exercise training programs may have a cardiological and muscular protective effect, as well as a healthy effect on the prevention and control of transplant complications, improving health outcomes.

Postural Control in Unipedal Quiet Stance in Young Female Gymnasts and the Effects of Training with Consideration of Transient Behavior of Postural Sway.

The purpose of this study was twofold: (a) to compare postural control between a group of young female gymnasts (n = 15; age: 11.2 ± 1.9 years) and non-trained peers (n = 15; age: 10.9 ± 2.0 years), and (b) to investigate the effect of an 8-week whole body exercise intervention program on postural control in young female gymnasts. Postural control was assessed by recording center of pressure (CoP) movements during unipedal quiet stance. Velocity and amplitude of CoP movement in anterior-posterior (AP) and medial-lateral (ML) directions were considered. In addition to common trial-averaged CoP outcomes, we also considered the transient behavior of CoP movements, by calculating relative differences between the 1st and 2nd, and the 1st and 3rd 10-s intervals within the whole trial (DIF_21 and DIF_31, respectively). The gymnast group had lower total CoP velocity (Cohen’s d = 0.97) and AP amplitude (Cohen’s d = 0.85), compared to their non-trained peers. The gymnasts also had lower CoP AP amplitude DIF21 (Cohen’s d = 0.73), with almost constant values across all intervals. After the training ML CoP velocity was reduced for 13.12% (Cohen’s d = 0.60), while ML CoP amplitude increased (Cohen’s d = −0.89).

Can exercise shape your brain? A review of aerobic exercise effects on cognitive function and neuro-physiological underpinning mechanisms.

It is widely accepted that physical exercise can be used as a tool for the prevention and treatment of various diseases or disorders. In addition, in the recent years, exercise has also been successfully used to enhance people's cognition. There is a large amount of research that has supported the benefits of physical exercise on human cognition, both in children and adults. Among these studies, some have focused on the acute or transitory effects of exercise on cognition, while others have focused on the effects of regular physical exercise. However, the relation between exercise and cognition is complex and we still have limited knowledge about the moderators and mechanisms underlying this relation. Most of human studies have focused on the behavioral aspects of exercise-effects on cognition, while animal studies have deepened in its possible neuro-physiological mechanisms. Even so, thanks to advances in neuroimaging techniques, there is a growing body of evidence that provides valuable information regarding these mechanisms in the human population. This review aims to analyze the effects of regular and acute aerobic exercise on cognition. The exercise-cognition relationship will be reviewed both from the behavioral perspective and from the neurophysiological mechanisms. The effects of exercise on animals, adult humans, and infant humans will be analyzed separately. Finally, physical exercise intervention programs aiming to increase cognitive performance in scholar and workplace environments will be reviewed.

Exercise Program: Tai Chi and Cognitive Stimulation to Improve Health Status of Elderly in Nursing Homes

The structure of the aging population reflects the higher average life expectancy, which possesses an impact on the emergence of degenerative non-communicable diseases. Promotive effort through an exercise program (tai-chi exercise and cognitive stimulation) is required for the elderly to enhance their physical and mental health. This study aims to determine an overview of the exercise program's effectiveness on the health status of the elderly in nursing homes. The research method administered Quasi experiment with a control group design. The sample was the elderly who live in nursing homes. This study employed simple random sampling with a total sample of 116 people in 2 provinces: DKI Jakarta and South Sumatra Province. The statistical test utilized a t-test and multiple linear regression test. The results revealed that there was a difference in the average value of the health status of the elderly before and after the exercise programs in the intervention group (p-value = 0.001), there was a difference in the average value of the health status of the elderly between the intervention group and the control group after the exercise intervention program (p-value = 0.001), there was a relationship between the length of stay in the orphanage on the health status of the elderly. Recommendation: the resulting exercise program can be employed as complementary therapies replicated more extensively in various health care settings.

A systematic review and meta-analysis examining the benefits of quantitative exercise intervention on effective bowel preparation prior to colonoscopy.

This study systematically evaluated and analyzed the efficacy of quantitative exercise intervention on colonoscopy intestinal preparation. A systematic search was performed using the Cochrane Library, the JBI evidence-based database, Embase, Web of Science, CINAHL, Medline, CNKI, the China Biomedical Literature Database (CBM), and the Wanfang database to identify literature relating to the efficacy of exercise intervention on bowel preparation for colonoscopy. Randomized controlled trials (RCTs) and clinical controlled trials (CCTs) published from the establishment of the database to July 2021 were included. After screening the literatures, relevant data was extracted and evaluated for quality. The RevMan 5.3 software was used for meta-analysis. A total of 8 studies with 1,486 patients, including 747 in the intervention group and 739 in the control group, were included in this meta-analysis. The results of 4 studies showed that the use of quantitative exercise intervention programs did significantly improve the quality of the patient's bowel preparations [mean difference (MD) =2.15, 95% confidence interval (CI): 0.04 to 4.26; P=0.046]. The results of 6 studies demonstrated that the use of quantitative exercise intervention programs can effectively improve the patient's bowel preparation adequacy rate [relative risk (RR) =1.25, 95% CI: 1.05 to 1.49; P=0.012]. Meta-analysis of 5 studies showed that the use of quantitative exercise intervention programs can reduce the incidence of nausea in patients (RR =0.52; 95% CI: 0.37 to 0.74; P=0.000). Analysis of 4 studies revealed that quantitative exercise intervention can reduce the incidence of vomiting in patients (RR =0.36; 95% CI: 0.23 to 0.56; P=0.000). Furthermore, evaluation of 4 studies demonstrated that quantitative exercise intervention reduced the incidence of abdominal pain in patients (RR =0.50; 95% CI: 0.28 to 0.89; P=0.019), and reduced the incidence of abdominal distension (RR =0.60; 95% CI: 0.36 to 0.99; P=0.047). Quantitative exercise intervention can effectively improve the quality of intestinal preparation before colonoscopy and reduce the incidence of adverse reactions.