Executive Vice President Research Articles

A tribute to Karen Greenwood and her contributions to the American Medical Informatics Association

After 25 years of service to the American Medical Informatics Association (AMIA), Ms Karen Greenwood, the Executive Vice President and Chief Operating Officer, is leaving the organization. In this perspective, we reflect on her accomplishments and her effect on the organization and the field of informatics nationally and globally. We also express our appreciation and gratitude for Ms Greenwood's role at AMIA.

CES 2022: Less is More

AbstractScaled‐down show still delivers top‐notch exhibits and innovation aplenty.

Editorial introductions.

Editorial introductions.

The Future of Uncertainty Factors With In Vitro Studies Using Human Cells.

New approach methodologies (NAMs), including in vitro toxicology methods such as human cells from simple cell cultures to 3D and organ-on-a-chip models of human lung, intestine, liver, and other organs, are challenging the traditional “norm” of current regulatory risk assessments. Uncertainty Factors continue to be used by regulatory agencies to account for perceived deficits in toxicology data. With the expanded use of human cell NAMs, the question “Are uncertainty factors needed when human cells are used?” becomes a key topic in the development of 21st-century regulatory risk assessment. M.D., PhD, the coauthor of an article detailing uncertainty factors within the U.S. EPA, and L.E., PhD., Executive Vice President, Science, Emulate, who is involved in developing organ-on-a-chip models, debated the topic. One important outcome of the debate was that in the case of in vitro human cells on a chip, the interspecies (animal to human) uncertainty factor of 10 could be eliminated. However, in the case of the intraspecies (average human to sensitive human), the uncertainty factor of 10, additional toxicokinetic and/or toxicodynamic data or related information will be needed to reduce much less eliminate this factor. In the case of other currently used uncertainty factors, such as lowest observable adverse effect level to no-observed adverse effect level extrapolation, missing important toxicity studies, and acute/subchronic to chronic exposure extrapolation, additional data might be needed even when using in vitro human cells. Collaboration between traditional risk assessors with decades of experience with in vivo data and risk assessors working with modern technologies like organ chips is needed to find a way forward.

In Case You Haven't Heard…

Women in the United States are 50% more likely than men to say their mental health has declined in the past year, according to new research from GWI, a global target audience insights company, and SeeHer, the leading global movement for increasing authentic portrayals of women and girls in advertising and media. Business Wire reported Oct. 20 that the research explores the mental health impact on particular groups like moms and women of color, as well as the role men play in this dynamic — in terms of both allyship and diverging perceptions. “As we emerge from this pandemic, it is evident that brands and the media will have to prioritize narratives that authentically and accurately represent the lived experiences of women, particularly in times of crisis and stress,” said SeeHer/Association of National Advertisers Executive Vice President of Analytics, Insights and Measurement Latha Sarathy. “Given the clear responsibility consumers believe brands have in addressing gender equality in media, now is the perfect opportunity for brands to reassess the messages they're putting into market.”

“Shovel-Ready”

“Shovel-Ready”

MintM: the start-up transforming businesses real-time

ABSTRACT In an increasingly digital world, technology-based start-ups face challenges which are of unique nature and hence cannot be fathomed by organizations belonging to another genre. The case study focuses on a series of strategic and business model redesigning challenges faced by Ashutosh Chouksey, Executive Vice President – Expansion and Strategic Operations, while co-leading a technology-based customer engagement and digital signage solutions start-up, MintM. MintM has a business to business (B2B) based model that relies on its own proprietary software to display targeted audio-visual content in stores and supermarkets, offering the unique value proposition of simultaneous last mile advertising connectivity and customer analysis. The core product of MintM requires regular upkeep creating a conflict: a chance of global outreach versus operational hassles hindering its growth trajectory. The case is an appropriate platform for demonstrating information technology-based business model management dilemma in a fast-changing digital milieu, whether to improvise on organizational structure or product particulars. The case also presents an opportunity to discuss operational challenges hindering expansion plans and how to strategize and redesign business model to overcome the same and cater to clientele in a niche nascent market while still maintaining a lean team.

E&P Notes (August 2021)

E&P Notes (August 2021)

Conversations about structural racism are uncomfortable. That’s the point.

Conversations about structural racism are uncomfortable. That’s the point.

In Memoriam: XU Hong (1963-2021)

1. The Chinese Journal of International Law mourns the passing on 7 March 2021 of Ambassador Dr. XU Hong, an Honorary Editor of this Journal and Executive Vice-President of the Chinese Society of International Law, formerly Ambassador of China to the Netherlands and Permanent Representative of China to the Organization for the Prohibition of Chemical Weapons, and Director-General of the Department of Treaty and Law in the Ministry of Foreign Affairs of China. 2. Ambassador Xu’s professional and scholarly achievements have been told elsewhere and will be told in the future, we are sure. Here in this academic forum, we do not repeat those efforts, but would like to express our gratitude to Ambassador Xu for his strong efforts to strengthen the interaction between his colleagues in the government and academia. During his term as Director-General of the Department of Treaty and Law, the Ministry of Foreign Affairs of China...

Jie Qiao: leading figure in China's reproductive health revolution

Four decades ago, Jie Qiao was studying medicine at what was then called Beijing Medical College, with little idea of how far her career would take her. Today, Qiao is Executive Vice President of Peking University, Director of Peking University Health Science Center, President of Peking University Third Hospital (PUTH), and is widely acknowledged as a leading figure in reproductive medicine in China. She is also a Co-Chair of the Lancet Commission on reproductive, maternal, newborn, child, and adolescent health (RMNCAH) in China. A Lancet Commission on 70 years of women's reproductive, maternal, newborn, child, and adolescent health in ChinaWomen's reproductive, maternal, newborn, child, and adolescent health (RMNCAH) is a cornerstone for the healthy development of the next generation and a driving force for the progress of population and society in the future, especially in this era of population ageing and low fertility in China. In past decades, China's RMNCAH has made remarkable achievements in development goals related to reducing maternal and child mortality. However, as China moves towards a thriving goal—namely, towards ensuring health and wellbeing—the country faces emerging problems and new challenges in RMNCAH. Full-Text PDF

Looking Back, 25 Years Later

I proudly served as Executive Vice President of CHRIE from 1986 to 1996. Looking back, 25 years later, my first thoughts are the wonderful memories I have of the tremendous people with whom I worked including CHRIE leaders, members, industry professionals, allied association executives and the CHRIE staff. We shared great experiences at Annual CHRIE Conferences and other events including Alligator Hours at the Copacabana during the New York Hotel Show; annual pilgrimages to the National Restaurant Association Show in Chicago including the Salute to Excellence, receptions at the Standard Oil Building (now Aon Center); the inauguration of EuroCHRIE in Switzerland in the early 90s; and regional CHRIE Conferences in the United States, Canada, and so on.

COVID-19 Pandemic as a Factor for the Paradigm Shift in International Communications. Book Review of ‘Pandémie médiatique. Com de crise/crise de com’ by S. Fouks

The review examines a new book ‘Media pandemic. Crisis communication / communication crisis’ (‘Pandémie médiatique. Com de crise / crise de com’) by the executive vice-president of the Havas Group Stephan Fouks, which was published in the midst of the COVID-19 pandemic. Building on his rich and unique practical experience as a head of a large media organization, a consultant at international organizations and a presidential campaign manager, the author assesses the role of media communications in the context of the coronavirus outbreak. The book under review is addressed primarily to experts in International Relations. It covers a wide range of issues including the causes of the crisis, which led to a paradigm shift in international communications, and specifi cs of the communication policies in France and some other European states. The author concludes that these policies refl ect a general crisis of the ruling elites (political establishment). Here the author continues to further elaborate on the ideas of his previous book — ‘The New Elites: portrait of a generation that will ignore’ (‘Les Nouvelles Elites: portrait d’une génération 1ui s’ignore’).The author provides a critical analysis of the key elements of communication strategies during the COVID-19 pandemic, from the ruling elites to the expert community, and delineates methods and the role of international communication in the future. The reviewers emphasize that the monograph by Stefan Fouks goes beyond the traditional formats of communication studies, which tended to focus either on the various crises, or on the organization of media structures in diff erent states, public-private partnership, and corporate communications, and thus were too narrow in scope. In ‘Media-pandemic’ the author stresses multidimensional nature of international communications and argues that their paradigmatic shift was brought by both the development of digital technologies and anthropogenic factors in the form of the global COVID-19 pandemic.

National Conference of Black Political Scientists Presidential Address

National Conference of Black Political Scientists Presidential Address

A Nurse Is Not Just a Nurse: The Challenges of Nursing During a Pandemic and Beyond

Summary The Executive Vice President and Chief Nursing Officer for CommonSpirit Health discusses challenges nurses are facing during the Covid-19 pandemic, predominantly in terms of staffing, burnout, and compassion fatigue and PTSD; how burnout has been a problem in nursing for decades; and involving nurses in the vision for the future of health care delivery.

IMPLEMENTATION OF LAND LEASE AGREEMENT MANAGED BY PT. INDONESIAN RAILWAYS IN THE OPERATING AREA 4 SEMARANG

The right to control from the state over land originates from the right of the Indonesian nation to land, which in essence is an assignment to carry out the duties of the nation's authority which contain elements of public law. PT. Kereta Api Indonesia (Persero) may diversify its business by utilizing its land in collaboration with third parties to support its main business. The purpose of this research is to determine the implementation procedure, the form of land lease agreements to the settlement of land lease defaults managed by PT. Kereta Api Indonesia (Persero) Operation Area 4 Semarang. This research is a sociological juridical research. The results of this research indicate that the implementation of the land lease agreement managed by PT. Kereta Api Indonesia (Persero) is carried out by submitting an application to the Executive Vice President of Daop 4 Semarang. If the contents of the contract have been agreed upon by both parties, the contract is made in 2 (two) copies and signed by both parties on a stamp duty. The form and content of the lease agreement is standard in nature, the contents of which are an agreement of two or more parties or a reciprocal standard agreement. Efforts made by PT. Kereta Api Indonesia (Persero) if there is default, but the contract period has expired and does not make an extension if 2 (two) months before the due date the tenant has not made an application letter for contract extension, the Asset Management Manager makes a notification letter to the tenant that the contract will end and concerned in order to complete the contract extension process.

Payment reform

I am excited to publish the first article in the new Journal of the American Pharmacists Association column: Perspectives in Pharmacy. This column is intended for concise reflections on relevant, pressing issues broadly facing pharmacy and health care. Scott J. Knoer, MS, PharmD, FASHP, Executive Vice President and Chief Executive Officer, American Pharmacists Association, Washington, DC CORRECTIONJournal of the American Pharmacists AssociationVol. 61Issue 4PreviewCorrection to Scott J. Knoer. Payment Reform. Journal of the American Pharmacists Association. 2021;61(2):129-130. Full-Text PDF

Leadership: Tested in a Crisis

Administrative Update| March 2021 Leadership: Tested in a Crisis Mary Dale Peterson, MD, MSCHA, FACHE, FASA Mary Dale Peterson, MD, MSCHA, FACHE, FASA Search for other works by this author on: This Site PubMed Google Scholar ASA Monitor March 2021, Vol. 85, 7. https://doi.org/10.1097/01.ASM.0000737028.02296.8d Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Search Site Citation Mary Dale Peterson; Leadership: Tested in a Crisis. ASA Monitor 2021; 85:7 doi: https://doi.org/10.1097/01.ASM.0000737028.02296.8d Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentAll PublicationsASA Monitor Search Advanced Search Topics: leadership Everyone knows a good leader when they see one, but what makes a good leader? I have read a lot of books on leadership and have gleaned tidbits from many in my journey as a leader that I will share with you. When I began my year as ASA President in October 2019, I had no idea the number of crises we would be faced with. I am also the COO and Executive Vice President of our children's health system, having to also deal with all the challenges of COVID-19. In the middle of our largest surge in July, I also had to deal with the emergence of a Category 1 Hurricane. So what have I learned from all of this? I will first discuss the actions of a leader that are helpful in a crisis and then the... © 2021 American Society of Anesthesiologists (ASA), All Rights Reserved.2021 You do not currently have access to this content.

Isolation and Characterization of Cross-Neutralizing Coronavirus Antibodies from COVID-19+ Subjects

SARS-CoV-2 is one of three coronaviruses that have crossed the animal-to-human barrier in the past two decades. The development of a universal human coronavirus vaccine could prevent future pandemics. We characterized 198 antibodies isolated from four COVID19+ subjects and identified 14 SARS-CoV-2 neutralizing antibodies. One targeted the NTD, one recognized an epitope in S2 and twelve bound the RBD. Three anti-RBD neutralizing antibodies cross-neutralized SARS-CoV-1 by effectively blocking binding of both the SARS-CoV-1 and SARS-CoV-2 RBDs to the ACE2 receptor. Using the K18-hACE transgenic mouse model, we demonstrate that the neutralization potency rather than the antibody epitope specificity regulates the in vivo protective potential of anti-SARS-CoV-2 antibodies. The anti-S2 antibody also neutralized SARS-CoV-1 and all four cross-neutralizing antibodies neutralized the B.1.351 mutant strain. Thus, our study reveals that epitopes in S2 can serve as blueprints for the design of immunogens capable of eliciting cross-neutralizing coronavirus antibodies.Funding: This work was supported by generous donations to the Fred Hutch COVID-19 Research Fund, by grants (P51OD011132 and 3U19AI057266-17S1) from the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), by the Bill and Melinda Gates Foundation (OPP1170236/INV-004923), by the Emory Executive Vice President for Health Affairs Synergy Fund award, the Pediatric Research Alliance Center for Childhood Infections and Vaccines and Children’s Healthcare of Atlanta, the Woodruff Health Sciences Center 2020 COVID-19 CURE Award and the Emergent Ventures Award (HYC). Support was also provided by leMinistère de l’Économie et de l’Innovation du Québec, Programme de soutien aux organismes de recherche et d’innovation to A.F., by the Fondation du CHUM and by a CIHR foundation grant #352417 to A.F. A.F. is the recipient of Canada Research Chair on Retroviral Entry no. RCHS0235 950-232424. We thank the J. B. Pendleton Charitable Trust for its generous support of Formulatrix robotic instruments. Results shown in this report are derived from work performed at Argonne National Laboratory, Structural Biology Center (SBC), ID-19, at the Advanced Photon Source. SBC-CAT is operated by U Chicago Argonne, LLC, for the U.S. Department of Energy, Office of Biological and Environmental Research under contract DE-AC02-06CH11357.Conflict of Interest: L.S., M.P., and A.T.M. have filed a provisional patent application on the SARS-CoV-2 specific monoclonal antibodies from CV1, CV2 and PCV1. L.S., M.P., A.T.M., and A.F. have filed a provisional patent application on the mAbs from CV3. H.C. reports grants from Bill and Melinda Gates Foundation, and NIH during the conduct of the study; consulting with Merck and the Bill & Melinda Gates Foundation, grants from Sanofi Pasteur and Gates Ventures outside the submitted work, and non-financial support from Cepheid and Ellume.Ethical Approval: Blood and peripheral blood mononuclear cells (PBMCs) were isolated from COVID19+ patients using protocols approved by Institutional Review Boards at Fred Hutch Cancer Research Center, University of Washington and Seattle Children’s Research Institute. Informed consent was obtained from all participants and the University of Washington and/or Fred Hutchinson Cancer Research Center and CHUM Institutional Review Boards approved the entire study and procedures. All experiments adhered to the guidelines approved by the Emory University Institutional Animal Care and Committee.

Pharmacists in Action

Pharmacists in Action