Executive Committee Research Articles

Collaborative data sharing: The International Acute Myeloid Leukemia Consortium (INTERACT).

169 Background: Outcomes for children and adolescents/young adults (AYAs) with acute myeloid leukemia (AML) remain suboptimal and are decidedly poor for patients with subtypes defined by high-risk features, including canonical genetic alterations and relapsed/refractory presentation. Due to their rarity, these subtypes are difficult to study within the existing clinical trials paradigm. Data sharing efforts aim to increase our understanding of rare cancer subtypes by pooling data from multiple sources. The INTERnational Acute myeloid leukemia ConsorTium (INTERACT) was established to pool and share data on pediatric and AYA patients with AML. Methods: In 2019, a data dictionary was created through an iterative, consensus-driven process that analyzed pre-existing clinical trials case report forms as the initial basis. By developing this standardized representation for data on patients with AML, data could be harmonized and integrated. A memorandum of understanding was signed in 2021, formally establishing INTERACT. An executive committee was convened to establish scientific priorities, facilitate ongoing data dictionary work, usher agreements with data contributors and review data requests submitted by investigators. In January 2024, the initial set of AML data was released on the Pediatric Cancer Data Commons (PCDC) data portal. Results: As of April 2024, the data dictionary includes 157 standardized data elements that were used to harmonize clinical data on 3,413 patients who participated in seven clinical trials conducted by four pediatric oncology cooperative groups across the United States, Europe, and Asia. Elements in the data dictionary include demographics, initial disease characteristics, genetic alterations, and survival status. Aggregate data can be freely explored using the publicly-available PCDC data portal (portal.pedscommons.org) and investigators seeking line-level access to data may submit a project request to the INTERACT executive committee for consideration. Conclusions: International collaborative data-sharing efforts will advance our understanding of pediatric and AYA AML by reducing barriers that constrain our study of AML to smaller cohorts of data. We hope that an early outcome of data sharing will be to increase our understanding of optimal treatments for patients with relapsed/refractory disease. Future goals of INTERACT include identifying data from additional studies to include, establishing relationships with new data contributors, and establishing working groups to advance the consortium’s scientific and clinical trials goals.

SELA Officers and Executive Committee, SELA State Representatives

SELA Officers and Executive Committee, SELA State Representatives

Writing about Masud Khan

This article tells the story of a three-decade delay in the publication of Masud Khan’s personal diary, which he called his Work Books. They were meant for publication after his death in 1989, yet he neglected to name a literary executor prior to his death, and the copyright was subsequently allocated to the International Psychoanalytical Association (IPA). The IPA chose to destroy their copy of the Work Books in 2019, alongside all other Khan-related materials in their possession, yet Linda Hopkins, author of an acclaimed biography of Khan, worked alongside Steven Kuchuck to obtain permission from the IPA Executive Committee to publish an edited version of an exact copy of the Work Books which Khan had given to his close friends Robert and Sybil Stoller for eventual publication. This is the story of a struggle to get permissions, after objections were raised by various psychoanalysts who mistakenly feared the contents of the Work Books would invade the privacy rights of Khan’s patients.

MODELS AND INSTITUTIONAL FACTORS OF THE CAREER OF HEADS OF LOCAL PUBLIC AUTHORITIES AND MANAGEMENT (1965–1985)

The article deals with the issues of personnel policy in relation to the heads of local government bodies – the chairmen of the executive committees of the Soviets of the period of "developed socialism". In the 1960s and 1980s, there were models of career growth worked out in practice, which assumed consistent, starting from grassroots leadership positions, and gradual, without sudden jerks, promotion along the vertical of power and management. Based on the analysis of statistical material and the study of the biographies of specific heads of local state bodies, three main trajectories of their career growth are distinguished: "Soviet-economic", "party-Soviet", "combined". It is noted that the most common was the third option – "combined": the alternation of party, Soviet and economic nomenclature positions. Institutional factors of career growth are highlighted: membership in the CPSU, higher specialized technical or agricultural education, higher party-political education, age and work experience in lower positions (including the beginning of work as workers or collective farmers). The article was prepared as part of the task of the state scientific research program "Society and Humanitarian Security of the Belarusian State", subprogram "History", topic 12.1.3.11 "Local government bodies of the Byelorussian SSR – the Republic of Belarus: organizational, legal, material, financial and personnel foundations of functioning (1944–2020)" for 2021–2025.

Legal Nature of the Central Executive Committee of the USSR under the Constitution of the USSR of 1924

The paper provides a comprehensive analysis of the role and status of the Central Executive Committee of the USSR (CEC of the USSR) in the context of the dynamic constitutional, legal and institutional development of the Soviet Union. The author provides the reader with a deep dive into the essence of the CEC of the USSR, providing a brief but meaningful historiographical description of the collective body of state power. The main attention is paid to a detailed analysis of the status of the CEC of the USSR before and after the adoption of the Constitution of the USSR in 1924, to identify and highlight key differences in its structure and functioning due to innovations introduced with the adoption of this legislative act. The paper examines the key areas of activity of the Central Executive Committee of the USSR in detail both in the period before the adoption of the Constitution (1922–1925) and in the post‑constitutional period (1925–1938), forming a categorical layer of the problematic issue. The paper highlights and explains the stable position of the CEC of the USSR in the political sphere of the USSR and gives a brief assessment of its activities and development. The paper is of interest to researchers of the history and law of the Soviet period and is an important contribution to understanding the organizational and regulatory aspects of the functioning of the CEC of the USSR in the broad context of constitutional construction in the first decades of Soviet history. The main emphasis is placed on the formation of a comprehensive framework for the perception of the CEC of the USSR as a body that is simultaneously characterized by isolation in the system of state bodies of Soviet power and close connection with other such bodies. Such an emphasis allows the reader to form a wide categorical and conceptual spectrum of opinions & sententiae on the problem of defining and analyzing the legal nature of the CEC of the USSR, which is important for Russian historiography.

People Don’t Give Up!

In 2017 images of demonstrations, riot police, and tanks filled social media worldwide. Most of the videos and media coverage reported on the first wave of #BlackLivesMatter uprisings were catalyzed by police brutality in Ferguson, New York, and Baltimore. In June of that year, similar footage came from Buenaventura, on the Pacific coast of Colombia. This predominantly Afro-descendantpo rt city is responsible for the transit of about 60 percent of the country’s commerce, while unemployment and inequality are rampant, and the infrastructure is on the brink of collapse. The affected local communities responded to these conditions of structural racism with a direct action named Paro Civico: a general strike planned for years by a coalition of grass-rootsAfro-Colombi an organizations demanding clean drinking water, health care, education, and policies to combat drug trafficking-related violence. Resisting police attacks while negotiating with a high-ranked delegation from the Colombian government, the months-long general strike achieved the majority of its goals and, most importantly, galvanized the momentum into the election of one of the movement’s leaders as mayor of Buenaventura. However, the leaders of the Paro Cívico’s Executive Committee have been emphatic in naming this a multiethnic movement and rejecting any specific racial discourses as organizing guiding principles for the direct action. In addition to contextualizing Paro Cívico, this article uses Tianna Paschel’s concept of “organizing while black,” to explain this omission in a racial context determined by the politics of mestizaje in Colombia. It also explains how Paro Cívico strategically exhibited the political power of the communities of the African diaspora without verbalizing it, becoming one of multiple factors that ushered in a new chapter of racial politics in the nation.

Основные тенденции функционирования системы местных Советов БССР периода «развитого социализма» (1965–1984 гг.)

The article examines the main trends in the functioning of the system of local Soviets and their executive committees as constitutionally fixed bodies of state power and management in their administrativeterritorial territories. It is noted that the changes in the organizational structure of the executive committees were bureaucratic in nature, and the practice of implementing an official course to increase the role of Soviets was limited only by a slight expansion of their financial capabilities. The qualitative composition of the executive staff of the executive committees of the Soviets met the needs of the existing centralized planned model of development of soviet society.

The Effectiveness of Cyber Threat Intelligence in Improving Security Operations

The purpose of this research was to comprehensively evaluate the effectiveness of Cyber Threat Intelligence (CTI) in enhancing security operations, while simultaneously identifying the various barriers to its adoption. Additionally, the study aimed to provide potential solutions to mitigate the identified barriers, to ensure successful adoption of CTI.A systematic review was undertaken to identify the main factors of enhanced security operations. Relevant questions and statements were then developed from these factors and a questionnaire was created using Google Forms. These questionnaires were then distributed via email to a sample size of 50 information technology professionals. These results were then analyzed using Microsoft Excel and SPSS. Overall, the research revealed that companies who used CTI reported significant gains in threat detection and response, risk management and threat-hunting abilities, which in turn lead to enhanced security operations. According to the research, several factors prevented organizations from adopting CTI. Among these were technological, regulatory, ignorance-related, and lack of executive support. Finally, to tackle these identified barriers the following were proposed adopting comprehensive awareness and education programs, the formation of an Executive CTI Steering Committees, structured CTI training and skills development programs, technology assessment and modernization initiative-based initiatives, proactive compliance, and legal strategies.

The German cochlear implant registry: one year experience and first results on demographic data

PurposeClinical registries have great potential for quality control of medical procedures regarding the indications, therapeutic processes and results, including their possible complications. This is particularly true when providing patients with severe hearing loss or deafness with a cochlear implant (CI). This treatment represents a lifelong care process that requires continuous quality control over time. On the initiative of the Executive Committee of the German Society of Otorhinolaryngology (Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V., DGHNO-KHC), a national German CI registry (Deutsches Cochlear Implant Register, DCIR) was established in January 2022. This article focuses on the first demographic and baseline data of the DCIR.MethodsThe DCIR covers the complete therapeutic process from indication, surgery, fitting and lifelong aftercare in CI therapy. By the end of 2022, 75 hospitals in Germany had agreed to contribute to the DCIR.ResultsDuring the year 2022, 63 hospitals actively contributed data to the DCIR. Pseudonymized data from 2,292 CI implantations (2,176 primary implantations, 99 explantations with immediate re-implantations and 17 re-implantations following an earlier explantation) in 2,108 patients were documented. Cochlear implantation was accomplished in 1,807 adults (≥ 18 years) and 301 children (< 18 years). Fourty patients (1,9%) were children < 1 year of age and 55 (2,6%) were patients > 85 years. From the total of 2,292 implantations, 226 (9.9%) were performed as simultaneous bilateral implantations (CI implantation in both ears of 113 patients on the same day of surgery) and 412 implantations (19.1% of 2,162 implantations with data provided on the contralateral ear’s hearing status) were in patients with single sided deafness (normal hearing in the contralateral ear). In addition, the reported complications in 2022 were also evaluated. Seven reports (0.4%) of mild to moderate severe facial nerve dysfunctions were documented. No reports of severe or total facial nerve dysfunction (House-Brackmann grade V/VI), meningitis or death related to CI therapy were documented.ConclusionAlthough still in the start-up phase, these initial DCIR data already provide an interesting first insight into the demographic structure and baseline data of CI therapy in Germany. The successful implementation of the DCIR represents an important step towards continuous quality control of CI care.

O-240 Embryo assessment: the Istanbul consensus revised

Abstract Study question What are the current recommended criteria for morphological assessment of oocytes, zygotes and embryos? Summary answer The present ESHRE/Alpha Scientists in Reproductive Medicine consensus document provides several novel recommendations to assess oocyte and embryo morphology and rank embryos for transfer. What is known already A previous Alpha Scientists in Reproductive Medicine / ESHRE consensus on oocyte and embryo morphological assessment was published in 2011. After more than a decade, a thorough review and update was needed. Study design, size, duration A working group consisting of Alpha Scientists in Reproductive Medicine executive board members and ESHRE Special interest group of Embryology members formulated recommendations on oocyte and embryo morphological assessment. Participants/materials, setting, methods The working group included 17 internationally recognized experts with extensive experience in clinical embryology. Seven members represented Alpha Scientists in Reproductive Medicine and 8 members represented ESHRE, in addition to two methodological experts from the ESHRE central office. Based on a systematic literature search and discussion of existing evidence, the recommendations of the Istanbul Consensus (2011) were reassessed and, where appropriate, updated based on consensus within the working group. After stakeholder review, the final version will be approved by the working group, the Alpha executive board and the ESHRE Executive Committee. Main results and the role of chance This updated consensus paper provides 20 recommendations focused on the timeline of preimplantation developmental events and morphological criteria for oocyte, zygote, and embryo assessment. Based on duration of embryo culture, recommendations are given on the frequency and timing of assessments to ensure safety and effectiveness. Limitations, reasons for caution Several criteria relevant to oocyte and embryo morphology have not been well studied, leading to either a recommendation against their use for grading or for use in ranking rather than grading. Future updates may require further revision of these recommendations. Wider implications of the findings This document provides embryologists with clear advice on best practices when assessing oocyte and embryo quality based on the most recent evidence.

Minutes of the 2024 Meetings of the Executive Committee of the Society of Southwestern Entomologists

Minutes of the 2024 Meetings of the Executive Committee of the Society of Southwestern Entomologists

Городское самоуправление Якутска при правительстве адмирала А.В. Колчака в 1919 г.: выборы, организация и упразднение

Статья посвящена анализу городского самоуправления Якутска в 1919 г., особое внимание уделено его состоянию в период Гражданской войны и последующей ликвидации городского управления после большевистского переворота. Исследование освещает выборы и структуру городского управления при А.В. Колчаке с учетом принципов историзма и объективности. В результате анализа стало ясно, что в декабре 1918 г. правительство ограничило избирательные права горожан. Последние выборы в городскую думу прошли в 1919 г., был сформирован новый состав органов городского самоуправления. The article explores the historical context of city self-government in Yakutsk during the revolution, addressing the lack of historical research on this topic during the Civil War in Russia. The study aimed to analyze the structure of self-government institutions, personnel composition, and the electoral process, considering the factors influencing these processes during the social upheaval of the Civil War. It also examines the liquidation of city self-government following the Bolshevik coup in December 1919, including the subsequent arrest of its members. The scientific innovation lies in providing the first comprehensive representation of the election process and the personal composition of the Yakutsk city government (City Duma and City Council) during Admiral A.V. Kolchak’s reign, using a methodology based on historicism, objectivity, consistency, and comprehensiveness. The retrospective method revealed cause-and-effect relationships and recurring patterns in the historical evolution. In December 1918, Admiral A.V. Kolchak annulled the decree issued by the Provisional Government in April 1917 and amended city government elections, limiting citizens’ electoral rights through changes to the electoral qualifications. The last elections were held in the fall of 1919, resulting in a city self-government consisting of 25 members with an average age of 47.96 years, predominantly holding official or employee positions and having secondary education. The composition and number of members of the city self-government changed multiple times, and the city authorities continued to rely on the city regulations of 1892 when forming the executive committees. On the night of December 14–15, 1919, the local Yakutsk garrison executed an armed revolt and apprehended Admiral A.V. Kolchak’s followers. From December 15, 1919 to January 1, 1920 Soviet power entities were established, marking the dissolution of the city government and the subsequent arrest of its members.

Черкешенки и советская власть: о ходе «раскрепощения горянки» на страницах журнала «Труженица Северного Кавказа» (1925-1927 гг.)

The article is devoted to the study of the representation of the processes included in the extensive set of measures called ‘emancipation of the mountain woman’ on the pages of the magazine ‘Tru-zhenitsa Severnogo Kavkaza’, the official press organ of the women’s department of the North Caucasian regional executive committee on the example of work with Circassian women. This study examines the demonstration to the public (in particular, to the female masses) of the results of the Soviet authorities’ activities regarding the Circassian women who inhabited the territory of several autonomous regions of the Soviet Union: Adygeya (Cherkessia), Kabardino-Balkaria and Karachay-Cherkessia: it highlights its various directions such as education, the elimination of domestic and political illiteracy, the involvement of women in industrial work, the opening not only of clubs for women but also of artels and workshops. The article presents the materials of the magazine reflecting the work of the Soviet authorities with Circassian women for 1925-1927, up to the time when the magazine was renamed.

Development of the Health Care System in the Documents of the Executive Committee of the Krasnoyarsk Council of Workers Deputies in 1960–1968

Development of the Health Care System in the Documents of the Executive Committee of the Krasnoyarsk Council of Workers Deputies in 1960–1968

Procedure for Holding a Meeting and Registering a Group of Voters to Support the Self-Nomination of a Candidate for the Position of President of the Russian Federation: Constitutional and Legal Responsibility for its Violation

Introduction. The article is based on an analysis of the decisions of the Central Election Commission of Russian Federation on the refusal to register groups of voters created to support the self-nomination of candidates for the position of President of the Russian Federation and their authorized representatives, within the framework of the elections of the President of the Russian Federation, scheduled for March 17, 2024, and the decisions of the Supreme Court of the Russian Federation, based on the results of challenging such decisions, revealed problematic aspects of the procedure for creating and registering a group of voters to support the self-nomination of a candidate. Methods. When writing the article, general scientific methods were used: analysis, synthesis, systematization. In addition, a formal legal method was used. In the process of analyzing the empirical material, which consists of decisions of the Supreme Court of the Russian Federation, decisions of the Central Election Commission of the Russian Federation, sociological methods were used. Results. It is noted that, taking into account the current legislation and resolutions of the Central Election Commission, the procedure for holding a meeting and registering a group of voters to support a candidate for the position of President of the Russian Federation has been established, which consists of a number of stages with a certain mode of conduct and documentation. For violation of the procedure, corresponding constitutional and legal liability is established in the form of cancellation of the decision of the meeting and its registration. Discussion and Conclusion. An analysis of the current legislation and the decisions of the All-Russian Central Executive Committee allows us to conclude that the currently established procedure is a guarantee of democracy and reliability in the implementation of electoral rights.

ON THE ENTRY INTO FORCE OF CONSTITUENT ACTS AND MEMBERSHIP IN THE COMMONWEALTH OF INDEPENDENT STATES

Based on an analysis of legal norms and the original texts of the constituent documents, the publication argues that the constituent acts of the Commonwealth of Independent States (CIS, i. e. the Agreement on the creation of the CIS of December 8, 1991 and the Protocol to it of December 21, 1991) came into full force on December 21, 1991. Thus, the Commonwealth as an interstate association was formed precisely on this date, December 21, 1991, and not December 8, 1991, as is widespread in domestic legal science. At the same time, based on an analysis of o cial information from the CIS Executive Committee, a reasoned answer is given to a question that has not previously been covered in legal science (Russian, and especially foreign) - on what date did the constituent acts of the Commonwealth fully come into force for each CIS member state? In addition, the publication assesses the legal status in the Commonwealth of Azerbaijan, Georgia (before its withdrawal from the CIS in 2009), Moldova and Ukraine.

Деятельность организационно-инструкторского отдела Ленинградского городского Совета депутатов трудящихся в 1943–1945 гг.

The activities of the Organizational and Instructional Department of the Leningrad City Council during the war and blockade have not previously been subjected to detailed study. The significance of this scientific problem is, first of all, due to the role of instructors, which they played in organizing and monitoring the implementation of regulatory decisions of the Leningrad City Executive Committee, as well as resolutions of local and central party authorities. The article reconstructs the main approaches to the work of an instructor in 1943–1945, identifies the most significant areas of activity, analyzes the problems of the functioning of Department and practical steps to solve them. During the period under study, the key vector of activity of the Leningrad City Executive Committee was the implementation of restoration measures in Leningrad. The study introduces into scientific circulation regulatory and records materials deposited in the Central State Archives of St. Petersburg. By reconstructing the main approaches to instructor work, analyzing key directions of activity, and evaluating challenges and solutions, this article sheds light on the multifaceted dynamics of governance amidst the exigencies of war and blockade.

Report from the EMS Executive Committee online meeting, 17–20 November 2023

The EMS Executive Committee (EC) holds two major meetings in each (non-exceptional) year, plus regular shorter virtual meetings. For reasons of environmental and financial sustainability, one of the major meetings is now also held virtually. So, the EC plus guests met online between 17 and 20 November 2023.

Правопорушення неповнолітніх у Житомирській області в 1970-х рр.: стан та заходи запобігання

The purpose of the study is to analyze the problem of juvenile delinquency in the 1970s in a regional context, using the example of Zhytomyr region and the measures of their prevention by the relevant state authorities. The methodological basis of the research is the methods of analysis and synthesis, comparative, statistical (to characterize juvenile delinquencies, their dynamics) methods; the principles of objectivity, scientific, and historicism were also used, which contributed to a more impartial and comprehensive analysis of the mentioned problem and period. The scientific novelty of the study consists of a comprehensive analysis of the delinquency problem among the minors in Zhytomyr region in the 1970s, based on archival sources (reports of relevant authorities). Conclusions. For the period of the 1970s in the social sphere of the Ukrainian SSR, one of the difficult tasks of the authorities was solving the problem of the delinquency among the minors. We considered the regional aspect of the problem, using the example of Zhytomyr region. In the mentioned period, offenses among the minors tended to increase, which was primarily due to the work of the relevant authorities, schools, vocational schools, which were supposed to control the teenagers’ behavior. The analysis of the juvenile delinquencies shows that crimes against citizens' property, hooliganism and rape were mainly committed. The tendency to commit group crimes intensified. Reports and resolutions of the relevant authorities (regional executive committee, juvenile commissions) show that the problem of juvenile delinquency was quite urgent in the districts of Zhytomyr region. It should also be noted that inspections of the juvenile commissions’ work revealed their insufficiency and formal attitude to solving those problems. The work of law enforcement agencies was also insufficient. The authorities proposed a number of measures to prevent delinquency among teenagers, but they were not always effective. The measures in educational sphere were also predominant. The problem of youth’s leisure was supposed to be solved among others. At the same time, the authorities also provided anti-religious upbringing of teenagers. Regional problems of the juvenile delinquency in Ukraine during the transitional period (years of “perestroika” 1985-1991) require further research.

Formation of the Kyrgyz State as a Political System of Kyrgyzstan

On October 14, 1924, the II session of the All-Russian Central Executive Committee of the Soviets, having considered the resolution of the Turk Central Executive Committee on national-state delimitation, made and approved the following changes: it was decided to transform the Tajik Autonomous Region into the Tajik Autonomous Soviet Socialist Republic within the Uzbek SSR; The Kara-Kalpak Autonomous Region was introduced into the Kyrgyz (Kazakh) Autonomous Soviet Socialist Republic, and the Kara-Kyrgyz (Kyrgyz) Autonomous Region directly into the RSFSR.Thus, the national statehood of the Kyrgyz people dates back to October 14, 1924.