Exchange Function Research Articles

Pulmonary AVM Embolization

Pulmonary arteriovenous malformations (PAVMs) are rare fistulous connections between pulmonary arteries and veins that, as in our case, are commonly associated with hereditary hemorrhagic telangiectasia (HHT). Embolotherapy, the mainstay of treatment for PAVMs, is a procedure in which the feeding arteries of a malformation are endovascularly occluded under fluoroscopic guidance. Effective and well-tolerated, embolotherapy has been shown to decrease right-to-left shunting following treatment and decrease risks of paradoxical embolization and lung hemorrhage and to improve pulmonary gas exchange and lung function. Patients are selected for treatment according to clinical suspicion for the presence of a PAVM and feeding artery diameter. The occlusion of PAVMs with arteries that exceed 2-3 mm in diameter is recommended. Diagnostic contrast-enhanced pulmonary angiography is performed via injection of contrast through a percutaneous catheter to characterize and confirm PAVMs suitable for embolization. Lesions are then treated by catheter-directed placement of embolic material— vascular plugs in our case—into the feeding artery, terminating blood flow to the area of the lesion. Although multiple PAVMs may be embolized during a single session, in patients with HHT, who may present with large numbers of PAVMs, treatment is limited by maximum contrast dosage, and additional sessions may be performed if PAVMs remain perfused.

The use of protective mechanical ventilation during extracorporeal membrane oxygenation for the treatment of acute respiratory failure.

Acute respiratory failure (ARF) strikes an estimated two million people in the United States each year, with care exceeding US$50 billion. The hallmark of ARF is a heterogeneous injury, with normal tissue intermingled with a large volume of low compliance and collapsed tissue. Mechanical ventilation is necessary to oxygenate and ventilate patients with ARF, but if set inappropriately, it can cause an unintended ventilator-induced lung injury (VILI). The mechanism of VILI is believed to be overdistension of the remaining normal tissue known as the 'baby' lung, causing volutrauma, repetitive collapse and reopening of lung tissue with each breath, causing atelectrauma, and inflammation secondary to this mechanical damage, causing biotrauma. To avoid VILI, extracorporeal membrane oxygenation (ECMO) can temporally replace the pulmonary function of gas exchange without requiring high tidal volumes (VT) or airway pressures. In theory, the lower VT and airway pressure will minimize all three VILI mechanisms, allowing the lung to 'rest' and heal in the collapsed state. The optimal method of mechanical ventilation for the patient on ECMO is unknown. The ARDSNetwork Acute Respiratory Management Approach (ARMA) is a Rest Lung Approach (RLA) that attempts to reduce the excessive stress and strain on the remaining normal lung tissue and buys time for the lung to heal in the collapsed state. Theoretically, excessive tissue stress and strain can also be avoided if the lung is fully open, as long as the alveolar re-collapse is prevented during expiration, an approach known as the Open Lung Approach (OLA). A third lung-protective strategy is the Stabilize Lung Approach (SLA), in which the lung is initially stabilized and gradually reopened over time. This review will analyze the physiologic efficacy and pathophysiologic potential of the above lung-protective approaches.

Ab initio thermodynamic properties of iridium: A high-pressure and high-temperature study

The high-pressure and high-temperature thermodynamic properties of iridium are studied using density functional theory in combination with the quasi-harmonic approximation, where both the contributions to the free energy of phonons and of electronic excitations are considered. The reliability of different exchange and correlational functionals [Perdew-Burke-Ernzerhof generalized gradient approximation (PBE) (Perdew et al. Phys. Rev. Lett. 77, 3865 (1996)), PBE modified for dense solids (PBEsol) (Perdew et al. Phys. Rev. B 100, 136,406 (2008)) and local density approximation (LDA) (Perdew et al. Phys. Rev. B 23, 5048 (1981))], for studying the equation of state (EOS), the phonon dispersions, the mode-Grüneisen parameter, and different thermodynamic properties like thermal pressure, volume thermal expansivity, isobaric heat capacity, bulk modulus, and the average Grüneisen parameter are tested. Elastic constants are studied at T = 0 K as a function of pressure. The predicted results are compared with the available experiments and previous theoretical data. We find generally a good agreement with experiments with at least one functional, but none of the three outperforms the others in all the investigated thermodynamic properties. The electronic excitations contribution is minimal in bulk modulus, but it is significant for other thermodynamic properties.

Designing Digital Platforms for Social Justice: Empowering End-Users Through the Dataswyft Platform

Digital platforms have radically transformed how we work, shop, and socialize. Despite their numerous benefits, they may also threaten social justice due to unforeseen or unintended consequences of specific design choices, preventing end-users from participating equitably in the digital economy. As platform owners compete by leveraging personal data, it remains unclear how digital platforms can be designed to empower end-users to control, legally own, and benefit from their data in a privacy-preserving way. Integrating design science research with heuristic theorizing, this study proposes a design theory for end-user-centric digital platforms. We derive design theory components from over nine years of data regarding the Dataswyft platform, including five meta-requirements and eight design principles. They reveal how digital platforms can be designed for social justice to address distributive and procedural social injustices by empowering end-users, both technically and legally, to protect and control their data through a containerized microservice platform infrastructure. This platform design includes multiple data protection layers, end-user-driven data collection, reconfiguration, and exchange functionalities, safeguarding mechanisms, and semi-centralized ecosystem governance structures. By evaluating an expository instantiation of the proposed design principles, we demonstrate the applicability and utility of our design theory, paving the way for data self-sovereignty and social sustainability.

Математические модели обменных процессов для идентификации и управления электромеханическими объектами

The issues of constructing mathematical models for systems that, in addition to the object, include a power converter, a measuring system and an on-board computer are considered. The last three elements are united by a single concept – «device». It is shown that the newly obtained «device–object» system, under certain conditions, should be considered and described as a single whole when solving problems of identification and control. Using a heuristic method, mathematical models of the «device–object» system are constructed and justified, in particular, the system of exchange equations, the exchange function and the Green’s function in the coordinate-time and pulse-energy representation.

ENSURING THE FINANCIAL STABILITY OF HOUSEHOLDS UNDER MARTIAL LAW

Introduction. Ensuring financial stability is one of the important aims of managing households’ financial resources. Exogenous factors constantly influence this process, the war with the russian federation is one of the most important of them. The introduction of martial law changed the regulatory rules for the functioning of the financial system, which significantly affected the process of ensuring the financial stability of households. The purpose of the article is to determine the extent to which the functioning of the financial system under martial law affects the financial stability of households. Results. The paper researches the functioning financial system under martial law and shows their positive and negative impact on ensuring the financial stability of households. The study proves the deterioration of the financial stability of internally displaced persons; the growth of income sufficiency indicators is shown only for those households that include military personnel. The analyzed trends in household incomes under martial law correlate with the dynamics of expenditures, some growth in the military government bonds. Due to the lack of full functioning of stock exchanges, the study substantiates the impossibility of realizing the investment potential of households under martial law. Conclusions. The proposed analysis shows the existence of significant limitations in ensuring the financial stability of households in wartime, namely, the inability to fully realize their investment potential and the use of certain financial instruments for savings.

Ab. No. 63 Immediate Effect of Intercostal Stretch Versus Anterior Stretch Basal Lift on Lung Compliance, Tidal Volume, Respiratory Rate, Heart Rate and SPO2 in Mechanically Ventilated Patients: An Experimental Study

Introduction: Mechanical ventilation is a useful modality for patients who are unable to sustain the level of ventilation necessary to maintain gas exchange function. Proprioceptive Neuromuscular Facilitation (PNF) of respiration is the use of selective external proprioceptive and tactile stimuli that alter depth and rate of breathing to assist respiration. Several PNF techniques are reported to increase the depth of breathing, decrease respiratory rate and increase arousal in patient with a decreased level of consciousness. Intercostal stretch and basal lift are commonly used techniques, having beneficial effects among ventilatory patients. The purpose is to compare the effect of the Intercostal stretch versus Anterior Stretch Basal Lift on Tidal Volume, Lung Compliance, SpO2, Heart Rate and Respiratory Rate Methods: After screening for inclusion and exclusion criteria, a total of 30 subjects were randomized into 2 groups of n=15 each: 1) Intercostal Stretch 2) Basal Lift. After randomization, along with chest physiotherapy, both groups received respective PNF techniques (3 sets of 10 repetition). Pre and post outcomes were analyzed. Result: Significant changes (p<0.05) seen in all the outcomes in Intercostal group. In Basal lift group, Tidal volume, compliance and SpO2 has shown significant improvement (p<0.05). Inter group analysis didn’t show significant improvement (p>0.05). Conclusion: Both these PNF techniques aids chest physiotherapy in enhancing the results for patients on mechanical ventilation. But Intercostal Stretch showed more significant results than Basal Lift, and is more feasible to perform in day to day practice. Implications: It is safe to apply these techniques in mechanically ventilated patients for better outcomes.

Restricted reaction of layered double hydroxide nanoparticles with phosphate in a confined microsphere space

Over the past decades, considerable efforts have been made to find useful solutions for phosphate pollution control. The state transition of nanomaterials from freely dispersed to encapsulated provides a realizable route for their application in phosphate elimination. The separation convenience offered by encapsulation has been widely recognized, however, the unique binding mode of nanostructures and phosphate in the confined space remains unclear, limiting its further development. Here, carboxymethyl cellulose (CMC) microspheres were used as hosts to deploy layered double hydroxide (LDH) nanoparticles. On this basis, we described an attempt to explore the adsorption behavior of LDH and phosphate in the microsphere space. Compared to their freely dispersed analogues, LDH particles exhibited higher structural stability, wider pH adaptability, and better phosphate selectivity when spatially confined in the CMC microsphere. Nevertheless, the kinetic process was severely inhibited by three orders of magnitude. Besides, the saturated phosphate adsorption capacity was also reduced to 74.6 % of the freely dispersed system. A combinative characterization revealed that the highly electronegative CMC host not only causes electrostatic repulsion to phosphate, but also extracts the electron density of the metal center of LDH, weakening its ability to act as a Lewis acid site for phosphate binding. Meanwhile, the microsphere encapsulation also hinders the ion exchange function of interlayer anions and phosphate. This study offers an objective insight into the reaction of LDH and phosphate in the confined microsphere space, which may contribute to the advanced design of encapsulation strategies for nanoparticles.

Relationship between Pulmonary Gas Exchange Function and Brain Uptake Dynamics Investigated with Hyperpolarized 129Xe MR Imaging and Spectroscopy in a Murine Model of Chronic Obstructive Pulmonary Disease.

Chronic obstructive pulmonary disease (COPD) is a complex multisystem disease associated with comorbidities outside the lungs. The aim of this study was to measure changes in metrics of pulmonary gas exchange function and brain tissue metabolism in a mouse model of COPD using hyperpolarized 129Xe (HP 129Xe) MRI/MR spectroscopy (MRS) and investigate the relationship between the metrics of lung and brain. COPD phenotypes were induced in 15 mice by 6-week administration of cigarette smoke extract (CSE) and lipopolysaccharide (LPS). A separate negative control (NC) group was formed of 6 mice administered with saline for 6 weeks. After these 6-week administrations, the pulmonary gas exchange function parameter fD (%) and the rate constant, α (s-1), which are composed of the cerebral blood flow Fi and the longitudinal relaxation rate 1/T1i in brain tissue, were evaluated by HP 129Xe MRI/MRS. The fD of CSE-LPS mice was significantly lower than that of NC mice, which was in parallel with an increase in bronchial wall thickness. The α in the CSE-LPS mice decreased with the decrease of fD in contrast to the trend in the NC mice. To further elucidate the opposed trend, the contribution of T1i was separately determined by measuring Fi. The T1i in the CSE-LPS mice was found to correlate negatively with fD as opposed to the positive trend in the NC mice. The opposite trend in T1i between CSE-LPS and NC mice suggests hypoxia in the brain, which is induced by the impaired oxygen uptake as indicated by the reduced fD. This study demonstrates the feasibility of using HP 129Xe MRI/MRS to study pathological mechanisms of brain dysfunction in comorbidities with COPD.

Cellular therapies for idiopathic pulmonary fibrosis: current progress and future prospects.

Idiopathic pulmonary fibrosis (IPF) is an interstitial, fibrotic lung disease characterized by progressive damage. Lung tissues with IPF are replaced by fibrotic tissues with increased collagen deposition, modified extracellular matrix, all which overall damages the alveoli. These changes eventually impede the gas exchange function of the alveoli, and eventually leads to fatal respiratory failure of the lung. Investigations have been conducted to further understand IPF's pathogenesis, and significant progress in understanding its development has been made. Additionally, two therapeutic treatments, Nintedanib and Pirfenidone, have been approved and are currently used in medical applications. Moreover, cell-based treatments have recently come to the forefront of developing disease therapeutics and are the focus of many current studies. Furthermore, a sizable body of research encompassing basic, pre-clinical, and even clinical trials have all been amassed in recent years and hold a great potential for more widespread applications in patient care. Herein, this article reviews the progress in understanding the pathogenesis and pathophysiology of IPF. Additionally, different cell types used in IPF therapy were reviewed, including alveolar epithelial cells (AECs), circulating endothelial progenitors (EPCs), mixed lung epithelial cells, different types of stem cells, and endogenous lung tissue-specific stem cells. Finally, we discussed the contemporary trials that employ or explore cell-based therapy for IPF.

Marketing of non-timber forest products as products from the Protected Forest Management Unit Batutegi, Lampung, Indonesia

Batutegi PFMU has much potential for NTFPs, which have been developed in coffee, palm sugar, and honey. The marketing of NTFPs needs attention because what often happens is inefficient marketing, so it doesn’t provide additional income for the community. This study aimed to identify marketing channels, functions, and efficiency based on marketing margins, farmers’ share, and profit-to-cost ratio. There are three marketing channels for coffee, two for palm sugar, and three for honey. The marketing functions performed by farmers, collectors, wholesalers, exporters, KUPS, cooperatives, and resellers are exchange, physical, and facilitation functions. Channel 1 palm sugar is an efficient marketing channel with a marketing margin of IDR 13,724.19 per kilogram, a farmer’s share of 100%, a profit ratio of 15.03, and marketing channel 1 honey with a marketing margin of IDR 224,112.70 per kilogram (Trigona honey), and IDR 124,494.35 per kilogram (Cerana and Dorsata honey), a farmer’s share of 100%, and profit ratio of 10.21 (Trigona honey) and 6.47 (Cerana and Dorsata honey).

A Study on the Multi-Cyber Range Application of Mission-Based Cybersecurity Testing and Evaluation in Association with the Risk Management Framework

With the advancement of IT technology, intelligent devices such as autonomous vehicles, unmanned equipment, and drones are rapidly evolving. Consequently, the proliferation of defense systems based on these technologies is increasing worldwide. In response, the U.S. Department of Defense is implementing the RMF (Risk Management Framework) to ensure the cybersecurity of defense systems and conducting cybersecurity T&E (test and evaluation) concurrently. However, RMF and cybersecurity T&E conducted during the acquisition phase of defense systems often result in fragmented cybersecurity assessments, excluding the operational environment of the defense systems. This omission fails to account for the complex network integration, data exchange functionalities, and mission-specific requirements in actual cyber attack scenarios. For these reasons, vulnerabilities in defense systems that remain unidentified during the acquisition phase can potentially pose significant cybersecurity threats during operational phases, necessitating substantial costs and efforts for remediation. Therefore, this paper proposes a mission-based cybersecurity T&E model using a Multi-Cyber Range to effectively apply these two systems in a practical manner. The Multi-Cyber Range integrates independently operated cyber ranges into a network to expand the evaluation environment, which better reflects the mission environment of defense systems. The proposed model’s effectiveness is validated using a cyber attack simulation system targeting a virtualized arbitrary defense system. This paper not only presents an enhanced model for mission-based cybersecurity T&E, but also contributes to the advancement of cybersecurity T&E methodologies by providing a concrete application process.

Examination of the effects of triacylglycerol lipase on astaxanthin conversion in the black tiger prawn Penaeus monodon

The enzyme triacylglycerol lipase (TGL) catalyses the hydrolysis of triacylglycerols, and is characterized by catalytic esterification and ester exchange functionality. However, at present, there is comparatively little information regarding the sequences and functional validation of TGLs in crustaceans. In this study, we cloned the TGL1 gene of the black tiger prawn Penaeus monodon. The full-length cDNA of PmTGL1 comprises 1807 base pairs (bp), including an 80-bp 5′-untranslated region (UTR), a 149-bp 3′-UTR, and a 1578-bp open-reading frame (ORF), and encodes a putative 525-amino acid protein of 58.71 kDa with a theoretical isoelectric point of 4.81. Homology and phylogenetic tree analyses revealed that PmTGL1 is most closely related to the TGL of Penaeus chinensis, with which it clusters in a single group (similarity of up to 97.52%). Quantitative real-time PCR analysis further revealed that PmTGL1 is most highly expressed in the shrimp hepatopancreas. Although the expression of PmTGL1 was not significantly influenced by the differences in the background colour of the rearing pond, it was significantly promoted in response to dietary supplementation with astaxanthin. As an adipokinetic hormone in P. monodon, PmRPCH (red pigment-concentrating hormone) plays an important role in body colour changes and lipid metabolism. Based on our findings, we speculate that the PmTGL1 facilitates astaxanthin metabolism in P. monodon via the hydrolysis of esterified astaxanthin to yield free astaxanthin and that the activity of TGL in these shrimps is regulated via an adipokinetic hormone cascade.

Childhood interstitial lung disease: When to suspect and what to do

Childhood Interstitial lung Disease (chILD) is a heterogeneous group of more than 200 respiratory disorders characterized by the impairement of alveolar-capillary gas exchange and lung function. These disorders usually have a chronic course. Morbidity and mortality greatly vary depending on the disorder considered. Interstitial lung disease are associated with respiratory distress. During infancy the most common symptom to pay attention to is tachypnea, whilst in older children clinical presentation may be more insidious. When chILD is suspected, it is advisable to send the patient to a pediatric pulmonology center in order to set up a diagnostic work-up and an adequate treatment. A European protocol called the “Delphi method” has been standardizing empirical treatment since 2015.

Effect of tocilizumab on pulmonary gas exchange function in patients with severe COVID-19

Introduction. COVID-19 causes cytokine storm and acute respiratory distress syndrome, which can lead to severe lung damage and multiple organ dysfunction. Early use of monoclonal antibodies has shown promising results in cytokine storm therapy, but the effects on lung gas exchange function have not yet been studied.Aim. To evaluate the effect of tocilizumab on the dynamics of gas exchange parameters in patients with severe COVID-19. Material and methods. The study included 26 patients in whom gas exchange parameters (PaO2, PaCO2, P/f ratio), blood oxygen saturation (saturation), respiration rate, duration and parameters of high-flow oxygen therapy and noninvasive mechanical ventilation, length of stay in intensive care unit and total hospital length of stay were assessed.Results. Tocilizumab significantly improved oxygenation on the third day (p=0.001) from the time of drug administration.Conclusion. In the presented and analyzed cohort of patients with severe COVID-19 and cytokine storm, the normalization and significant increase of oxygenation parameters (PaO2, p=0.001; P/f ratio, p=0.001) were observed within three days after a single-dose tocilizumab administration in a complex intensive therapy. No significant dynamics in the respiratory support parameters was revealed, nor an effect of this therapy on the duration of the respiratory support or the reduction in the aggressiveness of its parameters was observed within three days after tocilizumab administration (p>0.05).

The Use of Extracorporeal Membrane Oxygenation (ECMO) and Protective Mechanical Ventilation in the Treatment of Acute Respiratory Failure

Acute respiratory failure (ARF) affects 2 million people in the United States each year. The ARF's hallmark is a heterogeneous injury, with normal tissue intermingled with a large volume of low compliance and collapsed tissue. Mechanical ventilation is necessary to oxygenate and ventilate those patients but if set inappropriately can cause ventilator-induced lung injury (VILI). To avoid VILI, extracorporeal membrane oxygenation (ECMO) can replace the pulmonary function of gas exchange . The optimal method of mechanical ventilation for the patient on ECMO is unknown. Rest the Lung Approach (RLA) buys time for the lung to heal in the collapsed state. Open Lung Approach (OLA) attempts to open the entire lung very quickly. ARDS-related mortality has not been further reduced using the RLA and even it increases with OLA. Thus, the Mechanical Breath Profile (MBP) component of time would play a critical role in both lung opening and collapses. The Time-Controlled Adaptive Ventilation (TCAV) method of setting and adjusting the Airway Pressure Release Ventilation (APRV) mode uses an extended time at inspiration to open viscoelastic lung tissue and a very brief expiratory time to prevent re-collapse during exhalation. The expiratory time is personalized and adaptive as it is set by changes in respiratory system compliance (CRS). The TCAV method is a novel Stabilize the Lung Approach (SLA). We postulate that the SLA TCAV method would be a highly lung-protective ventilation strategy that would protect from VILI and gradually reopen the lung allowing the patient to be liberated from ECMO.

A study on the status and applicability of Korean medicine EMR for establishment of Korean medicine standard EMR certification criteria: Through surveys of Korean medical institutions and Korean medicine EMR companies

Objectives: The aim of this study is to explore and investigate the status of EMR currently used in Korean medical institutions and the suitability of the existing certification criteria for Korean medicine EMR certification.Methods: The survey was conducted using a related questionnaire from September to October 2022. The survey for current status and the suitability of the existing certification criteria was conducted separately between Korean medical institutions and Korean medicine EMR companies.Results: In a survey of Korean medical institutions on the current status of EMR, more than 80% answered that the imaging system and Korean medicine EMR could be linked. Most medical institutions did not exchange clinical information between institutions. When asked about the intention to develop standard EMR of Korean medicine in the future, 57% of institutions answered ‘yes’. In future, if Korean medicine EMR certification criteria are developed, all EMR companies are willing to develop the EMR that satisfy them. Looking at the satisfaction survey of the existing EMR certification criteria of the Korean medicine EMR system, it was found that high/low satisfaction was shown in various areas, and in particular, the overall clinical information exchange function was insufficient.Conclusion: In order to introduce the Korean medicine EMR certification criteria, it must be considered of the current status of EMR and applicability of Korean medicine EMR for establishment of Korean medicine standard EMR certification criteria. By developing Korean medicine EMR certification criteria, high-quality medical services can be provided to medical consumers who want Korean medical treatment.

A Story of Chinese Academic Migrant Workers Going to China－A Study on the Reasons Why Education PhD Holders Went to Mainland China for Development, as well as Their Life Adaptation and Career Planning

<p>本研究採多重個案研究，以三位在大陸地區取得教育學博士，並在大陸地區就業的臺灣地區人士為研究對象，透過文件分析以及深度訪談蒐集資料，以理解目前臺灣高等教育人才到大陸就業的原因、生活適應情形及未來的生涯規劃。主要發現去大陸的原因有五點，在陸生活適應的狀況有八種，而對未來生涯的規劃有三種看法。本研究建議赴陸博士內在應正向思考，外在提升跨文化適應力以融入當地以適應環境，也建議我國政府應落實兩會的交流實質功能。</p> <p> </p><p>This study used multiple case studies and enrolled three Taiwanese who have obtained doctorate degrees in education in Mainland China and are employed in Mainland China as the research subjects. This study collected data using document analysis and in-depth interviews to understand the reasons why current Taiwanese higher education talents seek employment in Mainland China, as well as their life adaptation situations and their future career planning. This study mainly found that there are 5 reasons for them to seek employment in Mainland China, 8 conditions encountered in life adaption, and 3 views on future career planning. This study suggests that PhD holders who intend to seek employment in Mainland China should think positively internally and improve cross-cultural adaptability externally to integrate into the local environment and adapt to the environment. Taiwan government is also advised to fulfill the substantive exchange function of the Straits Exchange Foundation and Association for Relations Across the Taiwan Straits.</p> <p> </p>

First-principles prediction of energy bandgaps in 18-valence electron semiconducting half-Heusler compounds: Exploring the role of exchange and correlation

The choice of exchange functional is a critical factor in determining the energy bandgap of semiconductors. Ab initio calculations using different exchange functionals, including the conventional generalized-gradient approximation (GGA) functionals, meta-GGA functionals, and hybrid functionals, show significant differences in the calculated energy bandgap for semiconducting half-Heusler compounds. These compounds, which have 18 valence electrons per unit cell, are of great interest due to their thermoelectric properties, making them suitable for energy conversion applications. In addition, accounting for electronic correlations using the GW method also affects the calculated energy bandgaps compared to standard GGA calculations. The variations in calculated energy bandgaps are specific to each material when using different functionals. Hence, a detailed investigation of the electronic properties of each compound is necessary to determine the most appropriate functional for an accurate description of the electronic properties. Our results indicate that no general rules can be established and a comparison with experimental results is required to determine the most appropriate functional.

First Principles Studies of Topological Insulating Behavior in Lanthanum‐Monopnictides and their Heterostructures

AbstractThe topological insulating behavior of LaX (X = Bi, Sb, As, and P) and their heterostructure combinations are investigated. The system's bulk‐band‐inversion is analyzed, and the ‐topological indexes are calculated using LDA and mBJLDA exchange functionals. Strong topological insulating behavior in LaBi is confirmed from bulk band inversion. Linearly dispersive Dirac‐cone in the (001)‐surface band structure is observed. The other LaX binaries also exhibit bulk‐band‐inversion under LDA+SOC settings but disappear after including the mBJ potential. The robustness of the surface Dirac cone is tested by estimating the surface band structure under uniaxial strain. The result shows that Dirac‐cone in the (001)‐surface is unaltered only for the LaBi system and destroyed in all other three binaries, concluding the topologically trivial nature of LaP, LaSb, and LaAs. The investigation is further extended to study the multilayer LaX1/LaX2 systems composed of an alternate stacking of two different LaX binaries. The findings suggest that the multilayer structures exhibit topological insulating behavior only when LaBi is present in the system. Bulk‐band‐inversion and surface Dirac‐cone structures in LaBi/LaAs, LaBi/LaSb, and LaBi/LaP multilayers are observed. Furthermore, the surface Dirac cones remain unchanged under the influence of TR‐preserving perturbation, confirming these systems possess strong topological insulating character.