Excessive Reduction Research Articles

Differences in the prevalence of musculoskeletal pain between health care students and students of sports and physical education

Introduction. Musculoskeletal pain is one of the most common types of pain affecting muscles, bones, joints, ligaments and tendons. The aim of this study was to determine the differences in the prevalence of musculoskeletal pain between students of sports and physical education and health care students. Material and Methods. The cross-sectional study included a total of 50 students, of whom 25 (50%) were students of sports and physical education, and 25 (50%) were students of health care. Data on the musculoskeletal system of students were collected through a questionnaire for the analysis of musculoskeletal symptoms. Results. The results showed that the neck and upper back pain was not negligible (14 respondents, 28%) as well as the lower back pain (27, 54%). Based on the Chi-square test, it was concluded that low back pain was significantly more common in students of health care (c2 = 3.945; p = 0.047 < 0.05) than in students of sports and physical education. Also, neck pain was significantly more common in health care students (c2 = 6.349; p = 0.012 < 0.05). Conclusion. Based on the obtained results, it can be concluded that students mostly presented with low back pain, followed by the neck and upper back pain. Engaging in proper exercises on weekly basis and excess weight reduction can prevent low back pain.

Influence of CeO2 nanoparticles on methyl tertiary butyl ether gasoline blend in spark ignition engine

The search for suitable alternative for fossil fuel has been a challenge to the research community for the past two decades. So many alternatives have been identified and tested. However, a complete replacement cannot be provided without any penalties of cost, excess emission, poor operation, etc. The alcohols gave a new opportunity and a solution for that problem but had some setbacks of increased density and lower octane number. The present work focuses on striking a balance between advantages and disadvantages by using oxygenated additive with gasoline fuel. The additive CeO2 along with methyl tertiary butyl ether (MTBE) offers many advantages. The seven samples, namely M10, M15, M20, M25, M20 + 50 mg/l, M20+100 mg/l, M20+150 mg/l have been prepared and tested on spark ignition engine. Here, 10, 15, 20, and 25 denote the MTBE volume in blends and 50 mg/l, 100 mg/l, and 150 mg/l indicate the CeO2 in blends. The results have shown that only MTBE has caused an increase of 4% in brake thermal efficiency with M15 and then brake thermal efficiency has improved by 3% with M15 + 100 mg/l compared with pure gasoline. Fuel consumption has also been reduced upto 9% with M20 and 11% with M15+150 mg/l compared with pure gasoline. The maximum HC and CO reductions have also been observed from M20 and M20 + 150 mg/l. It was up to 19% and 22%, 23%, and 25% of HC and CO with M20, M20 + 150 mg/l. However, there has been an increase in CO2 emission level because of excessive unburned HC reduction. The MTBE with CeO2 has proved to be suited to all running conditions. The blends having more amounts of additive produce good combustion characteristics yet it should be restricted within 20 vol.% of MTBE and 150 mg/l of CeO2.

Quantification of Soil-surface Roots in Seedlings and Mature Rice Plants.

Soil-surface roots (SORs) in rice are primary roots that elongate over or near the soil surface. SORs help avoid excessive reduction of stress that occurs in paddy, such as in saline conditions. SORs may also be beneficial for rice growth in phosphorus-deficient paddy fields. Thus, SOR is a useful trait for crop adaptation to certain environmental stresses. To identify a promising genetic material showing SOR, we established methods for evaluating SOR under different growth conditions. We introduced procedures to evaluate the genetic diversity of SOR in various growth stages and conditions: the Cup method allowed us to quantify SOR at the seedling stage, and the Basket method, using a basket buried in a pot or field, is useful in quantifying SOR at the adult stage. These protocols are expected to contribute not only to the evaluation of the genetic diversity of SOR, but also the isolation of related genes in rice.

Analysis of Chemical Compounds of Gaseous and Particulate Pollutants from the Open Burning of Agricultural HDPE Film Waste

Background and objective Illegal open-air incineration, which is criticized as a leading source of air pollutants among agricultural activities, currently requires constant effort and attention. Countries around the world have been undertaking studies on the emission of heavy metal substances in fine dust discharged during the incineration process. A precise analytical method is required to examine the harmful effects of particulate pollutants on the human body. Methods In order to simulate open-air incineration, the infrastructure needed for incineration tests complying with the United States Environmental Protection Agency (EPA) Method 5G was built, and a large-area analysis was conducted on particulate pollutants through automated scanning electron microscopy (SEM)-energy-dispersive X-ray spectroscopy (EDS). For the test specimen, high-density polyethylene (HDPE) waste collected by the DangJin Office located in Choongcheongnam-do was used. To increase the identifiability of the analyzed particles, the incineration experiment was conducted in an incinerator three times after dividing the film waste into 200 g specimens. Results Among the metal particulate matters detected in the HDPE waste incineration test, transition metals included C (20.8–37.1 wt%) and O (33.7–37.9 wt%). As for other chemical matters, the analysis showed that metal particulate matters such as metalloids, alkali metals, alkaline earth metals, and transition metals reacted to C and C-O. Si, a representative metalloid, was detected at 14.8–20.8 wt%, showing the highest weight ratio except for C and O. Conclusion In this study, the detection of metal chemicals in incinerated particulate matters was effectively confirmed through SEM-EDS. The results of this study verified that HDPE waste adsorbs metal chemicals originating from soil due to its own properties and deterioration, and that when incinerated, it emits particulate matters containing transition metals and other metals that contribute to the excessive production and reduction of reactive oxygen species.

Evaluation of salt content and effectiveness of excessive salt reduction methods in selected commercially available dried fish types in Sri Lanka

High salt intake elevates the risk of non-communicable diseases such as high blood pressure, cardiovascular diseases and stroke worldwide. Sri Lanka has recorded in 2010 as the country with highest average fish & fish products consumption in South Asia. In the current study, salt in ten types of commonly available dried fish namely; sprats, prawns, smoothbelly sardinella, queen fish, cat fish, sail fish, shark, skipjack tuna, Bombay duck and trenched sardinella was analyzed and determined salt reduction methods with minimal protein loss. Four salt reduction methods were tested; Method 1: washed with water at Room Temperature (RT) for five times; Method 2: washed with water for five times at RT and kept in hot water for 5min; Method 3: washed with water for five times at RT and boiled for 5min; Method 4: washed with water for five times at RT and kept in coconut water for 5min. Using Volhard method, sodium chloride was analyzed while protein was determined using Kjeldahl method. All four methods showed significant reduction of salt level in tested dried fish (p < 0.05). Among the tested salt reduction methods, Method 3 showed the highest salt reduction for all types of dried fish except smoothbelly sardinella and cat fish.The highest salt mean value of 28.8% was recorded in queen fish and the lowest mean value of 12.8% was recorded in smoothbelly sardinella. The highest protein loss was recorded in Method 3. To reduce considerable amount of salt, the easiest and fairly effective method is method 1 except for prawns and Shark. Although higher salt reduction showed in method 2 and 3, they are not recommended due to high protein loss, high energy expenditure and reduction of freshness of dried fish. Method 4 can be applied for all dried fish types because it is economical and reduces considerable amount of salt, removes less amount of protein comparatively. The results revealed that all tested dried fish except smoothbelly sardinella contain significantly high amount of salt (p < 0.05) than the standard value specified (12%) by the Sri Lanka Standards Institution (SLSI).Keywords: Dried fish, protein loss, salt-intake, salt reduction, non-communicable diseases

“超人類主義”是主體形而上學的新形式

LANGUAGE NOTE | Document text in Chinese; abstract also in English.
 Transhumanism is a contemporary form of Western “subject metaphysics” that combines the dual elements of Cartesianism and Nietzsche's “metaphysics of will.” The essence of Eros is the human desire for totality, which is interlinked with the secret desire for today's “human enhancement” technology. The Confucian idea of “the unity of heaven and man”（天人合一）can solve many problems in the debate between biological conservatism and bioprogressivism. The ideological foundation of this idea in Laozi's and Zhuangzi's thought should be taken seriously. Recognition of human limitations is an important aspect of traditional Confucian—Taoist wisdom, but human enhancement technology is in essence a tool for “excessive reduction”.

Top cast effect: Influence of bond length on splitting mode failure

AbstractIt is widely considered that bond strength of bars cast near the top of a pour is weaker than that of bars cast near the bottom. The lesser strength of top cast bars is attributed to: (a)The increase in binder/cement ratio toward the top of a pour due to consolidation of fluid concrete prior to setting. (b)The formation of voids beneath bars as solids in fluid and setting concrete consolidate when the bar is restrained from vertical movement. The difference in bond strength bars cast near the top of a pour and those cast near the bottom varies widely between individual studies, with little difference reported in some studies and reductions in excess of 50% reported in others. A markedly greater top bar effect observed in pullout type specimens with short bond lengths compared to that in studies based on conditions more representative of practical construction. Through a simple analytical model of behavior of a lapped joint based on the local bond slip model in fib Model Code 2010, it is shown that the casting position effect diminishes as bond length increases. This influence is supported by analysis of trends in the top cast section of the ACI408 bond test database. Conclusions demonstrate the casting position factor in current design Codes significantly overestimates the top cast effect and justifies a casting position factor of 1.0 for laps designed to develop the full design strength of Grade 500 bars. Increased bond lengths would still be required for top cast laps designed for lower bar stresses.

Carbon footprint of the Brazilian diet.

ABSTRACTOBJECTIVE:To estimate the carbon footprint of the Brazilian diet and of sociodemographic strata of this population.METHODS:Carbon footprint of the diet was estimated based on data from two 24-hour diet records, obtained in 2008 and 2009, from a probabilistic sample of the Brazilian population aged 10 years and over (n = 34,003) and on environmental impact coefficients of food and culinary preparations consumed in Brazil (gCO2e/kg). Means with 95% confidence intervals of food consumption (kcal/person/day) and the carbon footprint of the diet (gCO2e/person/day and in gCO2e/2,000kcal) were calculated for the population as a whole and for strata according to sex, age, income, education, macro-regions and Federative Unit. Linear regression models were used to identify significant differences (p < 0.05) in the dietary carbon footprint of different sociodemographic strata.RESULTS:The average carbon footprint of the Brazilian diet was 4,489gCO2e/person/day. It was higher for males, for the age group from 20 to 49 years and for the North and Midwest regions, and tended to increase with income and education. The pattern of association of footprint with sociodemographic variables did not change substantially with adjustment for differences in the amount of food consumed, except for a reduction in the relative excess of the footprint among males and an increase in the relative excess of the footprint in the Midwest region.CONCLUSION:The carbon footprint of the Brazilian diet exceeds by about 30% the footprint of the human diet, which could simultaneously meet the nutritional requirements of a healthy diet and the global goal of containing the increase in the planet's average temperature. The pattern of association of this footprint with sociodemographic variables can help identify priority targets for public actions aimed at reducing the environmental impacts of food consumption in Brazil.

Axilla versus Wrist as the Recipient Site in Vascularized Lymph Node Transfer for Breast Cancer-Related Lymphedema: A Systematic Review and Meta-Analysis.

Vascularized lymph node transfers (VLNT) are being used with increasing frequency for the treatment of breast cancer-related lymphedema (BCRL). However, there is a lack of consensus in the surgical field as to which recipient site should be utilized. We, therefore, aim to assess the evidence comparing the wrist and axilla as recipient sites for VLNT in BCRL. We conducted a systematic literature review to compare the wrist and axilla as recipient sites for VLNT in BCRL. Demographic data, as well as circumference reduction rate (CRR), excess volume reduction (EVR), postoperative decrease in infections per year, postoperative discontinuation of compression garments, and overall pooled complication rate were extracted from included studies. These were compared through a meta-analysis. A total of 37 studies met the inclusion criteria for a total of 689 patients. VLNTs to the wrist and axilla resulted in a decrease in CRR of 42.1 and 51.5%, and a decrease in EVR of 35.6 and 48.8%, respectively. However, our meta-analysis showed no significant differences between CRR or EVR and between wrist and axilla as recipient sites. Similarly, we found no differences in postoperative decrease in infections per year, postoperative discontinuation of compression garments, and overall pooled complication rate. These data suggest noninferiority between the wrist and axilla as recipient sites for VLNT in the context of BCRL. In the absence of randomized, prospective data, we hope these results can be used as an evidence-based reference and facilitate future studies.

K+-induced formation of granular and dense copper phyllosilicate precursor converts dimethyl oxalate to ethylene glycol in absence of H2

The reducibility of heterogeneous Cu-based precursor greatly influences the activity and stability of the final catalysts because the excessive reduction to metallic Cu significantly deactivates the catalysts. Herein, we develop a crystallization inhibition strategy to fabricate the granular and densely stacked copper phyllosilicate precursor which possesses stronger resistance to H2 reduction. The reduction-resistant CuSiO3 precursor contains more abundant Cu+ species and oxygen deficiencies, which was verified by O2-TPD, TGA, O XPS and Cu XAES measurements, and is beneficial for methanol dehydrogenation and dimethyl oxalate (DMO) adsorption. A high yield of 85.4% of ethylene glycol (EG) was achieved from DMO hydrogenation at 240 °C, with methanol as both the solvent and hydrogen supplier. The delicately designed synthesis of specific Cu precursor with unique properties resulted in an excellent multi-functional Cu catalyst for coupled methanol dehydrogenation and DMO hydrogenation to EG.

FEM analysis of the opposed-piston aircraft engine block

An important aspect of aircraft engine design is weight minimization. However, excessive weight reduction may reduce mechanical strength of the engine. This is especially important for aero-engines due to consequences of engine failure in flight. The article presents the results of the FEM opposed-piston diesel engine block model tests. The tested engine is a PZL-100 two-stroke three-cylinder aircraft engine with two crankshafts and six pistons. Air is supplied via a mechanical compressor and a turbocharger. Stress in the engine block is induced by the operating process of the engine block. The pressure in the combustion chamber of the analyzed engine is 13 MPa. The pistons in one of the cylinders are then near their TDC, the deflection angle of the connecting rods is small so almost the entire piston force is transferred to the crankshafts and then to the main bearing supports. This results in the occurence of a tensile force for the engine block applied in the bolt holes of the shaft supports. The calculation results are presented as stress and displacement distributions on the surface and selected block sections. The maximum values on the outer surfaces of the block occurred in the area of the compressor attached to the block and reached 39 MPa. Maximum stresses were, however, observed inside the block on the air and exhaust flow separators between the cylinder liners. The stress value on the outlet side reached 44 MPa.

Drug interactions with angiotensin-converting enzyme inhibitors

We reviewed potentially clinically significant drug–drug interactions (DDIs) with angiotensin-converting enzyme inhibitors (ACEIs) using Stockley’s Drug Interactions books and two online DDI databases. We identified &gt;10 such DDIs and described their mechanisms, clinical evidence and importance, as well as their management. Most DDIs with ACEIs were pharmacodynamic; only a few were pharmacokinetic. Most DDIs with ACEIs involved drugs that can lead to excessive reduction of blood pressure, hyperkalemia and impaired renal function. There is some evidence linking ACEIs with the induction of lithium toxicity. Severe hypersensitivity reactions may occur in patients treated with ACEIs with concomitant use of allopurinol or parenteral applications of iron. ACEIs should be combined carefully with hepatotoxic drugs due to their own potential hepatotoxic effects. The prevalence of adverse drug reactions due to DDIs might be high because they are prescribed frequently. Fortunately, most of such DDIs can be managed by clinical and laboratory monitoring of patients or by dosage adjustments of concomitantly used drugs.

Arterial Hypertension in Aortic Valve Stenosis: A Critical Update.

Aortic stenosis (AS) is a very common valve disease and is associated with high mortality once it becomes symptomatic. Arterial hypertension (HT) has a high prevalence among patients with AS leading to worse left ventricle remodeling and faster degeneration of the valve. HT also interferes with the assessment of the severity of AS, leading to an underestimation of the real degree of stenosis. Treatment of HT in AS has not historically been pursued due to the fear of excess reduction in afterload without a possibility of increasing stroke volume due to the fixed aortic valve, but most recent evidence shows that several drugs are safe and effective in reducing BP in patients with HT and AS. RAAS inhibitors and beta-blockers provide benefit in selected populations based on their profile of pharmacokinetics and pharmacodynamics. Different drugs, on the other hand, have proved to be unsafe, such as calcium channel blockers, or simply not easy enough to handle to be recommended in clinical practice, such as PDE5i, MRA or sodium nitroprusside. The present review highlights all available studies on HT and AS to guide antihypertensive treatment.

Stator Dynamics Depending on Sodium Concentration in Sodium-Driven Bacterial Flagellar Motors.

Bacterial flagellar motor (BFM) is a large membrane-spanning molecular rotary machine for swimming motility. Torque is generated by the interaction between the rotor and multiple stator units powered by ion-motive force (IMF). The number of bound stator units is dynamically changed in response to the external load and the IMF. However, the detailed dynamics of stator unit exchange process remains unclear. Here, we directly measured the speed changes of sodium-driven chimeric BFMs under fast perfusion of different sodium concentration conditions using computer-controlled, high-throughput microfluidic devices. We found the sodium-driven chimeric BFMs maintained constant speed over a wide range of sodium concentrations by adjusting stator units in compensation to the sodium-motive force (SMF) changes. The BFM has the maximum number of stator units and is most stable at 5 mM sodium concentration rather than higher sodium concentration. Upon rapid exchange from high to low sodium concentration, the number of functional stator units shows a rapidly excessive reduction and then resurrection that is different from predictions of simple absorption model. This may imply the existence of a metastable hidden state of the stator unit during the sudden loss of sodium ions.

Mitochondrial alternative oxidase pathway acts as an electron sink during photosynthetic induction in Rumex K-1 leaves

Chloroplast PSII photochemical efficiency is upregulated more rapidly than CO2 assimilation during photosynthesis induction, suggesting the existence of other electron sinks than that of CO2 assimilation. We hypothesized that the mitochondrial alternative oxidase (AOX) pathway could be such a sink. Inhibition of the AOX restricted light activation of the malate-oxaloacetate shuttle and caused an excessive reduction of PSI acceptor side and substantial accumulation of QA-, hindering the photosynthetic linear electron transport rate (ETR) and leading to an imbalance between light energy absorption and exploitation during photosynthetic induction. ETR limitation also restricted the formation of thylakoid pH gradient, evidenced by a decreased de-epoxidation of the xanthophyll cycle, thus preventing nonphotochemical quenching. Delayed CO2 assimilation due to thylakoid pH gradient restriction was partially reversed by exogenous ATP application. The AOX pathway acts as a photosynthetic electron sink, protecting the photosynthetic apparatus against photoinhibition and accelerating the induction of CO2 assimilation during photosynthetic induction in Rumex K-1 leaves.

Three-dimensional evaluation of tooth preparation forms in paediatric zirconia crowns: An in vitro study.

Though prefabricated zirconia crowns (PZCs) differ from stainless steel crowns and have different preparation guidelines for optimal crown adaptation, little is known about how clinicians prepare teeth for PZCs. To investigate the prepared tooth forms for PZCs and identify the shared patterns of tooth preparation. Twenty participants prepared primary maxillary first molars and mandibular second molars for PZCs. A model with ideally prepared tooth was digitally generated as a reference. The prepared teeth were digitally scanned and superimposed on the reference. Three-dimensional analysis software was used to evaluate the discrepancy between ideal and prepared surface for overall surface and subdivided area. Half of the surfaces received excessive reduction, and 24% showed error within 0.2mm (p<.001) in maxilla. 41.6% of surfaces showed error within 0.2mm, and 20% were excessively prepared (p=.002) in mandible. The highest discrepancies were found at the mesiopalatal line angles (maxillary) and at the distobuccal line angles (mandibular). Significant discrepancies were observed on the occlusal surfaces, especially at the cusps. Tooth preparations for PZCs showed wide variations related to depth among the participants.

Can climate-smart agriculture mitigate the Urmia Lake tragedy in its eastern basin?

Urmia Lake, which is one of the largest hypersaline lakes in the world, has experienced an excessive reduction of water level because of climatic change and anthropogenic influences. To mitigate this tragedy, several agricultural water management schemes have been initiated. However, many restoration programs have proven ineffective. To counter the lake’s disappearance, effective climate-smart agriculture (CSA) interventions are imperative. Nevertheless, the potential benefits, opportunities, risks, costs and incentive mechanisms of CSA interventions have not been well documented. Therefore, this qualitative research was performed in the eastern part of the Urmia Lake basin to identify the best CSA intervention for restoration of the lake and investigate the major drivers of CSA development. Using the “benefits, opportunities, risks, and costs” method, 14 influential factors were explored. Also, fuzzy VIKOR analysis indicated an urgent need of developing water-smart agriculture (WSA) in the Urmia Lake basin, where water scarcity, poor water governance and low water use efficiency are significant problems. Interpretive structural modeling and MICMAC analysis suggested that policy making and planning, research and development, monitoring and evaluation, education and extension services, supports and services, institutions and degree of their collaborations, knowledge and attitude, and infrastructures and farm structures can enhance the application of WSA interventions. Some recommendations and implications are offered to facilitate the adoption and development of WSA practices and technologies.

Nanofibrillar Collagen Scaffold Enhances Edema Reduction and Formation of New Lymphatic Collectors after Lymphedema Surgery.

Treatment of secondary lymphedema remains challenging, with suboptimal rates of edema reduction following physiologic procedures (i.e., lymphaticovenous anastomosis and vascularized lymph node transfer). The objective of this study was to investigate the long-term effect of a nanofibrillar collagen scaffold on edema reduction in lymphedema patients treated with lymphaticovenous anastomosis or vascularized lymph node transfer. A retrospective cohort study was performed, comparing stage 1 to 3 lymphedema patients who underwent lymphaticovenous anastomosis and/or vascularized lymph node transfer with or without delayed implantation of nanofibrillar collagen scaffold (BioBridge) from 2016 to 2019. The primary endpoint was excess volume reduction. Indocyanine green lymphatic mapping was performed to evaluate superficial lymphatic flow. Edema reduction was significantly greater for the BioBridge cohort (12-month follow-up, n = 18) compared to controls (18.2-month follow-up, n = 11) (111.5 ± 34.5 percent versus 70.0 ± 19.0 percent; p = 0.0004). This held true in lymphaticovenous anastomosis and vascularized lymph node transfer subgroup analysis. The average rate of edema reduction increased by 3.5-fold in lymphaticovenous anastomosis and 7.6-fold in vascularized lymph node transfer following BioBridge placement. Eighty-eight percent of patients with concurrent liposuction and BioBridge implantation maintained normal volumes at 13 months postoperatively. Lymphatic mapping following BioBridge placement showed significantly more new lymphatic collectors and decreased dermal backflow. The majority of patients (77.8 percent) achieved and maintained normal limb volume at an average total follow-up of 29 months. Nanofibrillar collagen scaffold implantation enhances overall effectiveness of physiologic procedures, even in the presence of liposuction, and is a promising adjunct therapy for treatment of lymphedema. Therapeutic, III.

Partial ozonation of returned sludge via high-concentration ozone to reduce excess sludge production: A pilot study

Partial ozonation of returned sludge via high and low concentration of ozone were compared to evaluate their efficiency in excess sludge production reduction. A pilot-scale system of anaerobic/anoxic/oxic (A/A/O) + ozonated sludge recycle (OSR) process was operated for 97 days, to investigate the effects of different ozone concentration (380 mg/L and 150 mg/L) on the nutrient removal capacity, sludge reduction rate, the excess sludge properties including settling, dewatering and anaerobic digestion (AD) performance. It was found that at the same total ozone dosage (13 mg/g MLSS, 25 mg/g MLVSS), the ozone of 380 mg/L achieved much higher organic matters and total excess sludge reduction (41.6% and 25.9%) than 150 mg/L applied (31.0% and 18.2%). It also laid less deterioration effect on the effluent quality and had better nutrient (COD, NH4+-N, TN) removal capacity than 150 mg/L applied. Meanwhile, little difference was found in the settling, dewatering and AD properties of excess sludge from the two A/A/O + OSR processes. Meanwhile, sludge solubilization rate, BIOLOG ECO microplate, 16S rRNA sequencing were applied comprehensively to illustrate the reasons for above advantages of the elevated ozone dosage applied. It was clarified that compared to 150 mg/L, A/A/O + OSR with ozone of 380 mg/L had higher sludge solubilization rate, less impact on bacterial community distribution and utilization capacity of carbon sources in bioreactors.

Optimal uric acid levels by febuxostat treatment and cerebral, cardiorenovascular risks: post hoc analysis of a randomized controlled trial.

Hyperuricaemia is recognized as an independent risk marker for cardiovascular and renal diseases. However, uric acid is a powerful free-radical scavenger, and the optimal level of serum uric acid (SUA) determining outcomes is unknown. This study explored whether interventional treatments for excessive SUA reduction were harmful and what constituted the optimal lowering of SUA levels for the prevention of events in patients with asymptomatic hyperuricaemia. This was a post hoc analysis of a randomized trial (Febuxostat for Cerebral and CaRdiorenovascular Events PrEvEntion StuDy [FREED]) in which 1070 older patients with asymptomatic hyperuricaemia were enrolled and allocated to febuxostat (n = 537) or non-febuxostat treatment group (n = 533). We assessed the relationship between the endpoint (withdrawal or study completion) SUA levels and clinical outcomes. Primary endpoint was defined as a composite of all-cause mortality, cerebral and cardiorenovascular events. In the febuxostat group, patients achieving SUA levels ≤4 mg/dl (hazard ratio: 2.01 [95% CI: 1.05, 3.87]), >4 to ≤5 mg/dl (2.12 [1.07, 4.20], >6 to ≤7 mg/dl (2.42 [1.05, 5.60]), and >7 mg/dl (4.73 [2.13, 10.5]) had significantly higher risks for a primary composite event than those achieving SUA levels >5 to ≤6 mg/dl (P = 0.003 [log-rank test]). This J-shaped relationship applied to patients with renal impairment (P = 0.007 [Gray's test]) and was not significant in the non-febuxostat treatment group (P = 0.212 [log-rank test]). Optimal SUA level by febuxostat treatment is 5-6 mg/dl for reducing all-cause mortality, cerebral, cardiovascular and renal events. Excessive SUA reduction may be harmful in older hyperuricaemic populations. ClinicalTrial.gov, https://clinicaltrials.gov, NCT01984749.