Influenced by the combined effects of crustal uplift and river downcutting, rivers with significant potential energy are often found in high mountain and canyon areas. Due to the active tectonic movements that these areas have experienced or are currently experiencing, geological hazards frequently occur on the mountains flanking the rivers. Therefore, evaluating the susceptibility and risk of earthquake landslides in river segments of these high mountain and canyon areas is of great importance for disaster prevention and mitigation, as well as for the safe construction and operation of hydropower stations. Currently, a major challenge in the study of landslide susceptibility and hazard is determining the thickness of potential landslide bodies. The presence of excess topography reflects the instability of the disrupted slopes, which is also a fundamental cause of landslides. This study takes the example of the Ludian earthquake in 2014, focusing on the IX and VIII intensity zones, to extract the excess topography in the study area and analyze its correlation with seismic landslides. The correlation between the critical acceleration value and the excess topography was validated using the Spearman’s rank correlation coefficient, resulting in a correlation coefficient of −0.771. This indicates a strong negative correlation between the excess topography and critical acceleration, with significant relevance. The landslide susceptibility distribution obtained by setting the potential landslide thickness based on the excess topography and proportion coefficient showed an ROC curve analysis AUC value of 0.829. This is higher than the AUC value of 0.755 for the landslide susceptibility result using a uniform potential landslide thickness of 3 m, indicating the higher model evaluation accuracy of this approach. Earthquake landslide hazard predictions for rapid post-earthquake assessments and earthquake landslide hazard zoning for pre-earthquake planning were made using actual seismic ground motion and a 2% exceedance probability in 50 years, respectively. Comparing these with the 10,559 coseismic landslides triggered by the Ludian earthquake and evaluating the seismic landslide development rate, the results were found to be consistent with reality. The improved model better reflects the control of excess topography and rock mechanics properties on the development of earthquake landslide hazards on high steep slopes. Identifying high-risk seismic landslide areas through this method and taking corresponding preventive and protective measures can help plan and construct safer hydropower and other infrastructure, thereby enhancing their disaster resistance.