Flexible pressure sensors have a wide range of applications in the field of human motion signal detection, but the electromagnetic radiation generated during the monitoring process has become an unavoidable problem. Nowadays, it is still a challenge to develop high-performance pressure sensors with excellent electromagnetic interference (EMI) shielding performance. Herein, the Ti3C2TX MXene/carbon fiber/multiwalled carbon nanotube/polydimethylsiloxane (MXene/CMP) films with a micropyramidal structure were developed by the technology of vacuum high-temperature hot pressing and spray deposition. Benefiting from the dielectric loss of the conductive fillers and the presence of the microstructure, the MXene/CMP film exhibits excellent EMI shielding performance, and the EMI shielding efficiency (SE) can reach 49.37 dB. Besides, the introduction of CF effectively improves the mechanical properties of the MXene/CMP films, and the MXene nanosheets deposited on the surface of the film can reduce stress concentration, which in turn delays the expansion of cracks. Furthermore, the MXene/CMP sensor exhibits high sensitivity (89.76 kPa-1) and fast response/recovery time (61/60 ms). The deformation of microstructure and the construction of conductive networks enable the sensor to realize the monitoring of human motion signals (such as finger bending, knee bending, wrist bending, etc.). Meanwhile, the sensor maintains sensing stability even after 2000 pressure cycles, which can be attributed to the improvement in mechanical properties. In summary, the developed high-performance flexible pressure sensor with micropyramid structure has great application prospects in wearable devices and healthcare.