Many antimicrobial coatings deliver a peak release of antimicrobial agent at an early age, after which they lost antimicrobial activity over time. In the present study a novel geopolymer paints with long term antimicrobial activity were developed based on natural zeolite modified with silver and copper ions. The obtained geopolymer paints were applied by brushing on concrete, ceramic, gypsum paperboard and steel. The coating was characterized by excellent adhesive strength and hiding properties. The long-term antimicrobial effect was evaluated by accelerated aging in carbonation chamber. Microstructural changes were analyzed by powder X-ray diffraction and Fourier transformed infrared spectroscopy. Cytotoxicity, antibacterial, antifungal and virucidal properties were investigated on raw and carbonated geopolymer paints. Geopolymer paints based on modified natural zeolite seems promising antimicrobial coating material that can be implemented in the global fight against the spread of diseases and pathogens.