Exact Treatment Research Articles

On the performance of QTP functionals applied to second-order response properties.

Correlated orbital theory (COT) is an exact one-particle treatment that adds essential electron correlation into its molecular orbitals, potentially reducing correlated treatments of response properties to one-particle coupled-perturbed Hartree-Fock- or Kohn-Sham-like calculations. Such a computation is vastly simpler than the usual abinitio correlated approach that would add correlation typically with EOM-CC after a perturbed mean-field solution. The question then is, how well can this be accomplished via the Quantum Theory Project (QTP) exchange-correlation (XC) functionals that are meant to emulate the rigorous COT framework? This paper addresses this question for response properties by making comparisons between such orbital-specific calculations and those from well-correlated EOM-CC solutions for static polarizabilities, nuclear magnetic resonance coupling constants, and chemical shifts. The simple orbital-specific version provides an accurate realization of the correlated EOM-CC results, but now in a mode that facilitates an orbital-by-orbital interpretation. Here, we compare 33 XC functionals from the different Jacob's ladder rungs always against the EOM-CCSD results. Thus, the smallest mean absolute deviation for the static polarizability comes from LC-QTP XC, 0.28a.u. Regarding the total nuclear spin-spin coupling constants, QTP01 performs best, %Error = 10.63% (QTP02 and LC-QTP are second and third best). Finally, the XC that stood out in the chemical shift analysis was TPSS0, which presented the best result for the majority of the chemical shifts. However, considering the overall performances based on linear fitting of all isotope data points, five functionals are recommended for a chemical shift study: TPSS0, ωB97X, QTP00, QTP01, and QTP02, all presenting R2 = 0.96.

Assessing XEN microstent's one-year efficacy: independent of site variability.

To evaluate the short-term efficacy of XEN45 Gel Stent (XEN) implantation for primary open angle glaucoma (POAG) and pseudoexfoliation (PEX) glaucoma across two university eye clinics, aiming to assess the impact of varying center-specific protocols during the first postoperative year. We retrospectively examined 282 patients (183 in center 1, 99 in center 2), who underwent XEN microstent implantation for uncontrolled POAG or PEX glaucoma. Parameters including intraocular pressure (IOP), IOP-lowering medication count, best corrected visual acuity (BCVA), and postoperative complications were evaluated over 12mo. Post-implantation, center 1 reported a mean IOP reduction from 25.3±7.4 to 14.1±4.7 mm Hg (P<0.01) and a decrease in IOP-lowering medications from 3.2±1.2 to 1.0±1.3 (P<0.01). Center 2 observed a similar reduction from 24.4±6.5 to 15.1±5.5 mm Hg (P<0.01) and medication decrease from 3.0±1.1 to 1.2±1.0 (P<0.01). BCVA remained stable in both cohorts. The most common complications were hypotony (center 1: 32; center 2: 20) and choroidal detachment (center 1: 22, center 2: 15), with nearly identical needling rates (40% in center 1, 41% in center 2). XEN implantation yields consistent reductions in IOP and medication use across different centers using comparable surgical and postoperative treatment regime. These findings underscore XEN's short-term effectiveness and suggest standardizable outcomes regardless of exact surgical procedure or treatment differences.

Automated brain tumor recognition using equilibrium optimizer with deep learning approach on MRI images

Brain tumours (BT) affect human health owing to their location. Artificial intelligence (AI) is intended to assist in diagnosing and treating complex diseases by combining technologies like deep learning (DL), big data analytics, and machine learning (ML). AI can identify and categorize tumours by analyzing brain imaging approaches like Magnetic Resonance Imaging (MRI). The medical sector has been promptly shifted by evolving technology, and an essential element of these transformations is AI technology. AI model determines tumours’ class, size, aggressiveness, and location. This assists medical doctors in making more exact diagnoses and treatment plans and helps patients better understand their health. Also, AI is used to track the progress of patients through treatment. AI-based analytics is used to predict potential tumour recurrence and assess treatment response. This study presents Brain Tumor Recognition using an Equilibrium Optimizer with a Deep Learning Approach (BTR-EODLA) technique for MRI images. The BTR-EODLA technique intends to recognize whether or not a BT presence exists. In the BTR-EODLA technique, median filtering (MF) is deployed to eliminate the noise in the input MRI. Besides, the squeeze-excitation ResNet (SE-ResNet50) model is applied to derive feature vectors, and its parameters are fine-tuned by the design of the EO model. The BTR-EODLA technique utilizes the stacked autoencoder (SAE) model for BT detection. A sequence of experiments is performed to ensure the improved performance of the BTR-EODLA technique. The investigational validation of the BTR-EODLA technique portrayed a superior accuracy value of 98.78% over existing models.

Long-term effects of the targeting the ultra-poor program—a reproducibility and replicability assessment of banerjee et al. (2021)

Abstract Banerjee, Duflo, and Sharma (BDS, 2021a) conduct a ten-year follow-up of a randomized transfer program in West Bengal. BDS find large effects on consumption, food security, income, and health. We conduct a replicability assessment. First, we successfully reproduce the results, thanks to a perfectly documented reproduction package. Results are robust across alternative specifications. We furthermore assess the paper's pre-specification diligence and the reporting in terms of external and construct validity. While the paper refers to a pre-registration, it lacks a pre-analysis plan. Assessing the validity of findings for other contexts is difficult absent necessary details about the exact treatment delivery.

A review article on the managements of Arshas (haemorrhoids)

A haemorrhoid is the most common affecting up to one quarter of all adults according to some estimates. Numerous interventions exist for their management, ranging from topical and medical therapies to outpatient treatments and surgical interventions that aim to fix or excise. The word Arsha is self-explanatory, indicating that the disease troubles a person like an enemy. Arshas can be corelated to haemorrhoids in modern science. Arshas is clinically an engorged condition of haemorrhoidal venous plexus characterized by prolapsed mass per anum, bleeding per anum mainly. In contemporary science there are treatments for haemorrhoids like sclerotherapy, banding, laser ablation, lifestyle modifications, surgical procedures like haemorrhoidectomy and other invasive technique. In Ayurvedic tests Chaturvidha Chikitsa is said, such as Bheshaja (medicinal), Kshara Karma (caustic treatment), Agni Karma (thermal hear burn) and Shastra Karma (surgery). In this review article, treatments from modern as well as Ayurvedic texts are documented so that proctologists around the world get a better understanding about the disease and its exact treatment modalities in both the sciences.

Hepatocyte-specific NR5A2 deficiency induces pyroptosis and exacerbates non-alcoholic steatohepatitis by downregulating ALDH1B1 expression

Nonalcoholic steatohepatitis (NASH) is a prevalent chronic disease, yet its exact mechanisms and effective treatments remain elusive. Nuclear receptor subfamily 5 group A member 2 (NR5A2), a transcription factor closely associated with cholesterol metabolism in the liver, has been hindered from comprehensive investigation due to the lethality of NR5A2 loss in cell lines and animal models. To elucidate the role of NR5A2 in NASH, we generated hepatocyte-specific knockout mice for Nr5a2 (Nr5a2HKO) and examined their liver morphology across different age groups under a regular diet. Furthermore, we established cell lines expressing haploid levels of NR5A2 and subsequently reintroduced various isoforms of NR5A2. In the liver of Nr5a2HKO mice, inflammation and fibrosis spontaneously emerged from an early age, independent of lipid accumulation. Pyroptosis occurred in NR5A2-deficient cell lines, and different isoforms of NR5A2 reversed this form of cell death. Our findings unveiled that inhibition of NR5A2 triggers pyroptosis, a proinflammatory mode of cell death primarily mediated by the activation of the NF-κB pathway induced by reactive oxygen species (ROS). As a transcriptionally regulated molecule of NR5A2, aldehyde dehydrogenase 1 family member B1 (ALDH1B1) participates in pyroptosis through modulation of ROS level. In conclusion, the diverse isoforms of NR5A2 exert hepatoprotective effects against NASH by maintaining a finely tuned balance of ROS, which is contingent upon the activity of ALDH1B1.

Extending Non-Perturbative Simulation Techniques for Open-Quantum Systems to Excited-State Proton Transfer and Ultrafast Non-Adiabatic Dynamics.

Excited state proton transfer is an ubiquitous phenomenon in biology and chemistry, spanning from the ultrafast reactions of photobases and acids to light-driven, enzymatic catalysis and photosynthesis. However, the simulation of such dynamics involves multiple challenges, since high-dimensional, out-of-equilibrium vibronic states play a crucial role, while a fully quantum description of the proton's dissipative, real-space dynamics is also required. In this work, we extend the powerful matrix product state approach to open quantum systems (TEDOPA) to study these demanding dynamics, and also more general nonadiabatic processes that can appear in complex photochemistry subject to strong laser driving. As an illustration, we initially consider an open model of a four-level electronic system interacting with hundreds of intramolecular vibrations that drive ultrafast excited state proton transfer, as well as an explicit photonic environment that allows us to directly monitor the resulting dual fluorescence in this system. We then demonstrate how to include a continuous "reaction coordinate" of the proton transfer that allows numerically exact simulations that can be understood, visualized and interpreted in the familiar language of diabatic and adiabatic dynamics on potential surfaces, while also retaining an exact quantum treatment of dissipation and driving effects that could be used to study diverse problems in ultrafast photochemistry.

Monte Carlo calculations taking into account the DLP theory to study multilayer adsorption of C2H4 and CF4 on graphite

Physisorption potentials are useful for deducing the properties of adsorption systems. The adsorption behavior is a consequence of the actual potential that describes the interactions among the adsorption system. Determining the actual isotherm is a test for the correctness of a calculated adsorption potential. The physisorption interactions decrease with the film thickness, d, according to a power law as −γ/d3, where γ is the Van der Waals coefficient. In the Dzyaloshinskii, Lifshitz, and Pitaevskii (DLP) theory, γ is a function of d where γ(d) decreases with d. In the present work, the general theory of Van der Waals forces, given by DLP, is used to derive a more exact treatment of interactions among the physisorbed systems. The Monte Carlo method is used to investigate multilayer films using a lattice gas model adsorption isotherm. Critical temperatures are determined for ethylene (C2H4) and tetrafluoromethane (CF4) on graphite. These systems exhibit comparable behavior. Unlike the findings of mean field theory, our data shows that the critical temperature rises gradually as the layer number increases. On the other hand, the comparison with experimental results and measurements has shown that our calculations are more reliable and provide a better approximation in predicting film thickness. Our isotherms appear to be in better agreement with the experimental ones.

Entanglement of Coupled Harmonic Oscillators without and with Tunneling Effect and Correction Factor

Seeing its simplicity of processing, the system of two coupled harmonic oscillators have witnessed a quick growth of research conducted to quantum information. This approach is explicitly investigated in this paper, in particularly entanglement concept is proved to be intimately related to the tunneling effect. We examine analytically entanglement dynamics by introducing the Lewis and Riesenfeld invariant operator in the Heisenberg picture approach to compute the density matrix on the based of an exact treatment. We use Wigner function of the mixed state as an essential tool to move to linear entanglement entropies and we compute the corresponding correction factor. We follow numerically the evolution of entanglement dynamics without and under tunneling through the quantum potential barrier by introducing two particular models between simple and damped coupled harmonic oscillators. Entanglement dynamics is considered to be average without tunneling, it grows upon encountering the potential barrier and remains moderately constant inside barrier. This specificity is extended for both models but with higher values for damped coupled harmonic oscillators consequently the damping effect rapidly increases entanglement. Correction factor is also considered for both models, it show that; low temperature and high potential barriers make the system more disruptive. An increase of the coupling parameter of the system increase correction factor. Damping make the correction factor more important so damping disturbs more the system. Interference effect increase correction factor and it shows an interference between the values of the barrier penetration integral.

Impact of nuclear level density and γ-ray strength function in (n,γ) and Maxwellian-averaged cross-section of 69Zn nucleus

The present paper highlights the impact of nuclear level density (NLD) and γ-ray strength function (γ-SF) on (n,γ) and Maxwellian-averaged cross-section of 69Zn nucleus. At first, the existing NLD and γ-SF models (in TALYS statistical model code) have been utilized to understand the role of NLD and γ-SF in neutron capture reaction cross-section. It is seen that most of the combinations of existing NLDs and γ-SFs (phenomenological and/or microscopic) cannot explain the experimental data. Therefore, the microscopic exact pairing plus independent particle model (EP+IPM) and exact pairing plus phonon damping model (EP+PDM) have been carried out to calculate the NLD and γ-SF of 69Zn nucleus, respectively, by employing the exact treatment of thermal pairing. It is seen that microscopic EP+IPM NLD and EP+PDM γ-SF explain the experimental data better than all other combinations available in TALYS-1.95, indicating the impact of the exact treatment of thermal pairing correlation. In addition, the inclusion of an upbend (UB) structure in γ-SF further improves the comparison with the experimental data in the low energy region (∼0.01–0.15 MeV), indicating the possibility of having an UB structure in γ-SF of 69Zn. The 68Zn(n,γ)69Zn reaction cross-section obtained by utilizing the EP+IPM NLD and EP+PDM γ-SF including UB structure is then used to predict the Maxwellian-averaged cross-sections, and the obtained results show reasonable agreement with all the available experimental data taken from the Karlsruhe Astrophysical Database of Nucleosynthesis in Stars. The present results reflect the impact of microscopic NLD and γ-SF on the precise description and/or prediction of the astrophysical reaction cross-section.

Ising-Like Model Hasn't Yet Said Its Last Word: Exact and Mean-Field Investigations of 2, 3 and 4-Body Interactions in 1D Ising Chain of Binuclear Spin-Crossover Solids.

We investigate the static properties of a new class of 1D Ising-like Hamiltonian for binuclear spin-crossover materials accounting for two-, three-, and four-body short-range interactions between binuclear units of spins and . The following 2-, 3-, and 4-body , , and terms are considered, in addition to intra-binuclear interactions, such as effective ligand-field energy and exchange-like coupling. An exact treatment is carried out within the frame of the transfer matrix method, leading to a 4×4 matrix from which, we obtained the thermal evolution of the thermodynamic quantities. Several situations of model parameter values were tested, among which that of competing intra- and inter-molecular interactions, leading to the occurrence of (i) one-step spin transition, (ii) two-, three-, and four-step transitions, obtained with a reasonable number of parameters. To reproduce first-order phase transitions, we accounted for inter-chains interactions, treated in the mean-field approach. Hysteretic multi-step transitions, recalling experimental observations, are then achieved. Overall, the present model not only suggests new landscapes of interaction configurations between SCO molecules but also opens new avenues to tackle the complex behaviors often observed in the properties of SCO materials.

XIAM-NQ: Implementation of exact quadrupole coupling

In rotational spectroscopy, the nuclear quadrupole coupling of spins to the rotation of a molecule frequently leads to significant hyperfine splittings of spectral lines, complicating spectral analysis. This complexity increases further when internal rotation fine splittings, particularly from methyl groups, are also present. The XIAM program, recognized in the community for its ability to address methyl internal rotation and handle nuclear quadrupole coupling for a single nucleus, while neglecting off-diagonal matrix elements in the quantum number J, has now been enhanced. The updated version, XIAM-NQ, includes the previously omitted matrix elements, enabling an exact treatment of quadrupole coupling. This new version offers precise spectral fits with minimal fitting times, even for molecules containing bromine and iodine nuclei. The effectiveness of XIAM-NQ is demonstrated on o-halotoluenes and m-chlorotoluene.

Abstract A017: Comprehensive evaluation of the therapeutic effects of whole-body hyperthermia for pancreatic ductal adenocarcinoma (PDAC) and the potential synergy with standard-of-care chemotherapeutics

Abstract Whole-body hyperthermia (WBHT) is a promising therapeutic approach that leverages elevated temperatures to enhance cancer treatment efficacy. By inducing controlled hyperthermia in the range of 39-42.5°C, cellular processes are disrupted and cancer cells can be sensitized to standard-of-care chemotherapies. However, the precise cellular and molecular mechanisms by which WBHT exerts its effects are not fully understood. Elucidating these mechanisms is particularly crucial for optimizing treatment protocols and improving outcomes in aggressive malignancies such as pancreatic ductal adenocarcinoma (PDAC). This study explores the impact of WBHT at 41.5°C on the cell cycle and associated molecular pathways in PDAC cells, providing insights into its therapeutic value and potential for combination regimens. PDAC cell lines, BxPC-3 and AsPC-1, were subjected to WBHT at 41.5°C for 1-6 hours and analyzed immediately, 24h and 48h post-WBHT Cell proliferation was assessed using the 5-ethynyl-2'-deoxyuridine (EdU) base-incorporation assay and proliferating cell nuclear antigen (PCNA) staining for immunofluorescence detection. Morphological changes post-WBHT were monitored using confocal fluorescence microscopy. Total RNA was extracted and sequenced using the Illumina platform. An in-house pipeline was used for QC, alignment and differential expression analysis. Enrichment analysis was performed to identify affected biological processes and pathways. In vivo experiments employed the chorioallantois membrane (CAM) assay per protocol published in STAR protocols. WBHT at 41.5°C significantly disrupted cell cycle progression in PDAC cell lines. The EdU incorporation assay revealed a dose-dependent decrease in DNA synthesis during and following WBHT, indicating cell cycle arrest in the S-phase. Decreases in Ki67, cyclin B1 and PCNA intensities further confirmed this reduction in cell proliferation. Moreover, cells showed notable signs of cellular and mitotic stress, such as the formation of multi-nucleated giant cells, aberrant metaphase morphology and micronuclei. Bulk RNA-seq confirmed alterations in gene expression profiles relating to the cell cycle immediately after HT exposure. Genes associated with the E2F targets and G2/M checkpoint pathways were negatively enriched, whereas genes involved in the Hallmark apoptosis pathway were positively enriched. Preliminary data from in ovo CAM experiments showed a significant inhibitory effect of WBHT monotherapy on growth of BxPC-3 tumors. Our data show that WBHT severely disrupts the cell cycle at the S- and M-phases, via multiple pathways involved in cell proliferation and apoptosis. These cancer hallmarks are targeted by conventional chemotherapeutics, paving the way for combination therapy as one-two punch cancer treatments. The synergy between WBHT with cisplatin and oxaliplatin, but also with gemcitabine and 5-fluorouracil (5-FU) could be optimized based on the improved understanding of the WBHT effects over time, in terms of WBHT duration, sequence of WBHT and chemo and the exact treatment schedule. Citation Format: Robin Colenbier, Tine Logghe, Gaëlle Boulet, Johannes Bogers, Jean-Pierre Timmermans. Comprehensive evaluation of the therapeutic effects of whole-body hyperthermia for pancreatic ductal adenocarcinoma (PDAC) and the potential synergy with standard-of-care chemotherapeutics [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Advances in Pancreatic Cancer Research; 2024 Sep 15-18; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2024;84(17 Suppl_2):Abstract nr A017.

An exact treatment of localization of electromagnetic plus separable potential

Equivalent local potential with energy-momentum dependence is developed for the combined interaction of Hulthén modified Yamaguchi potential by developing its exact Jost solution. The generated local potentials are applied to compute scattering phase parameters for (p-p) and (p-d) systems through the phase function method (PFM). The same are also calculated for the nonlocal potential from the expression of the Fredholm determinant. Our obtained data for both the energy-momentum dependent local and the pure nonlocal interactions are in reasonable agreement with the standard data. Reasonable correspondence between the results for the phase equivalent and the nonlocal potentials indicate that our equivalent local analysis is in proper order.

Estimated Annual Healthcare Costs After Acute Pulmonary Embolism: Results From a Prospective Multicentre Cohort Study.

Patients surviving acute pulmonary embolism (PE) necessitate long-term treatment and follow-up. However, the chronic economic impact of PE on European healthcare systems remains to be determined. We calculated the direct cost of illness during the first year after discharge for the index PE, analyzing data from a multicentre prospective cohort study in Germany. Main and accompanying readmission diagnoses were used to calculate DRG-based hospital reimbursements; anticoagulation costs were estimated from the exact treatment duration and each drug's unique national identifier; and outpatient post-PE care costs from guidelines-recommended algorithms and national reimbursement catalogues. Of 1017 patients enrolled at 17 centres, 958 (94%) completed≥3-month follow-up; of those, 24% were rehospitalized (0.34 [95% CI 0.30-0.39] readmissions per PE survivor). Age, coronary artery, pulmonary and kidney disease, diabetes, and (in the sensitivity analysis of 837 patients with complete 12-month follow-up) cancer, but not recurrent PE, were independent cost predictors by hurdle gamma regression accounting for zero readmissions. Estimated rehospitalization cost was €1138 (95% CI 896-1420) per patient. Anticoagulation duration was 329 (IQR 142-365) days, with estimated average per-patient costs of €1050 (median 972; IQR 458-1197); costs of scheduled ambulatory follow-up visits amounted to €181. Total estimated direct per-patient costs during the first year after PE ranged from €2369 (primary analysis) to €2542 (sensitivity analysis). By estimating per-patient costs and identifying cost drivers of post-PE care, our study may inform decisions concerning implementation and reimbursement of follow-up programmes aiming at improved cardiovascular prevention. (Trial registration number: DRKS00005939).

ChatGPT's Gastrointestinal Tumor Board Tango: A limping dance partner?

ObjectivesThis study aimed to assess the consistency and replicability of treatment recommendations provided by ChatGPT 3.5 compared to gastrointestinal tumor cases presented at multidisciplinary tumor boards (MTBs). It also aimed to distinguish between general and case-specific responses and investigated the precision of ChatGPT's recommendations in replicating exact treatment plans, particularly regarding chemotherapy regimens and follow-up protocols. Material and methodsA retrospective study was carried out on 115 cases of gastrointestinal malignancies, selected from 448 patients reviewed in MTB meetings. A senior resident fed patient data into ChatGPT 3.5 to produce treatment recommendations, which were then evaluated against the tumor board's decisions by senior oncology fellows. ResultsAmong the examined cases, ChatGPT 3.5 provided general information about the malignancy without considering individual patient characteristics in 19% of cases. However, only in 81% of cases, ChatGPT generated responses that were specific to the individual clinical scenarios. In the subset of case-specific responses, 83% of recommendations exhibited overall treatment strategy concordance between ChatGPT and MTB. However, the exact treatment concordance dropped to 65%, notably lower in recommending specific chemotherapy regimens. Cases recommended for surgery showed the highest concordance rates, while those involving chemotherapy recommendations faced challenges in precision. ConclusionsChatGPT 3.5 demonstrates potential in aligning conceptual approaches to treatment strategies with MTB guidelines. However, it falls short in accurately duplicating specific treatment plans, especially concerning chemotherapy regimens and follow-up procedures. Ethical concerns and challenges in achieving exact replication necessitate prudence when considering ChatGPT 3.5 for direct clinical decision-making in MTBs.

Effects of different treatment frequencies of electromagnetic stimulation for urinary incontinence in women: study protocol for a randomized controlled trial

BackgroundUrinary incontinence is highly prevalent in women while pelvic floor muscle training is recommended as the first-line therapy. However, the exact treatment regimen is poorly understood. Also, patients with pelvic floor muscle damage may have decreased muscle proprioception and cannot contract their muscles properly. Other conservative treatments including electromagnetic stimulation are suggested by several guidelines. Thus, the present study aims to compare the effectiveness of electromagnetic stimulation combined with pelvic floor muscle training as a conjunct treatment for urinary incontinence and different treatment frequencies will be investigated.Methods/designThis is a randomized, controlled clinical trial. We will include 165 patients with urinary incontinence from the outpatient center. Participants who meet the inclusion criteria will be randomly allocated to three groups: the pelvic floor muscle training group (active control group), the low-frequency electromagnetic stimulation group (group 1), and the high-frequency electromagnetic stimulation group (group 2). Both group 1 and group 2 will receive ten sessions of electromagnetic stimulation. Group 1 will be treated twice per week for 5 weeks while group 2 will receive 10 days of continuous treatment. The primary outcome is the change in International Consultation on Incontinence Questionnaire–Short Form cores after the ten sessions of the treatment, while the secondary outcomes include a 3-day bladder diary, pelvic floor muscle function, pelvic organ prolapse quantification, and quality of life assessed by SF-12. All the measurements will be assessed at baseline, after the intervention, and after 3 months of follow-up.DiscussionThe present trial is designed to investigate the effects of a conjunct physiotherapy program for urinary incontinence in women. We hypothesize that this strategy is more effective than pelvic floor muscle training alone, and high-frequency electromagnetic stimulation will be superior to the low-frequency magnetic stimulation group.

Systematic investigation of nucleon optical model potentials in (p, d) transfer reactions* *Supported by the National Natural Science Foundation of China (U2067205, 12205098), and the National Key Research and Development Program of China (2022YFA1602403)

The consistent three-body model reaction methodology (TBMRM) proposed by J. Lee et al. [ Phys. Rev. C 69, 064313 (2004); Phys. Rev. C 73, 044608 (2006); Phys. Rev. C 75, 064320 (2007)], which includes adopting the simple zero-range adiabatic wave approximation, constraining the single-particle potentials using modern Hartree–Fock calculations, and using global nucleon optical model potential (OMP) geometries, are widely applied in systematic studies of transfer reactions. In this study, we investigate the influence of different nucleon OMPs in extracting spectroscopic factors (SFs) from ( ) reactions. Our study covers 32 sets of angular distribution data of ( ) reactions on four targets and a large range of incident energies (20-200 MeV/nucleon). This study uses two semi-microscopic nucleon OMPs, i.e., Jeukenne, Lejeune, and Mahaux (JLM) [Phys. Rev. C 16, 80 (1977); Phys. Rev. C 58, 1118 (1998)] and CTOM [Phys. Rev. C 94, 034606 (2016)], and a pure microscopic nucleon potential, i.e., WLH [Phys. Rev. Lett. 127, 182502 (2021)]. The results are compared with those using the phenomenological global optical potential KD02 [Nucl. Phys. A 713, 231 (2003)]. We find that the incident energy dependence of spectroscopic factors extracted from ( ) reactions is evidently suppressed when microscopic OMPs are employed for 12C, 28Si, and 40Ca. In addition, spectroscopic factors extracted using the systematic microscopic optical potential CTOM based on the Dirac-Brueckner-Hartree-Fock theory are more in line with the results obtained from ( ) measurements, except for 16O and 40Ca at high energies (> 100 MeV), necessitating an exact treatment of double-magic nuclei. The results obtained by using the pure microscopic optical potential, WLH, based on the EFT theory show the same trend as those of CTOM but are generally higher. The JLM potential, which relies on simplified nuclear matter calculations with old-fashioned bare interactions, produces results that are very similar to those of the phenomenological potential KD02. Our results indicate that modern microscopic OMPs are reliable tools for probing the nuclear structure using transfer reactions across a wide energy range.

E034 Drug-induced accelerated nodulosis in a patient with rheumatoid arthritis

Abstract Background/Aims Drug-induced accelerated nodulosis (DIAN) is characterized by the occurrence or progression of multiple subcutaneous nodules in a patient treated for rheumatoid arthritis (RA). It was first and most commonly reported with methotrexate in RA patients. Methods A 37-year-old normotensive, non-diabetic, seropositive rheumatoid arthritis female presented with complaints of nodules over the bilateral hands and feet from the last three months. The treatment history included methotrexate therapy (10 mg/week) for one year. Methotrexate-induced rheumatoid accelerated nodulosis (MIAN) was suspected. Methotrexate was stopped and hydroxychloroquine was added considering the low disease activity. The nodules decreased in number as well as size. On follow-up, she presented with increased multiple joint pain and swelling with ESR 60 mm/hour, CRP 13.6 mg/L, and leflunomide was added. After six months of leflunomide use, she again developed multiple bilateral nodules on the extensor and palmar surface of fingers and feet, ranging from 0.5 to 1 cm. The CRP was 9.2 mg/L, ESR 80 mm/hour, complete blood count showed mild anaemia with normal renal and liver function tests. The nodule biopsy showed palisading granuloma consisting of lymphocytes and histiocytes in mid and deep reticular dermis with large foci of fibrin deposition and collagen degeneration s/o rheumatoid nodule. Leflunomide was stopped. Results The leflunomide was switched to sulfasalazine along with colchicine, and hydroxychloroquine was continued. The patient is doing well on follow-up in terms of disease activity and nodule size. Palmeiro. A.G., et al. 2022 reviewed 39 studies from 1st Jan 1988 to 1st Jan 2022 and found 109 cases of accelerated nodulosis. 99 patients had RA, methotrexate was the culprit drug in 89, followed by etanercept in 7 and leflunomide was in just 3 patients. Although there are no exact treatment guidelines, tumour necrosis factor inhibitors were avoided due to increased nodulosis risk. Recently, Valor-Méndez. L., et al 2020 reported improved nodulosis with Janus Kinase inhibitors like baricitinib, which seems to be a future option. Histologically, rheumatoid nodules and accelerated nodulosis are indistinguishable. The exact pathogenesis is unknown but, polymorphic variants of methionine synthase reductase or haplotype HLA-DRB1*0401, and adenosine A1 receptor promotion in multinucleated giant cells are associated. Conclusion Drug-induced accelerated nodulosis (DIAN) and MIAN are not that rare but diagnosis is challenging. It causes significant morbidity and affects the quality of life because of the predominant involvement of hands and feet. It should be suspected especially when disease activity is low or rapidly progressive nodules with a change in immunotherapy. Partial to total improvement can be achieved by identifying and stopping the culprit drug. We need specific guidelines, more treatment options, and a specific national registry to report such adverse effects with biologics and non-biologic disease-modifying antirheumatic drugs. Disclosure H. Singh: None. R. Kaur: None. G. Mohan: None.

Exact treatment of weak dark matter-baryon scattering for linear-cosmology observables

Exact treatment of weak dark matter-baryon scattering for linear-cosmology observables