Period Of Evolution Research Articles

Metabolomics and biochemical assays reveal the metabolic responses to hypo-salinity stress and osmoregulatory role of cAMP-PKA pathway in Mercenaria mercenaria

Hypo-salinity events frequently occur in marine ecosystem due to persistent rainfall and freshwater inflow, reducing the cytosol osmolarity and triggering cellular stress responses in aquatic organisms. Euryhaline bivalves have developed sophisticated regulatory mechanisms to adapt to salinity fluctuations over a long period of evolution. In this study, we performed multiple biochemical assays, widely targeted metabolomics, and gene expression analysis to investigate the comprehensive metabolic responses to hypo-salinity stress and osmoregulation mechanisms in hard clam Mercenaria mercenaria, which is a euryhaline bivalve species widely cultured in China. During hypo-salinity stress, increased vacuoles appeared in gill filaments. The Na+ and Cl- concentrations in gills significantly decreased because of the up-regulation of Na+/K+-ATPase (NKA) activity. The cAMP content dramatically decreased at 5 d post hypo-salinity stress. Meanwhile, the gene expression levels of adenylate cyclase, proteinkinase A, and sodium and calcium channel proteins were evidently down-regulated, suggesting that cAMP-PKA pathway was inhibited to prevent ambient inorganic ions from entering the gill cells. Antioxidant metabolites, such as serine and Tyr-containing dipeptides, were significantly up-regulated to resist oxidative stress. Glycerolipid metabolism was strengthened to stabilize membrane structure when hypo-salinity stress was prolonged to 5 days. At 1 d post hypo-salinity stress, an increase in alanine and lactate contents marked the initiation of anaerobic metabolism. Acylcarnitines accumulation indicated that fatty acids β-oxidation was promoted to provide energy for osmoregulation. The potential biomarkers of hypo-salinity stress were identified in hard clams. This study provides novel insights into the metabolic regulatory mechanisms to hypo-salinity stress in euryhaline bivalves.

ЕВОЛЮЦІЯ РЕКОМЕНДАЦІЙ GINA. ПРАКТИЧНІ АСПЕКТИ ЛІКУВАННЯ ПАЦІЄНТІВ З АСТМОЮ ЧЕРЕЗ ПРИЗМУ КЛІНІЧНИХ ДОСЛІДЖЕНЬ

EVOLUTION OF GINA GUIDELINES. PRACTICAL ASPECTS OF ASTHMA MANAGEMENT THROUGH THE PRISM OF CLINICAL TRIALS S. V. Zaikov, F. T. Bogomolov, G. L. Gumeniuk Abstract Through the 28 years lifetime of GINA (Global Initiative for Asthma) recommendations, there’s been a shift in the paradigm of asthma management. GINA is a Global Strategy of treatment and prophylaxis of asthma, established by National Heart, Lung and Blood Institute in collaboration with National Institute of Health and World Health Organization in 1993. First published in 1995 GINA report has become a widespread consensus, which made a basis for clinical recommendations on asthma worldwide. One can define three major periods in evolution of GINA. The first period covered 1994–2004 years since GINA originated and first edition published until experts have recognized the advantage of inhaled rout of asthma drugs administration. It was proved that in many patients the main goal was establishing asthma control, while combination of inhaled corticosteroid with long-acting beta agonist (ICS/LABA) was a preferred option in moderate persistent asthma. In this period it was recommended to chose an approach to managent of asthma, based on scientific evidence, rather then expert’s opinion. In this regard, a second period (2005–2014 years) should be considered outstanding, due to the change in perception of major goals of asthma management, considering exclusively data from numerous studies. Such concepts as patient-medical personnel partnership, patient’s education, guided self-control and goals of treatment have been introduced. GINA recommends to use asthma control as a major approach to treatment instead of severity of disease. Personalized treatment should be aimed on exacerbation risk reduction. Steps 3-5 of treatment algorithm were modified to include ISC-formoterol for maintenance therapy and relief of symptoms (MART-therapy). Third period of GINA started after SYGMA 1 and 2 studies results became available. It was demonstrated that on-demand symptom-relief use of anti-inflammatory therapy with ICS/formoterol combination was highly effective in mild asthma patients. Use of this combination as rescue medication decreased the risk of exacerbation in comparison with short-acting beta agonist (SABA) and may be used in any variant of asthma. Since GINA 2019 edition SABA became not the only one available option even for the mildest forms of asthma. Eventually, in 2021 the culmination of GINA evolution occurred: major algorithm of asthma management has been divided in two tracks: preferred (Track 1) therapy with ICS/formoterol and alternative (track 2) therapy with SABA as rescue medication. The authors of this article review in details the periods of GINA evolution, resulted in dividing asthma management into two tracks, which provide personalized treatment strategy considering all patient’s needs and characteristics such as fast relief of symptoms, decreased risk of exacerbation and establishing asthma control. Key words: asthma, GINA, evolution of treatment approaches. Ukr. Pulmonol. J. 2022;30(1):6–14

Surgical Treatment of Hyperparathyroidism Secondary to Chronic Renal Failure: Our Experience with the 7/8 Subtotal Parathyroidectomy Technique

Introduction: Surgical management takes place, after a certain period of evolution, on particularly severe forms of secondary hyperparathyroidism, resistant to medical treatment. Subtotal parathyroidectomy is an effective technique in the treatment of these disorders. Method: Our study is retrospective of 33 cases of hyperparathyroidism secondary to chronic renal failure in dialysis patients operated by the 7/8 technique. Identified over a period of 10 years (January 2010 to December 2019), in the ENT department of the Fann University Hospital. Results: Out of 33 cases of secondary hyperparathyroidism, the average age of our patients was 51.24 years with a sex ratio of 0.43. Causal nephropathy was dominated by nephro-angiosclerosis, which was found in 27.27% of cases. Bone pain found in 23 patients or 69.69% was the predominant clinical sign. The average calcemia was 92.7 mg/l. Parathormone was dosed in all our patients and the average was 1611.05 ng/l. The consequences were clinically marked by recurrent paresis in one patient. No case of hematoma or postoperative infection was found. On the biological level 10 patients or 30.30% had a transient hypocalcaemia. The results were marked by a drop in PTH in 23 patients or 78.78% of cases. Conclusion: Subtotal parathyroidectomy remains an effective and beneficial therapeutic method for kidney failure patients with secondary hyperparathyroidism.

Генезис и перспективы правового регулирования института ответственности за неуважение к суду

The article examines the main stages of the formation of the criminal law prohibition, which guarantees the maintenance of a correct form of communication when participating in court proceedings. Provisions on liability for contempt of court have undergone a long evolutionary period, in the course of which the need for the existence of special legal consequences arising in connection with insulting behavior towards judges and other participants of judicial proceedings was stated. In fact, their development accompanied the formation of judicial power in Russia. Exercising justice is an important way to resolve conflicts, as a consequence of which the current legislation establishes a special procedure for participation in court proceedings. This procedure is based on respect for the attributes of judicial power. Insulting the participants of judicial proceedings grossly contradicts the generally accepted norms of behavior in society, attacks the authority of the court, as well as the persons endowed with the status of a judge. As an intentional crime, contempt of court is accompanied by humiliation of honor and dignity of judges and other participants of court proceedings. At the same time, it has a relative prevalence, excluding both the need for decriminalization and absorption by other provisions of the law protecting the honor and dignity of the individual.

Dynamics of Frozen Orbit and Its Critical Case in the Zonal Problem

This paper investigates the dynamical behaviors of Earth frozen orbits including the critical inclination orbit in the zonal problem with terms of perturbations up to J15. From the mean element theory, an analytical expansion of the dynamics model is derived to obtain the frozen conditions. The global existence of Earth frozen orbits is numerically illustrated by exploration of equilibria in the equations of motion based on Lagrangian formulations. Frozen orbits are widely located at the inclination between 0° and 90°, which may be grouped into families: one for the elliptic orbit case, another for the quasicircular orbit case and the other for the critical inclination orbit case. For the elliptic and quasicircular orbit cases, orbits evolve periodically around the frozen ones, and elliptic orbits tend to be more sensitive than quasicircular ones with respect to variation of initial orbital elements. Frozen orbit bifurcations near the critical inclination are shown to illustrate the origins, evolutions, and stability of frozen orbits. For the last critical inclination case, it is observed that eccentricities keep evolving periodically instead of being frozen at the specified ones compared with that in the J2 problem, and then a relationship between the evolution period and terms of zonal perturbations is illustrated.

Spectral introductions of typical minerals during the periods of skarn formation and evolution at Zhuxi tungsten polymetallic deposit in Jiangxi Province

朱溪是近年来在江西塔前-赋春成矿带发现的一个世界级超大型钨铜矿床。本文采用短波红外+热红外光谱技术对矿区13个钻孔进行了光谱测量，结合岩石-矿物地球化学分析，探讨了朱溪矿床矽卡岩中典型蚀变矿物的形成与演化过程，厘定了矽卡岩形成不同阶段矿物组合的光谱特征，构建了朱溪矿床的短波红外+热红外光谱勘查模型。研究发现:（1）区内不同矿物组合形成了明显的蚀变分带，由内向外依次为绢云母（富Si）+长石（岩体顶层蚀变，多期流体叠加综合作用）→外矽卡岩:钙铝榴石+透辉石+（绢云母）→透辉石+蛇纹石+绿泥（帘）石+滑石→绢云母（富Al）+绿泥（帘）石（基底不整合面蚀变）；（2）Al-OH波长的移动可指示成矿流体压力、温度及pH值的变化；（3）研究区透辉石的形成、演化与矿体之间关系密切，虽然富矿体赋存于矽卡岩形成早期的透辉石-石榴子石蚀变带，但大量矿体则赋存于矽卡岩退蚀变阶段的蛇纹石-绿泥石蚀变带；（4）矿体的形成与流体的混合作用关系极大，伊利石光谱吸收特征能够指示外部冷水（大气降水或地下水）的灌入轨迹。;The Zhuxi tungsten polymetallic giant deposit is located in the Taqian- Fuchun metallogenic belt, Jiangxi Province. By measuring 13 drill cores with SWIR and TIR spectroscopy combined with geochemical analysis, we discussed the formation and evolution process of typical skarn minerals in the Zhuxi deposit, summarized their spectral characteristics, and constructed a spectral exploration model. It was found that:(1) different mineral assemblages form obvious alteration zones, i.e., sericite+feldspar (the top layer of the rock mass, caused by multistage fluid superposition probably) → grossular+diopside+(sericite) → diopside+serpentine+chlorite (epidote+talc) → sericite+chlorite (epidote) (alteration on the basement); (2) the shift of the Al-OH wavelength 2200nm can indicate the changes in pressure, temperature, and pH value of the ore-forming fluid; (3) diopside formation and evolution have a close relationship with ore bodies. Bonanza occurs in the grossular+diopside alteration zone, and a large number of ore bodies occur in the serpentine+chlorite alteration zone. It evidenced the importance of the fluid mixing and cooling for mineralization. The ore body emerged in the early stage of skarn formation, but the real enrichment stages occurred in the retrograde alteration stage; (4) the mixing fluid plays a key role in forming the deposit, and the illite spectrum can indicate the trace of the external cold water (atmospheric precipitation or groundwater).

Генезис розвитку та становлення податкової системи України

The article examines the patterns of development and formation of the tax system of Ukraine, highlighting certain time periods, and within them, the stages that are the most significant from the point of view of its formation and evolution. Based on the indicators of the tax burden, an assessment of the effectiveness of the implemented changes to the tax legislation and the reform of the tax system was carried out. On the basis of a thorough study and analysis of the provisions of legislative acts, starting from the moment of the declaration of independence of Ukraine and up to the present time, the trends in the development of the tax system of Ukraine have been determined and the main stages of its formation have been characterized. It is substantiated that a sign of the first stage of the formation of the tax system (covering the period 1991-2010) is the laying of the foundations for its creation, the formation of tax mechanisms for the payment of established taxes and fees, the expansion of the elements of the tax system and their periodic transformation. The second stage of the formation of the tax system (covering the period from 2011 to the present day) is characterized by the reform of the tax system and the renewal of tax mechanisms for the payment of individual taxes. It is proven that the reform of the tax system was mostly carried out in order to stabilize the financial situation in the country, to stimulate the processes of economic growth and increase the investment attractiveness of Ukraine in the international environment. At the same time, the current tax system of Ukraine did not fully ensure the balancing of the tax burden in accordance with the real capabilities of the economy. ased on the results of the analysis of the level of the tax burden throughout the entire period of development and evolution of the tax system of Ukraine, it was established that the most effective were the transformational processes that took place at the first stage of the formation of the tax system in the period of 1998-2004, and at the second stage - in the period of 2011 -2013. The reform of the tax system of Ukraine, which took place in other periods, did not bring the proper effect, since the tools for the implementation of tax reforms were not always adequate to the real socio-economic state of the country, and the implemented tax policy did not meet the goals and objectives of the economic strategy of the state.

Lithium disilicate (IPS” e.Max computer-aided design) veneers for the esthetic rehabilitation in a young adolescent

Dental fluorosis is a developmental disturbance of enamel wherein the patients often present with esthetic concerns. Previously available approaches for the management of dental fluorosis included composite restoration, microabrasion, bleaching, resin infiltration and/or use of full crowns. For young permanent teeth, it is desirable to follow a treatment plan that efficiently addresses both anatomic and esthetic concerns. Keeping in mind, a minimally invasive approach, lithium disilicate in its modern formulations (IPSTM e.Max CAD) fabricates thin veneers with 0.1–0.7 mm thickness with greater fracture toughness and biaxial strength. Lithium disilicate has high esthetic properties, and the material requires minimal tooth preparation. The advent of newer technology has led to a period of evolution with esthetic dentistry leading the forefront. The present report elucidates a novel approach depicting the use of maximal esthetics (E-Max) lithium disilicate veneers in a young adolescent with moderate fluorosis to provide a minimally invasive esthetic outcome with 6 months' follow-up.

Доктринальные и современные взгляды на вопрос о происхождении государстваиправа

. The article attempts to combine the doctrinal ideas of Russian legal science about the origin of the state and law, based on the Marxist postulate of class struggle, with a modern view of the causes of the origin and interrelation of these institutions. In the first part of the work, the author outlines the doctrinal positions on the issue of the emergence of the state, concludes about the key role of social stratification and the formation of the military estate in this process. In the second part, the concepts of modern domestic scientists on the problem of the origin of law are proposed for consideration, based on the analysis of which the reasons for the appearance of this social institution are established, it is shown that law has a longer evolutionary period and its formation began much earlier than the origin of the institution of the state. At the same time, the author does not deny the key importance of law for the resolution of social conflicts in the course of further historical development of mankind.

COVID-19 triggers attacks in HAE patients without worsening disease outcome

COVID-19 triggers attacks in HAE patients without worsening disease outcome

Analysis of long-term anatomic results of radical mastoidectomy.

A long-term, retrospective, non-controlled study was performed on the drainage results of mastoidectomy (both radical and modified radical) and the relevant statistical factors that could influence the anatomic outcome were defined. The present study took into consideration the same cohort of 200 patients we have communicated with before in our previous studies concerning the long-term functional results of mastoidectomy and long-term results of ossicular replacement with biovitroceramic prosthesis. The patients were clinically followed for the same period of 8.12 years. The drainage (anatomic) results, similar to previously published functional results, were defined by analytical function of the severity and the period of evolution of disease. The main goal was to define the situations and factors (presence of complications, type of disease, type of tympanic perforation or status of ossicular chain) that influenced the drainage results that could provide us with some type of anatomical prognosis. The follow-up started at the moment of complete epithelization for each cavity as time represents the main study comparison criteria. Drainage failure was assessed by the number of otorrhea episodes. It was concluded that practically and ideally, a maximum of 84% of the mastoid and petrous cells can be cleaned out. The results of 78% drainage success are congruent to this theory. The remaining 16% of cells may contain irreversible lesions.

Smartphone Abuse Amongst Adolescents: The Role of Impulsivity and Sensation Seeking.

Adolescence is the stage of development where the reward and emotional regulation systems are yet to be adjusted and where most excessive behaviors start, like smartphone abuse. In addition, in this evolutionary period adolescents are more susceptible to behavioral changes through specific interventions or educational programs. Thus, it is fundamental to analyze the personality profile of those adolescents showing excessive mobile phone usage to properly approach later prevention strategies. Impulsivity is one of the most repeated variables associated with teenage addictions, although it has been observed that not all impulsive behaviors need to be detrimental. The aim of this study is to analyze how impulsivity affects smartphone addiction directly, but also indirectly, by assessing its association with sensation seeking variables (thrill and adventure seeking, experience seeking, disinhibition, and boredom susceptibility) which are in turn decisive when using these technologies improperly. The sample was made up of 614 adolescents aged 13–18 attending secondary education from Burgos, Spain. Dickman Impulsivity Inventory, Sensation Seeking Scale, and Ad-hoc questionnaire on adolescent self-perception as to smartphone use were applied. Results show that 41.4% of participants admit to abusing smartphones sometimes, while 18.3% admit to abusing them more frequently and 24% to, at least ever, having defined themselves as smartphone addicts. Stepwise regression analysis revealed that gender (female), dysfunctional impulsivity and sensation seeking (disinhibition and thrill and adventure seeking) evidence 15.7% of variance in smartphone abuse. In addition, sensation seeking (thrill and adventure seeking, disinhibition, and boredom susceptibility) were found to mediate the relationship between dysfunctional impulsivity and smartphone abuse. Therefore, dysfunctional impulsivity was directly connected with teenage smartphone abuse, but also had an indirect stronger association through thrill and adventure seeking, disinhibition and boredom susceptibility.

EVOLUTION OF THE PRE-REGULAR SPATIAL AND PLANNING STRUCTURE OF THE TOWN OF TOTMA

The article is devoted to the pre-regular period of evolution of the planning structure of the town of Totma in the period from the second half of the XV to the beginning of the XIX century. Based on the sources, the main prerequisites and factors for the formation of a pre-regular town layout are considered, and the main stages are highlighted. The emergence and development of the city’s religious centers and the features of the pre-regional planting structure in accordance with the gradual formation of the city’s territory have been analyzed. The characteristic features of the architecture of the church complexes of the city and the creation of a panorama at diff erent stages of the existence of the city of Totma have been studied. The panoramas of the city from the river, the staging of the city’s temples on the relief are analyzed.

Teleportation affected by fluctuating electromagnetic field with a boundary

We study the quantum teleportation under fluctuating electromagnetic field in the presence of a perfectly reflecting boundary. The noisy scheme of quantum teleportation affected by electromagnetic fluctuation is proposed. Then we calculate and investigate the behaviors of entanglement and fidelity, which are closely related to the plane boundary and atomic polarization. After a period of evolution, entanglement and fidelity evolve to zero and nonzero stable value respectively. Fidelity is closely related to the weight parameter and phase parameter of the teleported state. Besides, small two-atom separation makes entanglement and fidelity have better enhancement. Furthermore, the presence of boundary, atomic polarization and two-atom separation offers us more freedom to adjust the performance of the quantum teleportation. The results would give us new insight into quantum communication in an open quantum system since quantum teleportation plays an important role in quantum communication and quantum information.

The historical evolution of the Brazilian aeronautical sector: a combined approach based on mission-oriented innovation policy (MOIP) and sectoral innovation system (SIS)

ABSTRACT This study aims to present the evolution of the Brazilian aeronautical industry, focusing on mission-oriented innovation policy (MOIP) and sectoral innovation system (SIS) theories. We argue that a consolidated arrangement in national boundaries was useful to improve a leading national firm to compete at the international level. This was achieved through changes in MOIP over time, from a Type-1 strategy for a heterogeneous one, combining Type-1 and Type-2 features (Robinson, D. K. R., and M. Mazzucato. 2019. “The evolution of mission-oriented policies: Exploring changing market creating policies in the US and European space sector.” Research Policy 48: 936–948). We identify three main periods of industrial evolution from the 1930s until now. As main conclusions, we highlight that the joint observation through MOIP and SIS theories is important to explain the evolution of the aeronautical sector in Brazil. As technological, market, and institutional conditions shift, government policies change, new results are achieved, and new goals are being established, in line with the MOIP theory. Hence, the need for evaluation and adjustment over time would be seen as a more general lesson from this study, and the role of government intervention emerges as a particular strategy for each nation-state. Moreover, these responses to particular strategies need to be coherent with industry preconditions (each country’s internal features) and industry discontinuities.

INDUSTRIALIZATION AS A FACTOR OF TECHNICAL AND TECHNOLOGICAL PROGRESS

The article analyzes the technique and technology of the industrial era – the period of evolution of the earthly civilization associated with large-scale production and widespread distribution of technical devices. The main types and phases of industrialization are highlighted and characterized. In the context of industrial progress, the modern stage of the evolution of technology and technology, associated with the digital transformation of the economy and society, has been investigated.

Palaeoenvironmental reconstruction of the late Miocene macroflora of La Bisbal d'Empordà (Catalonia, Spain). Comparison with small mammals

The late Miocene flora from La Bisbal d'Empordà (Catalonia, Spain) provides significant data for characterising the coastal vegetation from the north-eastern Iberian Peninsula during a key period in Neogene climatic evolution. To this end, a historical leaf collection from La Bisbal d'Empordà was re-examined, analysed from a palaeoenvironmental viewpoint and compared with data provided by the associated small mammal fauna. This flora dates from 9.6–9.7 Ma in age (early Tortonian) according to small mammal biostratigraphy.The fossil-bearing beds were deposited in the floodplain of a meandering river system. Three palaeoecological assemblages were recognized: 1) Helophytic plant stems related to a wetland community. 2) Torn leaves of Fraxinus sp., Ulmus sp., Zelkova sp., Cedrelospermum sp. Populus balsamoides, Alnus gaudinii, Carpinus sp., Platanus sp., Acer tricuspidatum, Daphnogene sp. and, Laurophyllum sp. which would have belonged to a riparian forest located beyond the wetland community, with Fraxinus being the plant growing in closest proximity; 3) Isolated complete Paliurus seeds, interpreted as mainly wind-transported, which provide evidence of an open and more arid landscape situated distally from the floodplain. The small mammal assemblages associated with this flora are consistent with this palaeoenvironmental interpretation. The paucity of small arboreal mammal taxa and insectivores suggests limited forested vegetation areas, while the more common terrestrial species indicate better developed open landscapes. Our results show a more heterogeneous environment than previously thought and that the riverine processes impinged the flora, somewhat limiting the climatic conclusions that might be derived from leaf physiognomic analyses such as CLAMP.

Gut Microbiota Linked with Reduced Fear of Humans in Red Junglefowl Has Implications for Early Domestication.

Domestication of animals can lead to profound phenotypic modifications within short evolutionary time periods, and for many species behavioral selection is likely at the forefront of this process. Animal studies have strongly implicated that the gut microbiome plays a major role in host behavior and cognition through the microbiome-gut-brain axis. Consequently, herein, it is hypothesized that host gut microbiota may be one of the earliest phenotypes to change as wild animals were domesticated. Here, the gut microbiome community in two selected lines of red junglefowl that are selected for either high or low fear of humans up to eight generations is examined. Microbiota profiles reveal taxonomic differences in gut bacteria known to produce neuroactive compounds between the two selection lines. Gut-brain module analysis by means of genome-resolved metagenomics identifies enrichment in the microbial synthesis and degradation potential of metabolites associated with fear extinction and reduces anxiety-like behaviors in low fear fowls. In contrast, high fear fowls are enriched in gut-brain modules from the butyrate and glutamate pathways, metabolites associated with fear conditioning. Overall, the results identify differences in the composition and functional potential of the gut microbiota across selection lines that may provide insights into the mechanistic explanations of the domestication process.

Structural dynamics in the evolution of a bilobed protein scaffold

Novel biophysical tools allow the structural dynamics of proteins and the regulation of such dynamics by binding partners to be explored in unprecedented detail. Although this has provided critical insights into protein function, the means by which structural dynamics direct protein evolution remain poorly understood. Here, we investigated how proteins with a bilobed structure, composed of two related domains from the periplasmic-binding protein-like II domain family, have undergone divergent evolution, leading to adaptation of their structural dynamics. We performed a structural analysis on ∼600 bilobed proteins with a common primordial structural core, which we complemented with biophysical studies to explore the structural dynamics of selected examples by single-molecule Förster resonance energy transfer and Hydrogen-Deuterium exchange mass spectrometry. We show that evolutionary modifications of the structural core, largely at its termini, enable distinct structural dynamics, allowing the diversification of these proteins into transcription factors, enzymes, and extracytoplasmic transport-related proteins. Structural embellishments of the core created interdomain interactions that stabilized structural states, reshaping the active site geometry, and ultimately altered substrate specificity. Our findings reveal an as-yet-unrecognized mechanism for the emergence of functional promiscuity during long periods of evolution and are applicable to a large number of domain architectures.

Coupling evolution effect between security system vulnerability and security incident in petrochemical plants

Security system vulnerability is closely related to the occurrence and development of security accidents in petrochemical plants. It also affects security accident evolution, and the state of security accident changes and in turn acts on the system vulnerability. However, few studies have been performed on the coupling effect of security system vulnerability and security incidents on this evolution process. In this study, the correlation between security system vulnerability and security incident is analyzed from three aspects, namely, evolutionary roots, time dimension, and space dimension. A full-cycle coupling evolution model between security system vulnerability and security incidents is established. The quantitative coupling evolution law among them is also obtained. The coupling evolution relationship between security system vulnerability and security incidents in petrochemical plants is examined in detail, and an illustrative case is used to explain the rationality of our findings. Results reveal that security system vulnerability plays a leading role in each of the four security incident evolution periods.