Trimaran as a high-performance vessel, possesses excellent characteristics such as high speed, low wave-making resistance, and good seakeeping performance. Different from conventional monohull ship, the design of a trimaran requires additional consideration of the outrigger layout, as the position of two outriggers can affect its hydrodynamic performance. In this study, high-speed slender body potential flow theory (also named the 2D+t theory or the 2.5D method) was employed to calculate the heave and pitch motion in order to evaluate the seakeeping performance of trimarans with different outrigger layouts at varying speeds. Model experiments were subsequently conducted to validate the effectiveness of the 2.5D method in simulating the motion of trimarans under different outrigger layouts. Three multi-objective evolutionary algorithms, including Non-dominated sorting genetic algorithm II (NSGA-II), Non-dominated sorting genetic algorithm III (NSGA-III), and Multi-objective evolutionary algorithm based on decomposition (MOEA/D), as well as their applications in the optimization of trimaran outrigger layouts were introduced. Utilizing the 2.5D method based computational program as the solver, the efficiency and performance of these multi-objective evolutionary algorithms were compared. Discuss the advantages and disadvantages of three multi-objective evolutionary algorithms in solving trimaran outrigger layout optimization problem by comparing the optimization results from two aspects: optimization efficiency, and optimal solution performance. The results indicate that for optimization efficiency, the weighted sum approach based MOEA/D exhibits best optimization efficiency. NSGA-II and NSGA-III show a good advantage in terms of optimal solution performance, and compared to NSGA-II, NSGA-III can obtain more Pareto solutions.