The Research and Development (R&D) programme in the National Health Service (NHS) is probably the first systematic attempt in any country to prioritize health care needs for R&D. The aims of the programme are described by its founding director, Sir Michael Peckham, in Research for health, and the essence of the enterprise is to identify pressing research questions requiring R&D solutions, rather than leaving the direction of research to investigators with vested interests. Although this needs-led approach to R&D funding is not without its critics, it is an essential component of an evidence-based medical culture which emphasizes the scientific basis of clinical practice. Indeed, the Scientific Basis of Health Services was the theme of a highprofile international conference held in London recently, which both affirmed the importance of developing a research base for the provision of health care and celebrated the considerable achievements of Peckham's NHS R&D programme. As well as emphasizing needs-led rather than investigator-led research, the R&D programme also underscores the importance of the sciences of implementation and evaluation. Applicants for funding in most of the initiatives in the programme have to consider not only the relevance of the research to the NHS, and the health gain that the results of research would bring, but also need to submit proposals relating to the dissemination and implementation of the research, and some thoughts about the way in which new research information can find its way into clinical practice. The mechanism for setting priorities for R&D in the NHS has recently been described. The Central Research and Development committee selects key topics, some of which are related to the health care priorities laid out in The health of the nation and expert advisory groups are set up to seek, through wide consultation, the most pressing research questions in the area of interest, and to advertise for and commission research into them. The priority topics so far identified include mental health, cardiovascular disease and stroke, maternal and child health, the primary:secondary care interface and physical and complex disabilities. In addition a health technology assessment programme continues to identify innovations in the delivery of health care,
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