Events In Male Patients Research Articles

Impact of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio as a risk factor of cardiovascular event after percutaneous coronary intervention in men

Background: Some clinical studies have demonstrated that Low-Density Lipoprotein Cholesterol/High-Density Lipoprotein Cholesterol (LDL-C/HDL-C) ratio was an excellent predictor of cardiovascular diseases. The aim of this study was to determine whether the LDL-C/HDL-C ratio may affect the outcomes after Percutaneous Coronary Intervention (PCI). Methods: Eight-hundred-seventy-seven male patients, who underwent successful PCI, were divided into the following three groups: those with LDL-C/HDL-C≤1.5 (n=178), 1.5-2.0 (n=261), >2.0 (n=438). In these groups, the incidence of Major Adverse Cardiac Events (MACE) was measured during the five years after PCI. MACE was defined as cardiac death, non-fatal myocardial infarction, new stenosis and restenosis. Results: Kaplan-Meier analysis demonstrated that patients with LDL-C/HDL-C≤1.5 had a significantly lower incidence of MACE than those with LDL-C/HDL-C>2.0 and also those with LDL-C/HDL-C of between 1.5 and 2 (P<0.001). In addition, Cox proportional hazards model indicated the LDL-C/HDL-C ratio was an independent risk factor of MACE. ![Figure][1] Cumulative incidence of MACE Conclusion: The LDL-C/HDL-C ratio was a valuable predictor of cardiovascular events in male patients. Furthermore, it is desirable to maintain the LDL-C/HDL-C raito to be less than 1.5 for secondary prevention after PCI. [1]: pending:yes

OP0130 Independent Risk Factors for Cardiovascular Events in Male Patients with Gout: Results of the 7-Year Prospective Follow-Up Study

BackgroundRisk of cardiovascular (CV) events is increased in gouty population due to high prevalence of traditional CV risk factors, metabolic syndrome, hyperuricemia and chronic inflammation [1, 2].ObjectivesTo determine factors that...

The Role of High Sensitivity C-Reactive Protein and Coronary Artery Calcium as Predictors of the Long-term Prognosis in Men with Coronary Artery Disease

Purpose Measurements of coronary artery calcium (CAC) and of high sensitivity C -reactive protein (hsCRP) are used to predict the risk of cardiovascular events in patients with coronary artery disease (CAD). The aim of our study was to investigate the hypothesis that combining the hsCRP level and CAC score can increase the predictive value of these parameters for future cardiovascular events in male patients with suspected CAD. Methods We included 90 male patients with stable angina. We measured their serum hsCRP and CAC scores by using electron-beam computerized tomography. These baseline parameters were correlated to the clinical cardiovascular events within the follow-up period. Results During the follow-up period of up to 50 months (median 27 months), 13 major cardiovascular events were recorded. In multivariate regression analysis, after being adjusted for conventional risk factors, hsCRP and CAC score, hsCRP level was the only independent predictor of cardiovascular events. Further analysis was performed among the four groups classified by CAC score (CAC score ≥100 or p = 0.018) for the cardiovascular events. Conclusion We concluded that risk stratification on the basis of both hsCRP level and CAC score might be of benefit to male patients with suspected CAD, as the combined use of these two markers allowed significantly more accurate prediction of cardiovascular events.

Age- and gender-specific differences in the prognostic value of CT coronary angiography

ObjectiveTo evaluate the potential age- and gender-specific differences in the incidence and prognostic value of coronary artery disease (CAD) in patients undergoing CT coronary angiography (CTA).Design and patientsIn this multicentre...

The Clinical and Radiological Characteristics of Male Patients who Underwent Vertebroplasty Due to Osteoporotic Compression Fracture

Objective: To investigate the clinical characteristics of male population who underwent vertebroplasty for osteoporotic compression fracture and evaluate the clinical, radiological outcomes compared to female group. Methods: The medical records and radiological data were reviewed in total 155 patients who underwent vertebroplasty for osteoporotic vertebral compression fracture from February 2006 to November 2009. We compared 32 male patients with 123 female patients in terms of preoperative factors, intraoperative factors, and clinical and radiologic outcomes. Results: The mean age of male group was 67.8±8.6 years and their mean T-score on bone mineral density (BMD) was -3.2±0.8. The mean age of female group was 71.8±8.9 years and their mean T-score was -3.7±0.7 (p=0.025 for age, p=0.002 for BMD). Male patients (21 out of 32, 65.6%) had more frequent traumatic event than female patients (51 out of 123, 41.5%) (p=0.012). The secondary osteoporosis was more frequently seen in male group than female group (53.1% vs 26.8%, p=0.005). The lump cement distribution pattern was found more frequently in male group than female group (46.9% vs 28.5 %, p=0.040). There was no statistically significant difference between the two groups in clinical outcomes. Conclusion: Male patients had significantly more risk factors for secondary osteoporosis and obvious traumatic event than female group. Clinicians should always be aware of secondary causes of osteoporosis and history of traumatic events in male patients with osteoporotic compression fracture and also pay attention to correct the cause of secondary osteoporosis and recommend anti-osteoporosis management.

Effects of Alcohol Consumption on Cardiovascular Events in Male Patients With Healed Myocardial Infarction

In Western countries, many studies have shown that among healthy people moderate drinkers have a lower incidence of cardiovascular events than abstainers and heavy drinkers. However, it is not clear whether this is true in patients with a healed myocardial infarction (MI). In the present study cardiovascular events were defined as cardiac events or strokes. Male patients only were included because the incidence of cardiovascular events is low in females. In patients younger than 65 years, the incidence of cardiovascular events was 34.6 persons per year (54 cases: 3.9%) of abstainers, 17.4 persons per year (20 cases: 1.9%) of moderate drinkers (p<0.01 vs abstainers) and 30.3 s persons per year (18 cases: 3.2%) of heavy drinkers. However, in those aged 65 years or older, the incidence was 47.8 persons per year (24 cases: 4.5%) of abstainers, 58.4 persons per year (14 cases: 5.6%) of moderate drinkers, and 314.8 persons per year (12 cases: 19.7%) of heavy drinkers. In this age group, cardiovascular events were significantly higher in heavy drinkers than in the other 2 groups (p<0.01), and the incidence was not lower in the moderate drinkers than in abstainers as shown in the younger group. In patients younger than 65 years with a healed MI, drinking limited less than 30 ml/day (moderate intake) reduces the incidence of cardiovascular events, but not in those aged 65 years or older.

Aspirin “failures,” clopidogrel added to aspirin, and secondary stroke prevention in veterans presenting with TIA or mild-to-moderate ischemic stroke

Our objective was to investigate whether clopidogrel added to low-dose aspirin reduced vascular events in male patients at our VA hospital who had “failed” aspirin therapy because of a mild-to-moderate stroke or a transient ischemic attack. Of 179 consecutive patients who both reported daily aspirin usage at the time of their newest ischemic event as well as were then operationally defined as aspirin “failures,” 134 (group A) were treated with combined aspirin-clopidogrel, 15 (group B) underwent an early arterial procedure, 25 (group C) were anticoagulated, and 5 were not entered or continued because of either non-compliance or a refusal to participate. Study therapies were modified because of a vascular event in 4.5% of group A (one non-fatal ischemic stroke, one non-fatal myocardial infarction, and four transient ischemic attacks) and 33% of group B (one non-fatal ischemic stroke, one non-fatal myocardial infarction, and three transient ischemic attacks). No major or fatal bleeding events occurred in any of those on combined aspirin-clopidogrel therapy, with minor bleeding in 10 of 134 (7.5%) and 2 of 15 (13.3%) of group A and B patients, respectively. Patients were followed for 18 ± 9.7 months. Combined aspirin-clopidogrel therapy appears both safe as well as effective in this single-center, observational study. Copyright © 2003 by National Stroke Association