Impact of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio as a risk factor of cardiovascular event after percutaneous coronary intervention in men

Abstract

Background: Some clinical studies have demonstrated that Low-Density Lipoprotein Cholesterol/High-Density Lipoprotein Cholesterol (LDL-C/HDL-C) ratio was an excellent predictor of cardiovascular diseases. The aim of this study was to determine whether the LDL-C/HDL-C ratio may affect the outcomes after Percutaneous Coronary Intervention (PCI). Methods: Eight-hundred-seventy-seven male patients, who underwent successful PCI, were divided into the following three groups: those with LDL-C/HDL-C≤1.5 (n=178), 1.5-2.0 (n=261), >2.0 (n=438). In these groups, the incidence of Major Adverse Cardiac Events (MACE) was measured during the five years after PCI. MACE was defined as cardiac death, non-fatal myocardial infarction, new stenosis and restenosis. Results: Kaplan-Meier analysis demonstrated that patients with LDL-C/HDL-C≤1.5 had a significantly lower incidence of MACE than those with LDL-C/HDL-C>2.0 and also those with LDL-C/HDL-C of between 1.5 and 2 (P<0.001). In addition, Cox proportional hazards model indicated the LDL-C/HDL-C ratio was an independent risk factor of MACE. ![Figure][1] Cumulative incidence of MACE Conclusion: The LDL-C/HDL-C ratio was a valuable predictor of cardiovascular events in male patients. Furthermore, it is desirable to maintain the LDL-C/HDL-C raito to be less than 1.5 for secondary prevention after PCI. [1]: pending:yes