This study focuses on the issue of secured observer based hybrid-triggered quantized reliable control design for semi-Markov jump cyber–physical systems (S-MJCPSs) with general uncertain transition rates, quantization, actuator faults, denial-of-service (DoS) attacks and disturbances. In particular, a mode-dependent observer is developed to estimate the unmeasurable states of the considered system. Further, to minimize unnecessary data transmissions within the network channel, we have implemented a hybrid-triggered mechanism in which, the swap process between the time-triggered and the event-triggered mechanisms is governed by a Bernoulli distribution. Moreover, an observer-based hybrid-triggered quantized reliable controller is devised by utilizing the state estimation information obtained from the observer, which assists the S-MJCPSs to achieve primary intent of this study. Subsequently, the control input signals are quantized before being transmitted into the actuator due to the limited capacity of the data transmission medium. Concurrently, periodic DoS jamming attacks are taken into consideration, which have a significant impact on control performances. A set of adequate criteria is established in the context of linear matrix inequalities by employing the mode-dependent time-varying piecewise Lyapunov-Krasovskii functional and the integral inequalities, guaranteeing that the undertaken system accomplishes the global exponential stability and meet a specific H∞ performance level. Following that, by means of the deduced adequate criteria, the values of the controller and observer gain are computed. At last, the efficacy and applicability of the derived theoretical findings are demonstrated through two practical examples.