Event-related Brain Potentials Research Articles

Arcuate fasciculus architecture is associated with individual differences in pre-attentive detection of unpredicted music changes

The mismatch negativity (MMN) is an event related brain potential (ERP) elicited by unpredicted sounds presented in a sequence of repeated auditory stimuli. The neural sources of the MMN have been previously attributed to a fronto-temporo-parietal network which crucially overlaps with the so-called auditory dorsal stream, involving inferior and middle frontal, inferior parietal, and superior and middle temporal regions. These cortical areas are structurally connected by the arcuate fasciculus (AF), a three-branch pathway supporting the feedback-feedforward loop involved in auditory-motor integration, auditory working memory, storage of acoustic templates, as well as comparison and update of those templates. Here, we characterized the individual differences in the white-matter macrostructural properties of the AF and explored their link to the electrophysiological marker of passive change detection gathered in a melodic multifeature MMN-EEG paradigm in 26 healthy young adults without musical training. Our results show that left fronto-temporal white-matter connectivity plays an important role in the pre-attentive detection of rhythm modulations within a melody. Previous studies have shown that this AF segment is also critical for language processing and learning. This strong coupling between structure and function in auditory change detection might be related to life-time linguistic (and possibly musical) exposure and experiences, as well as to timing processing specialization of the left auditory cortex. To the best of our knowledge, this is the first time in which the relationship between neurophysiological (EEG) and brain white-matter connectivity indexes using DTI-tractography are studied together. Thus, the present results, although still exploratory, add to the existing evidence on the importance of studying the constraints imposed on cognitive functions by the underlying structural connectivity.

Effects of holding soft objects during Cyberball tasks under frequent positive feedback

A previous study suggested that holding soft objects enhanced expectations of uncertain events and increased social pain under frequent negative feedback; i.e., higher expectations might have induced more disappointment. The present study examined the effects of holding a soft cushion under frequent positive feedback. Participants (n = 42) performed fair-play and over-inclusion blocks in the Cyberball task. Amplitudes of the contingent negative variation (CNV) of event-related brain potentials and subjective ratings of social pain were measured to estimate participants’ expectations and emotions, respectively. CNV amplitudes were higher in the over-inclusion block when participants held the soft than the hard cushion. There was a statistically marginal trend (p = .095) for lower social pain scores in the soft cushion condition than the hard cushion condition in contrast to previous findings. These results suggest that holding a soft object does not directly modulate emotions but instead acts through the mediation of enhanced expectations.

Supplemental Material for Examining the Influence of Perspective and Prosody on Expected Emotional Responses to Irony: Evidence From Event-Related Brain Potentials

Supplemental Material for Examining the Influence of Perspective and Prosody on Expected Emotional Responses to Irony: Evidence From Event-Related Brain Potentials

A Review of EEG and fMRI Measuring Aesthetic Processing in Visual User Experience Research.

In human-computer interaction, the visual interaction of user experience (UX) and user interface (UI) plays an important role in enriching the quality of daily life. The purpose of our study analyzes the use of brain-computer interface (BCI), wearable technology, and functional magnetic resonance imaging (fMRI) to explore the aesthetic processing of visual neural response to UI and UX designs. Specifically, this review aims to understand neuroaesthetic processing knowledge, aesthetic appreciation models, and the ways in which visual brain studies can improve the quality of current and future UI and UX designs. Recent research has found that subjective evaluations of aesthetic appreciation produce different results for objective evaluations of brain research analysis. We applied SWOT analysis and examined the advantages and disadvantages of both evaluation methods. Furthermore, we conducted a traditional literature review on topics pertaining to the use of aesthetic processing knowledge in the visual interaction field in terms of art therapy, information visualization, website or mobile applications, and other interactive platforms. Our main research findings from current studies have helped and motivated researchers and designers to use convincing scientific knowledge of brain event-related potential, electroencephalography, and fMRI to understand aesthetic judgment. The key trend finds that many designers, artists, and engineers use artistic BCI technology in the visual interaction experience. Herein, the scientific methods applied in the aesthetic appreciation to human-computer interface are summarized, and the influence of the latest wearable brain technology on visual interaction design is discussed. Furthermore, current possible research entry points for aesthetics, usability, and creativity in UI and UX designs are explicated. The study results have implications for the visual user experience research domain as well as for interaction industries, which produce interactive projects to improve people's daily lives.

Play it by ear? An ERP study of Chinese polysemous verb yǒu

Mandarin Chinese yŏu is a polysemous verb. It can be interpreted as meaning either ‘have’ or ‘there be/exist’ in sentences of the form ‘NP1yŏu NP2’, which can correspondingly be analyzed as either a Have-Possessive construction (‘NP1 has NP2’) or an existential/locative construction (‘(At/in) NP1 there is NP2’), or both. This study used event-related brain potentials to investigate whether and how the interpretation of yŏu in a given ‘NP1yŏu NP2’ construction is determined by the semantics of the nouns involved and their relationship. Twenty-seven participants read sentences of this construction. The results showed that there were different patterns of brain activity that can be attributed to the two functions of yǒu during sentence processing, in relation to the different roles yǒu plays in establishing a relationship between the nouns in the construction. In this way, the two functions of yǒu can basically be distinguished by their complementary distribution: the use of yǒu as a possessive verb ‘have’ is largely conditioned by the presence of human participants at the position of NP1 interpreted as possessors, while typical instances of its use as an existential verb are characterized by the absence of this property.

Neural time course of pain observation in infancy.

Perception of pain in others is of great evolutionary significance for the development of human empathy. However, infants' sensitivity to others' painful experiences has not been investigated so far. Here, we explored the neural time course of infants' processing of others' pain by measuring event-related brain potentials (ERPs) while 6-month-old infants observed a painful tactile stimulation directed towards the eye and a neutral tactile stimulation on the eyebrow. We analyzed both the Negative Central (Nc) and the later Late Positive Potential (LPP) ERP components, indexing respectively attention allocation and cognitive evaluation of perceptual stimuli. Results showed that observing painful touch elicits a mid-latency Nc (300-500ms) over the right fronto-central site, which is greater in amplitude as compared to neutral touch. A divergent activity was also visible in the centro-parietal early (550-750ms) and late (800-1000ms) LPP, showing increased amplitudes in response to neutral compared to painful touch. The cognitive evaluation of painful stimuli, reflected by the LPP, might thus not be fully developed at 6months of age, as adults typically show a larger LPP in response to painful as compared to neutral stimuli. Overall, infants show early attentional attuning to others' pain. This early sensitivity to others' painful tactile experiences might form a prerequisite for the development of human empathy.

Changes in attentional resources during the acquisition of laparoscopic surgical skills.

BackgroundIncreasing familiarity and practice might free up mental resources during laparoscopic surgical skills training. The aim of the study was to track changes in mental resource allocation during acquisition of laparoscopic surgical skills.MethodsMedical students with no previous experience in laparoscopic surgery took part in a 5-week laparoscopic training curriculum. At the beginning and end of the training period, one of the training tasks was combined with a secondary auditory detection task that required pressing a foot switch for defined target tones, creating a dual-task situation. During execution of the two concurrent tasks, continuous electroencephalographic measurements were made, with special attention to the P300 component, an index of mental resources. Accuracy and reaction times of the secondary task were determined.ResultsAll 14 participants successfully completed the training curriculum. Target times for successful completion of individual tasks decreased significantly during training sessions (P <0.001 for all tasks). Comparing results before and after training showed a significant decrease in event-related brain potential amplitude at the parietal electrode cluster (P300 component, W = 67, P = 0.026), but there were no differences in accuracy (percentage correct responses: W = 48, P = 0.518) or reaction times (W = 42, P = 0.850) in the auditory detection task.ConclusionThe P300 decrease in the secondary task over training demonstrated a shift of mental resources to the primary task: the surgical exercise. This indicates that, with more practice, mental resources are freed up for additional tasks.

Inter- and intra-individual coupling between pupillary, electrophysiological, and behavioral responses in a visual oddball task.

Although the P3b component of the event-related brain potential is one of the most widely studied components, its underlying generators are not currently well understood. Recent theories have suggested that the P3b is triggered by phasic activation of the locus-coeruleus norepinephrine (LC-NE) system, an important control center implicated in facilitating optimal task-relevant behavior. Previous research has reported strong correlations between pupil dilation and LC activity, suggesting that pupil diameter is a useful indicator for ongoing LC-NE activity. Given the strong relationship between LC activity and pupil dilation, if the P3b is driven by phasic LC activity, there should be a robust trial-to-trial relationship with the phasic pupillary dilation response (PDR). However, previous work examining relationships between concurrently recorded pupillary and P3b responses has not supported this. One possibility is that the relationship between the measures might be carried primarily by either inter-individual (i.e., between-participant) or intra-individual (i.e., within-participant) contributions to coupling, and prior work has not systematically delineated these relationships. Doing so in the current study, we do not find evidence for either inter-individual or intra-individual relationships between the PDR and P3b responses. However, baseline pupil dilation did predict the P3b. Interestingly, both the PDR and P3b independently predicted inter-individual and intra-individual variability in decision response time. Implications for the LC-P3b hypothesis are discussed.

Native language inhibition predicts more successful second language learning: Evidence of two ERP pathways during learning

How some individuals succeed in learning a second language as adults is still an unsolved question in cognitive neuroscience. At the brain level, adults' electrophysiological responses to input in a second language may differ after completing different types of training. However, there is limited understanding of what neural pathways are activated as learning unfolds, and which patterns of activation lead to successful learning. Using brain event-related potentials, this study explored whether individual brain responses to practice difficulty during second language learning predict learning outcomes. English-speaking learners of Spanish practiced completing newly learned phrases in their second language. For some learners, all the choices presented during practice were “easy” because non-target choices were unrelated distractors. In the more “difficult” practice mode, however, learners had to avoid choosing a competing word that would be acceptable based on their native language, but not in the second language being learned. Performance during practice was similar in both groups of learners. Critically, divergence in event-related potentials indicated alternative strategies to practice, based on the level of difficulty. At the group level, learners completing the easier practice revealed increased monitoring when making responses; in the difficult condition, learners showed inhibition of their native language (i.e., an N400 for phrases congruent with the native language) to avoid interference during word selection. Individual brain responses indexing the degree of native language inhibition predicted learning rates in tests.

The impact of emotional content on pseudoword recognition

The present study investigates the influence of emotional information on language processing. To this aim, we measured behavioral responses and event-related brain potentials (ERPs) during four Italian lexical decision experiments in which we used emotionally intense and neutral pseudowords—i.e., pseudowords derived from changing one letter in a word (e.g., cammelto, derived from cammello ‘camel’ vs. copezzolo, from capezzolo ‘nipple’)—as stimuli. In Experiment 1 and 2, half of the pseudowords were emotionally intense and half were neutral, and were mixed with neutral words. In Experiment 3, the list composition was manipulated, with ¼ of the pseudowords being derived from emotionally intense words and ¾ derived from neutral words. Experiment 4 was identical to Experiment 1, but ERPs were recorded. Emotionally intense pseudowords were categorized more slowly than neutral pseudowords, with the difference emerging both in the mean and at the leading edge of the response times distribution. Moreover, emotionally intense pseudowords elicited smaller N170 and N400 than neutral pseudowords. These results speak in favor of a fast and multi-level infiltration of the emotional information into the linguistic process of word recognition.

Face the food: Food plating with facial patterns influences appetite and event-related brain potentials

The presentation of visual food cues (e.g., food plating) can affect our appetite and leads to characteristic changes of early as well as late positivity in the electroencephalogram. The present event-related potential (ERP) study attempted to change ERPs and affective ratings for food pictures by rearranging the components of a depicted meal (conventional presentation) as a smiley or frowny. The images were presented to 68 women (mean age = 24 years), who rated the wanting and liking of the meals. Compared to conventional food plating, smiley and frowny meals elicited enhanced amplitudes of the P200, P300, and late positive potential (LPP) in a large occipito-parietal cluster. Frowny meals were rated as less appetizing than conventional food presentations. The mentioned ERP components are concomitants of face configuration processing (P200), automatic attention/novelty detection (P300), and voluntary attention/assignment of emotional meaning (LPP). Thus, the combination of two affective cues (food, face) in one stimulus changed the activation in motivational circuits of the brain. Also, serving a meal as a frowny could help to regulate appetite.

Differences in Explicit Stereotype Activation among Social Groups Based on the Stereotype Content Model: Behavioral and Electrophysiological Evidence in Chinese Sample.

The stereotype content model (SCM; Fiske, Cuddy, Glick and Xu, 2002) identifies four basic categories of stereotyped social groups: high warmth-high competence (HW-HC), high warmth-low competence (HW-LC), low warmth-high competence (LW-HC), and low warmth-low competence (LW-LC). However, many of these groups have not been directly examined in stereotype activation research. The purpose of the present research was to extend stereotype activation research to groups that more fully represent those identified under the SCM. Employing explicit sequential priming task, participants responded to prime-target stimulus pairs that were either congruent or incongruent with stereotypes of social groups from all four SCM quadrants in two studies in the current investigation. Study 1 was to determine the behavioral pattern of explicit stereotype activation among four quadrants (the sample included 60 Chinese undergraduate students, 51%—female). Study 2 further employed event-related brain potentials (ERPs) technique to track the time course and electrophysiological underpinnings of explicit stereotype activation (the sample included 22 right-handed Chinese undergraduate students, 76%—female). In Study 1, participants responded more quickly and accurately on stereotype congruent trials than incongruent trials for all social groups except LW-LC groups. This reverse priming effect on LW-LC social groups in RTs was also replicated in Study 2. ERPs findings further showed that incongruent targets elicited larger N400 amplitudes than congruent targets for all four SCM quadrants. Moreover, congruent targets elicited larger P2 than incongruent targets, but only found for the LW-LC social groups. In addition, congruent targets elicited larger amplitudes of late positive component than incongruent targets for the low warmth (LW-LC and LW-HC) groups. Together, these results highlight the unique processing that LW-LC groups receive throughout the cognitive stream, ultimately manifesting in distinctive behavioral responses. Unconscious activation of egalitarian goals, disgust, and distrust accounts are discussed.

A neurophysiological study of noun-adjective agreement in Arabic: The impact of animacy and diglossia on the dynamics of language processing

We used event-related brain potentials to identify the neurophysiological responses of Arabic speakers to processing full and deflected agreement in plural noun-adjective constructions in (written) Standard Arabic. Under full agreement, an adjective fully agrees in number and gender with a preceding plural noun; but this happens only when this noun is human. However, under deflected agreement, the adjective is marked feminine singular when the noun is non-human. We recorded grammaticality judgment and ERP responses from 32 speakers of Arabic to sentences violating full and deflected agreement and their well-formed counterparts. The participants were relatively fast and accurate in judging all the sentences, although violations, especially deflected agreement violations, were not always deemed ungrammatical. However, the ERP responses show a differential processing of human versus non-human violations. Violations of full agreement involving human nouns elicited larger N400 and P600 components than did violations of deflected agreement involving non-human nouns, whose ERP signatures were statistically identical to those of their acceptable counterparts. Our results present clear evidence for animacy (more specifically, humanness) effects on language processing and may also be taken to suggest possible effects of diglossia on the dynamics of language processing. We discuss these results in light of the ERP literature on agreement processing and the role of animacy/humanness in grammar, and the emerging results on idiosyncratic patterns of agreement as found in Spanish. Although it is not a central point in the paper, we discuss the potential effect of diglossia on the architecture of the mental grammar of Arabic speakers. • Noun-adjective agreement violations in Arabic elicited a biphasic N400–P600 effect. • The effect was observed with human nouns, but not with non-human animate nouns. • Long latency N400 due to processing complex morphology with humanness interaction. • A late P600 suggesting reanalysis/repair routines. • Animacy is highly salient, and diglossia may play a role in processing Standard Arabic.

Alcohol and Neural Dynamics: A Meta-analysis of Acute Alcohol Effects on Event-Related Brain Potentials

BackgroundAn understanding of alcohol’s acute neural effects could augment our knowledge of mechanisms underlying alcohol-related cognitive/motor impairment and inform interventions for addiction. Focusing on studies employing event-related brain potential methods, which offer a direct measurement of neural activity in functionally well-characterized brain networks, we present the first meta-analysis to explore acute effects of alcohol on the human brain. MethodsDatabases were searched for randomized laboratory alcohol-administration trials assessing brain activity using event-related potentials. Hedges’ g coefficients were pooled using 3-level random-effects meta-regression. ResultsSixty independent randomized controlled trials met inclusion (total N = 2149). Alcohol’s effects varied significantly across neural systems, with alcohol leading to reductions in event-related potential components linked with attention (P3b), g = −0.40, 95% CI (−0.50, −0.29), automatic auditory processing (mismatch negativity), g = −0.44, 95% CI (−0.66, −0.22), and performance monitoring (error-related negativity), g = −0.56, 95% CI (−0.79, −0.33). These effects were moderated by alcohol dose, emerging as significant at doses as low as 0.026% blood alcohol concentration and increasing to moderate/large at 0.12%. In contrast, irrespective of dose, relatively small or nonsignificant alcohol effects emerged in other processing domains, including those linked to executive control (N2b responses) and stimulus classification (N2c responses). ConclusionsContrary to traditional conceptualizations of alcohol as a “dirty drug” with broad central nervous system depressant effects, results instead support accounts positing targeted alcohol effects in specific processing domains. By identifying alcohol effects on brain systems involved in performance monitoring and attention, results move toward the identification of mechanisms underlying alcohol-related impairment as well as factors reinforcing addiction.

Neurophysiological markers of ADHD symptoms in typically-developing children

Children with attention-deficit/hyperactivity disorder (ADHD) are characterized by symptoms of inattention, impulsivity, and hyperactivity. Neurophysiological correlates of ADHD include changes in the P3 component of event-related brain potentials (ERPs). Motivated by recent advances towards a more dimensional understanding of ADHD, we investigate whether ADHD-related ERP markers relate to continuous variations in attention and executive functioning also in typically-developing children. ERPs were measured while 31 school children (9–11 years) completed an adapted version of the Continuous Performance Task that additionally to inhibitory processes also isolates effects of physical stimulus salience. Children with higher levels of parent-reported ADHD symptoms did not differ in task performance, but exhibited smaller P3 amplitudes related to stimulus salience. Furthermore, ADHD symptoms were associated with the variability of neural responses over time: Children with higher levels of ADHD symptoms demonstrated lower variability in inhibition- and salience-related P3 amplitudes. No effects were observed for ERP latencies and the salience-related N2. By demonstrating that ADHD-associated neurophysiological mechanisms of inhibition and salience processing covary with attention and executive functioning in a children community sample, our study provides neurophysiological support for dimensional models of ADHD. Also, temporal variability in event-related potentials is highlighted as additional indicator of ADHD requiring further investigation.

Recognising other-race faces is more effortful: The effect of individuation instructions on encoding-related ERP Dm effects

Humans are better at recognising faces from their own vs. another ethnic background. Socio-cognitive theories of this own-race bias (ORB) propose that reduced recognition of other-race faces results from less motivation to attend to individuating information during encoding. Accordingly, individuation instructions that explain the phenomenon and instruct participants to attend to other-race faces during learning attenuate or eliminate the ORB. However, it is still unclear how exactly such instructions affect other-race face processing. We addressed this question by investigating encoding-related event-related brain potentials, contrasting neural activity of subsequently remembered and forgotten items (Dm effects). In line with socio-cognitive accounts, individuation instructions reduced the ORB. Critically, instructions increased Dm effects for other-race faces, suggesting that more processing resources were allocated to these faces during encoding. Thus, compensating for reduced experience with other-race faces is possible to some extent, but additional resources are needed to decrease difficulties resulting from a lack of perceptual expertise.

The effects of acute aerobic exercise on inhibitory control and resting state heart rate variability in children with ADHD

The current study examined the effects of acute moderate-intensity aerobic exercise (MAE) on inhibitory control and resting-state heart rate variability (HRV) in children with Attention-Deficit/Hyperactivity Disorder (ADHD). Our data show that acute MAE resulted in higher response accuracy of a modified flanker task regardless of task difficulty for 60 min (p = .001). Aerobic exercise further resulted in more effective conflict detection, as measured by greater amplitude (p = .012) and shorter latency (p = .029) of the N2 component of event-related brain potential, for 60 min regardless of task difficulty. In contrast, acute MAE did not modulate sympathovagal balance signified by HRV at either 30 min or 60 min following exercise cessation. Collectively, our findings suggest that the beneficial effects of acute aerobic exercise on inhibitory control are sustained for 60 min in children with ADHD. However, acute aerobic exercise may not modulate sympathovagal balance during the post-exercise recovery. Overall, we highlight the importance of acute aerobic exercise for children with ADHD as a potential means to facilitate brain health.

Sense combinations influence the neural mechanism of L2 comprehension in semantically violated sentences: Insights from emotioncy

The influence of senses and their combinations has already proven invaluable to language comprehension studies; however, it is not clear to what extent they may add to the functional characteristics of the biphasic, language-related electrophysiological markers. Therefore, to integrate information from different sensory modalities and investigate how sense combinations modulate the N400 and LPC during L2 sentence processing, we used the emotioncy model. Based on the model, we instructed a number of unknown English words to 30 participants using a combination of three (exvolvement) and five senses (involvement). Using event-related brain potentials (ERPs) and a visual acceptability judgment task (with 216 English sentences under non-violated and semantically violated conditions), the participants' behavioral and neural responses to the words were examined. The results revealed that, taking the retrieval-integration (RI) account, different sense combinations modulated the LPC responses to semantically violated sentences, yet left the N400 unchanged. Thus, to boost comprehension and reduce the cognitive load during the integration and reinterpretation process, multisensory properties of the input need to be enriched. • Semantically violated L2 sentences form a biphasic ERP pattern. • Sense combinations modulated the LPC responses to semantically violated sentences. • Sense combinations left the N400 unchanged. • Rich multisensory information reduces cognitive load during the integration process.

Distractor-induced deafness: The effect of multiple auditory distractors on conscious target processing

Conscious access to a target stimulus embedded in a rapid serial visual presentation can be impaired by the preceding presentation of multiple task-irrelevant distractors. While this phenomenon – labeled distractor-induced blindness (DIB) – is established in vision, it is unknown whether a similar effect can be observed in the auditory modality. Considering the differences in the processing of visual and auditory stimuli, modality-specific effects in the inhibitory mechanisms triggered by distractors can be expected. First, we aimed to find evidence for a distractor-induced deafness (DID) for auditory targets in a behavioral experiment. The target was defined by a transient increase in amplitude in a continuous sinusoidal tone, which was to be detected if accompanied or preceded by a deviant tone (cue). Both events were embedded in separate streams in a binaural rapid serial auditory presentation. Distractors preceded the cue and shared the target's features. As previously observed for DIB, a failure to detect the auditory target critically relied on the presentation of multiple distractor episodes. This DID effect was followed up in a subsequent event-related brain potentials (ERP) study to identify the signature of target detection. In contrast to missed targets, hits were characterized by a larger frontal negativity and by a more pronounced centro-parietal P3b wave. Whereas the latter process was also observed in the visual domain, indicating a post-perceptual updating process, the frontal negativity was exclusively observed for auditory DID. This modality-specific process might signal that early attentional control processes support conscious access to relevant auditory events.

Testing limits: ERP evidence for word form preactivation during speeded sentence reading.

While it is commonly agreed upon that language comprehenders preactivate information at multiple levels, there is less consensus regarding what and when information is predicted, under which circumstances, and via which mechanism(s). Regarding when, Ito, Corley, Pickering, Martin, & Nieuwland (2016) concluded that during sentence processing, word form-unlike semantic-preactivation crucially relies on the time available to generate late-stage predictions via language production mechanisms, setting this limit between 500 and 700ms/word. The current event-related brain potential (ERP) study tests this proposal at a substantially faster serial visual presentation (SVP) rate of four words/s, on par with normal reading. We utilize the experimental design and replicate the general ERP findings of the two words/s SVP study of DeLong, Chan, & Kutas (2019), with results showing similar N400 reductions to unpredictable sentence continuations whether semantically or orthographically related to contextually predictable words, as well as an increased late posterior positivity to orthographic neighbors. These findings indicate that processing of written word information can be rapidly facilitated through context-based expectancies, establishing that if there is a time constraint for word form preactivation, it must be far less than limits specified by the prediction-by-production comprehension model championed by Ito et al.