This paper addresses the event-triggered prescribed-time control problem for a class of high-order nonlinear systems based on finite time-varying gain. Due to the existence of unknown gain functions and system uncertainties, the resultant control with prescribed-time convergence performance becomes nontrivial. The problem becomes even more complex due to the use of event-based communication instead of continuous communication. To tackle the aforementioned challenges, this paper proposes an event-triggered prescribed-time stabilization approach with the following key steps. Firstly, we establish a new prescribed-time stability lemma to overcome the technical difficulty arising from the prescribed-time controller design, and stability analysis. Secondly, we give the controller design procedure upon using the backstepping technique. Thirdly, we redesign the event-triggering threshold condition based on time-varying functions, which allows the controller terminal jitter to be mitigated and the controller to be implemented straightforwardly in practice. Furthermore, the proposed control scheme avoids Zeno behavior. The numerical simulation confirms the effectiveness of the proposed control scheme.