Tool For Evaluation Research Articles

Research Progress and Clinical Value of Subendocardial Viability Ratio.

Cardiovascular disease remains the leading cause of morbidity and mortality worldwide, with ischemic heart disease being a major contributor, either through coronary atherosclerotic plaque-related major vascular disease or coronary microvascular dysfunction. Obstruction of coronary blood flow impairs myocardial perfusion, which may lead to acute myocardial infarction in severe cases. The subendocardial viability ratio, also known as the Buckberg index, is a valuable tool for evaluation of myocardial perfusion because it reflects the balance between myocardial oxygen supply and oxygen demand. The subendocardial viability ratio can effectively evaluate the function of the coronary microcirculation and is associated with arterial stiffness. This ratio also has potential value in predicting adverse cardiovascular events and mortality in various populations. Moreover, the subendocardial viability ratio has demonstrated clinical significance in a range of diseases, including hypertension, aortic stenosis, peripheral arterial disease, chronic kidney disease, diabetes, and rheumatoid arthritis. This review summarizes the applications of the subendocardial viability ratio, its particular progress in the relevant research, and its clinical significance in cardiovascular diseases.

Student Perceptions Regarding the Use of a Computer-Based Test (CBT) System at State Junior High School 3 Sungai Betung

The use of computer-based assessment (CBT) in education is increasing, but students’ perceptions of it are still under-researched. This study aims to explore students’ perceptions of the use of CBT in SMPN 3 Sungai Betung, a junior high school in South Kalimantan. This study uses a quantitative method with a questionnaire instrument filled by 94 students. The results show that students have positive responses to CBT, in terms of trust, comfort, and academic performance. However, students also face technical constraints, such as network problems and HP operation. This study recommends improving technological literacy, additional training, and ensuring the availability of good and adequate networks for CBT optimization. This study also emphasizes the role of teachers in supporting students to overcome technical constraints, as well as attention to the aspect of justice in technology access. Thus, CBT can be an effective evaluation tool and a means of improving the quality of learning and students’ technological readiness.

Heterozygous mutations in factor H aggravate pathological damage in a stable IgA deposition model induced by Lactobacillus casei cell wall extract.

Activation of complement through the alternative pathway (AP) has a key role in the pathogenesis of IgA nephropathy (IgAN). We previously showed, by intraperitoneal injection of Lactobacillus casei cell wall extract (LCWE), C57BL/6 mice develop mild kidney damage in association with glomerular IgA deposition. To further address complement activity in causing glomerular histological alterations as suggested in the pathogenesis of IgAN, here we used mice with factor H mutation (FHW/R) to render AP overactivation in conjunction with LCWE injection to stimulate intestinal production of IgA. Dose response to LCWE were examined between two groups of FHW/R mice. Wild type (FHW/W) mice stimulated with LCWE were used as model control. The FHW/R mice primed with high dose LCWE showed elevated IgA and IgA-IgG complex levels in serum. In addition to 100% positive rate of IgA and C3, they display elevated biomarkers of kidney dysfunction, coincided with severe pathological lesions, resembling those of IgAN. As compared to wild type controls stimulated by the same high dose LCWE, these FHW/R mice exhibited stronger complement activation in the kidney and in circulation. The new mouse model shares many disease features with IgAN. The severity of glomerular lesions and the decline of kidney functions are further aggravated through complement overactivation. The model may be a useful tool for preclinical evaluation of treatment response to complement-inhibitors.

Rehabilitation in adults with burn injury: an overview of systematic reviews

Purpose To systematically evaluate evidence from published systematic reviews for the effectiveness of rehabilitation interventions in adults with burn injury. Materials and methods A comprehensive literature review conducted using medical and health science electronic databases up to 31 July 2022. Two independent reviewers selected studies, extracted data, and assessed methodological study quality using A Measurement Tool to Assess Systematic Reviews (AMSTAR-2), and the certainty of evidence for reported outcomes using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) tool. Results Twenty-one systematic reviews evaluated five categories of interventions: physical, psychological, technology-aided modalities, educational and occupational programs, complementary and alternative medicine. Outcomes included fitness level, hand function, oedema, pain, pruritus, psychological state, quality of life, range of motion, return to work, strength, scar characteristics, level of impairment and burn knowledge. The methodological quality was rated as “critically low” for all reviews. Quality of evidence for the effectiveness of evaluated interventions ranged from “moderate to very low.” Conclusions Beneficial effects of inhaled aromatherapy and extracorporeal shockwave therapy on pain reduction; inhaled or massage aromatherapy, music therapy on anxiety were reported. Safety of interventions was not evaluated, due to the lack of adverse event reporting in primary studies and the included reviews.

Cognitive phenomena measurement with time window-based multispectral brain mapping.

Cognitive neuroscience experiments require accurate and traceable methods of measuring cognitive phenomena, analyzing and processing data, and validating results, including measurement of impact of such phenomena on brain activity and consciousness. EEG measurement is the most widely used tool for evaluation of the experiment's progress. To extract more information from the EEG signal, continuous innovation is necessary to provide a broader range of information. This paper presents a new tool for measuring and mapping cognitive phenomena using time window-based multispectral brain mapping of electroencephalography (EEG) signals. The tool was developed using Python programming language and enables users to create brain maps images for six spectra (Delta, Theta, Alpha, Beta, Gamma, and Mu) of EEG signal. The system can accept an arbitrary number of EEG channels with standardized labels based on the 10-20 system, and users can select the channels, frequency bandwidth, type of signal processing, and time window length to perform the mapping. The key advantage of this tool is its ability to perform short-time brain mapping, which allows for the exploration and measurement of cognitive phenomena. The tool's performance was evaluated through testing on real EEG signals, and results demonstrated its effectiveness in accurately mapping cognitive phenomena. The developed tool can be used in various applications, including cognitive neuroscience research and clinical studies. Future work involves optimizing the tool's performance and expanding its capabilities.

Aleatoric and epistemic uncertainty extraction of patient-specific deep learning-based dose predictions in LDR prostate brachytherapy.

Objective.In brachytherapy, deep learning (DL) algorithms have shown the capability of predicting 3D dose volumes. The reliability and accuracy of such methodologies remain under scrutiny for prospective clinical applications. This study aims to establish fast DL-based predictive dose algorithms for low-dose rate (LDR) prostate brachytherapy and to evaluate their uncertainty and stability.Approach.Data from 200 prostate patients, treated with125I sources, was collected. The Monte Carlo (MC) ground truth dose volumes were calculated with TOPAS considering the interseed effects and an organ-based material assignment. Two 3D convolutional neural networks, UNet and ResUNet TSE, were trained using the patient geometry and the seed positions as the input data. The dataset was randomly split into training (150), validation (25) and test (25) sets. The aleatoric (associated with the input data) and epistemic (associated with the model) uncertainties of the DL models were assessed.Main results.For the full test set, with respect to the MC reference, the predicted prostateD90metric had mean differences of -0.64% and 0.08% for the UNet and ResUNet TSE models, respectively. In voxel-by-voxel comparisons, the average global dose difference ratio in the [-1%, 1%] range included 91.0% and 93.0% of voxels for the UNet and the ResUNet TSE, respectively. One forward pass or prediction took 4 ms for a 3D dose volume of 2.56 M voxels (128 × 160 × 128). The ResUNet TSE model closely encoded the well-known physics of the problem as seen in a set of uncertainty maps. The ResUNet TSE rectum D2cchad the largest uncertainty metric of 0.0042.Significance.The proposed DL models serve as rapid dose predictors that consider the patient anatomy and interseed attenuation effects. The derived uncertainty is interpretable, highlighting areas where DL models may struggle to provide accurate estimations. The uncertainty analysis offers a comprehensive evaluation tool for dose predictor model assessment.

Quality evaluation of physical education in colleges and universities based on fuzzy logic

This study aims to evaluate the quality of physical education in colleges and universities by using the evaluation method based on fuzzy logic. First, summarize the basic concept of fuzzy logic and its application in the evaluation process. Then, a physical education quality evaluation index system covering teaching quality and students’ physical quality, teachers’ team construction, sports facilities and management is constructed. Then, the evaluation object and evaluation level are determined, and the specific evaluation results and ranking are calculated by fuzzy comprehensive evaluation model. In the empirical analysis, use the simulation data for model application and result analysis, and further find the problems existing in college physical education. Finally, in view of these problems, a series of improvement and optimization suggestions are put forward. This study shows that the evaluation method of physical education quality based on fuzzy logic can effectively reflect the diversity and complexity of education quality, and provide a practical evaluation tool for colleges and universities. At the same time, this study also provides a reference for other universities to help them better understand their own problems, so that they can take effective measures to improve. In addition, this method can be applied to other fields of education quality evaluation in the future, so as to provide more useful information for education reform and development.

Exploring educational simulation platform features for addressing complexity in Industry 4.0: a qualitative analysis of insights from logistics experts

IntroductionThis study explores the transformative impact of Industry 4.0 on industrial operations, emphasizing the integration of advanced technologies like AI, IoT, and Big Data Analytics to enhance process optimization, automation, and connectivity. Despite its potential for efficiency, Industry 4.0 introduces significant complexities, challenging existing operational and decision-making frameworks. Addressing these challenges, the research investigates the role of simulation platforms in logistics, seeking to identify their critical attributes for effective complexity management. It highlights the need for innovative tools in system evaluation, performance measurement, and skill development, aiming to equip the workforce with essential Industry 4.0 competencies. Through qualitative insights from logistics experts, the study aims to offer practical recommendations for educators and industry professionals, contributing to the design and implementation of educational simulations that align with the intricate demands of Industry 4.0 logistics.MethodsThis study employs a qualitative content analysis approach to develop an Industry 4.0-adapted logistics simulator, leveraging the Asteraceae framework for digital game co-design and pedagogical reflection. Data were collected from six industry and academia experts through semi-structured interviews, designed around the framework’s key steps to explore simulator design, decision-making, impact, and skill development. Utilizing convenience sampling, the research engaged participants with experience in educational logistics platforms and simulators. Interviews were conducted online, with ethical considerations including informed consent. Transcription used OpenAI’s API for accuracy, followed by manual review. The analysis combined qualitative content with frequency analysis, employing Atlas.ti software to identify and code key simulation features as informed by expert insights. This methodology underscores a comprehensive approach to understanding and innovating logistics education for Industry 4.0, aiming to equip learners with necessary competencies through targeted simulation tools.ResultsThe study’s findings emphasize the critical role of simulation tools in Industry 4.0 logistics for risk mitigation, operational planning, and decision-making. Experts pointed out the significant benefits of simulations in providing safe spaces for experimentation, especially valuable for SMEs with limited access to advanced technologies. They advocated for simulators to incorporate current technological and e-commerce trends, suggesting a customizable business model based on diverse logistics requirements. Key insights included the necessity for adaptable simulation architectures to handle various operational variables, the importance of integrating multidisciplinary competencies like data analytics and strategic management, and the role of performance metrics in evaluating simulations and logistics operations. The analysis revealed essential features for an educational logistics simulator, highlighting the importance of operational knowledge, predictive analytics, and the need for a comprehensive tool that integrates technology, strategy, operations, and data analysis. This approach aims to equip users with the skills necessary for navigating the complexities of modern logistics, promoting a deep understanding of systems thinking and complex reasoning skills.DiscussionThe discussion centers on the essential requirement for a multidisciplinary approach in creating an educational logistics simulator for Industry 4.0, emphasizing the need for technological adaptability and operational efficiency. It highlights the importance of integrating advanced technologies and collaborative paradigms to enhance logistics operations and improve decision-making processes. The utility of simulation-based learning as a pedagogical tool is acknowledged, with an emphasis on its role in developing complex thinking and practical skills relevant to the digital transformation of the logistics sector. The discussion suggests that educational simulations are poised to play a pivotal role in preparing the workforce for Industry 4.0 challenges by bridging technological advancements and pedagogical strategies. However, it also points to the limitations of the current study, such as its sampling method and regional focus, and calls for future research to explore broader applications and the integration of comprehensive strategies to ensure the educational simulator’s effectiveness and relevance in a global context.

Digitized Printed Strategic Intervention Material in Science in District I of Antipolo City: Basis for Enhancement Model

Digitization, technology, and scientific education are strong educational reform drivers. Modern educational institutions use computers and the Internet for all their activities. It’s everywhere now. Thus, digitally printed science intervention material is crucial in schools and society. Today, digitalized printed materials are the main teaching and learning channel. The Philippine Department of Education (DepEd) uses extracurricular activities to help students who struggle in science, technology, and other subjects. Educators, administrators, and curriculum planners use digitally enhanced printed materials and multimedia instructions to develop every aspect of teaching and learning. This study assessed the validity and acceptability of the Digitized Printed Strategic Intervention Material (DPSIM) in teaching Science as expected against evaluation. The respondents of the study were one (1) Technology Expert, five (5) Science Administrators, and one hundred (100) Science teachers who were described in terms of position, educational attainment, training attended in ICT, teaching experiences, and the ability to handle ICT. The validity is assessed in terms of content, manner of presentation, language and style, and evaluative tools. Acceptability is assessed in terms of clarity, usefulness, suitability, adequacy, and timeliness. Various resources such as books, published studies on the net, and other materials were gathered in the construction of the research questionnaire. Descriptive Statistics such as Mean and Frequency, T-test, and ANOVA were utilized to test the statistical significance of the variables presented. Results revealed that there is no significant difference in the assessment of the two groups (expected and evaluated responses) of respondents on the validity of the Digitized Printed Strategic Intervention Material (DPSIM), but there is a significant difference in the assessment of respondents in terms of acceptability of DPSIM. When respondents were grouped according to their profile in terms of position, educational attainment, training attended in Information Communication Technology (ICT), teaching experience, and the ability to handle ICT in Teaching, it was identified that differences in the responses for validity were brought about by the respondent’s difference in ICT training attended and their ability to handle ICT in teaching. The validity of DPSIM is perceived to be a high extent, with Application, Method of Presentation, Language and Style, and Evaluative Tools as the criteria that need further improvement. For the acceptability of DPSIM, there is a significant difference in the responses when grouped according to profile. However, it is worth noting that overall, no criteria were perceived to be needing improvement. Acceptability has also been categorized to a very high extent. It concluded that the Digitized Printed Strategic Intervention Material (DPSIM) is an effective tool in teaching Science. The study included that school administrators should evaluate the DPSIM whether its contents conform to the curriculum standards. Teachers should first examine the DPSIM use to determine the contents that align with the objective of the lesson. Parents should support children with technology materials that supplement the lesson; pupils can explore the DPSIM, which promotes independent learning; and future researchers can conduct similar studies that assess developed DPSIM if the same education will be conducted in the future. Keyword: Digitized Printed Strategic Intervention Material (DPSIM)

“Reminds Me How Much You Ought to be Thinking About”: Advancing History Teachers’ Vetting and Adaption of Digital Curriculum Materials

The digital revolution has widened the array of curriculum materials available to history teachers. Given the variable quality of these new materials and the deeply contextual nature of teaching, educators need better tools for selecting among the vast options available. This study aimed to validate a device designed for that purpose, called the Curriculum Materials Evaluation Tool (CMET). Using a questionnaire and think-aloud interview, the study examined how four social studies teachers evaluated a novel material set for potential classroom use, and how the CMET mediated their analysis. Findings showed that the teachers preferred when materials are readily accessible and adaptable for their specific teaching context, in contrast to “one-size-fits-all” resources that dominate the Web. The CMET appeared to foster a deeper and broader analysis of the given material set, especially regarding its political and cultural orientation. The study suggests that teachers’ role in vetting and adapting digital materials be recognized and embraced. The CMET can contribute to that end through its use in district adoption committees, teacher professional development, and collaborative curriculum research.

The power of the communicative approach: An investigation of classroom practices of English teachers working in vocational high schools

AbstractThis research examines classroom methodologies aligned with the communicative approach, gauging the perspectives of English teachers working within vocational high schools (VHSs). The study, employing a qualitative case study research design, engaged 10 teachers from diverse backgrounds. The participants volunteered for the study and were selected through a maximum diversity sampling technique, a purposeful sampling method. The research methodology encompassed data collection through interviews, observations, and document analysis. Content analysis was applied to scrutinize interview data, whereas observational and document‐based findings were subjected to descriptive analysis techniques. The study revealed a prevalent utilization of teacher‐controlled activities and a predominant teacher‐centric classroom layout among teachers. Notably, a considerable proportion of in‐class time was allocated to grammar instruction, whereas comparatively lesser emphasis was placed on fostering reading, speaking, writing, and listening skills. Moreover, it was found that multiple‐choice tests and alternative assessment formats such as performance evaluations and projects were exclusively employed; using other alternative assessment approaches like observations, interviews, learning diaries, and portfolios was rare. It is also found that English instruction in VHSs heavily relies on textbooks, supplemented by the occasional integration of audiovisual materials. Overall, teachers expressed a consensus that there exists a need for enhancement in curricular frameworks, teaching aids, as well as assessment and evaluation tools within the English instruction domain.

Energy Sustainability Indicators for the Use of Biomass as Fuel for the Sugar Industry

There are numerous analytical and/or computational tools for evaluating the energetic sustainability of biomass in the sugar industry. However, the simultaneous integration of the energetic–exergetic and emergetic criteria for such evaluation is still insufficient. The objective of the present work is to propose a range of indicators to evaluate the sustainability of the use of biomass as fuel in the sugar industry. For this purpose, energy, exergy, and emergy evaluation tools were theoretically used as sustainability indicators. They were validated in five variants of different biomass and their mixtures in two studies of technologies used in Cuba for the sugar industry. As a result, the energy method showed, for all variants, an increase in efficiency of about 5% in the VU-40 technology compared to the Retal technology. There is an increase in energy efficiency when considering AHRs of 2.8% or Marabu (Dichrostachys cinerea) (5.3%) compared to the V1 variant. Through the study of the exergetic efficiency, an increase of 2% was determined in both technologies for the case of the V1 variant, and an increase in efficiency is observed in the V2 variant of 5% and the V3 variant (5.6%) over the V1 variant. The emergetic method showed superior results for the VU-40 technology over the Retal technology due to higher fuel utilization. In the case of the V1 variant, there was a 7% increase in the renewability ratio and an 11.07% increase in the sustainability index. This is because more energy is produced per unit of environmental load.

Changes in biomarkers levels from gingival crevicular fluid in pre- and postmenopausal women undergoing orthodontic treatment : Asystematic review.

This study aimed to verify whether there is adifference in biomarker levels in the gingival crevicular fluid between premenopausal and postmenopausal women undergoing orthodontic treatment. As eligibility criteria, prospective or retrospective observational studies evaluating women undergoing orthodontic treatment(P), comparing postmenopausal (E)and premenopausal(C) women, and analyzing differences in gingival crevicular fluid biomarkers (O)were included. An electronic search was conducted in seven databases (PubMed, Scopus, Web of Science, LILACS, The Cochrane Library, Embase, and EBSCO: Dentistry & Oral Science) and one grey literature source (Google Scholar). All databases were searched from September 2022 to March 2023. After duplicate exclusion and data extraction, the Newcastle-Ottawa scale was applied to assess the quality and risk of bias, and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) tool was used to verify the certainty of evidence. Three case-control studies that analyzed receptor activator of nuclear factor kappa‑B ligand (RANKL), osteopontin (OPN), and interleukin (IL)-17A levels were included. One study reported asignificant difference for RANKL and another for OPN levels. A third study reported that there was a higher expression of IL17‑A in the postmenopausal group. However, the small number of articles limits our systematic review. The heterogeneity and imprecision in the study results cast doubt on the findings' internal validity. The studies reported alterations in biomarker levels but differed in their conclusions. Therefore, further studies must include other types of bone and inflammatory biomarkers in female patients who are pre- or postmenopausal and undergoing orthodontic treatment. The review was registered at the Open Science Framework ( https://doi.org/10.17605/OSF.IO/Q9YZ8 ).

Group Validation in Recommender Systems: Framework for Multi-layer Performance Evaluation

Evaluation of recommendation systems continues evolving, especially in recent years. There have been several attempts to standardize the assessment processes and propose replacement metrics better oriented toward measuring effective personalization. However, standard evaluation tools merely possess the capacity to provide a general overview of a system’s performance; they lack consistency and effectiveness in their use, as evidenced by most recent studies on the topic. Furthermore, traditional evaluation techniques fail to detect potentially harmful data on small subsets. Moreover, they generally lack explainable features to interpret how such minor variations could affect the system’s performance. This proposal focuses on data clustering for recommender evaluation and applies a cluster assessment technique to locate such performance issues. Our new approach, named group validation , aids in spotting critical performance variability in compact subsets of the system’s data and unravels hidden weaknesses in predictions where such unfavorable variations generally go unnoticed with typical assessment methods. Group validation for recommenders is a modular evaluation layer that complements regular evaluation and includes a new unique perspective to the evaluation process. Additionally, it allows several applications to the recommender ecosystem, such as model evolution tests, fraud/attack detection, and the capacity for hosting a hybrid model setup.

Regioselectively Carboxylated Cellulose Nanofibril Models from Dissolving Pulp: C6 via TEMPO Oxidation and C2,C3 via Periodate-Chlorite Oxidation.

Regioselective C6 and C2,C3 carboxylated cellulose nanofibrils (CNFs) have been robustly generated from dissolving pulp, a readily available source of unmodified cellulose, via stoichiometrically optimized 2,2,6,6-tetramethylpyperidine-1-oxyl (TEMPO)-mediated and sequential sodium periodate-sodium chlorite (PC) oxidation coupled with high-speed blending. Both regioselectively optimized carboxylated CNF series possess the widest ranges of comparable charges (0.72-1.48 mmol/g for T-CNFs vs. 0.72-1.10 mmol/g for PC-CNFs), but similar ranges of thickness (1.3-2.4 nm for T-CNF, 1.8-2.7 nm PC-CNF), widths (4.6-6.6 nm T-CNF, 5.5-5.9 nm PC-CNF), and lengths (254-481 nm T-CNF, 247-442 nm PC-CNF). TEMPO-mediated oxidation is milder and one-pot, thus more time and process efficient, whereas the sequential periodate-chlorite oxidation produces C2,C3 dialdehyde intermediates that are amenable to further chemical functionalization or post-reactions. These two well-characterized regioselectively carboxylated CNF series represent coherent cellulose nanomaterial models from a single woody source and have served as references for their safety study toward the development of a safer-by-design substance evaluation tool.

Applicability of electromyography (EMG) as a prospective technique for textural evaluation of different types of biscuits

Bakery industry is an important segment of the food industry, worldwide, and texture is an important determinant in the consumer acceptability of baked products especially biscuits. In this study, six different textured biscuits namely, whole wheat flour biscuit, chocolate biscuit, cumin biscuit, cardamom biscuit, pistachio biscuit and cashew biscuit, procured from local bakery, were analyzed for their proximate composition and color characteristics. The biscuits were having significantly (p ≤ 0.05) different values for proximate composition and color parameters. This study primarily aimed at investigating the application of electromyography (EMG) as a prospective technique for texture evaluation of these different types of biscuits. EMG is an upcoming technique for in vivo food texture evaluation which gives real-time information about the dynamic textural changes occurring during mastication of a food product. The EMG study was conducted on ten human subjects who were served six samples of biscuits in duplicate. To eliminate subject factor variance, two-way ANOVA was applied on the relative values of EMG variables. Two recordings of same subject in an EMG session for a biscuit sample showed significant (p ≤ 0.05) degree of similarity indicating that human mastication behavior is reproducible. Initially, twenty-eight EMG parameters were obtained which were reduced to five representative parameters using cluster analysis. Principal component analysis further classified these five masticatory parameters into two independent principal components (PC1 and PC2) for explaining the data variance. Cumulative proportions for PC1 and PC2 were 37.6% and 70.8%, respectively. The results showed that mastication time obtained from electromyographic analysis can evaluate sensory fracturability, hardness and chewiness. While middle interburst duration can effectively evaluate sensory cohesiveness and instrumental flexural strength. The study concluded that EMG can serve as a comprehensive texture evaluation tool in the bakery industry.

Social Media Metrics as Predictors of Publishers’ Website Traffic

The relationship between legacy media and social media has become a crucial topic in the discussions about new media. The debate intensified after Facebook announced a reduction in news posts in user timelines in 2018. In the era of the “Like economy”, social media holds significant economic value, prompting media outlets to adopt a “let’s try and see” approach to reach new audiences and increase their online advertising share. The present study, based on a large-scale survey of 50 publishers’ websites, Facebook pages, and Twitter accounts, deepens our understanding of the relationship between legacy and social media as indicators of audience feedback. Through the lens of network gatekeeping and reciprocal journalism theories, it contributes to the development of new evaluation tools that predict publishers’ website traffic based on social media metrics. Results show that Facebook and Twitter metrics can predict publishers’ website traffic indicators at a rate exceeding 60%. This study underscores the importance of social media metrics in evaluating media practices and the need to shift research toward specific indicators to understand the relationship between legacy and social media.

Keratinocyte-derived circulating microRNAs in extracellular vesicles: a novel biomarker of psoriasis severity and potential therapeutic target

BackgroundPsoriasis is a chronic inflammatory disorder characterized by pathogenic hyperproliferation of keratinocytes and immune dysregulation. Currently, objective evaluation tools reflecting the severity of psoriasis are insufficient. MicroRNAs in extracellular vesicles (EV miRNAs) have been shown to be potential biomarkers for various inflammatory diseases. Our objective was to investigate the possibility of plasma-derived EV miRNAs as a marker for the psoriasis disease severity.MethodsEVs were extracted from the plasma of 63 patients with psoriasis and 12 with Behçet’s disease. We performed next-generation sequencing of the plasma-derived EV miRNAs from the psoriasis patients. Real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to validate the level of EV miRNA expression. In situ hybridization was used to discern the anatomical location of miRNAs. qRT-PCR, western blotting, and cell counting kits (CCKs) were used to investigate IGF-1 signaling in cells transfected with miRNA mimics.ResultsWe identified 19 differentially expressed EV miRNAs and validated the top three up-and down-regulated EV miRNAs. Among these, miR-625-3p was significantly increased in patients with severe psoriasis in both plasma and skin and most accurately distinguished moderate-to-severe psoriasis from mild-to-moderate psoriasis. It was produced and secreted by keratinocytes upon stimulation. We also observed a significant intensification of IGF-1 signalling and increased cell numbers in the miR-625-3p mimic transfected cells.ConclusionsWe propose keratinocyte-derived EV miR-625-3p as a novel and reliable biomarker for estimating the severity of psoriasis. This biomarker could objectively evaluate the severity of psoriasis in the clinical setting and might serve as a potential therapeutic target.Trial registration None.

Psychometric Properties of the Persian Version of Student Evaluation of Online Teaching Effectiveness (SEOTE) questionnaire Among Medical Sciences’ Students

Background: Due to the increasing number of online educations, traditional methods for evaluation of different on-line education methods are not suitable and there is a need for a valid and reliable tool in this field. This study aimed to examine the validity and reliability of the Student Evaluation of Online Teaching Effectiveness (SEOTE) questionnaire among Medical Sciences’ students in Tabriz, Iran.
 Methods: Using convenience sampling method, the present study included 230 students of Medical Sciences (e.g., mean age of 21.96 ±3.47 years) in Tabriz, Iran. The SEOTE questionnaire was used to collect the data. Forward–backward translation, construct validity and content validity were utilized to check the validity of the questionnaire. In addition, temporal stability was calculated using the test-retest method and Internal Consistency Coefficient (ICC).
 Results: It was confirmed that the SEOTE has appropriate content validity using the content validity index (CVI) of 0.80 and content validity ratio CVR of 0.70. Exploratory factor analysis (EFA) identified the following two factors for domain identification of “communication” and “learning”. A Cronbach’s alpha of 0.97 was obtained for the questionnaire’s reliability, and ICC was used to confirm the temporal stability of the questionnaire (95% Confidence Interval [CI]: 0.966-0.977).
 Conclusion: This study confirms that the Persian version of SEOTE questionnaire is a valid and reliable tool for evaluation of on-line teaching among Medical Sciences’ students.

Integration of a facile sustainable resonance Rayleigh scattering switchable-based system for feasible determination of centrophenoxine, a nootropic and antioxidant agent; application to crude materials and dosage forms

The proposed research adheres to a certain methodology to ensure that the technique used for analyzing the centrophenoxine drug is sustainable and green. It is important to highlight that several tools that have been recently developed were utilized as potential indicators of environmental sustainability and applicability. The present research presents a novel and entirely innovative method utilizing ultrasensitive spectrofluorimetry for the detection of centrophenoxine (CPX) drug. The employed methodology in this study involved the utilization of one-step, one-pot, and direct spectrofluorimetric technique, which was found to be both efficient and environmentally sustainable in the validation and assessment of the drug. Simply, when CPX and erythrosine B reagent were combined in an acidic environment, the highly resonance Rayleigh scattering product was immediately produced. The sensitivity limits were observed to be within the range of 15–47 ng mL−1, whereas the linearity was assessed to be in the range of 50–2000 ng mL−1. The optimal settings for all modifiable parameters of the system were ascertained through an analysis of centrophenoxine-erythrosine B complexes. Moreover, the system demonstrated compliance with International Council for Harmonization (ICH) specifications without encountering any issues. The suggested process was then rated on different recent environmental safety measuring metrics to see how good it was for the environment. Fortunately, the WAC standards that combine ecological and functional elements utilizing the Green/Red/Blue (RGB 12) design also acclaimed the current analytical technique as a white one. Additionally, a new applicability evaluation tool (BAGI) was employed to estimate the practicability of the planned method in the analytical chemistry field.