European Conference Research Articles

The 14th European conference on precision agriculture

The 14th European conference on precision agriculture

9th European Conference on Religion, Spirituality and Health

9th European Conference on Religion, Spirituality and Health

BK virus associated hemorrhagic cystitis in pediatric patients undergoing hematopoietic stem cell transplantation

Abstract Background BK virus (BKV) is one of the most common causes of hemorrhagic cystitis (HC) in children undergoing hematopoietic stem cell transplantation (HSCT). Methods Descriptive and retrospective study that included patients from 0-18 years old undergoing HSCT with a diagnosis of HC, admitted from 1/1/2018 to 11/30/2023 in a tertiary care pediatric hospital. Patients with HC were tested for BKV by quantitative polymerase chain reaction (PCR) in urine samples, if positive, plasma viral load was also requested. BKV-HC grading was defined by the European Conference on Infections in Leukemia (ECIL) consensus document. Asymptomatic patients did not undergo standardized screening for BKV. Results During this period 86 HSCT were performed for either malignant (75,6%) or non-malignant disorders (24,4%). Overall, 16 (18,6%) were autologous and 70 (81.4%) were allogeneic: 40 human leukocyte antigen (HLA) matched unrelated donor, 26 HLA-matched related donor and 4 haploidentical. Six patients (7%) suffered HC, all associated with BKV as the cause. These six patients underwent allogeneic HSCT, and 4 of them had HLA-matched unrelated donors. All patients were over 5 years old. Male sex predominated (n:5). All of the patients had hematologic malignancies as the underlying diagnosis (5 with acute lymphoblastic leukemia - ALL). The stem cell source was bone marrow in 3 patients and peripheral blood in the other 3. All patients received myeloablative conditioning regimen and 4 underwent total body irradiation. Only one patient received post-transplant cyclophosphamide. Symptoms (dysuria, abdominal pain, macroscopic hematuria, clots) began more than 14 days after HSCT in 100% of the cases. Hematuria was categorized as grade III in 5 patients and grade IV (severe) only in one. All patients tested positive for BKV PCR in urine samples. High-level BK viruria (>107 copies/mL) was found in 66,6%. BK viremia was detected in 4 patients. All of the patients had another concomitant viral infection, with cytomegalovirus reactivation being the most frequent (n:4). Two patients also had detectable adenovirus (ADV) PCR in urine samples. Acute graft versus host disease (GVHD) was diagnosed in 5 patients, all with skin involvement. All patients were hospitalized and prolonged the length of stay. Regarding treatment, they all received hyperhydration and Cidofovir (more than 3 doses). Dose of immunosuppressive treatment was reduced in 5 cases. Acute kidney failure (AKF) was found in 3 patients. One patient developed chronic kidney failure. The patient with no GVHD was the one who improved the fastest. The patient with severe hematuria required bladder irrigation, had dialysis indication and presented a related death. Conclusion The development of BKV-HC in HSCT patients results in suffering and pain, prolonged hospitalizations and significant morbidity (AKF). Literature shows that male sex, older age and acute GVHD are important risk factors, and this is what we also found in our case series. BKV-HC is considered a difficult and severe condition to manage, remaining troublesome so we should overcome this deficiency with new approaches, particularly emphasizing in preemptive or prophylaxis measures for the benefit of our patients.

Invasive fungal disease in patients with cancer in a tertiary care pediatric hospital

Abstract Background In the last two decades, the raise in invasive fungal diseases (IFD) has been associated with increased morbidity and mortality in immunosuppressed hosts. Its incidence varies between 2 to 21% and depends on the host´s underlying disease, the intensity of immunosuppressive treatment and the presence of comorbidities. The aim of this study is to describe the epidemiological, clinical and microbiological characteristics of IFD in patients with hematology-oncology disease. Methods Retrospective, descriptive study. Patients under 18 years of age with acute leukemias, lymphomas and solid tumors with a diagnosis of proven IFD (according to EORTC-MSG 2019 criteria) were included during the period from January 2020 to November 2023 in a tertiary care pediatric hospital. Results During the study period, 304 patients were under follow-up. 14 episodes of proven IFD were identified in 13 patients.The median age was 120 months. Male sex predominated (69.2%). The recognized factors associated were neutropenia (69.2%), use of corticosteroids in the last 3 months (61.5%) and use of previous antibiotics (92.3%). The most common underlying disease was Acute Lymphoblastic Leukemia (ALL) in 11 cases (78.5%), of which 3 were in relapse. The 21.4% of the episodes occurred in solid tumors (1 osteosarcoma of the tibia, 1 abdominal germ cell tumor, 1 neuroblastoma). Patients receiving primary prophylaxis for filamentous fungi were 3/14 (21.4%), according to the European Conference on Infections in Leukemia (ECIL-8). All received voriconazole. The fungal isolates identified were: 1 Rhizopus spp. (eye biopsy, paranasal sinuses) 1 Penicillum spp. (lung biopsy), 1 Exserohilum rostratum (skin biopsy), 1 Trichophyton asahii (blood cultures), 1 Purpuracillum lilacinus (skin biopsy), 1 Aspergillus fumigatus (Bronchoalveolar lavage, BAL),: 3 Candida parapsilosis (blood cultures), 1 Candida tropicalis (blood cultures), 1 Candida spp (blood cultures), 1 Malassezia (BAL). The patients with invasive molds infections were six, all of them with pathological chest tomography. Galactomannans (GM) were positive in 66% (4/6). BAL with positive GM was performed in 2 of them. The primary focus were: cutaneous (3/6), pulmonary (2/6) and orbital-rhinosinusal (1/6). Regarding IFD due to yeast fungi: all Candida infections were associated with central venous catheters fungemia. Malassezia infection presented with pulmonary involvement. Fungal co-infection was observed in 1 patient with documentation of Aspergillus fumigatus in BAL and Candida tropicalis in blood and urine cultures. Empirical antifungal therapy was liposomal amphotericin in 76.9 % of the patients. Two patients died (15.4%) at 30 days of follow-up. Conclusion Early diagnosis and timely antifungal therapy represent the main strategies to increase the survival of patients with IFD. Antifungal prophylaxis is postulated as an effective prevention measure and its indication should be defined according to the patient’s characteristics and the incidence of IFD at the treating center. We consider that patients with suspected IFD and clinical focus should undergo the corresponding tissue biopsy for culture, histological evaluation, and molecular biology, to direct the appropriate treatment. Candida species represent the most frequent isolates, however, Aspergillus and Rhizopus infections are associated with higher morbidity and mortality.

Earth science for all? The economic barrier to European geoscience conferences

Abstract. Scientific meetings are vital for research development and networking. However, these events often reflect unconscious biases and barriers to diversity, particularly affecting marginalized groups. The future success of the geosciences depends on diversity, which enhances problem-solving and innovation through varied perspectives. This study examines the attendance diversity at the European Geosciences Union (EGU) General Assembly from 2005 to 2024, focusing on the impact of economic factors, distance, and population size on participation. Using publicly available data from the World Bank and the EGU, this study finds that gross national income (GNI) is the primary determinant of attendance, especially post-COVID. Distance also influences attendance but to a lesser extent, while population size shows a weak correlation. To improve diversity in academic conferences, we suggest facilitating donations, offering affordable accommodations, establishing additional travel funds, and rotating the conference location. Our actions must go beyond the EGU General Assembly and other geoscience conferences, as these actions can also help dismantle barriers to inclusivity in other areas of our community. By addressing these financial and systemic barriers, geoscience conferences can become more inclusive, benefiting the entire scientific community.

Navigating the road to recovery after stroke

This article considers the patient experience of rehabilitation after stroke, the current situation and how things might be in the future. It draws on presentations given at the European Stroke Organisation's conference this year in Switzerland, and draws conclusions about unmet needs, and health and social care services.

Artificial intelligence improves bronchoscopy performance – a randomized cross-over trial

RationaleFlexible bronchoscopy is an operator dependent procedure. An automatic bronchial identification system based on artificial intelligence (AI) could help bronchoscopists to perform more complete and structured procedures through automatic guidance.Methods101 participants were included from six different continents at the European Respiratory Society annual conference in Milan, 9–13th September 2023. Participants were split into three groups based on experience: Novices (0 bronchoscopies), Intermediates (1-249 bronchoscopies), and Experienced (≥250 bronchoscopies). The participants performed two bronchoscopies on a realistic physical phantom, one with AI (AmbuBronchoSimulatorTrainingGUIDEv.0.0.1, Prototype version, Ambu) and one Standard procedure. The F1-group received AI-guidance for their first procedure, the F2-group for their second. A cross-over randomization controlled for learning by testing. All procedures were automatically rated according to the outcome measures: Inspected segments, Structured Progressions, and Procedure Time.ResultsAI guidance caused the participants to inspect more segments, (mean difference, paired t-test: +6.0 segments, p<0.001), perform more Structured Progressions (+5.2 progressions, p<0.001), and spend more time on the procedure (+72 s, p<0.001) compared to their standard procedures. The effects of AI guidance on inspected segments and structured progression were highest for novices but significant for all experience groups: Novices (+8.2 segments, p=.012 and +6.6 progressions p<0.001), Intermediates (+5.7 segments, p=.006 and +5.1 progressions p<0.001, and Experienced (+4.3 segments, p=.006 and +3.8 progressions p<0.016).ConclusionsAI-guidance helped bronchoscopists of all experience levels to inspect more segments in a more structured order. Clinical implementation of AI guidance could help ensure and document more complete bronchoscopy procedures in the future.

The 20th European Doctoral Conference in Nursing Science – EDCNS

The 20th European Doctoral Conference in Nursing Science – EDCNS

The 20th European Doctoral Conference in Nursing Science – EDCNS

The 20th European Doctoral Conference in Nursing Science – EDCNS

The 20th European Doctoral Conference in Nursing Science – EDCNS

The 20th European Doctoral Conference in Nursing Science – EDCNS

The 20th European Doctoral Conference in Nursing Science – EDCNS

The 20th European Doctoral Conference in Nursing Science – EDCNS

Knowledge and Awareness of Risk Factors for HIV Infection and about HIV Testing among Medical Students in Warsaw.

The number of late diagnoses of HIV remains very high in Poland, leading to a high proportion of patients developing and dying of HIV-related diseases. The main reason for this is the very low utilization of HIV testing. Our analyses aimed to investigate knowledge about the indications for HIV testing among medical university students, as well as identify their own HIV testing experiences. A cross-sectional survey study was designed to collect information on the students' demographics and their experiences of HIV testing, as well as their knowledge of virus transmission and the indications for testing. Data were collected as part of the HIV_week@WUM project conducted at the Medical University of Warsaw in parallel with the 18th European AIDS Conference, which took place in Warsaw between 18 and 21 October 2023. In total, 545 questionnaires were collected. The median age of the study participants was 20 (interquartile range (IQR): 19-22 years). The majority of respondents were as follows: women (67.5%), born in Poland (97.8%), and were attending the medical faculty (56.7%). Only 114 (21.43%) participants had ever been tested for HIV. For all modes of HIV transmission, most of the respondents overestimated the risk of acquiring HIV, but, at the same time, they had never been tested for HIV. Only one in five health sciences students has ever had a test for HIV, which is less than estimates for the general population of Warsaw. There is an ongoing need to popularize testing among future health care providers in order to address both the indications for testing for individuals and the better use of HIV testing in clinical practice.

Supreme Committee for the Liberation of Lithuania (VLIK) 1986–1992: the Mission of Liberation Accomplished

In the second half of the 1980s, the Supreme Committee for the Liberation of Lithuania (VLIK), which aimed at “restoration of the enforcement of the sovereign rights of Lithuania”, called on other Lithuanian emigrant political organisations, together with emigrants from all Baltic countries, to organise a broader campaign to this end during the meeting of the European Conference on Security and Cooperation (CSCE) in Vienna (for example, in 1986 Lithuanians, together with emigrants from all Baltic countries, took part in a joint demonstration in Vienna).

Gender and ethnicity intersect to reduce participation at a large European hybrid HIV conference

ObjectiveTo evaluate how gender and ethnicity of panel members intersect to effect audience participation at a large European hybrid conference.DesignAn observational cross-sectional study design was used to collect data at...

Singing Voice Teaching and Voice Science: Where is the Meeting Point?

Abstract: Five panelists gathered at the 14th Pan European Voice Conference for a round table session called Voice Science—Do We Need It? Finding Meeting Points Between the Science and the Craft . All were experienced singers, and most were also teachers, with all but one of them a published researcher. Each panelist was tasked with addressing the challenges of aligning two diverse communities of practice: namely, voice science and singing voice pedagogy. This article is a report of the individual perspectives of the panelists along with the session chair’s summary of the presentations and questions from the audience.

ECCB2024: The 23rd European Conference on Computational Biology.

ECCB2024: The 23rd European Conference on Computational Biology.

Barriers encountered with clinical data warehouses: Recommendations from a focus group

Background and ObjectiveThe increasing implementation and use of electronic health records over the last few decades has made a significant volume of clinical data being available. Over the past 20 years, hospitals have also adopted and implemented data warehouse technology to facilitate the reuse of administrative and clinical data for research. However, the implementation of clinical data warehouses encounters a set of barriers: ethical, legislative, technical, human and organizational. This paper proposes an overview of difficulties and barriers encountered during a clinical data warehouse (CDW) development and implementation project. MethodsWe conducted a focus group at the 2023 Medical Informatics Europe Conference and invited professionals involved in the implementation of CDW. These experts described their CDW and the difficulties and barriers they encountered at each phase: (i) launching of the data warehouse project, (ii) implementing the data warehouse and (iii) using a data warehouse in routine operations. They were also asked to propose solutions they were able to implement to address the barriers previously reported. ResultsAfter synthesis and consensus, a total of 26 barriers were identified, 10 pertained to tasks, 5 to tools and technologies, 4 to persons, 4 to organization, and 3 to the external environment. To address these challenges, a set of 15 practical recommendations was offered, covering essential aspects such as governance, stakeholder engagement, interdisciplinary collaboration, and external expertise utilization. ConclusionsThese recommendations serve as a valuable resource for healthcare institutions seeking to establish and optimize CDWs, offering a roadmap for leveraging clinical data for research, quality enhancement, and improved patient care.

7th European Conference of Immunology, 1–4 September, 2024, Dublin, Ireland

7^th European Conference of Immunology, 1–4 September, 2024, Dublin, Ireland

European Study of Cerebral Aspergillosis treated with Isavuconazole (ESCAI): A study by the ESCMID Fungal Infection Study Group.

Cerebral aspergillosis (CA) is associated with high mortality. According to the European Conference on Infections in Leukemia and the European Society of Clinical Microbiology and Infectious Diseases guidelines, the recommended first-line treatment for all forms of aspergillosis is voriconazole or isavuconazole. However, little is known about the efficacy and safety of isavuconazole in CA. We conducted a European multicenter retrospective study of patients treated with isavuconazole for proven or probable CA between 2014 and 2022 and compared the outcomes with those of weighted control groups from the previously published French national cohort of CA, the Cerebral Aspergillosis Lesional Study (CEREALS). Forty patients from 10 countries were included. The main underlying conditions were hematological malignancies (53%) and solid-organ transplantation (20%). Isavuconazole was administered as a first-line treatment to 10 patients, primarily in combination therapy, resulting in control of CA in 70% of these cases. Thirty patients received isavuconazole after a median of 65 days on another therapy, mostly because of side effects (50%) or therapeutic failure (23%) of the previous treatment. Predominantly given as monotherapy, it achieved control of CA in 73% of the patients. Seventeen patients (43%) underwent neurosurgery. When measured, isavuconazole levels were low in cerebrospinal fluid but adequate in serum and brain tissue. Isavuconazole toxicity led to treatment interruption in 7.5% of the patients. Twelve-week mortality was 18%. Comparison with the CEREALS cohort showed comparable survival in patients receiving isavuconazole or voriconazole as a first-line treatment. Isavuconazole appears to be a well-tolerated treatment. Mortality of CA treated with isavuconazole is similar to that reported with voriconazole.

Considering Diversity in Educational Research that Explores School-Community Relationships

This special issue of the Australian and International Journal of Rural Education explores school-community relationships from a diversity perspective. The contributions originated in presentations delivered as part of the European Educational Research Association’s Network 14 sessions at the annual European Conference in Educational Research in August 2023. The papers present perspectives from a wide range of contexts: from Asia and Australia to Europe and South America.