Ethylene Vinyl Alcohol Copolymer Research Articles

Bronchial artery embolization with an ethylene vinyl alcohol copolymer agent (Squid) and polyvinyl alcohol particles for treatment of hemoptysis.

Bronchial artery embolization (BAE) is considered the first choice treatment for hemoptysis. To our knowledge no cases of BAE using a recent ethylene vinyl alcohol copolymer agent (Squid) have been previously mentioned. Two cases of BAE for remitting hemoptysis using Squid and polyvinyl alcohol particles are reported in this technical note. The final angiographic control confirmed full exclusion of the target territory in both cases. Both patients felt some chest pain immediately after the embolization, not requiring any medications. No more episodes of hemoptysis occurred in the following 3 months after the procedure.

Endovascular Treatment of Pelvic Congestion Syndrome: Visual Analog Scale Follow-Up.

Purpose: To evaluate medium-term clinical outcomes of transcatheter embolization and stenting in women with several pelvic venous disorders responsible for chronic pelvic pain and varicose veins of the lower limbs.Materials and Methods: The study population included 327 consecutively recruited patients referred to the interventional radiology unit from January 2014 to December 2019 due to chronic pelvic congestion (91; 27.83%), lower limb varices (15; 4.59%), or a combination of both the symptoms (221; 67.58%). Preprocedural pelvic, transvaginal Doppler ultrasound (US), and MRI were conducted in all the patients and revealed anatomical varicosities and incompetent pelvic veins in 312 patients. In all the patients, selective catheterization demonstrated uterine venous engorgement, ovarian plexus congestion, or pelvic vein filling. Retrograde flow was detected on catheter venography in the left ovarian vein (250; 78%), the right ovarian vein (85; 26%), the left internal iliac vein (222; 68%), and the right internal iliac vein (185; 57%). Patients were followed-up at 1, 6, and 12 months, and years thereafter systematically by the referring angiologist and the interventional radiologist of center. They were contacted by telephone in November and December 2020 to assess pain perception and quality of life by using the visual analog scales from 0 to 10 with assessments made at the baseline and last follow-up. Of the 327 patients (mean age, 42 ± 12 years), 312 patients were suffering from pelvic congestion syndrome and 236 patients was suffering from lower limb varices. All underwent embolization by using ethylene vinyl alcohol copolymer (Onyx®). Eighty-five right ovarian veins, 249 left ovarian veins, 510 tributaries of the right internal iliac vein, and 624 tributaries of the left internal iliac vein were embolized. A cohort of patients also underwent nutcracker syndrome angioplasty (6.7%) and May–Thurner syndrome angioplasty (14%) with a stent placement.Results: The initial technical success rate was 80.9% for embolization of pathological veins and 100% for stenting of stenoses. Overall, 307 patients attended 12-month follow-up visits and 288 (82%) patients completed the telephone survey at mean 39 (±18)-month postintervention. Main pelvic pain significantly improved from 6.9 (±2.4) pre- to 2.0 (±2.4) postembolization (p < 0.001), as did specific symptoms in each category. Improvement or disappearance of pain was achieved in 266/288 (92.36%) patients with improved quality of life in 276/288 (95.8%) patients. There were 16 minor and 4 major adverse events reported on the follow-up.Conclusion: Pelvic vein embolization (Onyx®) is an effective and safe procedure with high clinical success and quality of life improvement rates.

Design of Novel PLA/OMMT Films with Improved Gas Barrier and Mechanical Properties by Intercalating OMMT Interlayer with High Gas Barrier Polymers.

Polymer/clay composites are an innovative class of materials. In this study, we present a facile method for the preparation of biodegradable and robust PLA/organomodified montmorillonite (OMMT) composite films with excellent gas barrier performance. When the design of PLA/OMMT composite films, in addition to making OMMT have good intercalation effect in the matrix, the compatibility of intercalating polymer and matrix should also be considered. In this work, two polymers with high gas barrier properties, namely poly(vinyl alcohol) (PVA) and ethylene vinyl alcohol copolymer (EVOH), were selected to intercalate OMMT. The morphology and microstructures of the prepared PLA/PVA/OMMT and PLA/EVOH/OMMT composites were characterized by the X-ray diffraction measurement, scanning electron microscopy, and differential scanning calorimetry. It was shown that the good dispersibility of PVA in the PLA matrix, rather than the intercalation effect, was responsible for the improved gas barrier and mechanical properties of PLA/PVA/OMMT composite. The elongation at break increases from 4.5% to 22.7% when 1 wt % PVA is added to PLA/OMMT. Moreover, gas barrier of PLA/PVA1/OMMT measured as O2 permeability is 52.8% higher than that of neat PLA. This work provides a route to intercalate OMMT interlayer with high gas barrier polymers and thus can be a useful reference to fabricate PLA/OMMT composites with improved gas barrier and mechanical properties. A comparison of oxygen permeabilities with existing commercial packaging films indicates that the biodegradable PLA/PVA/OMMT may serve as a viable substitute for packaging film applications.

CO2-Derived Methylene Oxazolidinone: A Platform Building Block for Functionalizing Ethylene–Vinyl Alcohol Copolymers

Ethylene–vinyl alcohol copolymers (EVOHs) are important materials available in a variety of compositions and valued in countless applications. In spite of their great adaptability offered by the ad...

Trancatheter embolization of pulmonary artery pseudoaneurysm with detachable coils in association with non-adhesive liquid embolizing agent (Squid).

A nodular lesion at the lower left pulmonary lobe was detected in a 46 years old male during a preoperative chest X-Ray for appendicitis. To further characterise the nodule, a contrast enhanced computed tomography (CE-CT) was performed showing a 20 mm vascular lesion, which was suspected to be a pseudoaneurysm. The diagnostic angiography detected a flattening of the vascular wall with a voluminous pseudoaneurysm (PSA) in the distal portion of the tributary branch of the inferior left lobe. To treat the lesion, a 2.9F microcatheter was advanced into the sac and 4 detachable coils were placed (16-18mm Penumbra Inc) to pack the PSA. To block vascular supply to the lesion, the feeding artery was embolized with an ethylene vinyl alcohol copolymer agent (Squid Peri 18, Emboflu). The final angiographic control showed the exclusion of the pseudoaneurysmal sac which was confirmed by SEMAR™ reconstructed CE-CT scan after 40 days. Furthermore, no signs of pulmonary infarction were reported. (www.actabiomedica.it).

Endovascular Management of Intracranial Dural AVFs: Transvenous Approach.

In this third review article on the endovascular management of intracranial dural AVFs, we discuss transvenous embolization approaches. Transvenous embolization is increasingly popular and now the first-line approach for ventral dural AVFs involving the cavernous sinus and hypoglossal canal. In addition, transvenous embolization is increasingly used in lateral epidural dural AVFs in high-risk locations such as the petrous and ethmoid regions. The advantage of transvenous embolization in these locations is the ability to retrogradely embolize the draining vein and fistula while reducing the risk of ischemic cranial neuropathy or brain parenchymal infarction commonly feared from a transarterial approach. By means of coils ± ethylene-vinyl alcohol copolymer, transvenous embolization can achieve angiographic cure rates of 80%-90% in ventral locations. Potential complications include transient cranial neuropathy, neurologic deterioration due to venous outflow obstruction, and perforation while navigating pial veins. Transvenous embolization should be considered when dural AVFs arise in proximity to the vasa nervosum or extracranial-intracranial anastomoses.

Elucidating molecular mechanisms of two-dimensional chemical reactions

Elucidating molecular mechanisms of two-dimensional chemical reactions

Endovascular Treatment of Chronic Subdural Hematomas through Embolization: A Pilot Study with a Non-Adhesive Liquid Embolic Agent of Minimal Viscosity (Squid).

Objective: Endovascular embolization using non-adhesive agents (e.g., ethylene vinyl alcohol copolymer with suspended micronized tantalum dissolved in dimethyl sulfoxide; Squid, Balt Extrusion) is an established treatment of brain arteriovenous malformations, dural arteriovenous fistulas, and hypervascular neoplasms. Middle meningeal artery (MMA) embolization is a relatively new concept for treating chronic subdural hematomas (CSDH). This study aimed to evaluate the safety and effectiveness of the use of Squid in the endovascular treatment of CSDH. Methods: Embolization was offered to patients with CSDH with minimal or moderate neurological deficits and patients who had previously undergone open surgery to evacuate their CSDH without a significant effect. Distal catheterization of the MMA was followed by embolization of the hematoma capsule with Squid 12 or Squid 18. Safety endpoints were ischemic or hemorrhagic stroke and any other adverse event of the endovascular procedure. Efficacy endpoints were the feasibility of the intended procedure and a ≥ 50% reduction of the maximum depth of the CSDH confirmed by follow-up computed tomography (CT) after >3 months. Results: Between November 2019 and July 2021, 10 patients (3 female and 7 male, age range 42–89 years) were enrolled. Five patients had bilateral hematomas, and five patients had previously been operated on with no significant effect and recurrent hematoma formation. The attempted embolization was technically possible in all patients. No technical or clinical complication was encountered. During a post-procedural follow-up (median 90 days), 10 patients improved clinically. A complete resolution of the CSDH was observed in 10 patients. The clinical condition of all enrolled patients during the so-far last contact was rated mRS 0 or 1. Conclusion: A distal catheterization of the MMA for the endovascular embolization of CSDH with Squid allowed for the devascularization of the MMA and the dependent vessels of the hematoma capsule. This procedure resulted in a partial or complete resolution of the CSDH. Procedural complications were not encountered.

Safety and Effectiveness of Ethylene Vinyl Alcohol Copolymer Embolization of Peripheral High-Flow Arteriovenous Malformations: Results of a Prospective Study

PurposeTo prospectively evaluate the efficacy and safety of a new ethylene vinyl alcohol (EVOH) copolymer–based embolic agent in the treatment of symptomatic peripheral arteriovenous malformations (AVMs). Materials and MethodsThis prospective single-center study evaluated EVOH embolization with 3 different formulations of EVOH (Squid Peri 12 cP, 18 cP, and 34 cP; BALT Germany GmbH, Düsseldorf, Germany) in patients with symptomatic AVMs. Between April 2018 and October 2019, 36 embolization procedures in 21 patients (3 males and 18 females; mean age, 34.7 years) were performed (inclusion criteria: symptomatic peripheral AVM, ≥14 years of age, and elective embolization). Symptoms, technical aspects (transarterial, transvenous, or percutaneous approach; plug or balloon occlusion), clinical and technical success (defined as the improvement of symptoms and complete angiographic eradication of the AVM nidus), adverse events, and short-term outcomes were assessed. ResultsThe mean volume of the embolic agent used per session was 3.4 mL of EVOH 34 cP (standard deviation [SD], ± 5.4), 6.2 mL ± 8.1 of EVOH 18 cP, and 4.6 mL ± 10.1 of EVOH 12 cP. Angiographic success was achieved in 18 patients (85.7%). The mean follow-up was 190 days (range, 90–538 days; median, 182 days). In the follow-up assessment, findings of magnetic resonance imaging showed that 19 patients (90.5%) had a persistent state of devascularization compared with postinterventional angiography. Amelioration or complete elimination of pain was achieved in 90.0% of the patients. One patient experienced a major adverse event; minor adverse events developed in 2 patients. ConclusionsIn this study, EVOH appeared to be a safe and effective embolic agent in peripheral AVMs and had a low rate of adverse events in a limited number of patients.

Processing and Characterization of Food-Grade Plasticizer-Compatibilized Cellulose Nanocrystals and Ethylene Vinyl Alcohol Copolymer Nanocomposites

Processing and Characterization of Food-Grade Plasticizer-Compatibilized Cellulose Nanocrystals and Ethylene Vinyl Alcohol Copolymer Nanocomposites

Dual-gating pH-responsive membranes with the heterogeneous structure for whey protein fractionation

Whey protein is a mixture of globular proteins with high nutritional value and excellent functional properties availability. Purified individual whey proteins exhibit better functionality than in their original mixture, thus there is an increasing interest in developing more efficient methods to recover individual whey protein fractions, especially membrane technology. However, whey protein fractionation from the protein mixture is still a huge challenge for membrane separation. Herein, a dual-gating pHresponsive membrane with the heterogeneous structure was developed for whey protein fractionation. The heterogeneous structure of the membranes was obtained by grafting the dimethylaminoethyl methacrylate (DMAEMA) and 4-vinylpyridine (4VP) near the topside and inside the pores of the ethylene vinyl alcohol copolymer (EVAL) membranes based on selective modification of grafting sites. The PDMAEMA and P4VP gates responded to pH individually and provided a multi-stage regulation of the surface charge and sieving property of the membranes. The major whey protein fractionation from the mixture could be achieved by single dual-gating pH-responsive membrane via the sequential stepwise pH gradient from 3.0 to 8.0. The α-Lactalbumin (α-La), β-Lactoglobulin (β-Lg), lactoferrin (LF) and bovine serum albumin (BSA) were separated and enriched in the permeate at pH 3.0, 4.2, 6.4 and 8.0 by the diafiltration process, respectively. This work not only proposed a novel concept of pHresponsive membrane, but also offered a sustainable solution to fractionate the whey protein from the complicated mixture.

Synthesis of chemical grafting pour point depressant EVAL-GO and its effect on the rheological properties of Daqing crude oil

The alkali-catalyzed alcoholysis of polyethylene vinyl acetate (EVA) was used to obtain the product ethylene-vinyl alcohol copolymer (EVAL), and the grafting product poly(ethylene-vinyl alcohol)-graphene oxide (EVAL-GO) was prepared in the form of chemical grafting by utilization of the groups on the surface of GO and EVAL through the esterification reaction. The products were analyzed by Fourier transform infrared (FTIR), 1H nuclear magnetic resonance (NMR) and Thermogravimetric (TG). The rheological properties of the oil sample and changes in the morphology of wax crystals were characterized by Advanced Hybrid Rheometer and polarized optical microscopy (POM) respectively. The degree of alcoholysis of EVAL reached 74.51%, and the grafting rate of EVAL-GO (0.5%) was 36.18%. Reduction of pour point and gel point of nanocomposite treated crude oil was 12 °C and 4 °C from undoped crude oil at the optimum additive concentration of 1000 mg/kg. Moreover, it decreased the viscosity and yield value of virgin crude oil by 99.5% and 78.3%, respectively. From the morphological analysis, it was indicated that EVAL-GO could make the wax crystals form sphere-like crystals, and the increased void space promoting more liquid oil to be released thus significantly improving the low-temperature fluidity of Daqing waxy crude oil.

Direct Nidal Ethyl Vinyl Alcohol Copolymer Embolization With Flow Reduction Techniques as a Primary Treatment for Intraosseous Mandibular Arteriolovenous Malformations

Intraosseous mandibular arteriovenous malformations are uncommon and can be an important cause of major oral bleeding if undiagnosed, especially in the setting of loose dentition. Catheter angiography and embolization has been reported with good success using several agents. This report describes the use of direct (percutaneous/intraoral) intranidal ethylene-vinyl alcohol copolymer injection with arterial flow reduction to treat 2 intraosseous mandibular arteriolovenous malformations without complication. This treatment in both cases resulted in a stable ethylene-vinyl alcohol copolymer cast, fixed dentition, and remodeling of the mandible to a normal architecture with clinical and imaging stability over a long follow-up period.

Hot-Melt-Extruded Active Films Prepared from EVOH/Trans-Cinnamaldehyde Blends Intended for Food Packaging Applications.

In this work, novel active films based on ethylene vinyl alcohol copolymer (EVOH) and cinnamaldehyde (CIN) were successfully obtained employing a hybrid technique consisting of a two-step protocol involving the preparation of a polymeric EVOH-CIN masterbatch by solvent-casting for its further utilization in the preparation of bioactive EVOH-based films by melt extrusion processing. The influence of CIN over the EVOH matrix was studied in terms of optical, morphological, thermal, and mechanical properties. Optically transparent films were obtained and the incorporation of cinnamaldehyde resulted in yellow-colored films, producing a blocking effect in the UV region. A decrease in the glass transition temperature was observed in the formulations containing cinnamaldehyde, indicating a plasticizing effect. This phenomenon was confirmed by an increase in the elongation at break values of the extruded films. Results from thermogravimetric analysis determined a slight decrease in the thermal stability of EVOH provoked by the vaporization of the bioactive compound. Bioactive properties of the films were also studied; the presence of residual cinnamaldehyde in EVOH after being subjected to an extrusion process conferred some radical scavenging activity determined by the DPPH assay whereas films were able to exert antifungal activity in vapor phase against Penicillium expansum. Therefore, the present work shows the potential of the hybrid technique employed in this study for the preparation of bioactive films by a ready industrial process technology for food packaging applications.

Chilled storage stability of spice marinated and high pressure processed Indian white prawns (Fenneropenaeus indicus)

ABSTRACT Chilled storage stability of marinated and high pressure treated peeled and undeveined Indian white prawns (Fenneropenaeus indicus) were studied. The prawns were marinated with condiments viz. chilli powder, salt and turmeric, and - vacuum packed in ethylene-vinyl alcohol copolymer pouches. Marinated unpressurized prawn samples were kept as control. The products were stored at 2 ± 1°C for evaluating - shelf life by analysing biochemical, microbiological and organoleptic parameters. Pressurization significantly altered the quality indices such as pH, total volatile basic nitrogen, free fatty acid, thiobarbituric acid, total plate count and overall acceptability of samples. The control and 200 MPa treated sample were rejected on 20th and 25th day of storage respectively, whereas 250 and 300 MPa treated samples achieved a shelf life of 35 days. Among the samples, the prawns treated at 250 MPa were found to be organoleptically superior with respect to its biochemical and microbiological quality parameters.

Development and Characterization of Electrospun Fiber-Based Poly(ethylene-co-vinyl Alcohol) Films of Application Interest as High-Gas-Barrier Interlayers in Food Packaging.

In the present study, poly(ethylene-co-vinyl alcohol) with 44 mol % ethylene content (EVOH44) was managed to be processed, for the first time, by electrospinning assisted by the coaxial technology of solvent jacket. In addition to this, different suspensions of cellulose nanocrystals (CNCs), with contents ranging from 0.1 to 1.0 wt %, were also electrospun to obtain hybrid bio-/non-bio nanocomposites. The resultant fiber mats were thereafter optimally annealed to promote interfiber coalescence at 145 °C, below the EVOH44 melting point, leading to continuous transparent fiber-based films. The morphological analysis revealed the successful distribution of CNCs into EVOH44 up to contents of 0.5 wt %. The incorporation of CNCs into the ethylene-vinyl alcohol copolymer caused a decrease in the crystallization and melting temperatures (TC and Tm) of about 12 and 7 °C, respectively, and also crystallinity. However, the incorporation of CNCs led to enhanced thermal stability of the copolymer matrix for a nanofiller content of 1.0 wt %. Furthermore, the incorporation of 0.1 and 0.5 wt % CNCs produced increases in the tensile modulus (E) of ca. 38% and 28%, respectively, but also yielded a reduction in the elongation at break and toughness. The oxygen barrier of the hybrid nanocomposite fiber-based films decreased with increasing the CNCs content, but they were seen to remain high barrier, especially in the low relative humidity (RH) regime, i.e., at 20% RH, showing permeability values lower than 0.6 × 10−20 m3·m·m−2·Pa−1·s−1. In general terms, an optimal balance in physical properties was found for the hybrid copolymer composite with a CNC loading of 0.1 wt %. On the overall, the present study demonstrates the potential of annealed electrospun fiber-based high-barrier polymers, with or without CNCs, to develop novel barrier interlayers to be used as food packaging constituents.

Embolization of Type 2 Endoleaks in the Abdominal Aorta Using Ethylene Vinyl Alcohol Copolymer.

Type 2 endoleaks (T2EL) are the most frequent complication following endovascular aortic repair. Multiple studies primarily deal with the technical and clinical success of the embolization of persisting T2EL, thereby revealing controversial outcomes. Current reports rarely focus on the detailed execution of such a complex interventional procedure with respect to the difficult anatomic setting. The present review provides an in-depth depiction and evaluation of the interventional methodology of the embolization of T2EL in the abdominal aorta with use of ethylene vinyl alcohol copolymer (EVOH). Complicating anatomic conditions are taken into account as well as technical and clinical success rates. Using the transarterial approach, there are at least 4different pathways to access the nidus of a T2EL. CT-guided direct puncture of the aneurysm sac provides an alternative method of high technical success. EVOH with its slow solidification characteristics enables good control to achieve complete filling of the T2EL. During the intervention, however, it remains difficult to meet exactly the embolization endpoint, especially in large T2ELs. T2EL embolization using EVOH is an effective treatment with low major complication rates when conducted by skilled interventionists with detailed knowledge of diverse complex access routes. · Many roads lead to Rome to access the nidus of a T2EL including diverse complex transarterial pathways and direct aneurysm sac puncture.. · Ethylene vinyl alcohol co-polymer enables good control for slow filling of the nidus with low risk of major complications.. · Identification of the embolization endpoint remains difficult during the procedure and may result in secondary interventions.. · Successful T2EL embolization requires detailed knowledge of all access routes to the nidus and skilled handling of liquid embolics.. · Nolte-Ernsting C, Mecklenbeck F, Stehr A. Embolization of Type 2 Endoleaks in the Abdominal Aorta Using Ethylene Vinyl Alcohol Copolymer. Fortschr Röntgenstr 2021; 193: 1426 - 1435.

Antimicrobial materials produced by incorporating copper acetate into ethylene-vinyl alcohol copolymer for its use in personal care and cosmetic packaging

Currently, there is a great demand for functional materials with effective pathogen-killing properties. In this research, we describe the use of green technology “reactive extrusion” for the synthesis of potent antimicrobial materials based on Ethylene-vinyl alcohol copolymer (EVOH). Herein, the antimicrobial agent, copper (II) acetate was used without pretreatment and introduced into the EVOH matrices at high temperatures. The thermal reaction of copper (II) acetate within the EVOH matrices and their effect on the thermal and thermomechanical properties of the polymer were investigated in regards to their concentration. The physicochemical, thermal, and rheological features, as well as, metal salt release kinetics were reported. The antimicrobial agent had significant effects on the properties of the matrix. Results showed a reduction in the glass transition temperatures and storage modulus of the materials in response to the incorporation of copper (II) acetate. Finally, the antimicrobial activity of the products was studied and demonstrated a possibility to create antimicrobial materials in a one-step, solvent-free extrusion process.

PMD6 Procedure Cost-Comparison Analysis of Liquid Embolic System Techniques Using EVOH and n-BCA in the Embolization of Brain Arteriovenous Malformations

To reduce bleeding risk during surgery, brain arteriovenous malformations (bAVMs) may be treated with liquid embolic systems (LES) such as the n-BCA (n-butyl cyanoacrylate) LES and the EVOH [(ethylene vinyl alcohol) copolymer dissolved in DMSO (dimethyl sulfoxide)] LES. To determine the procedure cost of embolization, technique and ancillary devices should be considered including specialized microcatheters developed to reduce complications. A cost-comparison analysis from a US healthcare-cost perspective was conducted to assess procedure costs using n-BCA or EVOH LES techniques. The analysis assumed a total of 4mL of liquid embolic was needed to treat 2 pedicles of a bAVM using four techniques. For the n-BCA technique, a 3:1 solution (3mL ethiodized oil/1ml n-BCA); 4mL total, 2mL of solution with 1 PROWLER10 microcatheter were used per pedicle. In the EVOH “Plug-and-Push” technique, 1 unit EVOH34, 2 units EVOH18 and 1 MARATHON microcatheter were used per pedicle. In the EVOH “Detachable-Tip” technique, 2 units EVOH18 and 1 APOLLO ONYX LES delivery microcatheter were used per pedicle. In the EVOH “Balloon-Assisted” technique, 2 units EVOH18 and 1 SCEPTER -XC balloon catheter were used per pedicle. Average selling price was used for devices. The Plug-and-Push technique had the highest total device cost ($16,998; $15,616 for EVOH, $1,382 for microcatheters). Followed by the Detachable-Tip technique ($14,524; $10,536 for EVOH, $3,988 for microcatheters) and Balloon-Assisted technique ($13,592; $10,536 for EVOH, $3,056 for balloon microcatheters). The least costly was the n-BCA technique $5,834 ($3,942 for n-BCA, $1,892 for microcatheters). Total device costs were 2.3 to 2.9-times higher with EVOH LES techniques compared with n-BCA owing to the need for additional units of EVOH and ancillary devices. This analysis illustrates that ancillary devices and number of LES kits impact procedure costs. The cost-sparing n-BCA technique for bAVM embolization may result in cost savings for US hospitals.

Highly Permeable Polyamide Nanofiltration Membrane Mediated by an Upscalable Wet-Laid EVOH Nanofibrous Scaffold.

For energy-saving purposes, the pursuit of ultrahigh permeance nanofiltration membranes without sacrificing selectivity is never-ending in desalination, wastewater treatment, and industrial product separation. Herein, we reported a novel facile route to engineer a highly porous and superhydrophilic nanofibrous substrate to mediate the interfacial polymerization between trimesoyl chloride and piperazine, generating an ultrathin PA active layer (∼13 nm) with a hierarchical crumpled surface. The wet laying process and subsequent plasma treatment endowed a rougher and more hydrophilic surface for ethylene vinyl alcohol copolymer (EVOH) nanofibers in the thin compact nanofibrous scaffold (∼9 μm) with a mean pore size of 210 nm, radically different from the nanofibrous membrane by other methods. Nanofibrous scaffold with these features provide abundant thin-thick alternative continuous water layers between nanofibers and organic phase, facilitating the formation of the abovementioned PA layer. As a result, an ultrahigh permeance of 42.25 L·m-2 h-1 bar-1 and a reasonably high rejection of 95.97% to 1000 ppm Na2SO4 feed solution were obtained, superior to most state-of-the-art NF membranes reported so far. Our work provides an easy and scalable method to fabricate advanced PA NF membranes with outstanding performance, highlighting its great potential in liquid separation.