Ethyl Acetate Solvent Mixtures Research Articles

Bioassays guided isolation of berberine from Berberis lycium and its neuroprotective role in aluminium chloride induced rat model of Alzheimer's disease combined with insilico molecular docking.

Berberis lycium is an indigenous plant of Pakistan that is known for its medicinal properties. In the current study, we investigated the anti-Alzheimer's effect of berberine isolated from Berberis lycium. Root extract of B. lycium was subjected to acetylcholinesterase inhibition assay and column chromatography for bioassays guided isolation of a compound. The neuroprotective and memory improving effects of isolated compound were evaluated by aluminium chloride induced Alzheimer's disease rat model, elevated plus maze (EPM) and Morris water maze (MWM) tests., Levels of dopamine and serotonin in rats brains were determined using HPLC. Moreover, western blot and docking were performed to determine interaction between berberine and β-secretase. During fractionation, ethyl acetate and methanol (3:7) fraction was collected from solvent mixture of ethyl acetate and methanol. This fraction showed the highest anti-acetylcholinesterase activity and was alkaloid positive. The results of TLC and HPLC analysis indicated the presence of the isolated compound as berberine. Additionally, the confirmation of isolated compound as berberine was carried out using FTIR and NMR analysis. In vivo EPM and MWM tests showed improved memory patterns after berberine treatment in Alzheimer's disease model. The levels of dopamine, serotonin and activity of antioxidant enzymes were significantly (p<0.05) enhanced in brain tissue homogenates of berberine treated group. This was supported by decreased expression of β-secretase in berberine treated rat brain homogenates and good binding affinity of berberine with β-secretase in docking studies. Binding energies for interaction of β-secretase with berberine and drug Rivastigmine is -7.0 kcal/mol and -5.8 kcal/mol respectively representing the strong interactions. The results of docked complex of secretase with berberine and Rivastigmine was carried out using Gromacs which showed significant stability of complex in terms of RMSD and radius of gyration. Overall, the study presents berberine as a potential drug against Alzheimer's disease by providing evidence of its effects in improving memory, neurotransmitter levels and reducing β-secretase expression in the Alzheimer's disease model.

Utilization of red and yellow Coffea arabica var. Caturra pulp: macronutrient analysis, carotenoid extraction, and encapsulation for dairy product enrichment.

This study aimed to investigate the macronutrient and carotenoid content of red and yellow Coffea arabica var. Caturra pulp, a by-product of coffee processing in Colombia. The study employed ultra-sound-assisted extraction (UAE) to extract carotenoids, and a 23 factorial design was used to evaluate the effects of pulp color, biomass-solvent ratio, and solvent mixture composition on carotenoid content and extraction yield. The condition that provided the highest carotenoid extraction was further encapsulated by spray drying and added to a dairy product. The results showed that coffee pulp has significant dietary fiber content and high levels of carotenoids, with yellow pulp having a higher content than red pulp. Lutein isomers and lutein esters were the most abundant carotenoids found in both red and yellow coffee pulp. The highest carotenoid extraction was achieved using a 1:40 (g/mL) biomass:solvent ratio and a 20:80% v/v Ethanol:Ethyl Acetate solvent mixture for the yellow pulp. The carotenoid extract also demonstrated high encapsulation efficiency (46.57 ± 4.03%) and was found to be stable when added to a fermented milk product. This study presents an alternative solution for utilizing coffee by-products in Colombia, which could positively impact the families of over half a million Colombian coffee producers.

Solubility Determination and Comprehensive Analysis of the New Heat-Resistant Energetic Material TNBP

To improve the crystal quality of 4,8-bis(2,4,6-trinitrophenyl)difurazolo [3,4-b:3',4'-e] pyrazine (TNBP), the solubility of TNBP in organic solvents (six pure and four mixed solvents) was determined by the laser monitoring technique from 293.15 to 353.15 K. The results showed that the solubility was positively correlated with the increase in the experimental temperature and the main solvent content, except for the co-solvent phenomenon in the DMSO + ethyl acetate solvent mixture. To explain the dissolution behavior of TNBP, the KAT-SER model was analyzed for pure solvent systems, and it was found that hydrogen bonding alkalinity and self-cohesiveness were the main influencing factors. The free energy of solvation and radial distribution function of TNBP in mixed solvents were also obtained by molecular dynamics simulation, and the effect of solute-solvent and solvent-solvent interactions on the solubility trend was analyzed. The experimental data were correlated using three empirical equations (van't Hoff equation, modified Apelblat equation, and λh equation), and the deviation analysis showed the good applicability of the modified Apelblat model. Furthermore, the dissolution of TNBP was heat-absorbing and not spontaneous, according to the thermodynamic characteristics estimated by the van't Hoff equation.

İran safranı (Crocus sativus L.) ile Türkiye'nin makro ve mikro lokasyonlarda yetiştirilen safranın kalite özelliklerinin karşılaştırılması

In this study, volatile and bioactive compositions of saffron samples collected from Khorasani region in Iran Razavi and different locations in Turkey containing Hatay (Kırıkhan, Iskenderun, Hassa and Yayladağı counties), Karabük (Safranbolu county Yukarıbucak and Ovacuma villages), Ankara (Ayaş, Nallıhan and Polatlı counties), Çukurova region (Adana-Cukurova, Mersin-Tarsus and Osmaniye-Kadirli counties) and Antalya (Korkuteli county) were investigated using gas chromatography-mass spectrometry (GC-MS/FID and GC-MS/MS) for identification and quantification of volatile compounds. Ultrasound-assisted extraction method using methanol:ethyl acetate solvent mixture was used to isolate the volatile components of saffron. This study revealed that the amounts of the volatile and bioactive compounds of saffron veried between different geographical locations. The most important bioactive compounds of saffron, safranal, crocin and crocetin, were also quantitatively analyzed in all saffron samples. The highest amount of safranal and crocin were observed in Hatay yayladağı saffron with 22532.97 mg kg-1 and 647.26 mg/kg, respectively. The highest amount of crocetin was obtained with 6.73 mg/kg in Ankara Ayaş saffron. While Hatay kırıkhan saffron contained the highest fraction of fatty acid content with 23.56%, the highest fraction of bioactive components was discovered in Karabük safranbolu ovacuma saffron with 90.84%. According to the obtained outcomes, the highest qualities saffron were determined to be observed in Hatay yayladağı and Karabük safranbolu ovacuma saffron, respectively.

Novel environment friendly TLC-densitometric method for the determination of anti-coronavirus drugs “Remdesivir and Favipiravir”: Green assessment with application to pharmaceutical formulations and human plasma

A great demand for discovering new therapeutic solutions has been considered all over the world for managing the rapidly progressing COVID-19 pandemic. Remdesivir (REM) and Favipiravir (FAV) are introduced as promising newly developed antiviral agents against the corona virus as evidenced by the clinical findings. Hence, the optimization of an analytical method for their simultaneous determination acquires potential importance in quality control labs and further confirmatory investigations. Herein, a green, sensitive, and selective densitometric method has been proposed and validated for determination of REM and FAV in pharmaceutical formulations and spiked human plasma on normal phase TLC plates. A solvent mixture of ethyl acetate–methanol-ammonia (8:2:0.2 by volume) has been chosen as developing mobile phase system. Well resolved spots have been detected at 235 nm with retardation factors (Rf) of 0.18 and 0.98 for REM and FAV, respectively. A validation study has been carried out in the light of ICH guidelines. Remdesivir and FAV have shown excellent sensitivities with quantitation limits down to 0.12 and 0.07 μg/band, respectively. The developed method has been successfully applied to tablet formulations and spiked plasma with excellent recoveries ranged from 97.21 to 101.31%. The greenness of the method has been evaluated using the standards of greenness profile and Eco-Scale. It has passed the four greenness profile quadrants and achieved 80 score in Eco-Scale.

Characterization of expanded polystyrene waste as binder and coating material

The growth of consumer culture entails a series of harmful results for the different natural environments, one of these evils being the high rate of waste generation, an example, expanded polystyrene (EPS) today has become a major problem due to the high rates of generation of this type of waste. This study presents the results of EPS waste characterization, obtained by the degradation of EPS with solvent mixtures of acetone and ethyl acetate in different proportions, for possible use as an asphalt adhesive. For the characterization of these EPS waste mixtures, stress tests of the asphalt adhesive were carried out and they were complemented with tests of resistance to cutting, stickiness, rheology and thermogravimetric. The results obtained in this work show that the EPS waste obtained by dissolution with acetone and ethyl acetate solvent mixtures, present greater mechanical resistance, although these wastes have a higher apparent viscosity and a faster drying as it increases the acetone content present in the solvent. Tests showed that this material could be used as an asphalt coating film or adhesive binder.

Antimalarial Activity of Sea Sponge Extract of Stylissa massa originating from waters of Rote Island

Research on the isolation, toxicity test, antimalarial test, and identification of the active compound from the ethyl acetate fraction of Stylissa massa sponge from Oenggae waters, Rote Island, has been conducted. This study aimed to investigate the antimalarial activity of the ethyl acetate fraction of the Stylissa massa sponge. Isolation was carried out by the extraction method using a mixed solvent of methanol: dichloromethane of 3: 2 (v/v), then the extract was partitioned in a solvent mixture of ethyl acetate: water of 1: 2 (v/v). The ethyl acetate extract obtained was separated by column chromatography using the gradient polarity system method. The toxicity test of each fraction was carried out by the Brine Shrimp Lethality Test (BSLT) method, and the antimalarial test was carried out by the haematin polymerization inhibition method. Identification of compounds from the active fraction in the antimalarial test was carried out using Liquid Chromatography-Mass Spectrometry (LC-MS). The extraction yield was 1.14 g (0.23%) of the ethyl acetate extract in the form of a dark brownish-yellow oily solid. Separation by column chromatography resulted in 15 fractions. Toxicity test results showed the four most active fractions with LC50 values, which are very promising for new drug discovery. The IC50 value in the antimalarial activity test of the four fractions indicated that the Stylissa massa sponge ethyl acetate extract was more active than the standard chloroquine compound (115 μg/mL). The LC-MS analysis indicates that fraction 11 contains two compounds that have been reported, and 1 compound is unknown. In contrast, fraction 14 indicates that it contains three compounds that have been reported and one unknown compound.

Bioactive compounds and ethnomedicinal uses of Syzygium cumini (L.) Skeels-A comprehensive review

Sea buckthorn fruits were used as raw material for the extraction of bioactive compounds as a first important step in phytochemicals further valorization in different industries using three extraction methods: ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE) and conventional extraction method. Both modern methods offer many advantages compared with the conventional solvent extraction, in terms of the solvent and parameters of extractions used. The results illustrated that the UAE gives comparable values for extraction efficiency. The process conditions for maximum phytochemical extraction were time of 45 min; temperature of 40 °C, frequency of 40 kHz, and power of 100 W. The extraction protocol revealed a total carotenoid content of 42.43±0.17μg/g DW, a β-carotene content of 35.35±0.06 μg/g DW, and a lycopene content of 9.82±0.03 μg/g DW when an solvent mixture of ethyl acetate:hexane (2:1) was used for extraction. Higher values of TPC (805.34±5.5 mg GAE/g DW), TFC, (211.65±0.75 mg CE/g DW) and antioxidant activity of 2.15±0.01 μg Trolox/ml extract (DPPH) and 3.47±0.03 μg Trolox/ml extract (ABTS) were obtained when using ethanol: acetone solvent mixture (4:3).

Diastereomeric Salt Formation by the γ-Amino Acid RS-Baclofen and L-Malic Acid: Stabilization by Strong Heterosynthons Based on Hydrogen Bonds between RNH3+ and COOH/COO– Groups

Baclofen (BAC) is an important chiral active pharmaceutical ingredient for the treatment of specific neurological disorders that is commercially available only as RS-BAC (racemate). Using the liquid-assisted grinding technique, combination of RS-BAC with DL-MA in 1:1 stoichiometric ratio yielded a crystalline solid phase mixture of the enantiomeric salts R-BAC:L-MA and S-BAC:D-MA. Single-crystals suitable for SCXRD analysis of R-BAC:L-MA were obtained by fractional crystallization from a solution of RS-BAC and L-MA in a solvent mixture of ethyl acetate and water. Analysis of the supramolecular interaction patterns revealed that the crystal structure is stabilized by strong N+–H···–O, N+–H···O and O–H···–O hydrogen-bonding interactions. A comparative study with structurally related compounds enabled to identify common homo- and heterosynthons involving RNH3+, OH, and COOH/COO– groups. The spectroscopic, structural and thermogravimetric studies of the enantiomeric solid phase mixture of R-BAC:L-MA and S-BAC...

Cosolvency and Mathematical Modeling Analysis of Chloroxine in Some Binary Solvent System

Equilibrium solubilities of chloroxine in binary solvent mixtures of ethyl acetate plus methanol, ethanol, n-propanol, and isopropanol were measured by the static equilibrium method in the temperat...

Remarks and further analysis on “Solubility and dissolution thermodynamic properties of 1,6-Bis[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionamido]hexane in pure solvents and binary solvent mixtures”

Errors are discovered regarding the published equation coefficients of Zhang and coworkers [J. Mol. Liq. 252 (2018) 103–111] for mathematically describing the solubility behavior of 1,6-bis[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propion-amido]hexane (Irganox 1098) in neat organic solvents using the NRTL model. Larger differences are found between our back-calculated data and those reported in the authors' published paper. The expression of NRTL model was corrected and the equation parameters were re-regressed. Furthermore, the preferential solvation parameters (δx1,3) of Irganox 1098 in two solvent mixtures of ethyl acetate (1) + ethanol (2) and acetone (1) + ethanol (2) at 298.15 K were derived from their available solubility data using the inverse Kirkwood–Buff integrals method. In the ethyl acetate (1) + ethanol (2) mixture with the composition 0.40 < x1 < 1, Irganox 1098 was preferentially solvated by ethanol. However in the ethyl acetate (1) + ethanol (2) mixture with the composition 0 < x1 < 0.40 and the acetone (1) + ethanol (2) mixture over the whole composition range, the Irganox 1098 is preferentially solvated neither by ethyl acetate or acetone nor by ethanol.

Solubility and Preferential Solvation of 3-Nitrobenzonitrile in Binary Solvent Mixtures of Ethyl Acetate Plus (Methanol, Ethanol, n-Propanol, and Isopropyl Alcohol)

The solubilities of 3-nitrobenzonitrile in solvent mixtures of ethyl acetate (1) + methanol (ethanol, n-propanol or isopropyl alcohol) (2) determined over the temperature range from 278.15 to 318.15 K under atmospheric pressure (101.1 kPa) with the isothermal dissolution equilibrium method were reported. They increased with a rise of temperature and mass fraction of ethyl acetate, and the largest solubility value was observed in neat ethyl acetate for all the binary mixtures investigated. The temperature and solvent composition dependence of 3-nitrobenzonitrile solubility was analyzed through the Jouyban–Acree, van’t Hoff–Jouyban–Acree, and Apelblat–Jouyban–Acree models acquiring average relative deviations lower than 1.57% and root-mean-square deviation lower than 11.52 × 10–4 for correlative investigations. In addition, the preferential solvation parameters (δx1,3) of 3-nitrobenzonitrile by ethyl acetate were determined from experimental solubility values by using the inverse Kirkwood–Buff integrals. It...

Determination and Correlation of the Solubility of Acetylpyrazine in Pure Solvents and Binary Solvent Mixtures

The solubilities of acetylpyrazine in seven pure solvents and one binary solvent mixture were determined by a dynamic analytic method at temperatures ranging from 268.15 to 308.15 K under atmospheric pressure. For pure solvents, the solubility of acetylpyrazine increases with increasing temperature and solvent polarity. For the binary solvent mixture of ethyl acetate and isopropanol, the solubility increases with increasing temperature and mole fraction of ethyl acetate. The solubility data were correlated with some thermodynamic models, including the modified Apelblat model, λh model, CNIBS/R-K model, and NRTL model. In addition, the relationship between solubility and solvent polarity was investigated by using the Arrhenius equation. All the models or equations gave satisfactory correlation results. The results showed that the solubility of acetylpyrazine generally rises with the increase of solvent polarity at the same temperature. Moreover, the dissolution thermodynamic properties of acetylpyrazine in different solvents were calculated and are discussed based on the NRTL model.

Thermodynamic equilibrium of hydrocortisone form I in different solvent systems

The solubility of hydrocortisone form I in seven pure solvents and one kind of binary solvent system from (278.15–323.15) K was experimentally determined by using a dynamic method under atmospheric pressure. The results show that the solubility of hydrocortisone form I monotonously increases with increasing of temperature and reaches the maximum at ethanol molar fraction of 0.60 in binary solvent mixture of ethyl acetate and ethanol at constant temperature. The experimental solubility data in pure solvents were correlated by the modified Apelblat equation, the λh equation and the van't Hoff equation while the experimental solubility data in binary solvent systems were correlated by the modified Apelblat equation and the CNIBS/R-K model. In addition, the apparent thermodynamic properties (enthalpy, entropy, and Gibbs energy) of mixing processes and dissolution processes were also calculated based on the NRTL model. The calculated results indicate that the dissolution process of hydrocortisone form I in tested solvents is spontaneous and endothermic.

Structurally simple D–A-type organic sensitizers for dye-sensitized solar cells: effect of anchoring moieties on the cell performance

In this work, we report synthesis and device fabrication studies of four metal-free D–A-type dyes (A1–A4) based on structurally simple N,N-dimethyl-4-vinyl aniline carrying four different acceptor/anchoring groups, as sensitizers for sensitizing photoanode (TiO2). In the sensitizers, N,N-dimethylaniline ring acts as an electron donor, while barbituric acid, N,N-dimethyl barbituric acid, thiobarbituric acid and N,N-diethyl thiobarbituric acid function as electron acceptor/anchoring units. They were synthesized in good yield via Knoevenagel protocol in neutral condition without any catalyst. Further, they were subjected to structural, electrochemical and optical characterization in order to evaluate their structure, band gap and absorption/emission behavior. The studies reveal that all the four dyes have thermodynamic feasibility of electron injection as well as electron recombination; their optical band gaps were found to be in the range of 2.35–2.56 eV. High-quality crystals of A2 and A4 were grown by slow evaporation technique using its solution with 1:1 pet ether (60–80 °C)/ethyl acetate solvent mixture at room temperature. Their SC-XRD studies disclose that the crystals are in the triclinic system with space group P-1. Further, DFT studies were performed using Turbomole V7.1 software package to evaluate their optimized geometry and HOMO and LUMO levels. Finally, DSSC device fabricated with the dye A1 showed relatively good efficiency when compared to other dyes mainly due to the effective binding of barbituric acid on the surface of TiO2 through NH or OH functional group.

Solubility modelling, solution thermodynamics and preferential solvation for nitroxoline in solvent mixtures of ethyl acetate + (methanol, ethanol, n-propanol and isopropanol)

Equilibrium solubility data of nitroxoline in mixed solvents of (ethyl acetate+methanol), (ethyl acetate+ethanol), (ethyl acetate+n-propanol) and (ethyl acetate+isopropanol) were obtained experimentally by using the static method within the temperature range from (278.15 to 313.15)K under atmospheric pressure of 101.1kPa. The mole fraction solubility of nitroxoline increased with increasing temperature and mass fraction of ethyl acetate. The obtained solubility data were mathematically represented by using five cosolvency models, including Jouyban–Acree model, van’t Hoff-Jouyban-Acree model, Apelblat-Jouyban-Acree model, Ma model, and Sun model. The maximum value of relative average deviation was 1.64×10−2, and root-mean-square deviation, 0.77×10−4. The dissolution process of nitroxoline in these mixed solvents was endothermic. The preferential solvation parameters were derived from their thermodynamic solution properties via the method of inverse Kirkwood–Buff integrals. The preferential solvation parameters for nitroxoline (δx1,3) were positive in intermediate compositions and ethyl acetate-rich mixtures but negative in alcohol-rich compositions. In the regions with intermediate composition, the preferential solvation magnitude of nitroxoline by the ethyl acetate is higher in {ethyl acetate (1) + ethanol (2)} mixtures than in the other solvent mixtures at 298.15K. The higher solvation by ethyl acetate in intermediate compositions and in ethyl acetate-rich mixtures could be explained in terms of the higher basic behaviour of ethyl acetate interacting with the Lewis acidic groups of the nitroxoline.

A new and highly sensitive TLC method to measure hypericin using chemiluminescence

ABSTRACTHypericin is a polyphenolic compound belonging to the group of polyphenols and is the active constituents of Hypericum perforatum (Saint John’s wort). We present a new high-performance thin-layer chromatography (HPTLC) method to measure a large number of hypericin extracts using chemiluminescence. On a 10 × 10 cm HPTLC plate (LiChrospher® Merck, 1.05586), more than 40 tracks can be simultaneously quantified using a piezoelectric application system (pipeJet) which can apply 56 nL of a methanolic hypericin extract contactless with high precision. For separation, a solvent mixture of ethyl acetate, water, formic acid, methyl tert-butyl ether, and cyclohexane (180 + 14 + 14 + 80 + 30, v/v) was used. The Rf-value of hypericin is 0.27. The method presented is specific for hypericin and offers a limit of quantification of 690 pg hypericin per band.

Determination and thermodynamic modelling for 2-methyl-6-nitroaniline solubility in binary solvent mixtures of ethyl acetate + (methanol, ethanol, n-propanol and isopropanol)

The solubility of 2-methyl-6-nitroaniline in binary mixed solvents of (ethyl acetate+methanol), (ethyl acetate+ethanol), (ethyl acetate+n-propanol) and (ethyl acetate+isopropanol) was determined experimentally by using the isothermal dissolution method within the temperature range from (278.15–313.15)K under atmosphere pressure. The solubility of 2-methyl-6-nitroaniline increased with increasing temperature and mass fraction of ethyl acetate in each binary system. At the same temperature and mass fraction of ethyl acetate, the mole fraction solubility of 2-methyl-6-nitroaniline was greater in (ethyl acetate+n-propanol) than in the other three mixed solvents. The achieved solubility values were correlated by employing Jouyban-Acree model, van’t Hoff-Jouyban-Acree model, Apelblat-Jouyban-Acree model, Ma model, Sun model and CNIBS/R-K model. The values of relative average deviations (RAD) and root-mean-square deviations (RMSD) were no greater than 1.79% and 20.56×10−4 for the six models. In general, the Jouyban-Acree model proved to provide better representation of the experimental solubility. Furthermore, the dissolution enthalpies of the dissolution process were calculated. Positive values of dissolution enthalpy showed that the dissolution process of 2-methyl-6-nitroaniline in these mixed solvents was endothermic. The experimental solubility results and models presented in the present work are essential in the practical process for production and purification of 2-methyl-6-nitroaniline.

Peroxyoxalate chemiluminescence efficiency in polar medium is moderately enhanced by solvent viscosity

Abstract The peroxyoxalate reaction is one of the most efficient chemiluminescence transformations and the only system which is believed to occur by an intermolecular Chemically Initiated Electron Exchange Luminescence (CIEEL) mechanism with proven high efficiency. Although this reaction system is utilized in a variety of analytical applications, its exact reaction mechanism is still unknown, specifically with respect to the structure of the high-energy intermediate, the mechanism of its interaction with a chemiluminescence activator, as well as the reason for the extraordinarily high chemiexcitation efficiency. The solvent viscosity influence on the singlet quantum yields of the peroxyoxalate reaction is studied in this work, using the polar binary solvent mixture of ethyl acetate and dimethyl phthalate spanning a viscosity range of 0.42–14.4 cP. The viscosity increase of about forty times leads to a quantum yield increase of a factor of around five. Although the viscosity effect on the quantum yields is significant, it is considerably lower than that obtained before in less polar media. The quantum yield dependency on the viscosity can be described with both the collisional and the frictional model, with good correlation coefficients ( R 2 > 0.95). However, the α values obtained from the frictional model would be more compatible with an intramolecular transformation than with the intermolecular interaction of a high-energy intermediate with an external activator. This apparent contradiction is thought to be due to stabilization of the charge-transfer complex between the high-energy intermediate and the activator by the polar medium, avoiding solvent cavity escape and increasing chemiexcitation efficiency. The high stability of the charge-transfer complex in the peroxyoxalate reaction might be due to the high planarity of the possible high-energy intermediate in this transformation, 1,2-dioxetanedione, the peroxidic carbon dioxide dimer.

Measurement and correlation of the solubility of rivaroxaban (form I) in binary mixtures of ethyl acetate with tetrahydrofuran, N,N-dimethylformamide, and N,N-dimethylacetamide from T = (278.15 to 318.15) K

In this work, the solubility of rivaroxaban (form I) in binary solvent mixtures of ethyl acetate (EA) with N,N-dimethylformamide (DMF), N,N-dimethylacetamide (DMA) and tetrahydrofuran (THF) was firstly experimentally measured over the temperature range from (278.15 to 318.15)K. Then the measured solubility data were correlated with such semiempirical thermodynamic models as Jouyban–Acree (JA) equation and Buchowski (λh) equation. The crystal form of the residual solids in equilibrium with liquids was identified by powder X-ray diffraction (PXRD). The melting temperature and fusion enthalpy were determined using differential scanning calorimetry (DSC). The results show that, the solubility of rivaroxaban generally increases with the temperature and decreases with the increase in the content of EA in the binary solvent mixtures. Furthermore, when λh equation is used to correlate the solubility of rivaroxaban with the temperature in each solvent mixture, the average relative deviation (ARD) between the experimental and calculated values is about 0.0671, while it is about 0.0905 when JA equation is employed to correlate the solubility with the temperature and the composition of solvent mixtures simultaneously.