Ethnic Backgrounds Research Articles

Implementing Board Rotation: A Potential Remedy for Nigeria’s “Boardroom Bubble”? Examining Benefits and Limitations

This article examines the potential and limitations of director rotation as a response to the "boardroom bubble" phenomenon in Nigerian companies. Gaining traction as a key corporate governance practice, director rotation seeks to mitigate stagnant decision-making within boards. The research explores how this approach can enhance corporate governance, accountability, and oversight. Our study suggests that while director rotation holds significant promise in reducing board entrenchment and strengthening corporate governance, it is not without drawbacks. These drawbacks include: Lack of independence among directors, reduced knowledge continuity on matters such as ESG (Environmental Social and Governance) factors or long-term strategies, difficulty finding suitable successors who share their predecessors’ characteristics (e.g., gender) as well as turmoil created when introducing inexperienced members onto Boards at times of crisis. Additionally, it does not address other important aspects of board diversity i.e., racial or ethnic background or educational achievements, which remain overlooked through this process alone. While acknowledging the benefits of rotation as a potential remedy for the “boardroom bubble,” this paper advocates for a nuanced approach to board rotation in Nigeria. Our research undertakes a comprehensive examination of Nigeria’s legal and regulatory landscape for implementing rotational boards, employing a rigorous doctrinal approach. The analysis delves into primary sources of data, such as the relevant Acts of the National Assembly and pertinent case law, while the secondary data are mainly books, journals, periodicals and web-based materials. In addition, the work proposes further research to explore specific regulatory frameworks and best practices tailored to the Nigerian context.

Efforts to Prevent Hypertension in The Kaili Tribe Community

Background: Hypertension causes many risks of premature death. The increase in hypertension sufferers in Palu City continues to fluctuate every year, the latest data for 2022 is that the number of hypertension sufferers is 7,848 cases and is in first place on the list of the highest non-communicable diseases. Based on medical record reports from the community health center, most of those suffering from hypertension complications from Kaili ethnic backgrounds are caused by lifestyle. Objective: This study aims to analyze efforts to prevent hypertension in the Kaili tribe community. Method: The type of research is qualitative research with an ethnographic approach. Data collection using independent interviews and observations. The research informants were 12 informants who were determined using the snowball sampling technique. Results: The research results show that the Kaili tribe community accepts health values in preventing hypertension through health activities such as Posbindu PTM and Sehat Friday, involving various parties. The general health protection norm is 5-30 minutes of light to heavy physical activity every day. The culture of consuming local fruit, such as bananas, is still strong with an average of 1-2 fruits per day, but the pattern of vegetable consumption is good even though there is an inappropriate habit of cooking vegetables with coconut milk. Routine health checks are carried out 1-3 times a month, including general examinations, blood pressure, blood sugar, urine and counseling. Conclusion: Suggestions for the Kaili tribe community to actively participate in health programs, so that they are aware, independent and able to avoid hypertension from an early age.

The Prevalence of Maternal Depression and Anxiety Beyond 1 Year Postpartum: A Systematic Review.

Maternal depression and anxiety occurring beyond the 1-year postpartum period can lead to significant suffering for both mother and child. This study aimed to systematically review and synthesize studies reporting the prevalence and incidence of maternal depression and anxiety beyond 1 year post-childbirth. A systematic literature review of the PsycINFO, Medline, and Embase databases identified studies reporting on the prevalence and/or incidence of depression and/or anxiety among mothers between 1 and 12years post-childbirth. The quality of the included studies was assessed. Findings were synthesized qualitatively. Twenty-one studies were identified that met the inclusion and exclusion criteria. All studies reported the prevalence of depression, with 31 estimates ranging from 6.6% at 3 to 11years post-childbirth to 41.4% at 3 to 4 years post-childbirth. Five of these studies also reported the prevalence of depression in subgroups (e.g., ethnic origin, income, marital status). Four studies reported the prevalence of anxiety, with nine estimates ranging from 3.7% at 5 years post-childbirth to 37.0% at 3 to 4 years post-childbirth. Only one study reported incidence. The quality of the included studies was variable, with most studies scoring above 7/9. Maternal anxiety and depression remain prevalent beyond the first year postpartum, particularly in marginalized subgroups. Current observational studies lack consistency and produce highly variable prevalence rates, calling for more standardized measures of depression and anxiety. Clinical practice and research should consider the prevalence of maternal anxiety and depression beyond this period.

Religious discrimination at the CJEU and the social inclusion approach

The social inclusion approach to EU anti-discrimination law, as set out by Ringelheim, is aimed at achieving inclusion and participation in employment and wider society of all groups, including the most disadvantaged. But is the CJEU using this social inclusion approach, especially in cases concerning religious discrimination? This article argues that the CJEU, in cases regarding racial and ethnic origin, disability and sexual orientation discrimination as well as in some cases regarding religion or belief discrimination, has indeed applied a social inclusion approach, but that the six judgments regarding the wearing of Islamic headscarves at work are an exception. In the latter cases, the CJEU did not appear to pay any attention to the effect of the judgments on the employment opportunities of Muslim women who want to wear religious symbols at work.

Exploring the perspectives of healthcare professionals on providing supported asthma self-management for Bangladeshi and Pakistani people in the UK.

Self-management support improves asthma outcomes and is widely recommended in guidelines, yet it is poorly implemented in routine practice. There may be additional challenges in the context of ethnic minority groups, where making sense of culture may be necessary. This study aimed to explore the perspectives of healthcare professionals on supporting UK Bangladeshi and Pakistani patients to self-manage their asthma. One-to-one semi-structured interviews with professionals (primary and secondary care; medical and nursing) who routinely provide asthma care to Bangladeshi or Pakistani patients. Topics addressed included perceptions of professionals in supporting patients with asthma self-management and ideas for improving culturally competent care. Data were analysed thematically. Nine professionals, from a range of ethnic backgrounds, with considerable experience of treating patients from these communities were interviewed. Despite organisational restrictions (language and time/resources) and expressed gaps in cultural knowledge and training, all interviewees reported attempting to tailor support according to culture. They used their perception of the patient's culture (e.g., big families and family involvement), integrated with their perception of patients' ability to self-manage (e.g., degree of responsibility taken for asthma), to formulate theories about how to culturally adapt their approach to supported self-management, e.g., supporting barriers in understanding asthma. There was consensus that gaps in cultural knowledge of professionals needed to be addressed through training or information. Interventions recommended for patients included basic education, group meetings, and culturally relevant action plans. In the absence of formal training and constrained by organisational limitations, self-management support was adapted based on personal and professional perception of culture. These ideas were based on experience and formulated a chain of reasoning. Professionals recognised the limitations of this approach and potential to overgeneralise their perceptions of culture and adaptations of supported self-management. Interventions were desired and need to address professional training in cultural competence and the provision of culturally relevant materials.

Breaking the concrete ceiling: Resources and strategies for career success amongst Black and Asian minority ethnic women leaders

AbstractDespite ongoing research efforts to resolve the pertinent issues with the underrepresentation of women from Black and Asian Minority Ethnic backgrounds in senior leadership positions, the problem persists. We suggest that one reason for the lack of progress is that management research has predominantly focused on the manifestation of race and gender inequality, the barriers experienced by these women, and the resulting adverse outcomes, with inadequate attention given to practical interventions for resolving these issues. We argue that an urgent and critical paradigm shift from problems to solutions is required in order to advance the field. Using the conservation of resource theory as a lens, we explore the lived experiences of 50 highly successful Black and Asian women and how they navigated the organizational labyrinth to achieve success in their careers. Our findings revealed that despite discriminatory experiences that threatened their career advancement, there were several personal and contextual resources which they drew upon to achieve career success. We develop a resource taxonomy framework illustrating these salient career advancement resources across their career journey, alongside strategies they used to protect these valuable resources. Our findings have theoretical and practical implications for career, leadership and diversity scholars and practitioners.

Exploring British student-athletes' receptivity to sport psychology consultation

Student-athlete's receptivity to sport psychology (SP) is a significant contributor to effective SP service delivery. Previous studies among American student-athletes suggests that stigma and negative beliefs, which affect receptivity, remain significant barriers to seeking SP support. However, there is a paucity of research focusing on the British student-athlete population. The aim of this study was to explore how demographic factors affect British student-athletes' receptivity to SP consultation. Following institutional ethics approval, student-athletes (n = 96, 48 males and 48 females) completed a series of demographic questions and the Sport Psychology Attitudes Revised Form (SPAR-R) (25 items answered on a seven-point Likert scale). The survey measured stigma tolerance (Cronbach’s alphas (α) = 0.821), confidence in SP consultation (α = 0.882), personal openness (α = 0.462) and cultural preference (α = 0.534). A one-way multivariate analysis of variance (MANCOVA) was used to examine the relationship between demographic constructs and the SPAR-R responses. Compared to females, males reported significantly higher scores in personal openness (P = 0.44, P < 0.05, mean difference [MD]: 0.54), and cultural preference (P = 0.01, P < 0.05, MD: 0.54). Compared to athletes who compete in a team sport, individual athletes reported significantly higher scores of confidence in SP consultation (P = 0.013, P < 0.05, MD: 0.7). There were no influences of age and level of sporting competition on confidence in SP and cultural preference, respectively (P > 0.05). The results suggest that males and athletes who compete in a team sport may be less receptive towards SP consultation than females and athletes who compete in an individual sport. These results are similar to those found within an American student-athlete population yet provide applied SP practitioners with novel insights into working with British student-athletes. Future research should focus on student-athletes from various ethnic backgrounds and further expand methodological approaches to understanding why demographic factors affect receptivity to SP consultation. In conclusion, these results could inform and encourage practitioners to adopt a tailored approach when providing SP consultation to persons possessing different demographic characteristics.

A qualitative study exploring experiences of racial minority stress in pharmacy education and practice

BackgroundDespite 49.1% of registered pharmacists in the UK being from a Black, Asian and Minority Ethnic (BAME) background, senior management roles within pharmacy are dominated by white males. People from BAME communities may experience minority stress which contributes to a professional attainment gap compared with non-BAME colleagues. Minority stress describes additional stressors, such as unconscious bias, micro-aggression and racial minority stress, experienced by minoritized people to adhere to the social norms of the majority. There is little evidence describing experiences of minority stress in pharmacy practice and education. The aim was to explore experiences of racial minority stress in pharmacy education and practice. MethodsA convenience sample of pharmacy students and pharmacists were recruited via email and social media posts to volunteer to take part in interviews and focus groups. A topic guide was used to explore experiences of unconscious bias, microaggressions and racial minority stress in education and practice. Interviews and focus groups were transcribed verbatim and inductively analysed using thematic analysis underpinned by a phenomenological approach. Ethical approval was granted from Newcastle University (5340/2020, 2430/2593). ResultsForty-five participants were recruited. Six focus groups and sixteen one-to-one semi-structured interviews were conducted. The sample was varied, with 56% (n = 25) students and 33% (n = 15) registered pharmacists from community, hospital, primary care, academia and an additional 11% (n = 5) still in foundation training in these sectors. The sample include diversity of racial identities, including 40% (n = 18) South Asian, 27% (n = 12) White, 15% (n = 7) Black, 7% (n = 3) Chinese and Arab mixed, 2% (n = 1) and 2% (n = 1) Not disclosed. Three themes were identified – Theme 1) Experiences of racial minority stress, Theme 2) Making sense of racial minority stress, and Theme 3) Responding to racial minority stress. Participants characteristics (for example skin colour, dialect, religious dress) made them feel susceptible to judgement, racist comments and microaggressions in education and practice. Participants required time to interpret, understand and make sense of incidents of racial minority stress. Responses to stressors included ‘ignoring ignorance’ and using a ‘professional identity’ to mask feelings. However, malicious comments and actions from other pharmacy staff were responded to differently to experiences from patients. Participants reported poor self-confidence to challenge racist behaviours in the workplace. ConclusionsThe aim of this study was to explore experiences of racial minority stress in pharmacy education and practice. This study shows dealing with microaggression, racial minority stress and judgement in pharmacy education and practice is a burden experienced by people from BAME backgrounds. These experiences could contribute to the professional attainment gap in pharmacy, as making sense of these experiences is an additional burden pharmacists and trainees must bear in comparison to people from non-BAME backgrounds. Further work is needed to explore interventions to reduce minority stress in pharmacy practice and education to reduce the attainment gap across the sector.

Early family socioeconomic status and asthma-related outcomes in school-aged children: Results from seven birth cohort studies

ObjectiveTo examine the associations between maternal education and household income during early childhood with asthma-related outcomes in children aged 9–12 years in the UK, the Netherlands, Sweden, Australia, the USA...

Disaggregating trends in alcohol involvement among Hispanic, Black, and White female and male U.S. adolescents: 2002 to 2019.

Alcohol involvement is declining among U.S. adolescents, however studies examining population-level trends in alcohol involvement among females and males from diverse racial and ethnic backgrounds are scarce. Therefore, the current study examined alcohol involvement from 2002 to 2019 among Hispanic, Black, and White U.S. adolescent females and males. Data were from the National Survey on Drug Use and Health, years 2002-2019. Participants were between 12 to 17 years old and Hispanic, non-Hispanic Black, or non-Hispanic White. Annualized change estimates within each subgroup were analyzed separately for four alcohol variables: 1) lifetime alcohol use; 2) age at alcohol initiation; 3) past-year drinking days; 4) respondent's perceived risk of alcohol misuse. Lifetime alcohol use decreased for all groups, and the decrease was strongest for Hispanic males. Age at alcohol initiation similarly increased for Hispanic and White females and males, with no change in age at alcohol initiation for Black adolescents. Past-year drinking days declined for all groups but was not significant for Black females. Perceiving alcohol misuse as a "great risk" increased only for Hispanic males and females. Although alcohol involvement is declining among U.S. adolescents, results from this study highlight that engaging with alcohol is normative among many adolescent groups. Also, when considering sex as well as race and ethnicity, there are important distinctions in patterns of decline in alcohol involvement that should be accounted for to inform future research and screening.

Visuospatial, oculomotor, and executive reading skills evolve in elementary school, and errors are significant: a topological RAN study.

We investigate the development of visuospatial and oculomotor reading skills in a cohort of elementary school children. Employing a longitudinal methodology, the study applies the Topological serial digit Rapid Automated Naming (Top-RAN) battery, which evaluates visuospatial reading skills leveraging metrics addressing crowding, distractors, and voluntary attention orientation. The participant pool comprises 142 students (66 males, 76 females), including 46 non-native speakers (21 males, 25 females), representing a diverse range of ethnic backgrounds. The Top-RAN dataset encompasses performance, error, and self-correction metrics for each subtest and student, underscoring the significance of these factors in the process of reading acquisition. Analytical methods include dimensionality reduction, clustering, and classification algorithms, consolidated into a Python package to facilitate reproducible results. Our results indicate that visuospatial reading abilities vary according to the task and demonstrate a marked evolution over time, as seen in the progressive decrease in execution times, errors, and self-corrections. This pattern supports the hypothesis that the growth of oculomotor, attentional, and executive skills is primarily fostered by educational experiences and maturation. This investigation provides valuable insights into the dynamic nature of these skills during pivotal educational stages.

Analysis of financial barriers experienced by prospective genetic counseling students

PurposeHigh costs of applying to genetic counseling graduate programs (GCGPs) are likely a barrier to workforce diversification. We sought to determine application costs and assess differences between individuals of historically underrepresented racial and ethnic backgrounds in medicine (hURM) and non-hURM applicants. MethodsApplicants to GCGPs between 2005 to 2020 were surveyed about application history, related expenses, volunteer hours, and financial resources; 383 responses were analyzed. ResultsMedian total application costs (MTAC) were $2634, $4762, and $5607 (1, 2, and 3 or more application cycles, respectively). Interview-related items (which includes travel) had the highest median cost (1 application cycle: $879). Among those who applied to multiple cycles, hURM respondents had higher MTAC than those of non-hURM ($6713 versus $4762, P = .03) and lower median total volunteer hours (246 versus 381, P = .03). Parental education level differed by hURM status (P = .04). Median financial contribution from parents with and without advanced degrees varied significantly (60% versus 2%, P = .0009). ConclusionSignificant costs are incurred during the GCGP application process, but notable differences in costs and resources were observed between hURM and non-hURM applicants. Stakeholders within the profession should implement strategies to reduce financial barriers and the resulting inequities in the application process.

The Use of Expanded Carrier Screening in Reproductive Medicine: Scientific Impact Paper No. 74.

Expanded carrier screening (ECS) is a genetic screening test carried out by analysing a blood sample. This screen can be used to detect whether the individual unknowingly carries gene variants associated with common genetic conditions, such as cystic fibrosis, that may be passed on to their children. It is typically performed in reproductive medicine for those who are considering having a family either naturally or via fertility treatment. Many donor sperm and egg banks, particularly in the USA and Europe, also perform blanket ECS testing on all their prospective sperm and egg donors. ECS is not currently routine practice in the UK, but a growing number of patients are requesting it before treatment. All of us carry gene variants of some sort that may cause autosomal recessive disease in their children if their partner or donor also carry a variant in the same gene. An autosomal recessive disease means two copies of an abnormal gene must be present in order for the disease or trait (such as cystic fibrosis or sickle cell disease) to develop. One copy of the variant means the person is a carrier but does not have the condition. Two copies, i.e. from the mother and father, means the child has a 25% chance of having the genetic disease. Carrying a gene variant does not mean that the individual would necessarily have any symptoms of the disease or any features of the condition. Genetic tests for specific conditions are currently available either before or during pregnancy for prospective parents who have a family or personal history of a genetic condition, or for those from ethnic backgrounds where certain conditions - such as haemoglobinopathies (blood disorders) - are common, prompting referral to a clinical genetics department. Expanded carrier screens may test for more than 100 genetic conditions. The list of conditions screened for is called a panel. Common panels are 250 or 600 genes. Not all expanded carrier screens that are available analyse the same genes. Some may test for genes that do not cause serious disease, or cause diseases that occur in later life; others test for genes that cause severe conditions in childhood. There is no agreement as to which panel of genes should be tested for in an ECS. Understanding the screening that is being offered, and the meaning of any results, is complicated and requires support from appropriately trained professionals to best inform the prospective parent or parents.

INCLUSIVE EDUCATION

Inclusive education is an educational model that aims to ensure the access and participation of all students, regardless of their individual characteristics, such as disabilities, ethnic, socioeconomic, or cultural backgrounds. It promotes pedagogical practices that recognize and value diversity, aiming for meaningful learning for all students. The concept of inclusive education has evolved over the years, moving beyond simply integrating students with disabilities into schools. It now encompasses the promotion of educational environments that value the diversity and individuality of each student, regardless of their personal characteristics. This implies curriculum adaptations, specialized support, and actions to ensure that all students have equal access to learning and development opportunities.

One Classroom, Different Perspectives: Promoting Mutual Understanding between “Secular” and “Religious” Students of Islamic Studies in Russia and the United States

Abstract The article discusses the results from several co-taught courses in Islamic studies shared as a virtual exchange between the University of Michigan (U-M), USA, and Saint Petersburg State University (SPbU), Russian Federation. These courses were designed and taught to expand the range of perspectives to which students were exposed and allow them to learn how their study subject is conceptualized and studied by their peers in the partner country. The SPbU student cohort included graduates of Islamic religious colleges from different regions of the Russian Federation who shared the classroom with “secular” university students specializing in Islamic studies. The U-M cohort included students of various religious, ethnic, and academic backgrounds. In addition to weekly online meetings, the international teams met virtually outside class to prepare questions for weekly synchronous discussions and to work on a group presentation to be delivered at the end of the semester.

Screening Options in Autism Telediagnosis: Examination of TAP, M-CHAT-R, and DCI Concordance and Predictive Value in a Telediagnostic Model.

Tele-assessment of autism in early childhood has increased. However, it is unclear how autism screening tools (M-CHAT-R, DCI) function as part of tele-assessment and relate to a commonly used tele-assessment instrument, the TAP. 361 families from a clinically referred sample of children (mean age: 27.63 months, sd = 4.86 months) completed the M-CHAT-R and DCI prior to a tele-assessment visit utilizing the TAP. Data was collected on demographic background, measure scores, and diagnostic outcome. No significant differences in measure scores or diagnostic findings emerged in age at referral, age group, age at diagnosis, or child sex, ethnicity, or racial background. The M-CHAT-R and DCI correlated strongly and positively. Older age was associated with lower risk scores on screening instruments. Children with autism had significantly higher scores on all screener and subdomain scores, with the exception of DCI Behavior. Subdomains of the DCI emerged as the strongest predictor of diagnostic outcome. Both the DCI total score and the M-CHAT-R significantly related to diagnostic outcome and TAP score in this tele-assessment model, regardless of child age or sex. Findings also support use of the DCI for children under 24 months of age.

Mother-infant interaction characteristics associate with infant falling reactivity and child peer problems at pre-school age.

This longitudinal study investigated the associations between mother-infant interaction characteristics at 9 months of age, maternal mental health, infant temperament in the first year postpartum, and child behaviour at 3 years of age. The infants (N = 54, 22 females) mainly had White British ethnic backgrounds (85.7%). Results showed that i) mother-infant dyadic affective mutuality positively correlated with infant falling reactivity, suggesting that better infant regulatory skills are associated with the dyad's ability to share and understand each other's emotions; and ii) maternal respect for infant autonomy predicted fewer child peer problems at 3 years of age, suggesting that maternal respect for the validity of the infant's individuality promotes better social and emotional development in early childhood.

Morphological structure and ethnic background of the Sudanese Shagia tribe (East Africa)

North Sudan, especially the 4th Nile Cataract region, is home to one of the world’s most isolated human populations. This study aimed to clarify the ethnic background of the Shagia based on anthropological analyses. This study provides a morphological and ethnographic characterisation of the previously unstudied Shagia tribe. Head and body measurements were conducted among 64 adults from three villages. There were observable but relatively small admixture proportions of non-African population genes (light skin colour, narrow noses and masculine proportions) in their morphological build. The Shagia’s uniqueness may have been the result of severe genetic drift episodes resulting from founding events, such as long-term isolation and traditionally small population size. It is useful to trace the ethnic history of Africans and, specifically, for the tribal members of Shagia so that they may better understand and learn about their history. This study shows that the Shagia tribe was displaced from their territory due to the construction of the Merowe Dam. Thus, the results of this research fulfil the assumptions of urgent anthropology, as it contributes to the protection of the heritage of the 4th Nile Cataract region: an area of historical value to the study of the evolution of contemporary civilisation.

What Matters in Choosing School for Children’s Education? Experiences from Kottayam, Kerala

While the role of education in fostering social stability and increasing a country’s human capital is well recognised, there are debates on policies and institutional arrangements in this regard. In particular, parents’ choice of schools appears to be a critical issue as it can influence both educational outcomes and inclusiveness. Given that there is a broader homogeneity in infrastructure facilities available at both household and school levels, one would expect that household-related factors will influence the choice of schooling of children. This article examines such household-level factors that influence households’ choice of schools for children in selected areas of Kottayam District, Kerala. A primary survey was conducted in December 2021 comprising 300 households. Based on the results of the estimated binary logit and probit models, this article reports that the choice of school for children is significantly influenced by households’ ethnic background and economic status, and sex, education, and primary occupation of the family head. There is a higher likelihood of choosing public schools by households from the Scheduled Caste/Scheduled Tribe category, those living below the poverty line, or those with agriculture as the primary occupation. On the contrary, this likelihood is less for households with educated and male heads. However, the choice of school for children does not differ significantly between rural and urban households. Further, there is no gender inequality in choosing schools. The findings suggest that future government policies should emphasise infrastructure development and quality improvement in government schools to promote socio-economic inclusion in education.

Saturation genome editing-based functional evaluation and clinical classification of BRCA2 single nucleotide variants.

10511 Background: Germline BRCA2 loss-of function (LOF) variants identified by clinical genetic testing predispose to breast, ovarian, prostate and pancreatic cancer. However, variants of uncertain significance (VUS) (n > 4000) limit the clinical use of testing results. Thus, there is an urgent need for functional characterization and clinical classification of all BRCA2 variants. Here we report on comprehensive saturation genome editing (SGE)-based functional characterization of 97% of all possible single nucleotide variants (SNVs) in the BRCA2 DNA Binding Domain hotspot encoded by exons 15 to 26 for pathogenic missense variants. Methods: SGE of exons 15 to 26 of BRCA2(MANE transcript ENST00000380152.8) was performed in the haploid human HAP1 cell line. Each exon along with 10bp flanking intronic sequence was studied as an independent target region. The most efficient sgRNA for each target region was selected and cloned into a Cas9 expressing plasmid. Site-saturation mutagenesis (SSM) libraries for each of the 14 target regions were designed to target every nucleotide and were generated by site directed mutagenesis using NNN-tailed PCR primers. HAP1 cells were transfected and harvested at Day5 and 14. Cell survival in response to each variant was assessed based on deep sequence analysis of the surviving endogenously targeted HAP1 cells at Day 5 and Day 14. Results: A total of 7013 SNVs were characterized as functionally abnormal (n = 955), intermediate/uncertain, or functionally normal (n = 5224) based on 95% precision for ClinVar known pathogenic and benign standards. Results were validated relative to batches of nonsense and synonymous variants and variants evaluated using a homology directed repair (HDR) functional assay. Breast cancer case-control association studies showed that pooled SNVs encoding functionally abnormal missense variants were associated with increased risk of breast cancer (odds ratio (OR) 3.89, 95%CI: 2.77-5.51). The functional data were added to other sources of information in a ClinGen/ACMG/AMP-like model and 700 functionally abnormal SNVs, including 220 missense SNVs, were classified as pathogenic or likely pathogenic, while 4862 functionally normal SNVs, including 3084 missense SNVs, were classified as benign or likely benign. Conclusions: The production of functional maps for 97% of all SNVs in the BRCA2 DBD allowed for separation of nucleotide/protein-level functional aberrations. When coupled with genetic and clinical sources of evidence this study led to clinical classification of 5500 individual variants. These data will prove useful in the future, through integration with other datasets, for characterization and clinical classification of all variants in this region in individuals from all racial and ethnic backgrounds and for all BRCA2 associated forms of cancer.