The Electrophoresis series on Fundamentals has run for ten years, so this issue marks an important anniversary. Ten years ago we wondered whether a Fundamentals issue should be established; but it has since become a success story: it is among the most cited issues of Electrophoresis. Among scientists, it is the theoreticians who contribute most to Fundamentals, with the result that this special issue has established itself as a common platform where theoreticians can meet and share their results and knowledge. In almost all the papers in the Fundamentals series, you will find many formulae and mathematical equations. The beauty of mathematics when applied to physical and chemical problems lies in its ability to formulate models from first principles. The problem, of course, is the solution of the mathematical models, either analytically or numerically. If the mathematical model is correct, it explains the observed phenomena, and also predicts as yet unknown phenomena. And if the experimental results are not in accordance with the prediction of the model, either the mathematical model is incorrect (which, of course, is the less favorable case), or it is incomplete and additional principles should be considered. What will you find in this issue? The first paper is a review on high-voltage power supplies to capillary andmicrochip electrophoresis. The subsequent series of three papers in the section “Electromigration in microchip channels” analyzes various aspects of chip electrophoresis, especially the phenomena connected with electroosmosis. In spite of my long engagement with electromigration, I am still fascinated by the fact that it is a thin diffusion layer (only a few nanometers thick) at the boundary between solid and liquid phases that is responsible for such macroscopic phenomena as the electroosmotic flow. Computer simulation can still reveal various aspects of electromigration. The papers from my group describe the approximate nonlinear mathematical model of electromigration and a new version of PeakMaster software, which can now predict the shape of system zones. The new PeakMaster 5.3 remains free and publicly available. The following three papers deal with an important physicochemical interaction often used in electrophoresis: the ability of analytes to form weak complexes with other constituents of the background electrolyte. This is utilized, for example, by affinity electrophoresis or in chiral electrophoretic separations. My group interacted with the Thormann group to formulate the dynamical mathematical model of electromigration coupled with complexforming equilibria. The result was two independent simulation programs, the extended Gentrans and Simul 5 Complex, capable of explaining the phenomena observed in such systems. All five papers in the section “Theory of electromigration” deal in various ways with the most important quantity in electrophoresis – mobility. Mobility indeed deserves such attention, as it is the key parameter responsible for the discrimination of analytes during separation. Of all the papers in this section, the paper by Wernersson is worth a special mention as it utilizes molecular modeling for the prediction of electrophoretic mobility. Also the paper by Phillies is innovative and brings up an original idea of “an inversion on perspective: instead of treating the migrating species as the objects of experimental importance and the support medium as being of importance only because it facilitates separations, one treats the polymer solution as being of experimental importance, and the choice of migrating species as being of interest only because different species may probe different aspects of polymer dynamics. The last section, “New approaches in electromigration”, offers seven methodological papers on various aspects of electrophoresis. I would like to express great thanks to all the authors who contributed to this issue, as well as to the referees for their careful work. The series of Special Issues of Electrophoresis on Fundamentals will continue next year and hopefully will remain a great source of fundamental knowledge in this field.