Established Patterns Research Articles

Natural Pattern of Cognitive Aging.

Considering the world's rapidly increasing life expectancy, with people working and maintaining active lifestyles longer than ever before, addressing the effects of aging on cognition is of utmost importance. A greater understanding of cognitive aging may also be critical in distinguishing natural cognitive aging from pre-clinical stages of Alzheimer's disease and related cognitive disorders. To systematically examine the association between aging and cognitive performance in a cognitively and otherwise healthy probability population-based sample using a computer-based method. This cross-sectional study enrolled 673 cognitively and otherwise healthy participants aged 25-89 years (mean age 52.3±14.2 years, 52.5% of whom were female) from the Kardiovize study cohort. Mild cognitive impairment and dementia cases were excluded, followed by measurement of cognitive performance with the computer-administered Cogstate Brief Battery. We used ANCOVA and Modified Signed-Likelihood Ratio tests to examine patterns of cognition across age groups. We found a gradual decrease in cognitive performance across the lifespan, which required two decades to demonstrate significant changes. In contrast to attention and learning, psychomotor speed and working memory showed the most significant age-related decrease and variability in performance. The established pattern of cognitive aging was not altered by sex or education. These findings corroborate, validate, and extend the current understanding of natural cognitive aging and pinpoint specific cognitive domains with the most extensive age-related interindividual differences. This will contribute to the development of strategies to preserve cognition with aging and may also serve to improve early diagnostics of cognitive disorders using computer-based methods.

History-dependent phase transition character

We consider history-dependent behavior in domain-type configurations in orientational order that are formed in configurations reached via continuous symmetry-breaking phase transitions. In equilibrium, these systems exhibit in absence of impurities a spatially homogeneous order. We focus on cases where domains are formed via (i) Kibble-Zurek mechanism in fast enough quenches or by (ii) Kibble mechanism in strongly supercooled phases. In both cases, domains could be arrested due to pinned topological defects that are formed at domain walls. In systems exhibiting polar or quadrupolar order, point and line defects (disclinations) dominate, respectively. In particular, the disclinations could form complex entangled structures and are more efficient in stabilizing domains. Domain patterns formed by fast quenches could be arrested by impurities imposing a strong enough random-field type disorder, as suggested by the Imry-Ma theorem. On the other hand, domains formed in supercooled systems could be also formed if large enough energy barriers arresting domains are established due to large enough systems’ stiffness. The resulting effective interactions in established domain-type patterns could be described by random matrices. The resulting eigenvectors reveal expected structural excitations formed in such structures. The most important role is commonly played by the random matrix largest eigenvector. Qualitatively different behavior is expected if this eigenvector exhibits a localized or extended character. In the former case, one expects a gradual, non-critical-type transition into a glass-type structure. However, in the latter case, a critical-like phase behavior could be observed.Graphical abstract

Possible substance use disorders among first responders during the COVID-19 era: a quasi-experimental study of personal and residential vulnerability

ABSTRACT Background: During the COVID-19 pandemic possible substance use disorders (SUD) were exacerbated from increased stress and isolation. Experiences of symptomology differ widely by occupations. Objectives: The objectives were to determine if there is a temporal relationship between COVID-19 vulnerability and possible SUDs among first responders, and to examine the association with neighborhood vulnerability. Methods:We conducted an analysis with two distinct cohorts dependent on time of entry: 1) First responders that began counseling prior to COVID-19 and 2) First responders that began counseling after the start of COVID-19. Data were collected at intake from first responders seeking mental health services between 2017 and 2021 at an organization in Dallas/Fort Worth, Texas. The study sample included 195 mostly male (75%) first responders (51% law enforcement officers; 49% emergency medical technicians/firefighters). Bivariate models tested unadjusted relationships between covariates and possible SUD. Adjusted models consisted of a two-level multivariable logistic regression models. Results:Nearly 40% (n = 77) screened positive for a possible SUD. Those beginning counseling after COVID-19 did not have higher odds of SUDs. For every unit increase in neighborhood Severe COVID-19 Health Risk Index at a first responder’s residential location there was an increase in the odds of a possible SUD (AOR = 3.14, 95% CI: 1.47, 6.75). Conclusions:Our study highlights the degree to which personal and residential vulnerability to COVID-19 impacted first responders. The increased occupational stress of this population, and an established pattern of maladaptive coping, elucidates the need for preventative and clinical approaches to strengthen the resilience of this population.

Socio-economic and behavioral «portrait» of patients with myocardial infarction

Aim. To identify the specifics of socioeconomic status and behavioral patterns in patients with myocardial infarction (MI) compared with the data of regional epidemiological study participants.Material and methods. The study included participants aged 35–70 years permanently residing in the Kemerovo city or Kemerovo region. The study group consisted of patients with MI (n = 60), and the comparison group consisted of clinical and epidemiological study participants (the study was conducted by the Research Institute for Complex Issues of Cardiovascular Diseases in 2015–2020 (n = 752). After matching, the study group included 28 patients; the comparison group included 428 participants. The data were collected using a questionnaire to identify the characteristics that determine the socioeconomic and behavioral «portrait» of the participants, their health status. Food Frequency Questionnaire was used to assess how often each food item was consumed over a specified period of time. International Questionnaire on Physical Activity was used to measure health-related physical activity of the subjects.Results. All participants (with MI and from the epidemiological study) display negative behavior patterns that greatly increase the risk of experiencing cardiovascular events. However, patients with MI had a higher incidence of type 2 diabetes mellitus in the medical history (p = 0.044), prior MI, peripheral arterial disease (p = 0.001); obesity was noted less frequently (p = 0.014). Patients with MI were more likely to be prescribed antihypertensive drugs (p = 0.001), at the time of the survey they were more likely to be active (p = 0.017) and passive (p = 0.001) smokers. Alcohol consumption at the time of the survey was noted more frequently in patients with MI (p = 0.040), while the majority of respondents from the general population did not consume alcohol (p = 0.038). Patients with MI were less likely to display low physical activity at work 7 days prior to hospitalization (p = 0.001). Simultaneously, patients with MI were less likely to consume cooked and seasonal vegetables, seasonal fruits (p = 0.001). Moreover, patients with MI were more likely to incorporate fatty (p = 0.003) and low-fat dairy products (p = 0.001), lean (p = 0.013) and fatty meat (p = 0.036) in their diet.Conclusion. The established patterns of behavior in patients with MI and in the general population of the Kemerovo region do not differ significantly. A large number of people residing in Russia routinely makes unhealthy lifestyle choices, however, several «pro-atherogenic» characteristics can be identified in patients with MI.

Peculiarities of suction, extraction and assignment of calcium in experimental chronic hepatitis in rats

The aim. Study the degree of absorption, assimilation, and excretion of calcium in rats with chronic toxic hepatitis.
 Materials and methods. The studies were carried out on 1 month old Wistar rats. Toxic hepatitis in the experimental group was reproduced by intraperitoneal injection of hydrazine sulfate at a dose of 50 mg / kg twice a week. Studies of the absorption of substances in rats were carried out under thiopental anesthesia according to the Tyri method after 3 months of pathology modelling. In the intestinal contents, the amount of unabsorbed calcium and amino acids was determined. To determine the amount of assimilated and excreted calcium metabolic chambers were used for daily collection of urine, faeces and food residues, in which the calcium content was determined (average for three days per animal). After removing the rats from the experiment, the level of calcium in the blood serum was determined, in the bone tissue – the degree of its resorption by the activity of acid phosphatase and the content of calcium.
 Results and discussion. Toxic hepatitis reduced calcium absorption by 34.5 % in the small intestine of rats and did not have a significant effect on amino acids, the inhibition of absorption of which in hepatitis was only 5.5 %. The excretion of calcium in the urine of rats with toxic hepatitis was reduced by 1.8 times, and with faeces, on the contrary, increased by 1.5 times. As a result, calcium absorption in rats with hepatitis decreased by 24.2 %. Decreased absorption of calcium, and its increased excretion in the faeces, led to a decrease in the level of this element in the blood of animals with hepatitis by 14.7 %. Our studies found bone destruction in rats with hepatitis: an increase in bone acid phosphatase activity by 65.3 % and a decrease in calcium levels by 15.5 %.
 Conclusion. The triggering mechanism for the development of hepatic osteodystrophy is the inhibition of calcium absorption in the small intestine of rats with hepatitis, consequently - a decrease in its absorption and level in the blood, which ultimately leads to the activation of bone resorption. The established patterns will form the basis of the pathogenetic scheme for the prevention of hepatic osteodystrophy

Maternal Dietary Patterns during Pregnancy and Child Autism-Related Traits: Results from Two US Cohorts

We examined the relationship between maternal intake of established dietary patterns and child autism-related outcomes in two prospective cohorts in the United States. Participants were drawn from the Early Autism Risk Longitudinal Investigation (EARLI, n = 154) and the Nurses’ Health Study II (NHSII, n = 727). Dietary information was collected via food frequency questionnaires (FFQs) and used to calculate the empirical dietary inflammatory pattern (EDIP), Alternative Healthy Eating Index (AHEI), Western and Prudent dietary patterns, and the alternative Mediterranean Diet (aMED) score. Primary analyses examined associations with continuous autism-related traits as measured by the Social Responsiveness Scale (SRS), and secondary analyses with autism spectrum disorder (ASD) diagnosis. We used crude and multivariable quantile regression fixed at the 50th percentile to examine associations between quartiles of dietary patterns and SRS scores, and logistic regression to examine associations with ASD diagnosis. There was suggestion of a positive association with the Western diet (Q4 vs. Q1, ß = 11.19, 95% CI: 3.30, 19.90) in EARLI, though the association was attenuated with adjustment for total energy intake, and no clear associations were observed with other dietary patterns and ASD diagnosis or SRS scores. Further work is needed to better understand the role of maternal dietary patterns in ASD and related outcomes.

Закономірності зміни оптимальних складу і параметрів силових установок з прямоточними контурами від швидкості надзвукового крейсерського польоту

There are two aircraft concepts for transoceanic flights at supersonic speed. The first is the aircraft with moderate supersonic cruising speed M = 1.7...2.2, and the second is the aircraft with cruising speed M ≥ 3. Propulsion with a ramjet engine (ramjet) is preferable for high supersonic speeds. However, a ramjet has no starting thrust and is uneconomical at subsonic flight speeds. Combined propulsion with a turbojet duct for takeoff and a ramjet duct for supersonic cruise flight are used to overcome this contradiction. There are known propulsion with turboramjet engines, as well as various propulsion schemes with turbofan engines (afterburning and duct-burning ones), in which the outer contour together with the afterburner and nozzle can be considered the ramjet duct. When the turbojet duct is turned off, the operating process of such turbofan engines is practically the same as the ramjet, which allows using the advantages of a ramjet in supersonic cruise flight. Because flight at supersonic cruising speed can be provided by different propulsion compositions, the choosing problem of the composition and parameters of the propulsion for an aircraft with supersonic cruising speed is relevant. A calculation-analytical method was used to select the composition and parameters of the propulsion, which is based on the maximum relative mass of the payload criterion. Using the aircraft mass balance equation this criterion can be represented as a minimum conditions for the relative mass of the fuel and propulsion. Using this method, for an aircraft with a given mass, aerodynamic characteristics and a given flight profile, for the indicated propulsion compositions, the change patterns of the minimum relative mass of fuel and propulsion in the range of M = 2.5...4 are established. The established patterns allow choosing the propulsion composition and parameters depending on the speed of the supersonic cruising flight or choosing the flight speed of the aircraft at a given propulsion composition. The dependance of the propulsion working process optimal parameters for takeoff and cruising mode on the speed of supersonic cruising flight according to the criterion minimum of relative mass of fuel and propulsion were obtained.

The economic geography of European Union’s discontent: Lessons from Greece

The regions of the European Union are currently experiencing a period of seismic change that has transformed their established voting patterns and increased anti–European Union voting. Applying objective economic measures, spatial econometrics and municipal voting data from recent elections and a referendum, this study examines the factors shaping anti–European Union votes in Greece. The results indicate a strong link between the country’s changing economic geography and the geography of the anti–European Union vote, providing evidence not only of the ‘geography of discontent’ and the ‘left-behind hypothesis’ but also of the ‘geography of austerity’ associated with the heterogeneous effects of fiscal consolidation and austerity policies.

Personality and Alcohol Use across College: Examining Context-Dependent Pathways toward Alcohol Problems

Background College life is characterized by marked increases in alcohol consumption. Extraversion and neuroticism are associated with alcohol use problems in college and throughout adulthood, each with alcohol use patterns consistent with an externalizing and internalizing pathway respectively. Students higher in extraversion drink more frequently and consume more alcohol, while neuroticism is paradoxically not consistently associated with elevated alcohol use. Objective This study examined whether students higher in neuroticism may drink the day before stressors, namely tests and assignment deadlines. Method Multilevel generalized linear models were performed using data from a longitudinal study of first-time, first-year undergraduates assessing alcohol use across four years of college, with daily diary bursts each semester. Results Students higher in extraversion had heavier alcohol use and greater alcohol use problems in their fourth year of college. Neuroticism was not associated with drinking behaviors or with drinking before a test or assignment, but was associated with greater fourth year alcohol problems. Students lower in extraversion who reduced heavy drinking the day before academic events had fewer alcohol use problems at the fourth year of college relative to students higher in extraversion. Conclusions Students higher in extraversion appear to exhibit a continuity of established alcohol use patterns from adolescence, predisposing them to a more hazardous trajectory of college alcohol use. Characteristics of low extraversion may afford some protection from alcohol-positive college culture. High neuroticism appears associated with a hazardous trajectory of college alcohol use, but continued research into situational factors of alcohol use in high neuroticism is warranted.

The Darwinian shortfall in plants: phylogenetic knowledge is driven by range size

The Darwinian shortfall, i.e. the lack of knowledge of phylogenetic relationships, significantly impedes our understanding of evolutionary drivers of global patterns of biodiversity. Spatial bias in the Darwinian shortfall, where phylogenetic knowledge in some regions is more complete than others, could undermine eco‐ and biogeographic inferences. Yet, spatial biases in phylogenetic knowledge for major groups – such as plants – remain poorly understood. Using data for 337 023 species (99.7%) of seed plants (Spermatophyta), we produced a global map of phylogenetic knowledge based on regional data and tested several potential drivers of the observed spatial variation. Regional phylogenetic knowledge was defined as the proportion of the regional seed plant flora represented in GenBank's nucleotide database with phylogenetically relevant data. We used simultaneous autoregressive models to explain variation in phylogenetic knowledge based on three biodiversity variables (species richness, range size and endemism) and six socioeconomic variables representing funding and accessibility. We compared observed patterns and relationships to established patterns of the Wallacean shortfall (the lack of knowledge of species distributions). We found that the Darwinian shortfall is strongly and significantly related to the macroecological distribution of species' range sizes. Small‐ranged species were significantly less likely to have phylogenetic data, leading to a concentration of the Darwinian shortfall in species‐rich, tropical countries where range sizes are small on average. Socioeconomic factors were less important, with significant but quantitatively small effects of accessibility and funding. In conclusion, reducing the Darwinian shortfall and smoothen its spatial bias will require increased efforts to sequence the world's small‐ranged (endemic) species.

Wastelanding Arabia: America's ‘Garden of Eden’ in Al Kharj, Saudi Arabia

In the late 1930s, the American oil company Aramco helped Saudi Arabia's King Ibn Saud develop his royal farm outside Riyadh. On the king's request, Aramco introduced new technology to tap the Al Kharj region's rich aquifer water and establish vast fields of wheat, alfalfa, and other water-intensive crops. Saudi Arabia's aquifers have since been pumped dry in service of the ‘Garden of Eden’ idyll promised by American advocates, who boasted of their ability to reclaim thousands of acres of ‘desert wasteland.’ This article draws on Traci Voyles' formulation of ‘wastelanding’ to interrogate the agricultural spectacle of Al Kharj in the 1930s–50s. The project was an early exemplar what came to be an established pattern of wastelanding Arabia, built on the unsustainable use of groundwater and social inequalities to create an ‘Eden’ in the desert. Agricultural wastelanding has unique spatial and temporal dimensions that set it apart from other extractive industries, like the uranium mining that Voyles examines in Diné lands. But as this article shows, desert greening projects draw on and produce similar structures of social and environmental violence – with America's ‘Garden of Eden’ in central Arabia being just one case among many of wastelanding across space and time.

Energetics and Water Flux in the Subterranean Rodent Family Bathyergidae

The doubly labeled water (DLW) technique and indirect calorimetry enable measurement of an animal’s daily energy expenditure (DEE, kJ/day), resting metabolic rate (RMR, kJ/d), sustained metabolic scope (SusMS), body fat content (BF, %) as well as water turnover (WTO, ml/day), and water economy index (ml/kJ). Small mammals have been the primary focus of many of the DLW studies to date. From large multi-species analyses of the energetics and water flux of aboveground small mammals, well-defined trends have been observed. These trends mainly refer to an adaptive advantage for lower RMR, DEE, SusMS, WTO and WEI in more ariddwelling animals to increase water and energy savings under low and unpredictable resource availability. The study of the subterranean rodent family Bathyergidae (African mole-rats) has been of particular interest with regards to field metabolic rate and metabolic studies. Although a great deal of research has been conducted on the Bathyergidae, a complete overview and multi-species analysis of the energetics and water flux of this family is lacking. Consequently, we assessed DEE, RMR, SusMS, BF, WTO and WEI across several different species of bathyergids from various climatic regions, and compared these to the established patterns of energetics and water flux for aboveground rodents. There was notable variation across the Bathyergidae inhabiting areas with different aridities, often contrary to the variations observed in above-ground species. These include increased DEE and WEI in arid-dwelling bathyergid species. While the climate was not a clear factor when predicting the SusMS of a bathyergid species, rather the degree of group living was a strong driver of SusMS, with solitary species possessing the highest SusMS compared to the socially living species. We conclude that the constraints of the underground lifestyle and the consequent spectrum of social behaviors possessed by the family Bathyergidae are most likely to be more crucial to their energetics and water flux than their habitat; however other important unstudied factors may still be at play. More so, this study provides evidence that often unreported parameters, measured through use of the DLW technique (such as BF and WEI) can enable species to be identified that might be at particular risk to climate change.

Review: Balkrishna Doshi: Writings on Architecture and Identity and One Continuous Line: Art, Architecture and Urbanism of Aditya Prakash

Review: <i>Balkrishna Doshi: Writings on Architecture and Identity</i> and <i>One Continuous Line: Art, Architecture and Urbanism of Aditya Prakash</i>

THE IMPACT OF BROILER FARMING BUSINESS PARTNERSHIP ON PRODUCTION COST AND INCOME IN METRO CITY

Partnership pattern was the pattern of managing broiler chicken business through cooperation with companies that offered many benefits so that most breeders were encouraged to established partnership patterns. But in the implementation of partnerships not always run in accordance with the agreement because there were some frauds committed by farmers and companies. The risk of frauds made some farmers chose to manage the broiler breed chicken business independently. The difference in implementation between partnership patterns and self-sustaining patterns can have a performance impact on broiler chicken breeders. This study aims to analyze the partnership patterns, analyze the partnership's driving factors and analyze the impact of partnerships on the production and income costs of broiler breed chicken farmers in Metro City. This study was conducted from October 12 to November 30, 2020 located in Metro City. The methods were used in this research were qualitative and quantitative combined methods. The data was collected through a survey by interviewing directly 59 respondents. The result of this research were The pattern of partnerships of broiler breed chicken farmers in Metro City was the plasma core pattern, 2) The driving factors of partnership in broiler chicken breeders were capital availability motivation, market guarantee motivation, price guarantee motivation and high income motivation, 3) Statistically the partnership pattern had an impact on income and labor allocation. The company could improve the services that were felt by farmer tobe lacking, such as the accuracy of providing production facillities and payment of harverts and could provide competitive sell prices to breeders partner.

Fire, grazers, and browsers interact with grass competition to determine tree establishment in an African savanna.

In savanna ecosystems, fire and herbivory alter the competitive relationship between trees and grasses. Mechanistically, grazing herbivores favor trees by removing grass, which reduces tree-grass competition and limits fire. Conversely, browsing herbivores consume trees and limit their recovery from fire. Herbivore feeding decisions are in turn shaped by risk-resource trade-offs that potentially determine the spatial patterns of herbivory. Identifying the dominant mechanistic pathways by which fire and herbivores control tree cover remains challenging, but is essential for understanding savanna dynamics. We used an experiment in the Serengeti ecosystem and a simple simulation driven by experimental results to address two main aims: (1) determine the importance of direct and indirect effects of grass, fire, and herbivory on seedling establishment and (2) establish whether predators determine the spatial pattern of successful seedling establishment via effects on mesoherbivore distribution. We transplanted tree seedlings into plots with a factorial combination of grass and herbivores (present/absent) across a lion-kill-risk gradient in the Serengeti, burning half of the plots near the end of the experiment. Ungrazed grass limited tree seedling survival directly via competition, indirectly via fire, and by slowing seedling growth, which drove higher seedling mortality during fires. These effects restricted seedling establishment to below 18% and, in conjunction with browsing, resulted in seedling establishment dropping below 5%. In the absence of browsing and fire, grazing drove a 7.5-fold increase in seedling establishment. Lion predation risk had no observable impact on herbivore effects on seedling establishment. The severe negative effects of grass on seedling mortality suggests that regional patterns of tree cover and fire may overestimate the role of fire in limiting tree cover, with regular fires representing a proxy for the competitive effects of grass.

Revisiting the guns-butter tradeoff: a wavelet analysis of the US and Britain

ABSTRACT This study applies continuous wavelet analysis to examine defense-education and defense-healthcare relations in the US and Britain. It discovers four empirical patterns that have not been shown in the existing literature. First, the defense-welfare tradeoff rarely occurs at cycles less than 6 years and hence is not a short-run phenomenon. Second, very noticeable bilateral tradeoffs between education and defense can be detected. The effect, however, is more pronounced in the direction from education to defense. Third, the defense-welfare tradeoff is much less likely to occur in defense-healthcare relations than defense-education relations. Fourth, a structural change in the defense-healthcare relationship occurred during the 1960s, after which the defense-healthcare connection became primarily complementary. Together, the established patterns question the assumption that the defense sector has a dominant power in budget allocation. They also raise new theoretical and empirical questions demanding future research efforts.

Translation essay: “the problems of onomatopoeia in manga” two chapter essays from the principles of manga (manga genron) by Yomota Inuhiko

Abstract One of Japan’s most versatile scholars of film, television, and manga (comic books), Yomota Inuhiko (1953–) made a deep impact on Manga Studies, where he engaged in a form of manga analysis commonly called “expression theory” (hyōgen-ron). In the present translated twin essays from Yomota’s now-classic study, The Principles of Manga (Manga Genron, 1994), he demonstrates his awareness of the possibilities of applying a linguistic lens to the study of Japanese comics. In Part One, Yomota explores the idea of onomatopoeia in manga, considering how they are very much cultural constructions that can be difficult to translate into other languages. In Part Two, Yomota delves deeper into the way onomatopoeia appear on the page, often creating impossible-to-utter expressions but ones easily understood nonetheless by readers. While there is already a great deal of research on onomatopoeia mimetics in spoken Japanese, Yomota here expounds on how manga artists have invented new ways of employing onomatopoeia outside of these established patterns in the spoken language. He gives clear examples of the evolution and representation of mimetics in manga, discusses several key features of comic-book mimetics, and makes a clear argument that they have spurred the evolution of modern-day manga.

Identification of alveolar proteins associated with claudin‐18 using BioID

Tight junctions are protein complexes that form at sites of cell contact that function to regulate paracellular flow of small molecules, water, and ions. Distinct protein components contribute to the barrier function of tight junctions including the claudin family of transmembrane proteins and scaffolding proteins such as Zonula Occludens‐1(ZO‐1). Changes in tight junction morphology from the established smooth cobblestone patterning to a spiked junction are associated with an increase in barrier permeability (leak). Tight junction spike formation is associated with changes in claudin‐18 interacting partners, including ZO‐1. This suggests that protein‐claudin‐18 interactions are essential for tight junction morphology and therefore function. Using rat alveolar epithelial cells (rAECs), we used BioID to investigate the proximal claudin‐18 proteome. BioID uses a promiscuous biotinylating enzyme, BirA, which we fused to claudin‐18 to biotinylate proximal and interacting proteins. To determine that BirA‐claudin‐18 localized to tight junctions, rAECs were transduced with adenovirus to express BirA‐claudin‐18 and stained with claudin‐18 and streptavidin‐Cy3. This showed that the assay was functional and our chimera trafficked to tight junctions and colocalized to proximal proteins. To identify biotinylated proteins, we used tandem mass spectrometry (MS/MS) and identified 3771 protein matches within the BirA‐claudin‐18 sample. Proteins of interest were vetted, and a list of protein candidates were compiled based on peptide spectrum matches (PSMs) and known protein localization. Proteins of interest include retinoic acid and palladin, which are of specific interest because they are associated with a spike like structure found in the testis, the tubulobulbar complex, which we hypothesize behaves as a signaling platform in the testis and is comparable to tight junction spikes found in the lung. These findings show that BioID is a valid method for identification of proteins to claudin‐18, providing a discovery‐based approach to identify novel proteins that play a role in barrier function and tight junction regulation.

ANTROPOLOGI EKONOMI : MASYARAKAT MEYBRAT DI KEPALA BURUNG PAPUA BARAT

The purpose of this study is to explain in depth and thorough about the value of kinship and consumptive pattern that gives a clear impact on the pattern of the business establishment of Meybrat people. The sample access is all kinds of Meybrat people’s business. This study used a qualitative analysis of a single case study approach. The results of this study found that (1) the business of Meybrat people is still at the stage of looking for shapes (innovation , triggering) where the personal character (personal values, education, experience, risk taking, internal control) are still weak in shaping the behavior of Meybrat people’s business; (2) business groups (micro, small and medium enterprises) are more successful and grow well on an individual level than on groups; (3) Factors of kinship consumptive pattern systems and communities include: payment of dowry, families and relatives’ education costs which is still a strong influence in shaping the conduct of business of Meybrat people.Keywords: Kinship, Consumer Pattern, Productive Economy

Ambivalence in the stand-up acts of Nigeria’s Klint da Drunk and Mr Paul

In a progressively permissive world, stand-up art is experiencing repressions and censure for its dependence on potentially politically incorrect jokes. Stand-up’s primary purpose is to instigate laughter, but its greatest ambivalence is that its mirth comes primarily from abuse/insult. Through performance analyses of the humor acts of Mr Paul and Klint da Drunk, this paper discusses their use of non-traditional stand-up forms, underscoring how these jokesters balance offence and abuse, and the complexities of being different. Specifically, Mr Paul builds his jokes around non-sequitur meandering narratives riddled with implausible claims, while Klint enacts the stock character of a drunk who depends heavily on heckling, direct insults, and disparaging jokes for the evocation of mirth. Though not using the more established joke-telling patterns, these two still elicit laughter, entertain audiences, and provide politically charged critiques of the harsh and unsavory socio-political conditions in Nigeria, albeit conveyed through the agency of humor.