Scientists and researchers widely recognize the effectiveness of artificial intelligence (AI)-based machine learning and intelligent computing solvers, demonstrating qualities such as resilience, robustness, stability, and rapid convergence. One particularly significant and rapidly growing field within AI is artificial neural networks. This research uses a supervised neural network model based on Levenberg–Marquardt backpropagation (LMB-SNNs) to examine the Sisko fluid model for the forward roll coating process (SFM-FRCP). A suitable transformation is applied to the partial differential equations based SFM-FRCP mathematical model, resulting in a set of nonlinear ordinary differential equations. The perturbation method has been used to find the analytical solutions for the velocity profile, pressure gradient, and pressure profile. A dataset for varying the pertinent parameters is generated, and the LMB-SNNs technique has been used to estimate the velocity profile, pressure gradient, and pressure profile behavior during FRCP for numerous scenarios. The numerical solution for SFM-FRCP in different scenarios, such as the validation, training, and testing procedures of LMB-SNNs, is carried out. Moreover, the state transition index, fitness outline, mean square error, histogram error, and regression presentation also endorse the strength and reliability of the solver LMB-SNNs for SFM-FRCP. The comparative analyses and performance studies through outputs of regression drawings, absolute error, and error histograms validate the effectiveness of the suggested solver LMB-SNNs. The method's precision is verified by the closest numerical outputs of both built and dataset values with similar levels 10−11–10−14. Furthermore, it has been observed that as the non-Newtonian parameter increases, the fluid velocity decreases. The research work carried out in this paper is original and fills a gap in the existing research by showing the rheological properties of the Sisko fluid model and the implementation of the LMB-SNNs during the FRCP.