Based on the first-order shear deformation shell theory, the free vibration model of Multilayer Damping Sandwich Composite Open Cylindrical Shell (MDSCOCS) under different lay-up angles is established. The Navier double series and Rayleigh-Ritz method are used to solve the free vibration equation under four sided simply supported boundary conditions. The theoretical solutions are compared with the existing literature and finite element simulation results respectively to verify the validity of theoretical calculation model. The influences of the thickness, position, shell opening angle, composite lay-up angle and other factors on the natural frequency and loss factor of the structure under different number of core layers are investigated in detail. The analysis shows that the damping loss factor of the composite structure is greatly improved by the addition of multilayer damping sandwich, and the dynamic performance of the composite structure is optimized, compared with that of single-layer damping sandwich composite structure. It provides a theoretical basis for the design of multilayer damping sandwich composite open cylindrical shell.