Since the so-called phase one of the Coronavirus pandemic, media professionals have shown great attention to communication about the epidemic, so much so that a “glottology of COVID-19” has even been advocated to reflect on war metaphors referring to the disease. Despite media solicitations, however, reflection on communication at the time of COVID was not immediately the subject of linguistic analysis, at least in the Italian context. However, the issue of the relationship between language and culture, society, and thought has recently been explored in the face of the limitation of only formal analyses on language at the time of COVID. In the first stage, it quickly became apparent that the people in charge of institutional communication were used to talking mostly with experts on public health problems or research results, without the necessary training to modulate their language according to the degree of specialization of the audience. Instead, it is currently possible to detect an improvement in communication skills, and to observe the emergence of opposing factions with respect to the new resources of both preventive and therapeutic medicine, respectively the pro-vax and no-vax movements. These issues have been the focus of many Italian TV talk shows, such as the program “Non è l'Arena.” In the episode of 9/25/21, which is the subject of this article, the positions expressed in favor of one argument or the other would seem to adopt different mechanisms for managing the epistemic mode of certainty/uncertainty, such as semantic-syntactic and rhetorical-pragmatic devices, as well as conversational moves. This paper is aimed at describing the management of certainty/uncertainty in a media context through the qualitative fine-grained analysis of the interactional exchanges between host and representatives of opposite views in the dual theoretical framework of classical rhetoric and conversational analysis (CA), which, although starting from different scientific paths, share the vision of the centrality of speech in human action. The CA analysis indicated that, whilst the interviewer maintained a neutral stance in conducting the interview, he showed a position of affiliation toward the doctor who recommended therapies not in line with the Italian medical guidelines. This was evident through the space provided to him to explain his expertise, as well as through the repetition and emphasis of the evaluative elements expressed. The rhetorical analysis, focusing on the participants' ethos, reveals that the interviewer deliberately intervened in the construction of the epistemic authority of the representatives of the two positions. The rhetorical analysis, focusing on the ethos of the three participants in the interaction, shed light on selected strategies and argumentative chains used to gain credibility and to prevail in the discussion. The linguistic-rhetorical mechanisms used do not pertain to the field of dialectical discussion and aim at a direct attack on the opponent's thesis. Nevertheless, the clash remained balanced without any epistemic authority overpowering the other: both the rhetorical and conversation analyses demonstrate a polarized dialogue, wherein the two sides are portrayed as representatives of two distinct and incompatible perspectives.