Adrenalin Chloride Research Articles

The relation of the vagus to auricular paroxysmal tachycardia.

A female, age 23, suffering from mitral stenosis and insufficiency of rheumatic etiology, predisposed to spontaneous attacks of auricular paroxysmal tachycardia lasting five to six hours, was observed during two of these spontaneous paroxysms. The injection of adrenalin chloride (1:1000) in a dose of 1 cc. and repeated again in 15 minutes, never failed, whenever she was not previously subjected to the influence of other drugs, to induce a paroxysm of tachycardia, following approximately 15 minutes after the second injection of adrenalin. These induced attacks of tachycardia were indistinguishable from the spontaneous paroxysms in symptoms, rate, duration and electrocardiography. The inference, therefore, is justifiable that the focus or area of origin of the tachycardias must have been identical in both spontaneous and induced paroxysms. This was repeated four times, and in all the result was the same. When four milligrams of atropin (a vagal paralyzing dose) were administered hypodermically before the exhibition of the adrenalin, a paroxysm of tachycardia failed to appear. This procedure was performed twice. Atropin, therefore, is not a drug which will induce a paroxysm of auricular tachycardia. It seems that the presence of the reflex vagal stimulation induced by adrenalin was a necessary factor in the induction of the paroxysms, and since spontaneous and induced attacks were alike in every respect, it suggests the vagus as a factor in the induction of the spontaneous paroxysms. These findings are in harmony with those of Lewis and in opposition to those of Galli and others on the subject, to wit “that tachycardia1 attacks can be provoked in man by atropin, and that withdrawal of vagal influence predisposes to paroxysms of tachycardia.”

COLLEGE OF PHYSICIANS OF PHILADELPHIA, SECTION ON OTOLOGY AND LARYNGOLOGY: Nov. 18, 1925

SOMEPHARMACOLOGICALPROBLEMS OFLARYNGOLOGY. Presented byDR.HORATIOC.WOOD,JR. (by invitation). Dr. Wood called attention to the new grouping of silver compounds in the revised pharmacopeia. Those relatively low in silver content, about 8 per cent., of low specific gravity, and lighter in color being classified in the first group termed argentum proteinum fortus. The second group, argentum proteinum mite, includes the thick, viscid preparations containing approximately 20 per cent. of silver. The protein silver combinations probably owe their germicidal superiority to a slow but continuous liberation of ionic silver. Various local anesthetics were considered, and the two groups of toxic phenomena discussed, that is, convulsions and syncope. In the treatment of syncope following the administration of a local anesthetic, Dr. Wood considered epinephrin chlorid intravenously and artificial respiration to be of great importance and value. Pituitary products, too, are efficacious. Attention was called to the fact

STUDIES ON THE RABBIT'S HEART

Clinical studies on the changes in the size of the heart are frequently difficult to control. A patient with cardiac decompensation lends himself poorly to the manipulation necessary for roentgen-ray studies, and furthermore, fluid in the chest frequently renders accurate measurements of the heart difficult. There are, therefore, few exact studies on the changes in the size of the decompensated heart that may occur in response to treatment; neither has the experimental study of this problem been sufficiently investigated. It is generally recognized, following the work of Fleischer and Loeb1and Walker,2that a chronic myocarditis can be produced in rabbits by the repeated injection of spartein sulphate and epinephrin chlorid. Fraser3further showed that a permanent enlargement followed repeated injections of these drugs. It occurred to us that this offered a means of studying the effect of various measures on the damaged heart, and the study of the effect

RESUSCITATION BY INTRACARDIAC INJECTION OF EPINEPHRIN CHLORID

Intracardiac injection of heart stimulants in acute cardiac failure had been tried many times without promising results until Dennis Crile 1 of Chicago reported the use of massive doses of epinephrin chlorid. He introduced this both by direct puncture into the ventricle and by the intravenous route, showing beneficial results in all five cases reported, with recovery in two of them. Bodon 2 has since reported ninety cases from the literature with permanent results in twentyfour, including one case of his own. In this series, a variety of stimulants were used, with no special emphasis on any single one. In Bodon's case, a patient with syphilitic coronary arteritis with acute cardiac failure, he used 1 c.c. of a 1: 1,000 epinephrin chlorid solution as a last resort after cessation of heart and respiration. A few seconds after this had been given by direct puncture into the ventricle, the heart began

AN UNEXPECTED EPINEPHRIN REACTION FOLLOWING INFILTRATION WITH PROCAIN-EPINEPHRIN SOLUTION AS A LOCAL ANESTHETIC

M. S., a woman, aged 31, was admitted to the Piedmont Sanatorium, Feb. 1, 1923, with a diagnosis of tumor of the cerebellum. Her symptoms had begun one year before, and consisted principally of dimness of vision, headaches, vomiting, and staggering gait. The general examination was negative for hyperthyroidism. The blood pressure was systolic, 100; diastolic, 70; the pulse was 80; hemoglobin, 70 per cent. The neurologic examination disclosed bilateral choking of the optic disks, a markedly staggering gait with tendency to lean to the right, and asynergia of the right arm and right leg. February 7, the patient was prepared for operation. The field of operation was infiltrated with 5 ounces of 1 per cent. procain solution, each ounce of the solution containing 7 minims of epinephrin chlorid solution (1:1,000). Before the infiltration was begun the systolic blood pressure was 102 mm. of mercury; the pulse, 80. At the

Hepatic Reactions in Anaphylaxis

Summary Simons' theory as to the nature of the fundamental reaction in canine anaphylaxis was tested by perfusion methods with isolated tissues. Distinct vaso-constriction can be demonstrated in the canine lungs by perfusion with a mixture of barium chloride and adrenalin chloride, and marked vaso-constriction by perfusion with ergotin or with Vaughan's protein split-product. No veno-constriction can be demonstrated in canine livers however by perfusion with any of these agents. Simons' hepatic veno-constrictor theory, therefore, does not appear to represent a physiologic possibility.

Urine acidity after the injection of adrenalin chloride

The following experiment was planned to study the effect of adrenalin chloride upon the acidity of the urine, and to determine, if possible, whether the “acidosis” which has been described as one of the results of such injections was due to the respiratory changes which follow the administration of the drug. A normal man (the author) who weighed 165 pounds took a standard simple breakfast on each of four successive days. On each day hourly samples of urine were collected throughout the morning. The collection and determination of the degree of acidity was carried out by the method of Marshall; other determinations were done as described in previous papers. On the second day of the experiment 1 c.c. of a 1 to 1000 solution of adrenalin chloride (Parke-Davis) was injected subcutaneously into the arm. Samples of blood were collected from the median basilic vein one half hour before and one half, one, and two hours after the injection was given. The results are given in the tables. Table 1 shows that the subject developed the decrease in the carbon dioxide combining capacity of the plasma described by Peters and Geyelin, and Hubbard and Wright (loc. cit.) as well as a rise in blood sugar. The determinations of the alveolar carbon dioxide tension were not very satisfactory, but they showed a decrease which roughly paralleled the changes in the carbon dioxide combining capacity of the plasma. Table 2 shows the determination made on the urine on the day when adrenalin was given contrasted with similar determinations on the three control days. The acidity of the urine alone showed any change, and that change was slight. The reaction of the specimen collected from eleven to twelve o'clock after the adrenalin was given showed a more marked increase in acidity (1.2 PH) over the specimen collected during the preceeding hour than did similar specimens on the control days.

The Effect of the Subcutaneous Injection of Adrenalin Chloride on the Heat Production, Blood-pressure and Pulse-rate in Man

The Effect of the Subcutaneous Injection of Adrenalin Chloride on the Heat Production, Blood-pressure and Pulse-rate in Man

A Severe Case of Post-Partum Hæmorrhage in a Cow Successfully Treated by Adrenalin Chloride

A Severe Case of Post-Partum Hæmorrhage in a Cow Successfully Treated by Adrenalin Chloride

Erratum to "A Note On the Use of Adrenalin Chloride in Prolapse of the Uterus in a Mare"

Erratum to "A Note On the Use of Adrenalin Chloride in Prolapse of the Uterus in a Mare"

The influence of the salts of calcium and potassium on the degree of hypertrophy produced by adrenalin injections in rabbits

A series of experiments was conducted with a view to determine whether the antagonism between calcium and adrenalin, as recently described by Meltzer and Auer, Schrank and others, holds good also as regards the hypertrophy of the heart which adrenalin produces when injected intravenously into rabbits. The method of investigation was as follows: One lot of rabbits was given every second day 0.2 c.c. of adrenalin chloride (1 in 1,000) in 2 c.c. of physiological salt solution. Throughout the whole series, twenty-four injections were given. A second lot received the same amount of adrenalin in 2 c.c. of a 10 per cent, solution of calcium chloride for the same length of time. Still a third lot was given 0.2 c.c. of adrenalin (1 in 1,000) in 2 c.c. of physiological salt solution every second day for twenty-four injections. The animals of this lot, however, were kept on a diet of carrots and potatoes only, the object being to give a diet containing a minimal amount of calcium. A fourth lot received the same amount of adrenalin in 2 c.c. of a 2 per cent. solution of potassium chloride. II. That on a diet poor in calcium, the degree of hypertrophy is insignificant. From this it would seem that a certain percentage of calcium in the tissues is necessary in order that injections of adrenalin will produce hypertrophy.

The effects of intraperitoneal injections of adrenalin on the partition of nitrogen in the urine of dogs

Underhill and Closson have shown that the subcutaneous injection of adrenalin chlorid solutions into dogs is not attended by any significant change in the proportion of the urea, ammonia and creatinin nitrogen of the urine.In our work we used two specimens of the colorless adrenalin chloride, 1:1000, of Parke, Davis and Co. They were purchased in the open market. Each was tested for its pressor action at the conclusion of the corresponding injection experiments and was then found to be practically as active as ever.The metabolism experiments were carried out by the methods in use in this laboratory.Intraperitoneal injection of adrenalin chloride solutions was without effect on the proportions of nitrogen in the forms of urea, ammonia, creatin and creatinin, purins and allantoin.In one adrenalin injection period of eighteen days, a total of 62 C.C. of a I :10,000 adrenalin solution was given intraperitoneally and in another injection period of six days a total of 29 C.C. of a I :1OOO adrenalin chloride sol...

The effect of instilling adrenalin chloride into the mammalian eye

The effect of instilling adrenalin chloride into the mammalian eye

Oedematous swelling in acute septic inflammations of the neck and throat, dispersed by adrenalin chloride

Oedematous swelling in acute septic inflammations of the neck and throat, dispersed by adrenalin chloride

“Some experiences with adrenalin chloride”

“Some experiences with adrenalin chloride”

A Case of Haemophilia Treated with Adrenalin Chloride

A Case of Haemophilia Treated with Adrenalin Chloride

The histological changes produced by the injection of adrenalin chloride

The Journal of PhysiologyVolume 31, Issue 2 p. 81-91 ArticleFree Access The histological changes produced by the injection of adrenalin chloride W. B. Drummond, W. B. DrummondSearch for more papers by this author W. B. Drummond, W. B. DrummondSearch for more papers by this author First published: 03 May 1904 https://doi.org/10.1113/jphysiol.1904.sp001024Citations: 6AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume31, Issue2May 3, 1904Pages 81-91 RelatedInformation