Abstract
Clinical studies on the changes in the size of the heart are frequently difficult to control. A patient with cardiac decompensation lends himself poorly to the manipulation necessary for roentgen-ray studies, and furthermore, fluid in the chest frequently renders accurate measurements of the heart difficult. There are, therefore, few exact studies on the changes in the size of the decompensated heart that may occur in response to treatment; neither has the experimental study of this problem been sufficiently investigated. It is generally recognized, following the work of Fleischer and Loeb1and Walker,2that a chronic myocarditis can be produced in rabbits by the repeated injection of spartein sulphate and epinephrin chlorid. Fraser3further showed that a permanent enlargement followed repeated injections of these drugs. It occurred to us that this offered a means of studying the effect of various measures on the damaged heart, and the study of the effect
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