Epilepsy Detection Research Articles

Epilepsy detection based on multi-head self-attention mechanism.

CNN has demonstrated remarkable performance in EEG signal detection, yet it still faces limitations in terms of global perception. Additionally, due to individual differences in EEG signals, the generalization ability of epilepsy detection models is week. To address this issue, this paper presents a cross-patient epilepsy detection method utilizing a multi-head self-attention mechanism. This method first utilizes Short-Time Fourier Transform (STFT) to transform the original EEG signals into time-frequency features, then models local information using Convolutional Neural Network (CNN), subsequently captures global dependency relationships between features using the multi-head self-attention mechanism of Transformer, and finally performs epilepsy detection using these features. Meanwhile, this model employs a light multi-head attention mechanism module with an alternating structure, which can comprehensively extract multi-scale features while significantly reducing computational costs. Experimental results on the CHB-MIT dataset show that the proposed model achieves accuracy, sensitivity, specificity, F1 score, and AUC of 92.89%, 96.17%, 92.99%, 94.41%, and 96.77%, respectively. Compared to the existing methods, the method proposed in this paper obtains better performance along with better generalization.

Retraction Note: Automatic epilepsy detection using hybrid decomposition with multi class support vector method

Retraction Note: Automatic epilepsy detection using hybrid decomposition with multi class support vector method

Automatic detection of epilepsy from EEGs using a temporal convolutional network with a self-attention layer

BackgroundOver 60% of epilepsy patients globally are children, whose early diagnosis and treatment are critical for their development and can substantially reduce the disease’s burden on both families and society. Numerous algorithms for automated epilepsy detection from EEGs have been proposed. Yet, the occurrence of epileptic seizures during an EEG exam cannot always be guaranteed in clinical practice. Models that exclusively use seizure EEGs for detection risk artificially enhanced performance metrics. Therefore, there is a pressing need for a universally applicable model that can perform automatic epilepsy detection in a variety of complex real-world scenarios.MethodTo address this problem, we have devised a novel technique employing a temporal convolutional neural network with self-attention (TCN-SA). Our model comprises two primary components: a TCN for extracting time-variant features from EEG signals, followed by a self-attention (SA) layer that assigns importance to these features. By focusing on key features, our model achieves heightened classification accuracy for epilepsy detection.ResultsThe efficacy of our model was validated on a pediatric epilepsy dataset we collected and on the Bonn dataset, attaining accuracies of 95.50% on our dataset, and 97.37% (A v. E), and 93.50% (B vs E), respectively. When compared with other deep learning architectures (temporal convolutional neural network, self-attention network, and standardized convolutional neural network) using the same datasets, our TCN-SA model demonstrated superior performance in the automated detection of epilepsy.ConclusionThe proven effectiveness of the TCN-SA approach substantiates its potential as a valuable tool for the automated detection of epilepsy, offering significant benefits in diverse and complex real-world clinical settings.

Performance investigation of epilepsy detection from noisy EEG signals using base-2-meta stacking classifier

Epilepsy is a chronic neurological disease, characterized by spontaneous, unprovoked, recurrent seizures that may lead to long-term disability and premature death. Despite significant efforts made to improve epilepsy detection clinically and pre-clinically, the pervasive presence of noise in EEG signals continues to pose substantial challenges to their effective application. In addition, discriminant features for epilepsy detection have not been investigated yet. The objective of this study is to develop a hybrid model for epilepsy detection from noisy and fragmented EEG signals. We hypothesized that a hybrid model could surpass existing single models in epilepsy detection. Our approach involves manual noise rejection and a novel statistical channel selection technique to detect epilepsy even from noisy EEG signals. Our proposed Base-2-Meta stacking classifier achieved notable accuracy (0.98 ± 0.05), precision (0.98 ± 0.07), recall (0.98 ± 0.05), and F1 score (0.98 ± 0.04) even with noisy 5-s segmented EEG signals. Application of our approach to the specific problem like detection of epilepsy from noisy and fragmented EEG data reveals a performance that is not only superior to others, but also is translationally relevant, highlighting its potential application in a clinic setting, where EEG signals are often noisy or scanty. Our proposed metric DF-A (Discriminant feature-accuracy), for the first time, identified the most discriminant feature with models that give A accuracy or above (A = 95 used in this study). This groundbreaking approach allows for detecting discriminant features and can be used as potential electrographic biomarkers in epilepsy detection research. Moreover, our study introduces innovative insights into the understanding of these features, epilepsy detection, and cross-validation, markedly improving epilepsy detection in ways previously unavailable.

Mobilenet, inception ResNet and GoogleNet for epilepsy detection using spectrogram images

Epilepsy is considered the most common cerebral disorder, around 1% of the worldwide population suffer from it. Recently, detection of epilepsy has attracted more and more attention. It has become a hastily increasing problem that can worsen their conditions which necessitate a specific and crucial attention where the symptoms can be an impaired awareness or motor symptoms. Besides that, the difficult process of manual inspection of electroencephalography electroencephalogram (EEG). This paper proposes using transfer learning models to detect both normal and epileptic brain activity and auto-classify signals from the brain. The models considered for this study are GoogleNet, MobileNet, and inception residual neural network inception ResNet. These models were associated with seven different classifiers such as discriminant. These classifiers were tested, analyzed and compared with each other. The efficiency of models is comparatively evaluated through result using multiple metrics. We therefore attained an accuracy of 96.53%, a precision of 97.18%, a false positive rate of 2.78% and an F1-score of 96.50%. Finally, comparison of the suggested approach with existing research shows that the performance of epilepsy classification has been markedly enhanced.

Automatic epilepsy detection with an attention-based multiscale residual network

The deep learning-based automatic detection of epilepsy electroencephalogram (EEG), which can avoid the artificial influence, has attracted much attention, and its effectiveness mainly depends on the deep neural network model. In this paper, an attention-based multi-scale residual network (AMSRN) was proposed in consideration of the multiscale, spatio-temporal characteristics of epilepsy EEG and the information flow among channels, and it was combined with multiscale principal component analysis (MSPCA) to realize the automatic epilepsy detection. Firstly, MSPCA was used for noise reduction and feature enhancement of original epilepsy EEG. Then, we designed the structure and parameters of AMSRN. Among them, the attention module (AM), multiscale convolutional module (MCM), spatio-temporal feature extraction module (STFEM) and classification module (CM) were applied successively to signal reexpression with attention weighted mechanism as well as extraction, fusion and classification for multiscale and spatio-temporal features. Based on the Children's Hospital Boston-Massachusetts Institute of Technology (CHB-MIT) public dataset, the AMSRN model achieved good results in sensitivity (98.56%), F1 score (98.35%), accuracy (98.41%) and precision (98.43%). The results show that AMSRN can make good use of brain network information flow caused by seizures to enhance the difference among channels, and effectively capture the multiscale and spatio-temporal features of EEG to improve the performance of epilepsy detection.

An epilepsy detection method based on multi-dimensional feature extraction and dual-branch hypergraph convolutional network.

Epilepsy is a disease caused by abnormal neural discharge, which severely harms the health of patients. Its pathogenesis is complex and variable with various forms of seizures, leading to significant differences in epilepsy manifestations among different patients. The changes of brain network are strongly correlated with related pathologies. Therefore, it is crucial to effectively and deeply explore the intrinsic features of epilepsy signals to reveal the rules of epilepsy occurrence and achieve accurate detection. Existing methods have faced the following issues: 1) single approach for feature extraction, resulting in insufficient classification information due to the lack of rich dimensions in captured features; 2) inability to deeply analyze the essential commonality of epilepsy signal after feature extraction, making the model susceptible to data distribution and noise interference. Thus, we proposed a high-precision and robust model for epileptic seizure detection, which, for the first time, applies hypergraph convolution to the field of epilepsy detection. Through a hypergraph network structure constructed based on relationships between channels in electroencephalogram (EEG) signals, the model explores higher-order characteristics of epilepsy EEG data. Specifically, we use the Conv-LSTM module and Power spectral density (PSD), a two-branch parallel method, to extract channel features from space-time and frequency domains to solve the problem of insufficient feature extraction, and can adequately describe the data structure and distribution from multiple perspectives through double-branch parallel feature extraction. In addition, we construct a hypergraph on the captured features to explore the intrinsic features in the high-dimensional space in an attempt to reveal the essential commonality of epileptic signal feature extraction. Finally, using the ensemble learning concept, we accomplished epilepsy detection on the dual-branch hypergraph convolution. The model underwent leave-one-out cross-validation on the TUH dataset, achieving an average accuracy of 96.9%, F1 score of 97.3%, Pre of 98.2% and Re of 96.7%. In addition, the model was generalized performance tested on CHB-MIT scalp EEG dataset with leave-one-out cross-validation, and the average ACC, F1 score, Pre and Re were 94.4%, 95.1%, 95.8%, and 93.9% respectively. Experimental results indicate that the model outperforms related literature, providing valuable reference for the clinical application of epilepsy detection.

Combining data augmentation and deep learning for improved epilepsy detection.

In recent years, the use of EEG signals for seizure detection has gained widespread academic attention. Aiming at the problem of overfitting deep learning models due to the small number of EEG signal data during epilepsy detection, this paper proposes an epilepsy detection method that combines data augmentation and deep learning. First, the Adversarial and Mixup Data Augmentation (AMDA) method is used to realize the data augmentation, which effectively enriches the number of training samples. To further improve the classification accuracy and robustness of epilepsy detection, this paper proposes a one-dimensional convolutional neural network and gated recurrent unit (AM-1D CNN-GRU) network model based on attention mechanism for epilepsy detection. The experimental results show that the performance of epilepsy detection achieved by using augmented data is significantly improved, and the accuracy, sensitivity, and area under the subject's working characteristic curve are up to 96.06, 95.48%, and 0.9637, respectively. Compared with the non-augmented data, all indicators are increased by more than 6.2%. Meanwhile, the detection performance was significantly improved compared with other epilepsy detection methods. The results of this research can provide a reference for the clinical application of epilepsy detection.

Continuous ambulatory epilepsy detection system incorporating feature engineering

Epilepsy is a prevailing disease that affects people from different age brackets and demographic backgrounds. It leads to uncontrollable onset of seizures and can result in severe neurological injuries. In this paper, we devised a novel seizure prediction system as a real-time early warning system for patients. By using real-time transmissible, portable, and wireless devices, we can acquire raw data from scalp electroencephalogram (EEG) without any pre-processing for the input. After pre-processing, the data is fed into selected prediction algorithms based on literature review and a combination of methodologies. After times of iteration, our result shows a promising performance, with an accuracy rate of 100% Bonn dataset. We further designed a hardware data acquisition apparatus (with our program built-in) to smooth and ameliorate the data acquisition process when eliminating overmuch electrodes, which may serve as a promising seizure onset detecting device in the new era.

Transfer learning for epilepsy detection using spectrogram images

<span>Epilepsy stands out as one of the common neurological diseases. The neural activity of the brain is observed using electroencephalography (EEG). Manual inspection of EEG brain signals is a slow and arduous process, which puts heavy load on neurologists and affects their performance. The aim of this study is to find the best result of classification using the transfer learning model that automatically identify the epileptic and the normal activity, to classify EEG signals by using images of spectrogram which represents the percentage of energy for each coefficient of the continuous wavelet. Dataset includes the EEG signals recorded at monitoring unit of epilepsy used in this study to presents an application of transfer learning by comparing three models Alexnet, visual geometry group (VGG19) and residual neural network ResNet using different combinations with seven different classifiers. This study tested the models and reached a different value of accuracy and other metrics used to judge their performances, and as a result the best combination has been achieved with ResNet combined with support vector machine (SVM) classifier that classified EEG signals with a high success rate using multiple performance metrics such as 97.22% accuracy and 2.78% the value of the error rate.</span>

Technological Vanguard: the outstanding performance of the LTY-CNN model for the early prediction of epileptic seizures

Background:Epilepsy is a common neurological disorder that affects approximately 60 million people worldwide. Characterized by unpredictable neural electrical activity abnormalities, it results in seizures with varying intensity levels. Electroencephalography (EEG), as a crucial technology for monitoring and predicting epileptic seizures, plays an essential role in improving the quality of life for people with epilepsy.Method:This study introduces an innovative deep learning model, a lightweight triscale yielding convolutional neural network” (LTY-CNN), that is specifically designed for EEG signal analysis. The model integrates a parallel convolutional structure with a multihead attention mechanism to capture complex EEG signal features across multiple scales and enhance the efficiency achieved when processing time series data. The lightweight design of the LTY-CNN enables it to maintain high performance in environments with limited computational resources while preserving the interpretability and maintainability of the model.Results:In tests conducted on the SWEC-ETHZ and CHB-MIT datasets, the LTY-CNN demonstrated outstanding performance. On the SWEC-ETHZ dataset, the LTY-CNN achieved an accuracy of 99.9%, an area under the receiver operating characteristic curve (AUROC) of 0.99, a sensitivity of 99.9%, and a specificity of 98.8%. Furthermore, on the CHB-MIT dataset, it recorded an accuracy of 99%, an AUROC of 0.932, a sensitivity of 99.1%, and a specificity of 93.2%. These results signify the remarkable ability of the LTY-CNN to distinguish between epileptic seizures and nonseizure events. Compared to other existing epilepsy detection classifiers, the LTY-CNN attained higher accuracy and sensitivity.Conclusion:The high accuracy and sensitivity of the LTY-CNN model demonstrate its significant potential for epilepsy management, particularly in terms of predicting and mitigating epileptic seizures. Its value in personalized treatments and widespread clinical applications reflects the broad prospects of deep learning in the health care sector. This also highlights the crucial role of technological innovation in enhancing the quality of life experienced by patients.

Optimized machine learning model for Alzheimer and epilepsy detection from EEG signals

ABSTRACT One of the common nervous system diseases in older adults is Alzheimer's and epilepsy, and the possibility of occurrence increases with age. The chances of seizure are high for patients with mild cognitive impairment and Alzheimer's disease. So, there is a bidirectional association between Alzheimer's and epilepsy, as both affect the neurodegenerative processes. Electroencephalogram (EEG) is a possible non-invasive measurement technique widely used to measure the variations in brain signals. EEG signal is analyzed to discriminate the Alzheimer and epilepsy. Numerous research works evaluated the clinical relevance of Alzheimer's and epilepsy. Specifically, machine learning-based evaluation models developed recently bring the facts by extracting features from the EEG signals. However, machine learning-based models lag in performance due to high dimensional EEG features. For initial feature selection particle swarm optimization is included in the proposed model and to reduce the computation complexity of the classifier, kernel PCA is incorporated for dimensionality reduction. Experimentations using benchmark Bon and Dementia datasets confirms the proposed model better performances in terms of precision, recall, f1-score and accuracy. The attained accuracy of 94% is much better than existing Gaussian Mixture Model (GMM), Relevance Vector Machine (RVM), Support Vector Machine (SVM), and Artificial Neural Network (ANN) methods.

Literature Survey Paper on Epilepsy and Autism Spectrum Disorder Detection and Analysis Using Machine Learning

The detection and cure of epilepsy and autism spectrum disorder (ASD) are significantly complicated by their co-occurrence. This survey research investigates an integrated method for identifying ASD using behavioural characteristic questionnaires and epilepsy using EEG corpus inside a single system. We provide an overview of all the relevant research, emphasizing the difficulties in diagnosing each of these disorders separately and in combination. Our suggested approach combines behavioural questionnaire assessments for ASD with EEG-based analysis for epilepsy detection in an effort to improve diagnostic accuracy and expedite the evaluation process. This study examines the approaches, difficulties, and developments in both domains, providing perspectives on possible overlaps and prospects for further investigation. So, an attempt has been made to review on the pattern detection methods for epilepsy seizure detection from EEG signals. More than 150 research papers have been discussed to determine the techniques for detecting epileptic seizures. Further, the literature review confirms that the pattern recognition techniques required to detect epileptic seizures varies across the electroencephalogram (EEG) datasets of different conditions. This is mostly owing to the fact that EEG detected under different conditions have different characteristics.

Using Nonlinear Features and Logistic Regression for Epilepsy Detection with Linear Complexity

Introduction: In this specific research study, a remarkably accurate and significantly simplified approach has been presented.Material and Metods: this research is encompasses three crucial stages. Firstly, the length of the signal is effectively diminished to an optimal magnitude through the utilization of a technique widely known as windowing. This technique plays a pivotal role in reducing the signal to an ideal size, ensuring the subsequent stages are executed with utmost precision. Secondly, the pertinent features are extracted from the shortened signal, specifically focusing on the Fractal Dimension, the Hurst Exponent, and the Ratio of Determinism to Recurrence Rate. These features are chosen due to the inherent nonlinear nature of the signal, as they provide valuable insights into the complex patterns and structures present within. Lastly, the extracted features undergo Logistic Regression, a widely employed classification algorithm, to effectively categorize and classify them. This step plays a crucial role in providing a clear and concise understanding of the underlying characteristics of the signal.Results: The implementation of the proposed method not only achieves an outstanding accuracy rate of 99.66%, but it also exhibits a linear time complexity, ensuring efficient processing. Additionally, this method leads to a significant reduction in the length of EEG signals, which is of utmost importance in practical applications.Conclusion: The primary objective of this proposed method revolves around the introduction of an online approach that can seamlessly integrate into healthcare systems. This objective is derived from a comprehensive analysis and evaluation of the obtained results, ensuring the method's practicality and effectiveness are thoroughly assessed.

Automated detection of MRI-negative temporal lobe epilepsy with ROI-based morphometric features and machine learning.

Temporal lobe epilepsy (TLE) predominantly originates from the anteromedial basal region of the temporal lobe, and its prognosis is generally favorable following surgical intervention. However, TLE often appears negative in magnetic resonance imaging (MRI), making it difficult to quantitatively diagnose the condition solely based on clinical symptoms. There is a pressing need for a quantitative, automated method for detecting TLE. This study employed MRI scans and clinical data from 51 retrospective epilepsy cases, dividing them into two groups: 34 patients in TLE group and 17 patients in non-TLE group. The criteria for defining the TLE group were successful surgical removal of the epileptogenic zone in the temporal lobe and a favorable postoperative prognosis. A standard procedure was used for normalization, brain extraction, tissue segmentation, regional brain partitioning, and cortical reconstruction of T1 structural MRI images. Morphometric features such as gray matter volume, cortical thickness, and surface area were extracted from a total of 20 temporal lobe regions in both hemispheres. Support vector machine (SVM), extreme learning machine (ELM), and cmcRVFL+ classifiers were employed for model training and validated using 10-fold cross-validation. The results demonstrated that employing ELM classifiers in conjunction with specific temporal lobe gray matter volume features led to a better identification of TLE. The classification accuracy was 92.79%, with an area under the curve (AUC) value of 0.8019. The method proposed in this study can significantly assist in the preoperative identification of TLE patients. By employing this method, TLE can be included in surgical criteria, which could alleviate patient symptoms and improve prognosis, thereby bearing substantial clinical significance.

Advanced framework for epilepsy detection through image-based EEG signal analysis.

Recurrent and unpredictable seizures characterize epilepsy, a neurological disorder affecting millions worldwide. Epilepsy diagnosis is crucial for timely treatment and better outcomes. Electroencephalography (EEG) time-series data analysis is essential for epilepsy diagnosis and surveillance. Complex signal processing methods used in traditional EEG analysis are computationally demanding and difficult to generalize across patients. Researchers are using machine learning to improve epilepsy detection, particularly visual feature extraction from EEG time-series data. This study examines the application of a Gramian Angular Summation Field (GASF) approach for the analysis of EEG signals. Additionally, it explores the utilization of image features, specifically the Scale-Invariant Feature Transform (SIFT) and Oriented FAST and Rotated BRIEF (ORB) techniques, for the purpose of epilepsy detection in EEG data. The proposed methodology encompasses the transformation of EEG signals into images based on GASF, followed by the extraction of features utilizing SIFT and ORB techniques, and ultimately, the selection of relevant features. A state-of-the-art machine learning classifier is employed to classify GASF images into two categories: normal EEG patterns and focal EEG patterns. Bern-Barcelona EEG recordings were used to test the proposed method. This method classifies EEG signals with 96% accuracy using SIFT features and 94% using ORB features. The Random Forest (RF) classifier surpasses state-of-the-art approaches in precision, recall, F1-score, specificity, and Area Under Curve (AUC). The Receiver Operating Characteristic (ROC) curve shows that Random Forest outperforms Support Vector Machine (SVM) and k-Nearest Neighbors (k-NN) classifiers. The suggested method has many advantages over time-series EEG data analysis and machine learning classifiers used in epilepsy detection studies. A novel image-based preprocessing pipeline using GASF for robust image synthesis and SIFT and ORB for feature extraction is presented here. The study found that the suggested method can accurately discriminate between normal and focal EEG signals, improving patient outcomes through early and accurate epilepsy diagnosis.

Enhanced Epileptic Seizure Identification using Sparse ELM-ABO Fusion with Feature Reduction and Multi-class Classification

The interpretation of the electroencephalogram (EEG) signal is one method that can be utilized to diagnose epilepsy, which is one of the most prevalent brain illnesses. The length of an EEG signal is typically quite long, making it difficult to interpret manually. Extreme Learning Machine (ELM) is used to detection of Epilepsy and Seizure. But in ELM Storage space and training time is high. In order to reduce training time and storage space African Buffalo Optimization (ABO) algorithm is used. ABO is combined with Sparse ELM to improve the speed, accuracy of detection and reduce the storage space. First, Wavelet transform is used to extract relevant features. Due to their high dimensionality, these features are then reduced by using linear discriminant analysis (LDA). The proposed Hybrid Sparse ELM technique is successfully implemented for diagnosing epileptic seizure disease. For classification, the Sparse ELM-ABO classifier is applied to the UCI Epileptic Seizure Recognition Data Set training dataset, and the experimental findings are compared to those of the SVM, Sparse ELM, and ELM classifiers applied to the same database. The proposed model was tested in two scenarios: binary classification and multi-label classification. Seizure identification is the only factor in binary classification. Seizure and epilepsy identification are part of multi-label classification. It is observed that the proposed method obtained high accuracy in classification with less execution time along with performance evaluation of parameters such as prediction accuracy, specificity, precision, recall and F-score. Binary classification scores 96.08%, while multi-label classification achieves 90.89%.

Optimization of epilepsy detection method based on dynamic EEG channel screening

To decrease the interference in the process of epileptic feature extraction caused by insufficient detection capability in partial channels of focal epilepsy, this paper proposes a novel epilepsy detection method based on dynamic electroencephalogram (EEG) channel screening. This method not only extracts more effective epilepsy features but also finds common features among different epilepsy subjects, providing an effective approach and theoretical support for across-subject epilepsy detection in clinical scenarios.Firstly, we use the Refine Composite Multiscale Dispersion Entropy (RCMDE) to measure the complexity of EEG signals between normal and seizure states and realize the dynamic EEG channel screening among different subjects, which can enhance the capability of feature extraction and the robustness of epilepsy detection. Subsequently, we discover common epilepsy features in 3–15 Hz among different subjects by the screened EEG channels. By this finding, we construct the Residual Convolutional Long Short-Term Memory (ResCon-LSTM) neural network to accomplish across-subject epilepsy detection.The experiment results on the CHB-MIT dataset indicate that the highest accuracy of epilepsy detection in the single-subject experiment is 98.523 %, improved by 5.298 % compared with non-channel screening. In the across-subject experiment, the average accuracy is 96.596 %. Therefore, this method could be effectively applied to different subjects by dynamically screening optimal channels and keep a good detection performance.

Retracted: Automatic Detection of Epilepsy Based on Entropy Feature Fusion and Convolutional Neural Network.

[This retracts the article DOI: 10.1155/2022/1322826.].

Combining general and personal models for epilepsy detection with hyperdimensional computing

Epilepsy is a highly prevalent chronic neurological disorder with great negative impact on patients’ daily lives. Despite this there is still no adequate technological support to enable epilepsy detection and continuous outpatient monitoring in everyday life. Hyperdimensional (HD) computing is a promising method for epilepsy detection via wearable devices, characterized by a simpler learning process and lower memory requirements compared to other methods. In this work, we demonstrate additional avenues in which HD computing and the manner in which its models are built and stored can be used to better understand, compare and create more advanced machine learning models for epilepsy detection. These possibilities are not feasible with other state-of-the-art models, such as random forests or neural networks. We compare inter-subject model similarity of different classes (seizure and non-seizure), study the process of creating general models from personal ones, and finally posit a method of combining personal and general models to create hybrid models. This results in an improved epilepsy detection performance. We also tested knowledge transfer between models trained on two different datasets. The attained insights are highly interesting not only from an engineering perspective, to create better models for wearables, but also from a neurological perspective, to better understand individual epilepsy patterns.