Epidemiology Of Peptic Ulcer Disease Research Articles

Duodenal ulcer perforation in the rural population of Andhra Pradesh: A tertiary care hospital based study

Hyperacidity is not a prerequisite for duodenal ulcers. Failure of mucosal defenses against gastric acid and pepsin results in ulceration Based on today’s life style it is evident that the epidemiology of peptic ulcer disease largely are related to environmental factors, primarily Helicobacter pylori infection, NSAID use, and smoking, Out of 52 cases of perforated duodenal ulcers, 38 cases (73%) belonged to lower socioeconomi status. Mortality of perforated duodenal ulcer has declined from 40 percent to the present level of less than 10 percent, Perforation is an acute emergency which has to be treated without delay to decrease the mortality.

Из истории эпидемиологии язвенной болезни в XX веке: социальные факторы и уровень заболеваемости

Из истории эпидемиологии язвенной болезни в XX веке: социальные факторы и уровень заболеваемости

Из истории эпидемиологии язвенной болезни в XX веке: социальные факторы и уровень заболеваемости

Из истории эпидемиологии язвенной болезни в XX веке: социальные факторы и уровень заболеваемости

A clinical study of duodenal ulcer perforation

Background: Time trends in the epidemiology of perforated peptic ulcer disease reflect complex, multifactorial etiologies. Based on today’s fast and instant life style it is evident that the epidemiology of peptic ulcer disease largely reflects environmental factors, primarily Helicobacter pylori infection, NSAID use, and smoking . Methods: Surgery was defined as urgent less as 4 hours between admission and surgery, same day (4-24 hours) and delayed at a later time during the same admission. This study comprises of 60 cases of duodenal ulcer perforation admitted in the Department of Surgery, Tertiary care Hospital. Operative details included the site and nature of operation performed. Results: Highest incidence was found in 40 – 49 years of age (25%) followed by 20 – 29 years (21.67%), 30 – 39 years (20%), and 50 – 59 years (15%) . Conclusions: Duodenal ulcer perforation was more common in the age group of 40-49 years.

Epidemiology of Peptic Ulcer Disease in Korea

Epidemiology of Peptic Ulcer Disease in Korea

Time trends in epidemiology of peptic ulcer disease in India over two decades

Epidemiology of peptic ulcer disease (PUD) in India differs from that in the West. It may have undergone a change with recent improvement in hygiene and availability of potent antisecretory and ulcerogenic drugs. We therefore tried to assess time-trends in the frequency of PUD over the past two decades. Records of patients with uninvestigated dyspepsia and no alarm symptoms who had undergone upper gastrointestinal endoscopy at our institution during the years 1988 (n = 2,358), 1992 (n = 2,240), 1996 (n = 5,261), 2000 (n = 7,051), 2004 (n = 5,767) and 2008 (n = 7,539) were retrospectively reviewed. The frequencies of duodenal and gastric ulcer disease in these groups were compared. Of the 30,216 patients (age:41.7±12.7 years, 34 % females) during the six study periods, 2,360 (7.8 %) had PUD. The frequencies of both duodenal ulcer and gastric ulcer showed a decline from 1988 to 2008, i.e. from 12 % to 2.9 % and 4.5 % to 2.7 %, respectively (p-value <0.001 for trend for each). The decline was more marked for duodenal ulcer, and the ratio of duodenal to gastric ulcer declined from 2.7 in 1988 to 1.1 in 2008. The epidemiology of PUD in India may have changed in the past two decades with the incidence of duodenal ulcer declining more rapidly than that of gastric ulcer.

Therapeutic Management of Recurrent Peptic Ulcer Disease

The epidemiology of peptic ulcer disease (PUD) has undergone significant changes since the discovery of Helicobacter pylori. Various aetiologies contribute to recurrent PUD. Ulcers related to untreated H. pylori infection tend to recur. Use of NSAIDs, low-dose aspirin and dual anti-platelet therapy have become important risk factors for recurrent ulcers and their complications as the proportion of H. pylori-related ulcers declines. Recent data have shown that H. pylori-negative, NSAID-negative idiopathic peptic ulcers are on the rise and carry a higher risk of recurrent ulcer bleeding and mortality. Effective management of recurrent PUD relies on identification and modification of treatable risk factors. Persistent H. pylori infection should be carefully ruled out. Choice of an effective H. pylori eradication regimen should be based on local antibacterial resistance patterns. For patients who need long-term NSAID therapy, the initial choice of an NSAID relates to a patient's cardiovascular risk, and the need for therapy to decrease gastrointestinal (GI) complications is determined by the severity and number of GI risk factors. For patients on dual anti-platelet therapy, strategies to prevent recurrent ulcer disease and its complications centre on balancing the bleeding and thrombotic risks of individual patients. Long-term proton pump inhibitor maintenance therapy may be necessary to prevent recurrent ulcer bleeding for patients with ulcer bleeding from H. pylori-negative, NSAID-negative ulcers, and for patients who require NSAID or aspirin maintenance therapy.

Epidemiology of Peptic Ulcer Disease: Endoscopic Results of the Systematic Investigation of Gastrointestinal Disease in China

Epidemiology of Peptic Ulcer Disease: Endoscopic Results of the Systematic Investigation of Gastrointestinal Disease in China

Epidemiology of Peptic Ulcer Disease: Endoscopic Results of the Systematic Investigation of Gastrointestinal Disease in China

Complications of peptic ulcer disease (PUD) are common in China. Population-based estimates of the prevalence of PUD are needed to quantify and characterize the population at risk of these complications. As part of a large epidemiological study, 3,600 randomly selected residents of Shanghai (aged 18-80 years) were asked to undergo endoscopy and to provide blood samples for Helicobacter pylori serology. All participants also completed a general information questionnaire and Chinese versions of the reflux disease questionnaire (RDQ) and Rome II questionnaire. Associations between PUD and other factors were analyzed using a multiple logistic regression model. In total, 3,153 individuals (87.6%) completed the survey. All underwent blood tests, and 1,030 patients (32.7%) agreed to undergo endoscopy. Results from 1,022 patients were suitable for analysis. In all, 176 participants (17.2%) had PUD (62 with gastric ulcer; 136 with duodenal ulcer). The prevalence of H. pylori infection was 73.3% in the total population and 92.6% among those with PUD. H. pylori infection was associated with the presence of PUD (odds ratio (OR), 6.77; 95% confidence interval (CI), 2.85-16.10). The majority (72.2%) of individuals with PUD had none of the upper gastrointestinal symptoms assessed by the RDQ. PUD was not significantly associated with symptom-defined gastroesophageal reflux disease (GERD) (OR, 0.80; 95% CI, 0.32-2.03), reflux esophagitis (OR, 1.46; 95% CI, 0.76-2.79) or dyspepsia (OR, 1.69; 95% CI, 0.94-3.04). The prevalence of endoscopically confirmed PUD in this Shanghai population (17.2%) is substantially higher than in Western populations (4.1%). The majority of individuals with PUD were asymptomatic.

The Changing Epidemiology of Peptic Ulcer Disease

The two most common causes of peptic ulcer disease are Helicobacter pylori infection and the use of nonsteroidal anti-inflammatory drugs (NSAIDs). As the prevalence of H. pylori infection decreases and NSAID use increases, the relative contribution of each factor to the incidence of peptic ulcer disease (PUD) will change. To evaluate such changes, investigators conducted a 10-year, population-based, cohort …

Epidemiology of peptic ulcer disease in Wuhan area of China from 1997 to 2002.

To describe the epidemiological features of peptic ulcer disease in Wuhan area during 1997-2002, to analyze the sex, age and occupation characteristics, as well as the geographic distribution of peptic ulcer disease, and to determine the effective methods of preventing and controlling peptic ulcer disease. In the early 1980s, the peptic ulcer disease registry system was established to collect the data of peptic ulcer disease in Wuhan area. Here we performed a statistically detailed analysis of 4876 cases of peptic ulcer disease during 1997-2002. The morbidity of peptic ulcer disease between males and females was significantly different (chi(2) = 337.9, P<0.001). The majority of peptic ulcer diseases were found at the age of 20 to 50 years. Because of different occupations, the incidence of peptic ulcer disease was different in different areas. The incidence of peptic ulcer disease is highly associated with sex, age, occupation and geographic environmental factors. By analyzing the epidemiological features of peptic ulcer disease, we can provide the scientific data for prevention and control of peptic ulcer disease.

Epidemiology of peptic ulcer disease in Thailand

Peptic ulcers are common in all regions in Thailand. The true prevalence and incidence of peptic ulcer among the population can never be accurately assessed. National data compiled from official annual reports from provincial hospitals as well as hospital-based data are at best selective and carry several drawbacks in the process of data collection. some generalizations can be made nevertheless. Between 1981 and 1988, the hospitalization rate for peptic ulcer cases throughout the country remained fairly constant at around 111 to 112 per 100,000 population. At a large hospital in Bangkok, the proportions of gastric ulcers and duodenal ulcers cases between 1983 and 1988 were comparable, with more gastric ulcers among females than the males. Mortality among hospitalized peptic ulcer cases declined from 3.4 in 1977 to approximately 2 cases per 100,000 population in 1981 and fell further slightly thereafter. Much more statistical compilation is needed, while clearer diagnostic criteria should be followed in documenting reporting peptic ulcer cases in hospitals in order to arrive at more meaningful interpretations.

Descriptive and analytical epidemiology of peptic ulcer disease in Japan

Descriptive and analytical epidemiology of peptic ulcer disease in Japan

Natural History and Epidemiologic Studies of Peptic Ulcer Disease in Japan

Japanese research on the natural history and epidemiology of peptic ulcer disease is presented. Descriptive summaries from several national and regional studies provide information that may be useful for comparison with corresponding information from Western nations.

Techniques related to the clinical epidemiology of peptic ulcer disease

Techniques related to the clinical epidemiology of peptic ulcer disease

Evidence for a sex-linked difference in aspirin metabolism.

ASPIRIN is the most widely consumed drug on Earth. Although adverse reactions to its use are relatively rare, they are nevertheless clinically common because of the universal use of this “everyman's medicine”. These complications may present as hypersensitivity reactions such as asthma and rhinorrhoea, but most often they take the form of gastric erosions and/or ulcerations with mucosal bleeding. The relative rarity of gastric complications of aspirin ingestion suggests that they occur only in individuals who, for one reason or another, are at greater risk or in circumstances, such as the prior abuse of alcohol, which favour their development. Several studies conducted in Australia provide an important clue to the identification of a population at risk from ingestion of aspirin. In 1963 Billington1,2 reported that the incidence of chronic gastric ulcer in women began to increase after 1943 in New South Wales, something which had not occurred in Australian men. Billington theorized that the factor responsible for this change in the epidemiology of peptic ulcer disease in that part of the world was extraneous and probably behavioural. Then, Chapman and Duggan reported a significant association between gastric ulceration in young women of New South Wales and the regular use of compounds containing aspirin3,4. They found no such association with gastric ulceration in males or with duodenal ulceration in either sex. Other Australian authors have confirmed the existence of an association between chronic usage of aspirin and gastric ulceration5,6. These well controlled clinical studies suggest that women who consume ASA regularly are at a greater risk of developing gastric complications than are men.