Introduction. Economic activity without taking into account the ecological potential of the territory, the possibilities of self-purification of the natural environment, as well as the adaptive capabilities of the population has led to irreversible changes in many territories. This reduces the level of health of the population and hinders the socio-economic development of the regions.Material and methods. The research was conducted in seven cities located in four climatic zones with varying degrees of air pollution. To assess the level of atmospheric air pollution, the P-Pinigin index was used, and the WBGT index was used for meteorological factors. Data on a medico-biological and social nature were obtained through a questionnaire survey of parents (2380 children). The incidence rates were studied based on the materials of primary accounting documents of forms F. 112-u and F. 026-u (2400 children). In 506 children, indices of the functional state of the cardiorespiratory system, the function of the respiratory system, as well as the functional state of children before and after dosed physical activity were studied.Results. The study revealed more numerous groups of frequently and long-term ill children, children with lower indices of respiratory function, and adverse responses to the dosed physical activity. A more adverse effect of the combined effects of harsh climatic conditions and high levels of atmospheric pollution on the studied indices of children’s health was found.Conclusion. The results obtained should be taken into account when organizing medical services and ensuring the sanitary and epidemiological well-being of the population living in the industrial cities of the Northern regions.