Abstract This paper proposes a way to innovate the teaching content and methods centered on building an online teaching system and information management system for innovation and entrepreneurship. In the J2EE-based innovation and entrepreneurship online teaching system, the genetic algorithm is used to improve the Pick-KX algorithm, and the resource allocation scheme is optimized and processed by the genetic algorithm, which effectively improves the efficiency of the Pick-KX algorithm on heterogeneous servers. In the innovation and entrepreneurship information management system, the TF-IDF algorithm and Word2vec are used to convert the text into document vectors, and K-Means clustering is used to realize document clustering, while the HyperLogLog algorithm is used to carry out the system website data statistics. The 2022 computer science and technology students of a teacher training school in Chongqing, China, were used as research subjects to carry out innovative and entrepreneurial teaching practices. The student’s performance on all dimensions of innovation and entrepreneurship practice ability was above 3.5, which was a good performance. In the evaluation of the online teaching system and information management system for innovation and entrepreneurship, the evaluation scores for each dimension are higher than 3.5, which meets the needs of students. After the practice, the average scores of satisfaction with the innovation and entrepreneurship practice course and their development were 9.2 and 9.02, which were improved by 0.42 and 0.68 compared to the pre-practice.
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